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Showing 9781 to 9789 of 9789 entries
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History-Driven Genetic Modification Design Technique Using a Domain-Specific Lexical Model for the Acceleration of DBTL Cycles for Microbial Cell Factories.

ACS synthetic biology

Nakazawa S, Imaichi O, Kogure T, Kubota T, Toyoda K, Suda M, Inui M, Ito K, Shirai T, Araki M.
PMID: 34351735
ACS Synth Biol. 2021 Sep 17;10(9):2308-2317. doi: 10.1021/acssynbio.1c00234. Epub 2021 Aug 05.

The development of microbes for conducting bioprocessing

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation.

Nature

Saito A, Irie T, Suzuki R, Maemura T, Nasser H, Uriu K, Kosugi Y, Shirakawa K, Sadamasu K, Kimura I, Ito J, Wu J, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Loeber S, Tsuda M, Wang L, Ozono S, Butlertanaka EP, Tanaka YL, Shimizu R, Shimizu K, Yoshimatsu K, Kawabata R, Sakaguchi T, Tokunaga K, Yoshida I, Asakura H, Nagashima M, Kazuma Y, Nomura R, Horisawa Y, Yoshimura K, Takaori-Kondo A, Imai M, Tanaka S, Nakagawa S, Ikeda T, Fukuhara T, Kawaoka Y, Sato K.
PMID: 34823256
Nature. 2021 Nov 25; doi: 10.1038/s41586-021-04266-9. Epub 2021 Nov 25.

During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to...

A case of hypertensive disorders of pregnancy that developed at 9 weeks of gestation.

CEN case reports

Hayashi S, Ohashi N, Goto D, Isomura N, Isobe S, Fujikura T, Fujigaki Y, Shimizu A, Ito H, Yasuda H.
PMID: 33721266
CEN Case Rep. 2021 Nov;10(4):476-482. doi: 10.1007/s13730-021-00592-z. Epub 2021 Mar 15.

Preeclampsia and superimposed preeclampsia usually develop after 20 weeks of gestation. We report a case of a 35-year-old Japanese woman who developed hypertensive disorders of pregnancy (HDP) before 20 weeks of gestation. She presented with hypertension and proteinuria at...

Functional changes of cocultured hepatocyte sheets subjected to continuous liver regeneration stimulation in cDNA-uPA/SCID mouse: Differences in transplantation sites.

Regenerative therapy

Miyamoto D, Sakai Y, Huang Y, Yamasaki C, Tateno C, Hasegawa H, Murai T, Hara T, Adachi T, Soyama A, Hidaka M, Ito S, Kanetaka K, Eguchi S.
PMID: 33816721
Regen Ther. 2021 Mar 18;18:7-11. doi: 10.1016/j.reth.2021.02.004. eCollection 2021 Dec.

AIM: The formation of a secondary liver is expected in ectopic transplants in liver therapy. It is reported that the transplantation of hepatocyte sheets constitutes one of the techniques used to form a secondary liver. Accordingly, we established a...

Factors characterizing gait performance of patients before and soon after knee arthroplasty.

Journal of physical therapy science

Ito H, Ichihara K, Tamari K, Amano T, Tanaka S, Uchida S.
PMID: 33814716
J Phys Ther Sci. 2021 Mar;33(3):274-282. doi: 10.1589/jpts.33.274. Epub 2021 Mar 17.

[Purpose] For monitoring patients with knee osteoarthritis undergoing knee arthroplasty, the Timed Up and Go and maximum walking speed tests are commonly used. To provide appropriate peri-surgical rehabilitation, we evaluated the factors associated with postsurgical changes in Timed Up...

The Establishment of an Optimal Protocol for Contrast-Enhanced Micro-Computed Tomography in the Cloudy Catshark Scyliorhinus torazame.

Journal of aquatic animal health

Ito T, Furuya M, Sasai K.
PMID: 34363233
J Aquat Anim Health. 2021 Aug 07; doi: 10.1002/aah.10143. Epub 2021 Aug 07.

The purpose of this study was to determine the optimal imaging protocol for contrast-enhanced computed tomography (CECT) using micro-CT (μ-CT) for the posterior cardinal vein (PCV), dorsal aorta (DA), hepatic portal vein (HPV), kidney, liver, cephalic arteries (CAs), and...

Assessment of the Implementation of Pharmacogenomic Testing in a Pediatric Tertiary Care Setting.

JAMA network open

Cohn I, Manshaei R, Liston E, Okello JBA, Khan R, Curtis MR, Krupski AJ, Jobling RK, Kalbfleisch K, Paton TA, Reuter MS, Hayeems RZ, Verstegen RHJ, Goldman A, Kim RH, Ito S.
PMID: 34037732
JAMA Netw Open. 2021 May 03;4(5):e2110446. doi: 10.1001/jamanetworkopen.2021.10446.

IMPORTANCE: Pharmacogenomic (PGx) testing provides preemptive pharmacotherapeutic guidance regarding the lack of therapeutic benefit or adverse drug reactions of PGx targeted drugs. Pharmacogenomic information is of particular value among children with complex medical conditions who receive multiple medications and...

β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway.

IBRO neuroscience reports

Minato T, Nakamura N, Saiki T, Miyabe M, Ito M, Matsubara T, Naruse K.
PMID: 35024688
IBRO Neurosci Rep. 2021 Dec 07;12:65-72. doi: 10.1016/j.ibneur.2021.12.001. eCollection 2022 Jun.

β-Aminoisobutyric acid (BAIBA) is a myokine that is secreted from skeletal muscles by the exercise. Recently, increasing evidence has suggested the multifocal physiological activities of BAIBA. In this study, we investigated whether L-BAIBA has protective effects on rat pheochromocytoma...

Visit-to-Visit Blood PressureVariations and Hemodynamic Deterioration in Atherosclerotic Major Cerebral ArteryDisease.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Yamauchi H, Kagawa S, Kusano K, Ito M, Okuyama C.
PMID: 34781205
J Stroke Cerebrovasc Dis. 2022 Jan;31(1):106206. doi: 10.1016/j.jstrokecerebrovasdis.2021.106206. Epub 2021 Nov 12.

OBJECTIVE: Visit-to-visit variations in blood pressure (BP) in patients with atherosclerotic major cerebral artery disease could impair the function of cerebral collaterals, leading to hemodynamic deterioration at follow-up. However, few studies have investigated the relationship between visit-to-visit BP variability...

Showing 9781 to 9789 of 9789 entries