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Showing 1 to 12 of 79 entries
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Peptide array functionalization via the Ugi four-component reaction.

Chemical communications (Cambridge, England)

Ridder B, Mattes DS, Nesterov-Mueller A, Breitling F, Meier MAR.
PMID: 28474022
Chem Commun (Camb). 2017 May 17;53(40):5553-5556. doi: 10.1039/c7cc01945a.

The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arrays via post-synthetic side-chain modification, mimicking post-translational processes. Additionally, as a proof of concept for the synthesis of peptidomimetics on arrays, the integration of an...

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond.

Epigenetics & chromatin

Breiling A, Lyko F.
PMID: 26195987
Epigenetics Chromatin. 2015 Jul 21;8:24. doi: 10.1186/s13072-015-0016-6. eCollection 2015.

The chemical modification of DNA bases plays a key role in epigenetic gene regulation. While much attention has been focused on the classical epigenetic mark, 5-methylcytosine, the field garnered increased interest through the recent discovery of additional modifications. In...

[On the question of organ tolerance and the median dose in various radiation qualities].

Strahlentherapie

BAUER R, BREITLING G, PETERS K.
PMID: 13797668
Strahlentherapie. 1959 Jun-Jul;109:246-50.

No abstract available.

High-energy particle acceleration in the shell of a supernova remnant.

Nature

Aharonian FA, Akhperjanian AG, Aye KM, Bazer-Bachi AR, Beilicke M, Benbow W, Berge D, Berghaus P, Bernlöhr K, Bolz O, Boisson C, Borgmeier C, Breitling F, Brown AM, Gordo JB, Chadwick PM, Chitnis VR, Chounet LM, Cornils R, Costamante L, Degrange B, Djannati-Ataï A, Drury LO, Ergin T, Espigat P, Feinstein F, Fleury P, Fontaine G, Funk S, Gallant YA, Giebels B, Gillessen S, Goret P, Guy J, Hadjichristidis C, Hauser M, Heinzelmann G, Henri G, Hermann G, Hinton JA, Hofmann W, Holleran M, Horns D, De Jager OC, Jung I, Khélifi B, Komin N, Konopelko A, Latham IJ, Le Gallou R, Lemoine M, Lemière A, Leroy N, Lohse T, Marcowith A, Masterson C, McComb TJ, De Naurois M, Nolan SJ, Noutsos A, Orford KJ, Osborne JL, Ouchrif M, Panter M, Pelletier G, Pita S, Pohl M, Pühlhofer G, Punch M, Raubenheimer BC, Raue M, Raux J, Rayner SM, Redondo I, Reimer A, Reimer O, Ripken J, Rivoal M, Rob L, Rolland L, Rowell G, Sahakian V, Saugé L, Schlenker S, Schlickeiser R, Schuster C, Schwanke U, Siewert M, Sol H, Steenkamp R, Stegmann C, Tavernet JP, Théoret CG, Tluczykont M, Van Der Walt DJ, Vasileiadis G, Vincent P, Visser B, Völk HJ, Wagner SJ.
PMID: 15525982
Nature. 2004 Nov 04;432(7013):75-7. doi: 10.1038/nature02960.

A significant fraction of the energy density of the interstellar medium is in the form of high-energy charged particles (cosmic rays). The origin of these particles remains uncertain. Although it is generally accepted that the only sources capable of...

dagR: a suite of R functions for directed acyclic graphs.

Epidemiology (Cambridge, Mass.)

Breitling LP.
PMID: 20539116
Epidemiology. 2010 Jul;21(4):586-7. doi: 10.1097/EDE.0b013e3181e09112.

No abstract available.

Synchronous x-ray and radio mode switches: a rapid global transformation of the pulsar magnetosphere.

Science (New York, N.Y.)

Hermsen W, Hessels JW, Kuiper L, van Leeuwen J, Mitra D, de Plaa J, Rankin JM, Stappers BW, Wright GA, Basu R, Alexov A, Coenen T, Grießmeier JM, Hassall TE, Karastergiou A, Keane E, Kondratiev VI, Kramer M, Kuniyoshi M, Noutsos A, Serylak M, Pilia M, Sobey C, Weltevrede P, Zagkouris K, Asgekar A, Avruch IM, Batejat F, Bell ME, Bell MR, Bentum MJ, Bernardi G, Best P, Bîrzan L, Bonafede A, Breitling F, Broderick J, Brüggen M, Butcher HR, Ciardi B, Duscha S, Eislöffel J, Falcke H, Fender R, Ferrari C, Frieswijk W, Garrett MA, de Gasperin F, de Geus E, Gunst AW, Heald G, Hoeft M, Horneffer A, Iacobelli M, Kuper G, Maat P, Macario G, Markoff S, McKean JP, Mevius M, Miller-Jones JC, Morganti R, Munk H, Orrú E, Paas H, Pandey-Pommier M, Pandey VN, Pizzo R, Polatidis AG, Rawlings S, Reich W, Röttgering H, Scaife AM, Schoenmakers A, Shulevski A, Sluman J, Steinmetz M, Tagger M, Tang Y, Tasse C, ter Veen S, Vermeulen R, van de Brink RH, van Weeren RJ, Wijers RA, Wise MW, Wucknitz O, Yatawatta S, Zarka P.
PMID: 23349288
Science. 2013 Jan 25;339(6118):436-9. doi: 10.1126/science.1230960.

Pulsars emit from low-frequency radio waves up to high-energy gamma-rays, generated anywhere from the stellar surface out to the edge of the magnetosphere. Detecting correlated mode changes across the electromagnetic spectrum is therefore key to understanding the physical relationship...

Metabolomics : Official journal of the Metabolomic Society

Breitling R, Ritchie S, Goodenowe D, Stewart ML, Barrett MP.
PMID: 24489532
Metabolomics. 2006;2(3):155-164. doi: 10.1007/s11306-006-0029-z. Epub 2006 Jul 25.

Fourier transform mass spectrometry has recently been introduced into the field of metabolomics as a technique that enables the mass separation of complex mixtures at very high resolution and with ultra high mass accuracy. Here we show that this...

LC-MS metabolomics from study design to data-analysis - using a versatile pathogen as a test case.

Computational and structural biotechnology journal

Berg M, Vanaerschot M, Jankevics A, Cuypers B, Breitling R, Dujardin JC.
PMID: 24688684
Comput Struct Biotechnol J. 2013 Feb 06;4:e201301002. doi: 10.5936/csbj.201301002. eCollection 2013.

Thanks to significant improvements in LC-MS technology, metabolomics is increasingly used as a tool to discriminate the responses of organisms to various stimuli or drugs. In this minireview we discuss all aspects of the LC-MS metabolomics pipeline, using a...

Cloning and Expression of Single-Chain Fragments (scFv) from Mouse and Rat Hybridomas.

Methods in molecular medicine

Breitling F, Dübel S.
PMID: 21390867
Methods Mol Med. 1998;13:581-91. doi: 10.1385/0-89603-485-2:581.

For cloning and expressing the antigen-binding variable (Fv) portion of an antibody in Escherzchia coli, vectors have been constructed that combine the two variable regions (V(H) and V(L)) with a peptide linker (1-3). The genetic information for V(H) and...

SecA is required for membrane targeting of the cell division protein DivIVA in vivo.

Frontiers in microbiology

Halbedel S, Kawai M, Breitling R, Hamoen LW.
PMID: 24592260
Front Microbiol. 2014 Feb 14;5:58. doi: 10.3389/fmicb.2014.00058. eCollection 2014.

The conserved protein DivIVA is involved in different morphogenetic processes in Gram-positive bacteria. In Bacillus subtilis, the protein localizes to the cell division site and cell poles, and functions as a scaffold for proteins that regulate division site selection,...

biochem4j: Integrated and extensible biochemical knowledge through graph databases.

PloS one

Swainston N, Batista-Navarro R, Carbonell P, Dobson PD, Dunstan M, Jervis AJ, Vinaixa M, Williams AR, Ananiadou S, Faulon JL, Mendes P, Kell DB, Scrutton NS, Breitling R.
PMID: 28708831
PLoS One. 2017 Jul 14;12(7):e0179130. doi: 10.1371/journal.pone.0179130. eCollection 2017.

Biologists and biochemists have at their disposal a number of excellent, publicly available data resources such as UniProt, KEGG, and NCBI Taxonomy, which catalogue biological entities. Despite the usefulness of these resources, they remain fundamentally unconnected. While links may...

Respectful Modeling: Addressing Uncertainty in Dynamic System Models for Molecular Biology.

Trends in biotechnology

Tsigkinopoulou A, Baker SM, Breitling R.
PMID: 28094080
Trends Biotechnol. 2017 Jun;35(6):518-529. doi: 10.1016/j.tibtech.2016.12.008. Epub 2017 Jan 13.

Although there is still some skepticism in the biological community regarding the value and significance of quantitative computational modeling, important steps are continually being taken to enhance its accessibility and predictive power. We view these developments as essential components...

Showing 1 to 12 of 79 entries