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Showing 1 to 12 of 16 entries
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The inflammation in cutaneous lichen planus is dominated by IFN-ϒ and IL-21-A basis for therapeutic JAK1 inhibition.

Experimental dermatology

Pietschke K, Holstein J, Meier K, Schäfer I, Müller-Hermelink E, Gonzalez-Menendez I, Quintanilla-Martinez L, Ghoreschi FC, Solimani F, Ghoreschi K.
PMID: 33113249
Exp Dermatol. 2021 Feb;30(2):262-270. doi: 10.1111/exd.14226. Epub 2020 Nov 12.

Cutaneous lichen planus (CLP) and psoriasis (PSO) are both common chronic inflammatory skin diseases for which development of new treatments requires the identification of key targets. While PSO is a typical Th17/IL-17-disorder, there is some evidence that Th1/IFN-ɣ dominate...

Epstein-Barr virus and Hodgkin's lymphoma in Cairo, Egypt.

Journal of hematopathology

Audouin J, Diebold J, Nathwani B, Ishak E, Maclennan K, Mueller-Hermelink HK, Armitage JO, Weisenburger DD.
PMID: 21625283
J Hematop. 2010 Jun;3(1):11-8. doi: 10.1007/s12308-010-0059-3. Epub 2010 May 28.

Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1...

Ki-67 as a prognostic marker in mantle cell lymphoma-consensus guidelines of the pathology panel of the European MCL Network.

Journal of hematopathology

Klapper W, Hoster E, Determann O, Oschlies I, van der Laak J, Berger F, Bernd HW, Cabeçadas J, Campo E, Cogliatti S, Hansmann ML, Kluin PM, Kodet R, Krivolapov YA, Loddenkemper C, Stein H, Möller P, Barth TE, Müller-Hermelink K, Rosenwald A, Ott G, Pileri S, Ralfkiaer E, Rymkiewicz G, van Krieken JH, Wacker HH, Unterhalt M, Hiddemann W, Dreyling M.
PMID: 19669190
J Hematop. 2009 Jul;2(2):103-11. doi: 10.1007/s12308-009-0036-x. Epub 2009 Jun 16.

Mantle cell lymphoma (MCL) has a heterogeneous clinical course and is mainly an aggressive B cell non-Hodgkin lymphoma; however, there are some indolent cases The Ki-67 index, defined by the percentage of Ki-67-positive lymphoma cells on histopathological slides, has...

Fatal Human Meningoencephalitis due to Halicephalobus Nematodes, Germany.

Open forum infectious diseases

Monoranu CM, Müllges W, Keppler M, Brehm K, Ondrejka SL, Muntau B, Tannich E, Müller-Hermelink HK, Tappe D.
PMID: 26125032
Open Forum Infect Dis. 2015 May 22;2(2):ofv061. doi: 10.1093/ofid/ofv061. eCollection 2015 Apr.

Infections with Halicephalobus nematodes, causative agents of severe meningoencephalitis in horses, have rarely been reported in humans. In this study, the clinical, serological, cytokine, and histopathological findings of a rapidly progressive and eventually fatal meningoencephalitis in a previously healthy...

Expression of p-AKT characterizes adenoid cystic carcinomas of head and neck with a higher risk for tumor relapses.

Diagnostic pathology

Völker HU, Scheich M, Berndt A, Haubitz I, Metzger A, Müller-Hermelink HK, Kämmerer U, Schmidt M.
PMID: 19545368
Diagn Pathol. 2009 Jun 19;4:18. doi: 10.1186/1746-1596-4-18.

BACKGROUND: Adenoid cystic carcinomas are rare tumors with an indolent clinical course, but frequent local relapses. The identification of tumors with a higher relapse risk seems to be interesting. Hence we investigated parameters of glucose metabolism, which were found...

Genomic deletion and promoter methylation status of Hypermethylated in Cancer 1 (HIC1) in mantle cell lymphoma.

Journal of hematopathology

Stöcklein H, Hutter G, Kalla J, Hartmann E, Zimmermann Y, Katzenberger T, Adam P, Leich E, Höller S, Müller-Hermelink HK, Rosenwald A, Ott G, Dreyling M.
PMID: 19669207
J Hematop. 2008 Sep;1(2):85-95. doi: 10.1007/s12308-008-0008-6. Epub 2008 Jul 05.

