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Showing 1 to 12 of 314 entries
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Novel Asymmetric Synthesis of Atropisomeric 6-Aryl Pyrazinones via an Unusual Chirality Transfer Process.

The Journal of organic chemistry

Tulinsky J, Cheney BV, Mizsak SA, Watt W, Han F, Dolak LA, Judge T, Gammill RB.
PMID: 11674090
J Org Chem. 1999 Jan 08;64(1):93-100. doi: 10.1021/jo9811930.

Cyclization of (S,S)-alpha-[(1-phenylethyl)amino]-alpha-(2-iodophenyl)acetonitrile with (COCl)(2) in toluene or chlorobenzene afforded the atropisomeric pyrazinone (aS,S) 6-(2-alpha-iodophenyl)-3,5-dichloro-1-(1-phenylethyl)-2(1H)-pyrazinone in 57% yield. With smaller ortho substituents (F, Cl, CH(3), CF(3), OCH(3)) on the aromatic ring, mixtures of atropisomers were obtained from the cyclization...

Observations on prostate intrafraction motion and the effect of reduced treatment time using volumetric modulated arc therapy.

Practical radiation oncology

Shelton J, