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Showing 25 to 36 of 130 entries
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Radiolysis reduction in liquid solution targets for the production of .

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Zacchia NA, Martinez DM, Hoehr C.
PMID: 31756554
Appl Radiat Isot. 2020 Jan;155:108791. doi: 10.1016/j.apradiso.2019.06.037. Epub 2019 Jun 29.

Increased interest in radiometals for nuclear medicine and imaging can be hampered by radionuclide supply.

Production and Supply of α-Particle-Emitting Radionuclides for Targeted α-Therapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Radchenko V, Morgenstern A, Jalilian AR, Ramogida CF, Cutler C, Duchemin C, Hoehr C, Haddad F, Bruchertseifer F, Gausemel H, Yang H, Osso JA, Washiyama K, Czerwinski K, Leufgen K, Pruszyński M, Valzdorf O, Causey P, Schaffer P, Perron R, Maxim S, Wilbur DS, Stora T, Li Y.
PMID: 34301779
J Nucl Med. 2021 Nov;62(11):1495-1503. doi: 10.2967/jnumed.120.261016. Epub 2021 Jul 22.

Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application...

Rucaparib in patients presenting a metastatic breast cancer with homologous recombination deficiency, without germline BRCA1/2 mutation.

European journal of cancer (Oxford, England : 1990)

Patsouris A, Diop K, Tredan O, Nenciu D, Gonçalves A, Arnedos M, Sablin MP, Jézéquel P, Jimenez M, Droin N, Bièche I, Callens C, Loehr A, Vicier C, Guerin C, Filleron T, André F.
PMID: 34837859
Eur J Cancer. 2021 Dec;159:283-295. doi: 10.1016/j.ejca.2021.09.028. Epub 2021 Nov 25.

BACKGROUND: Breast cancer may present genomic alterations leading to homologous recombination deficiency (HRD). PARP inhibitors have proven their efficacy in patients with HER2-negative (HER2-) metastatic breast cancer (mBC) harbouring germline (g) BRCA1/2 mutations in 3 phases III trials. The...

Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction.

Brain research

Ericsson M, von Saucken V, Newman AJ, Doehr L, Hoesch C, Kim TE, Dettmer U.
PMID: 33571519
Brain Res. 2021 May 01;1758:147349. doi: 10.1016/j.brainres.2021.147349. Epub 2021 Feb 09.

Previous work from our group showed that certain engineered missense mutations to the α-synuclein (αS) KTKEGV repeat motifs abrogate the protein's ability to form native multimers. The resultant excess monomers accumulate in lipid-membrane-rich inclusions associated with neurotoxicity exceeding that...

Convolutional neural network-based automated segmentation and labeling of the lumbar spine X-ray.

Journal of craniovertebral junction & spine

Kónya S, Natarajan TS, Allouch H, Nahleh KA, Dogheim OY, Boehm H.
PMID: 34194159
J Craniovertebr Junction Spine. 2021 Apr-Jun;12(2):136-143. doi: 10.4103/jcvjs.jcvjs_186_20. Epub 2021 Jun 10.

PURPOSE: This study investigated the segmentation metrics of different segmentation networks trained on 730 manually annotated lateral lumbar spine X-rays to test the generalization ability and robustness which are the basis of clinical decision support algorithms.METHODS: Instance segmentation networks...

Limited proteolysis by acrosin affects sperm-binding and mechanical resilience of the mouse zona pellucida.

Molecular human reproduction

Kuske M, Floehr J, Yiallouros I, Michna T, Jahnen-Dechent W, Tenzer S, Stöcker W, Körschgen H.
PMID: 33779727
Mol Hum Reprod. 2021 Mar 24;27(4). doi: 10.1093/molehr/gaab022.

The encounter of oocyte and sperm is the key event initiating embryonic development in mammals. Crucial functions of this existential interaction are determined by proteolytic enzymes, such as acrosin, carried in the sperm head acrosome, and ovastacin, stored in...

Comparison of Technetium-99m-MIBI imaging with MRI for detection of spine involvement in patients with multiple myeloma.

BMC nuclear medicine

Mirzaei S, Filipits M, Keck A, Bergmayer W, Knoll P, Koehn H, Ludwig H, Pecherstorfer M.
PMID: 14670090
BMC Nucl Med. 2003 Dec 11;3(1):2. doi: 10.1186/1471-2385-3-2.

BACKGROUND: Recently, radiopharmaceutical scanning with Tc-99m-MIBI was reported to depict areas with active bone disease in multiple myeloma (MM) with both high sensitivity and specificity. This observation was explained by the uptake of Tc-99m-MIBI by neoplastic cells. The present...

Residency positions offered in three specialties.

Health services research

Lee RH, Hadley J.
PMID: 3570812
Health Serv Res. 1987 Apr;22(1):49-68.
Free PMC Article

Many believe that the changing economic environment might have dramatic effects on the quality or quantity of graduate medical training, yet the evidence is scant. This article assesses the impact of economic factors on the number of residency positions...

Probabilistic analysis and resistance factor calibration for deep foundation design using Monte Carlo simulation.

Heliyon

Vu T, Loehr E, Smith D.
PMID: 30112458
Heliyon. 2018 Aug 13;4(8):e00727. doi: 10.1016/j.heliyon.2018.e00727. eCollection 2018 Aug.

The method of incorporating the sources of parameter uncertainty is crucial when conducting probabilistic analysis for service limit state (SLS) design of a deep foundation. This paper describes the method of using Monte Carlo simulation for probabilistic analyses and...

Letters. Groundwater.

Environmental science & technology

Lehr JH.
PMID: 22276703
Environ Sci Technol. 1980 Mar 01;14(3):244-5. doi: 10.1021/es60163a604.

No abstract available.

For knowledge of the dithioamics of pimelic acid.

Helvetica chimica acta

LEHR H, GUEX W, ERLENMEYER H.
PMID: 18875084
Helv Chim Acta. 1948;31(5):1350. doi: 10.1002/hlca.19480310520.

No abstract available.

New Mauna Loa coronagraph systems.

Applied optics

Fisher RR, Lee RH, Macqueen RM, Poland AI.
PMID: 20309264
Appl Opt. 1981 Mar 15;20(6):1094-101. doi: 10.1364/AO.20.001094.

A new set of instruments, consisting of two coronagraph systems, has been installed and is operating at the Mauna Loa Observing Station, Hawaii, operated by the High Altitude Observatory of Boulder, Colorado. The instruments are the 23-cm objective Mark...

Showing 25 to 36 of 130 entries