Mantle cell lymphomas (MCL), characterized by the t(11;14)(q13;q32), frequently carry secondary genetic alterations such as deletions in chromosome 17p involving the TP53 locus. Given that the association between TP53-deletions and concurrent mutations of the remaining allele is weak and...

Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.

Journal of hematopathology

Bonzheim I, Geissinger E, Chuang WY, Roth S, Ströbel P, Marx A, Reimer P, Wilhelm M, Puppe B, Rosenwald A, Müller-Hermelink HK, Rüdiger T.
PMID: 19669200
J Hematop. 2008 Jul;1(1):11-21. doi: 10.1007/s12308-008-0003-y. Epub 2008 Apr 24.

Angioimmunoblastic T-cell lymphoma (AILT) represents a subset of T-cell lymphomas but resembles an autoimmune disease in many of its clinical aspects. Despite the phenotype of effector T-cells and high expression of FAS and CTLA-4 receptor molecules, tumor cells fail...

Lethal pneumatosis coli in a 12-month-old child caused by acute intestinal gas gangrene after prolonged artificial nutrition: a case report.

Journal of medical case reports

Kircher S, Wössner R, Müller-Hermelink HK, Völker HU.
PMID: 18652650
J Med Case Rep. 2008 Jul 24;2:238. doi: 10.1186/1752-1947-2-238.

INTRODUCTION: Pneumatosis coli is a rare disease with heterogeneous symptoms which can be detected in the course of various acute and chronic intestinal diseases in children, such as necrotizing enterocolitis, intestinal obstruction and intestinal bacteriological infections.CASE PRESENTATION: We report...

Differential diagnosis of laryngeal spindle cell carcinoma and inflammatory myofibroblastic tumor--report of two cases with similar morphology.

Diagnostic pathology

Völker HU, Scheich M, Höller S, Ströbel P, Hagen R, Müller-Hermelink HK, Eck M.
PMID: 17212821
Diagn Pathol. 2007 Jan 09;2:1. doi: 10.1186/1746-1596-2-1.

BACKGROUND: Spindle cell tumors of the larynx are rare. In some cases, the dignity is difficult to determine. We report two cases of laryngeal spindle cell tumors.CASE PRESENTATION: Case 1 is a spindle cell carcinoma (SPC) in a 55...

A cytomorphological and immunohistochemical profile of aggressive B-cell lymphoma: high clinical impact of a cumulative immunohistochemical outcome predictor score.

Journal of hematopathology

Höller S, Horn H, Lohr A, Mäder U, Katzenberger T, Kalla J, Bernd HW, Went P, Ott MM, Müller-Hermelink HK, Rosenwald A, Ott G.
PMID: 20309427
J Hematop. 2009 Sep 02;2(4):187-94. doi: 10.1007/s12308-009-0044-x.

We analyzed morphological and immunohistochemical features in 174 aggressive B-cell lymphomas of nodal and extranodal origin. Morphological features included presence or absence of a follicular component and cytologic criteria according to the Kiel classification, whereas immunohistochemical studies included expression...

Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas - Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c.

Frontiers in oncology

Huang B, Belharazem D, Li L, Kneitz S, Schnabel PA, Rieker RJ, Körner D, Nix W, Schalke B, Müller-Hermelink HK, Ott G, Rosenwald A, Ströbel P, Marx A.
PMID: 24427739
Front Oncol. 2013 Dec 31;3:316. doi: 10.3389/fonc.2013.00316. eCollection 2013.

The molecular pathogenesis of thymomas and thymic carcinomas (TCs) is poorly understood and results of adjuvant therapy are unsatisfactory in case of metastatic disease and tumor recurrence. For these clinical settings, novel therapeutic strategies are urgently needed. Recently, limited...

Expression of CD56 isoforms in primary and relapsed adult granulosa cell tumors of the ovary.

Diagnostic pathology

Völker HU, Engert S, Cramer A, Schmidt M, Kämmerer U, Müller-Hermelink HK, Gattenlöhner S.
PMID: 18613980
Diagn Pathol. 2008 Jul 09;3:29. doi: 10.1186/1746-1596-3-29.

BACKGROUND: Adult granulosa cell tumors of the ovary (GCTs) are sex cord stromal tumors of unpredictable behaviour. Up to now, the prediction of the relapsing/malignant potential remains difficult. CD56 (NCAM) in GCTs was previously described in only two studies....

Showing 1 to 12 of 16 entries