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Science in the UK - whereto now?.

Biomolecular detection and quantification

Bustin S.
PMID: 27679763
Biomol Detect Quantif. 2016 Aug 21;9:A1-4. doi: 10.1016/j.bdq.2016.08.001. eCollection 2016 Sep.

No abstract available.

Triangulation research among culturally diverse populations.

Journal of allied health

Bechtel GA, Davidhizar R, Bunting S.
PMID: 10874331
J Allied Health. 2000;29(2):61-3.

There exists an ongoing challenge in the health sciences to develop research methods that effectively describe patterns of health beliefs and actions in different cultures. While the dominant framework for research has traditionally been the quantitative paradigm, qualitative methods...

First Report of a Single Exon Deletion in TCOF1 Causing Treacher Collins Syndrome.

Molecular syndromology

Beygo J, Buiting K, Seland S, Lüdecke HJ, Hehr U, Lich C, Prager B, Lohmann DR, Wieczorek D.
PMID: 22712005
Mol Syndromol. 2012 Jan;2(2):53-59. doi: 10.1159/000335545. Epub 2012 Jan 26.

Treacher Collins syndrome (TCS) is a rare craniofacial disorder characterized by facial anomalies and ear defects. TCS is caused by mutations in the TCOF1 gene and follows autosomal dominant inheritance. Recently, mutations in the POLR1D and POLR1C genes have...

Homogeneous and digital proximity ligation assays for the detection of .

Biomolecular detection and quantification

Dhillon HS, Johnson G, Shannon M, Greenwood C, Roberts D, Bustin S.
PMID: 27990343
Biomol Detect Quantif. 2016 Aug 31;10:2-8. doi: 10.1016/j.bdq.2016.06.003. eCollection 2016 Dec.

BACKGROUND: The proximity ligation assay (PLA) detects proteins via their interaction with pairs of proximity probes, which are antibodies coupled to noncomplementary DNA oligonucleotides. The binding of both proximity probes to their epitopes on the target protein brings the...

A large light-mass component of cosmic rays at 10(17)-10(17.5) electronvolts from radio observations.

Nature

Buitink S, Corstanje A, Falcke H, Hörandel JR, Huege T, Nelles A, Rachen JP, Rossetto L, Schellart P, Scholten O, ter Veen S, Thoudam S, Trinh TN, Anderson J, Asgekar A, Avruch IM, Bell ME, Bentum MJ, Bernardi G, Best P, Bonafede A, Breitling F, Broderick JW, Brouw WN, Brüggen M, Butcher HR, Carbone D, Ciardi B, Conway JE, de Gasperin F, de Geus E, Deller A, Dettmar RJ, van Diepen G, Duscha S, Eislöffel J, Engels D, Enriquez JE, Fallows RA, Fender R, Ferrari C, Frieswijk W, Garrett MA, Grießmeier JM, Gunst AW, van Haarlem MP, Hassall TE, Heald G, Hessels JW, Hoeft M, Horneffer A, Iacobelli M, Intema H, Juette E, Karastergiou A, Kondratiev VI, Kramer M, Kuniyoshi M, Kuper G, van Leeuwen J, Loose GM, Maat P, Mann G, Markoff S, McFadden R, McKay-Bukowski D, McKean JP, Mevius M, Mulcahy DD, Munk H, Norden MJ, Orru E, Paas H, Pandey-Pommier M, Pandey VN, Pietka M, Pizzo R, Polatidis AG, Reich W, Röttgering HJ, Scaife AM, Schwarz DJ, Serylak M, Sluman J, Smirnov O, Stappers BW, Steinmetz M, Stewart A, Swinbank J, Tagger M, Tang Y, Tasse C, Toribio MC, Vermeulen R, Vocks C, Vogt C, van Weeren RJ, Wijers RA, Wijnholds SJ, Wise MW, Wucknitz O, Yatawatta S, Zarka P, Zensus JA.
PMID: 26935696
Nature. 2016 Mar 03;531(7592):70-3. doi: 10.1038/nature16976.

