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Showing 625 to 636 of 642 entries
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Oxidative Stress in Cancer Cell Metabolism.

Antioxidants (Basel, Switzerland)

Arfin S, Jha NK, Jha SK, Kesari KK, Ruokolainen J, Roychoudhury S, Rathi B, Kumar D.
PMID: 33922139
Antioxidants (Basel). 2021 Apr 22;10(5). doi: 10.3390/antiox10050642.

Reactive oxygen species (ROS) are important in regulating normal cellular processes whereas deregulated ROS leads to the development of a diseased state in humans including cancers. Several studies have been found to be marked with increased ROS production which...

Xenin and Related Peptides: Potential Therapeutic Role in Diabetes and Related Metabolic Disorders.

Clinical medicine insights. Endocrinology and diabetes

Craig SL, Irwin N, Gault VA.
PMID: 34588834
Clin Med Insights Endocrinol Diabetes. 2021 Sep 22;14:11795514211043868. doi: 10.1177/11795514211043868. eCollection 2021.

Xenin bioactivity and its role in normal physiology has been investigated by several research groups since its discovery in 1992. The 25 amino acid peptide hormone is secreted from the same enteroendocrine K-cells as the incretin hormone glucose-dependent insulinotropic...

Eight Weeks of Self-Resisted Neck Strength Training Improves Neck Strength in Age-Grade Rugby Union Players: A Pilot Randomized Controlled Trial.

Sports health

Attwood MJ, Hudd LW, Roberts SP, Irwin G, Stokes KA.
PMID: 34558993
Sports Health. 2021 Sep 24;19417381211044736. doi: 10.1177/19417381211044736. Epub 2021 Sep 24.

BACKGROUND: Greater neck strength is associated with fewer head and neck injuries. Neck-strengthening programs are commonly burdensome, requiring specialist equipment or significant time commitment, which are barriers to implementation.HYPOTHESIS: Completing a neck-strengthening program will increase isometric neck strength in...

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators.

Retrovirology

Zhang S, Holmes AP, Dick A, Rashad AA, Enríquez Rodríguez L, Canziani GA, Root MJ, Chaiken IM.
PMID: 34627310
Retrovirology. 2021 Oct 09;18(1):31. doi: 10.1186/s12977-021-00575-z.

BACKGROUND: We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms of viral escape from this promising class of HIV-1 entry inhibitors.RESULTS: HIV-1...

P054 IBD Associated Surveillance Dysplasia Program: New Integrated Model: Audit, Summary, Future Directions and Literature Review.

The American journal of gastroenterology

Irwin K.
PMID: 34848641
Am J Gastroenterol. 2021 Dec 01;116:S14. doi: 10.14309/01.ajg.0000798816.58077.a6.

No abstract available.

Clostridioides difficile Infection in a Rural New Zealand Secondary Care Centre: An Incidence Case-Control Study.

Internal medicine journal

Johnston M, Irwin J, Roberts S, Leung A, Andersson HS, Orme G, Deroles-Main J, Bakker S.
PMID: 33528096
Intern Med J. 2021 Feb 02; doi: 10.1111/imj.15220. Epub 2021 Feb 02.

BACKGROUND: Clostridioides difficile Infection (CDI) is a form of antibiotic associated infectious diarrhoea resulting in significant morbidity and mortality. Community acquired disease in low risk individuals is increasingly recognised. There are limited New Zealand data published.AIM: To determine the...

Using deep-neural-network-driven facial recognition to identify distinct Kabuki syndrome 1 and 2 gestalt.

European journal of human genetics : EJHG

Rouxel F, Yauy K, Boursier G, Gatinois V, Barat-Houari M, Sanchez E, Lacombe D, Arpin S, Giuliano F, Haye D, Rio M, Toutain A, Dieterich K, Brischoux-Boucher E, Julia S, Nizon M, Afenjar A, Keren B, Jacquette A, Moutton S, Jacquemont ML, Duflos C, Capri Y, Amiel J, Blanchet P, Lyonnet S, Sanlaville D, Genevieve D.
PMID: 34803161
Eur J Hum Genet. 2021 Nov 22; doi: 10.1038/s41431-021-00994-8. Epub 2021 Nov 22.

Kabuki syndrome (KS) is a rare genetic disorder caused by mutations in two major genes, KMT2D and KDM6A, that are responsible for Kabuki syndrome 1 (KS1, OMIM147920) and Kabuki syndrome 2 (KS2, OMIM300867), respectively. We lack a description of...

Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase.

Cell chemical biology

Dawson CD, Irwin SM, Backman LRF, Le C, Wang JX, Vennelakanti V, Yang Z, Kulik HJ, Drennan CL, Balskus EP.
PMID: 33773110
Cell Chem Biol. 2021 Sep 16;28(9):1333-1346.e7. doi: 10.1016/j.chembiol.2021.03.001. Epub 2021 Mar 26.

Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we present a 2.7 Å resolution X-ray structure of wild-type...

A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia.

The Journal of clinical investigation

Bar KJ, Shaw PA, Choi GH, Aqui N, Fesnak A, Yang JB, Soto-Calderon H, Grajales L, Starr J, Andronov M, Mastellone M, Amonu C, Feret G, DeMarshall M, Buchanan M, Caturla M, Gordon J, Wanicur A, Monroy MA, Mampe F, Lindemuth E, Gouma S, Mullin AM, Barilla H, Pronina A, Irwin L, Thomas R, Eichinger RA, Demuth F, Luning Prak ET, Pascual JL, Short WR, Elovitz MA, Baron J, Meyer NJ, Degnan KO, Frank I, Hensley SE, Siegel DL, Tebas P.
PMID: 34788233
J Clin Invest. 2021 Dec 15;131(24). doi: 10.1172/JCI155114.

BackgroundAntibody-based strategies for COVID-19 have shown promise in prevention and treatment of early disease. COVID-19 convalescent plasma (CCP) has been widely used but results from randomized trials supporting its benefit in hospitalized patients with pneumonia are limited. Here, we...

Cellular mechanism of bile acid-accelerated hepatocyte polarity.

Small GTPases

Fu D, Lippincott-Schwartz J, Arias IM.
PMID: 22545229
Small GTPases. 2011 Nov 01;2(6):314-317. doi: 10.4161/sgtp.18087.

We recently discovered that the major mammalian bile acid, taurocholate, accelerated polarity in primary rat hepatocytes. Taurocholate increased cellular cAMP and signals through an Epac-Rap1-MEK-LKB1-AMPK pathway for its polarity effect. This review discusses possible mechanisms for how taurocholate affects...

2D single crystal Bragg-dip mapping by time-of-flight energy-resolved neutron imaging on IMAT@ISIS.

Scientific reports

Strickland J, Tassenberg K, Sheppard G, Nenchev B, Perry S, Li J, Dong H, Burca G, Kelleher J, Irwin S.
PMID: 33247196
Sci Rep. 2020 Nov 27;10(1):20751. doi: 10.1038/s41598-020-77572-3.

The cold neutron imaging and diffraction instrument IMAT, at the second target station of the pulsed neutron and muon source ISIS, is used to investigate bulk mosaicity within as-cast single crystal CMSX-4 and CMSX-10 Ni-base superalloys. Within this study,...

Continuity of Cancer Care: The Surgical Experience of Two Large Cancer Hubs in London and Milan.

Cancers

Monroy-Iglesias MJ, Tagliabue M, Dickinson H, Roberts G, De Berardinis R, Russell B, Moss C, Irwin S, Olsburgh J, Cocco IMF, Schizas A, McCrindle S, Nath R, Brunet A, Simo R, Tornari C, Srinivasan P, Prachalias A, Davies A, Geh J, Fraser S, Routledge T, Ma R, Doerge E, Challacombe B, Nair R, Hadjipavlou M, Scarpinata R, Sorelli P, Dolly S, Mistretta FA, Musi G, Casiraghi M, Aloisi A, Dell'Acqua A, Scaglione D, Zanoni S, Rampazio Da Silva D, Brambilla D, Bertolotti R, Peruzzotti G, Maggioni A, de Cobelli O, Spaggiari L, Ansarin M, Mastrilli F, Gandini S, Jain U, Hamed H, Haire K, Van Hemelrijck M.
PMID: 33808375
Cancers (Basel). 2021 Mar 30;13(7). doi: 10.3390/cancers13071597.

The SARS-CoV-2 (COVID-19) pandemic is having a large effect on the management of cancer patients. This study reports on the approach and outcomes of cancer patients receiving radical surgery with curative intent between March and September 2020 (in comparison...

Showing 625 to 636 of 642 entries