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Showing 157 to 161 of 161 entries
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Effect of Matrix-Modulating Enzymes on The Cellular Uptake of Magnetic Nanoparticles and on Magnetic Hyperthermia Treatment of Pancreatic Cancer Models In Vivo.

Nanomaterials (Basel, Switzerland)

Tansi FL, Fröbel F, Maduabuchi WO, Steiniger F, Westermann M, Quaas R, Teichgräber UK, Hilger I.
PMID: 33572222
Nanomaterials (Basel). 2021 Feb 09;11(2). doi: 10.3390/nano11020438.

Magnetic hyperthermia can cause localized thermal eradication of several solid cancers. However, a localized and homogenous deposition of high concentrations of magnetic nanomaterials into the tumor stroma and tumor cells is mostly required. Poorly responsive cancers such as the...

Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.

Gut

Jiménez-Vargas NN, Yu Y, Jensen DD, Bok DD, Wisdom M, Latorre R, Lopez C, Jaramillo-Polanco JO, Degro C, Guzman-Rodriguez M, Tsang Q, Snow Z, Schmidt BL, Reed DE, Lomax AE, Margolis KG, Stein C, Bunnett NW, Vanner SJ.
PMID: 33785555
Gut. 2021 Mar 30; doi: 10.1136/gutjnl-2021-324070. Epub 2021 Mar 30.

OBJECTIVE: The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), which preferentially activates MOPr in acidified diseased tissues,...

Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects.

Gut

Jiménez-Vargas NN, Yu Y, Jensen DD, Bok DD, Wisdom M, Latorre R, Lopez C, Jaramillo-Polanco JO, Degro C, Guzman-Rodriguez M, Tsang Q, Snow Z, Schmidt BL, Reed DE, Lomax AE, Margolis KG, Stein C, Bunnett NW, Vanner SJ.
PMID: 33785555
Gut. 2021 Mar 30; doi: 10.1136/gutjnl-2021-324070. Epub 2021 Mar 30.

OBJECTIVE: The effectiveness of µ-opioid receptor (MOPr) agonists for treatment of visceral pain is compromised by constipation, respiratory depression, sedation and addiction. We investigated whether a fentanyl analogue, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), which preferentially activates MOPr in acidified diseased tissues,...

A critique of the English national policy from a social determinants of health perspective using a realist and problem representation approach: the 'Childhood Obesity: a plan for action' (2016, 2018, 2019).

BMC public health

Griffin N, Phillips SM, Hillier-Brown F, Wistow J, Fairbrother H, Holding E, Powell K, Summerbell C.
PMID: 34906093
BMC Public Health. 2021 Dec 14;21(1):2284. doi: 10.1186/s12889-021-12364-6.

BACKGROUND: The UK government released Chapter 1 of the 'Childhood Obesity: a plan for action' (2016), followed by Chapter 2 (2018) and preliminary Chapter 3 was published for consultation in 2019 (hereon collectively 'The Policy'). The stated policy aims...

Creating Exercise Habits Using Incentives: The Tradeoff between Flexibility and Routinization.

Management science

Beshears J, Lee HN, Milkman KL, Mislavsky R, Wisdom J.
PMID: 35001975
Manage Sci. 2021 Jul;67(7):3985-4642. doi: 10.1287/mnsc.2020.3706. Epub 2020 Oct 15.

Habits involve regular, cue-triggered routines. In a field experiment, we tested whether incentivizing exercise routines-paying participants each time they visit the gym within a planned, daily two-hour window-leads to more persistent exercise than offering flexible incentives-paying participants each day...

Showing 157 to 161 of 161 entries