Cosmic rays are the highest-energy particles found in nature. Measurements of the mass composition of cosmic rays with energies of 10(17)-10(18) electronvolts are essential to understanding whether they have galactic or extragalactic sources. It has also been proposed that...

Degradation of polyvinyl alcohol under mechanothermal stretching.

Journal of molecular modeling

Cristancho D, Zhou Y, Cooper R, Huitink D, Aksoy F, Liu Z, Liang H, Seminario JM.
PMID: 23649348
J Mol Model. 2013 Aug;19(8):3245-53. doi: 10.1007/s00894-013-1828-6. Epub 2013 May 07.

Mechanical and thermal properties of polyvinyl alcohol (PVA) are characterized and analyzed using in situ X-ray photoelectron spectroscopy (XPS) and quantum chemistry calculations. It is found that the carbon peaks-commonly used as the reference for spectroscopic analysis-shift under mechanical...

Angelman Syndrome-Affected Individual with a Numerically Normal Karyotype and Isodisomic Paternal Uniparental Disomy of Chromosome 15 due to Maternal Robertsonian Translocation (14;15) by Monosomy Rescue.

Cytogenetic and genome research

Bramswig NC, Buiting K, Bechtel N, Horsthemke B, Rostasy K, Wieczorek D.
PMID: 30016768
Cytogenet Genome Res. 2018 Jul 18; doi: 10.1159/000490838. Epub 2018 Jul 18.

Angelman syndrome (AS) is a neurodevelopmental disorder caused by deletion of the maternally inherited 15q11q13 region, paternal uniparental disomy 15 [upd(15)pat], an imprinting defect of the maternal chromosome region 15q11q13, or a pathogenic mutation of the maternal UBE3A allele....

Deep learning-based detection of seedling development.

Plant methods

Samiei S, Rasti P, Ly Vu J, Buitink J, Rousseau D.
PMID: 32742300
Plant Methods. 2020 Jul 30;16:103. doi: 10.1186/s13007-020-00647-9. eCollection 2020.

BACKGROUND: Monitoring the timing of seedling emergence and early development via high-throughput phenotyping with computer vision is a challenging topic of high interest in plant science. While most studies focus on the measurements of leaf area index or detection...

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.

ACS medicinal chemistry letters

Saraswati AP, Relitti N, Brindisi M, Osko JD, Chemi G, Federico S, Grillo A, Brogi S, McCabe NH, Turkington RC, Ibrahim O, O'Sullivan J, Lamponi S, Ghanim M, Kelly VP, Zisterer D, Amet R, Hannon Barroeta P, Vanni F, Ulivieri C, Herp D, Sarno F, Di Costanzo A, Saccoccia F, Ruberti G, Jung M, Altucci L, Gemma S, Butini S, Christianson DW, Campiani G.
PMID: 33214839
ACS Med Chem Lett. 2020 Sep 29;11(11):2268-2276. doi: 10.1021/acsmedchemlett.0c00395. eCollection 2020 Nov 12.

Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-selective inhibitors based on the X-ray crystal studies of the...

Correction: Intermittent enzyme replacement therapy prevents Neu1 deficiency.

The Journal of biological chemistry

Luu AR, Wong C, Agrawal V, Wise N, Handyside B, Lo MJ, Pacheco G, Felix JB, Giaramita A, d'Azzo A, Vincelette J, Bullens S, Bunting S, Christianson TM, Hague CM, LeBowitz JH, Yogalingam G.
PMID: 33188082
J Biol Chem. 2020 Nov 13;295(46):15794. doi: 10.1074/jbc.AAC120.016409.

No abstract available.

Features of the Energy Spectrum of Cosmic Rays above 2.5×10^{18}  eV Using the Pierre Auger Observatory.

