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For debate: substituting placebo controls in long-term Alzheimer's prevention trials.

Alzheimer's research & therapy

Spiegel R, Berres M, Miserez AR, Monsch AU.
PMID: 21418632
Alzheimers Res Ther. 2011 Mar 21;3(2):9. doi: 10.1186/alzrt68.

INTRODUCTION: Novel compounds with potential to attenuate or stop the progression of Alzheimer's disease (AD) from its presymptomatic stage to dementia are being tested in man. The study design commonly used is the long-term randomized, placebo-controlled trial (RPCT), meaning...

Are we missing non-motor seizures in Parkinson's disease? Two case reports.

Journal of clinical movement disorders

Son AY, Cucca A, Agarwal S, Liu A, Di Rocco A, Biagioni MC.
PMID: 28879018
J Clin Mov Disord. 2017 Sep 05;4:14. doi: 10.1186/s40734-017-0061-3. eCollection 2017.

BACKGROUND: Parkinson's disease (PD) is predominantly recognized for its motor symptoms, but patients struggle from a morbid and heterogeneous collection of non-motor symptoms (NMS-PD) that can affect their quality of life even more. NMS-PD is a rather generalized term...

Outcomes following out-of-hospital cardiac arrest: What is the potential for donation after circulatory death?.

Journal of the Intensive Care Society

Tordoff CC, Bodenham AR.
PMID: 28979472
J Intensive Care Soc. 2016 May;17(2):97-102. doi: 10.1177/1751143715613796. Epub 2015 Nov 25.

We conducted a prospective observational study on 100 consecutive patients admitted to intensive care units at Leeds General Infirmary following out-of-hospital cardiac arrest. In the non-survivors, we reviewed their potential for organ donation via donation after circulatory death. Out...

The Synthesis and Characterization of Highly Fluorescent Polycyclic Azaborine Chromophores.

The Journal of organic chemistry

Saint-Louis CJ, Magill LL, Wilson JA, Schroeder AR, Harrell SE, Jackson NS, Trindell JA, Kim S, Fisch AR, Munro L, Catalano VJ, Webster CE, Vaughan PP, Molek KS, Schrock AK, Huggins MT.
PMID: 27704820
J Org Chem. 2016 Nov 18;81(22):10955-10963. doi: 10.1021/acs.joc.6b01998. Epub 2016 Oct 25.

Six new heteroaromatic polycyclic azaborine chromophores were designed, synthesized, and investigated as easily tunable high-luminescent organic materials. The impact of the nitrogen-boron-hydroxy (N-BOH) unit in the azaborines was investigated by comparison with their N-carbonyl analogs. Insertion of the N-B(OH)-C...

Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging.

Analytical chemistry

Cobice DF, Livingstone DE, Mackay CL, Goodwin RJ, Smith LB, Walker BR, Andrew R.
PMID: 27676129
Anal Chem. 2016 Nov 01;88(21):10362-10367. doi: 10.1021/acs.analchem.6b02242. Epub 2016 Oct 14.

Androgens are essential for male development and reproductive function. They are transported to their site of action as blood-borne endocrine hormones but can also be produced within tissues to act in intracrine and paracrine fashions. Because of this, circulating...

Viral Outbreak in Corals Associated with an In Situ Bleaching Event: Atypical Herpes-Like Viruses and a New Megavirus Infecting Symbiodinium.

Frontiers in microbiology

Correa AM, Ainsworth TD, Rosales SM, Thurber AR, Butler CR, Vega Thurber RL.
PMID: 26941712
Front Microbiol. 2016 Feb 22;7:127. doi: 10.3389/fmicb.2016.00127. eCollection 2016.

Previous studies of coral viruses have employed either microscopy or metagenomics, but few have attempted to comprehensively link the presence of a virus-like particle (VLP) to a genomic sequence. We conducted transmission electron microscopy imaging and virome analysis in...

Study of Salmonella Typhimurium Infection in Laying Hens.

Frontiers in microbiology

Pande VV, Devon RL, Sharma P, McWhorter AR, Chousalkar KK.
PMID: 26941727
Front Microbiol. 2016 Feb 25;7:203. doi: 10.3389/fmicb.2016.00203. eCollection 2016.

Members of Salmonella enterica are frequently involved in egg and egg product related human food poisoning outbreaks worldwide. In Australia, Salmonella Typhimurium is frequently involved in egg and egg product related foodborne illness and Salmonella Mbandaka has also been...

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Open forum infectious diseases

Page K, Mirzazadeh A, Rice TM, Grebely J, Kim AY, Cox AL, Morris MD, Hellard M, Bruneau J, Shoukry NH, Dore GJ, Maher L, Lloyd AR, Lauer G, Prins M, McGovern BH.
PMID: 26973850
Open Forum Infect Dis. 2016 Feb 08;3(1):ofw024. doi: 10.1093/ofid/ofw024. eCollection 2016 Jan.

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of...

Superhydrophilic Functionalization of Microfiltration Ceramic Membranes Enables Separation of Hydrocarbons from Frac and Produced Water.

Scientific reports

Maguire-Boyle SJ, Huseman JE, Ainscough TJ, Oatley-Radcliffe DL, Alabdulkarem AA, Al-Mojil SF, Barron AR.
PMID: 28947793
Sci Rep. 2017 Sep 25;7(1):12267. doi: 10.1038/s41598-017-12499-w.

The environmental impact of shale oil and gas production by hydraulic fracturing (fracking) is of increasing concern. The biggest potential source of environmental contamination is flowback and produced water, which is highly contaminated with hydrocarbons, bacteria and particulates, meaning...

Preservation of the Sterile Matrix, Hyponychium, and Fingertip Pad in Fingertip Reconstruction With Composite Fingertip and Nail Bed Graft and Volar V-Y Advancement Flap.


Henderson JT, Schulz SA, Swiergosz AM, Hiller AR, Gunn JS, Choo JH, Kasdan ML, Wilhelmi BJ.
PMID: 28943994
Eplasty. 2017 Sep 08;17:e28. eCollection 2017.

No abstract available.

The role of cognitive dysfunction in the symptoms and remission from depression.

Annals of general psychiatry

Gonda X, Pompili M, Serafini G, Carvalho AF, Rihmer Z, Dome P.
PMID: 26396586
Ann Gen Psychiatry. 2015 Sep 22;14:27. doi: 10.1186/s12991-015-0068-9. eCollection 2015.

The disability and burden associated with major depression comes only in part from its affective symptoms; cognitive dysfunctions associated with depression also play a crucial role. Furthermore, these cognitive impairments during depression are manifold and multilevel affecting elementary and...

Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells.

Stem cells international

Yu D, Du Z, Pian L, Li T, Wen X, Li W, Kim SJ, Xiao J, Cohen P, Cui J, Hoffman AR, Hu JF.
PMID: 28484495
Stem Cells Int. 2017;2017:1764549. doi: 10.1155/2017/1764549. Epub 2017 Apr 06.

No abstract available.

Showing 1 to 12 of 4236 entries