Physical review letters

Aab A, Abreu P, Aglietta M, Albury JM, Allekotte I, Almela A, Alvarez Castillo J, Alvarez-Muñiz J, Alves Batista R, Anastasi GA, Anchordoqui L, Andrada B, Andringa S, Aramo C, Araújo Ferreira PR, Asorey H, Assis P, Avila G, Badescu AM, Bakalova A, Balaceanu A, Barbato F, Barreira Luz RJ, Becker KH, Bellido JA, Berat C, Bertaina ME, Bertou X, Biermann PL, Bister T, Biteau J, Blanco A, Blazek J, Bleve C, Boháčová M, Boncioli D, Bonifazi C, Bonneau Arbeletche L, Borodai N, Botti AM, Brack J, Bretz T, Briechle FL, Buchholz P, Bueno A, Buitink S, Buscemi M, Caballero-Mora KS, Caccianiga L, Calcagni L, Cancio A, Canfora F, Caracas I, Carceller JM, Caruso R, Castellina A, Catalani F, Cataldi G, Cazon L, Cerda M, Chinellato JA, Choi K, Chudoba J, Chytka L, Clay RW, Cobos Cerutti AC, Colalillo R, Coleman A, Coluccia MR, Conceição R, Condorelli A, Consolati G, Contreras F, Convenga F, Covault CE, Dasso S, Daumiller K, Dawson BR, Day JA, de Almeida RM, de Jesús J, de Jong SJ, De Mauro G, de Mello Neto JRT, De Mitri I, de Oliveira J, de Oliveira Franco D, de Souza V, De Vito E, Debatin J, Del Río M, Deligny O, Dembinski H, Dhital N, Di Giulio C, Di Matteo A, Díaz Castro ML, Dobrigkeit C, D'Olivo JC, Dorosti Q, Dos Anjos RC, Dova MT, Ebr J, Engel R, Epicoco I, Erdmann M, Escobar CO, Etchegoyen A, Falcke H, Farmer J, Farrar G, Fauth AC, Fazzini N, Feldbusch F, Fenu F, Fick B, Figueira JM, Filipčič A, Fodran T, Freire MM, Fujii T, Fuster A, Galea C, Galelli C, García B, Garcia Vegas AL, Gemmeke H, Gesualdi F, Gherghel-Lascu A, Ghia PL, Giaccari U, Giammarchi M, Giller M, Glombitza J, Gobbi F, Gollan F, Golup G, Gómez Berisso M, Gómez Vitale PF, Gongora JP, González N, Goos I, Góra D, Gorgi A, Gottowik M, Grubb TD, Guarino F, Guedes GP, Guido E, Hahn S, Halliday R, Hampel MR, Hansen P, Harari D, Harvey VM, Haungs A, Hebbeker T, Heck D, Hill GC, Hojvat C, Hörandel JR, Horvath P, Hrabovský M, Huege T, Hulsman J, Insolia A, Isar PG, Johnsen JA, Jurysek J, Kääpä A, Kampert KH, Keilhauer B, Kemp J, Klages HO, Kleifges M, Kleinfeller J, Köpke M, Kukec Mezek G, Lago BL, LaHurd D, Lang RG, Leigui de Oliveira MA, Lenok V, Letessier-Selvon A, Lhenry-Yvon I, Lo Presti D, Lopes L, López R, Lorek R, Luce Q, Lucero A, Machado Payeras A, Malacari M, Mancarella G, Mandat D, Manning BC, Manshanden J, Mantsch P, Marafico S, Mariazzi AG, Mariş IC, Marsella G, Martello D, Martinez H, Martínez Bravo O, Mastrodicasa M, Mathes HJ, Matthews J, Matthiae G, Mayotte E, Mazur PO, Medina-Tanco G, Melo D, Menshikov A, Merenda KD, Michal S, Micheletti MI, Miramonti L, Mockler D, Mollerach S, Montanet F, Morello C, Mostafá M, Müller AL, Muller MA, Mulrey K, Mussa R, Muzio M, Namasaka WM, Nellen L, Nguyen PH, Niculescu-Oglinzanu M, Niechciol M, Nitz D, Nosek D, Novotny V, Nožka L, Nucita A, Núñez LA, Palatka M, Pallotta J, Panetta MP, Papenbreer P, Parente G, Parra A, Pech M, Pedreira F, Pȩkala J, Pelayo R, Peña-Rodriguez J, Perez Armand J, Perlin M, Perrone L, Peters C, Petrera S, Pierog T, Pimenta M, Pirronello V, Platino M, Pont B, Pothast M, Privitera P, Prouza M, Puyleart A, Querchfeld S, Rautenberg J, Ravignani D, Reininghaus M, Ridky J, Riehn F, Risse M, Ristori P, Rizi V, Rodrigues de Carvalho W, Rodriguez Fernandez G, Rodriguez Rojo J, Roncoroni MJ, Roth M, Roulet E, Rovero AC, Ruehl P, Saffi SJ, Saftoiu A, Salamida F, Salazar H, Salina G, Sanabria Gomez JD, Sánchez F, Santos EM, Santos E, Sarazin F, Sarmento R, Sarmiento-Cano C, Sato R, Savina P, Schäfer C, Scherini V, Schieler H, Schimassek M, Schimp M, Schlüter F, Schmidt D, Scholten O, Schovánek P, Schröder FG, Schröder S, Schulz A, Sciutto SJ, Scornavacche M, Shellard RC, Sigl G, Silli G, Sima O, Šmída R, Sommers P, Soriano JF, Souchard J, Squartini R, Stadelmaier M, Stanca D, Stanič S, Stasielak J, Stassi P, Streich A, Suárez-Durán M, Sudholz T, Suomijärvi T, Supanitsky AD, Šupík J, Szadkowski Z, Taboada A, Tapia A, Timmermans C, Tkachenko O, Tobiska P, Todero Peixoto CJ, Tomé B, Torralba Elipe G, Travaini A, Travnicek P, Trimarelli C, Trini M, Tueros M, Ulrich R, Unger M, Urban M, Vaclavek L, Vacula M, Valdés Galicia JF, Valiño I, Valore L, van Vliet A, Varela E, Vargas Cárdenas B, Vásquez-Ramírez A, Veberič D, Ventura C, Vergara Quispe ID, Verzi V, Vicha J, Villaseñor L, Vink J, Vorobiov S, Wahlberg H, Watson AA, Weber M, Weindl A, Wiencke L, Wilczyński H, Winchen T, Wirtz M, Wittkowski D, Wundheiler B, Yushkov A, Zapparrata O, Zas E, Zavrtanik D, Zavrtanik M, Zehrer L, Zepeda A, Ziolkowski M, Zuccarello F.
PMID: 33016715
Phys Rev Lett. 2020 Sep 18;125(12):121106. doi: 10.1103/PhysRevLett.125.121106.

We report a measurement of the energy spectrum of cosmic rays above 2.5×10^{18}  eV based on 215 030 events. New results are presented: at about 1.3×10^{19}  eV, the spectral index changes from 2.51±0.03(stat)±0.05(syst) to 3.05±0.05(stat)±0.10(syst), evolving to 5.1±0.3(stat)±0.1(syst) beyond...

A distinct negative leader propagation mode.

Scientific reports

Scholten O, Hare BM, Dwyer J, Liu N, Sterpka C, Kolmašová I, Santolík O, Lán R, Uhlíř L, Buitink S, Corstanje A, Falcke H, Huege T, Hörandel JR, Krampah GK, Mitra P, Mulrey K, Nelles A, Pandya H, Rachen JP, Trinh TNG, Ter Veen S, Thoudam S, Winchen T.
PMID: 34376724
Sci Rep. 2021 Aug 10;11(1):16256. doi: 10.1038/s41598-021-95433-5.

The common phenomenon of lightning still harbors many secrets such as what are the conditions for lightning initiation and what is driving the discharge to propagate over several tens of kilometers through the atmosphere forming conducting ionized channels called...

Showing 1 to 12 of 89 entries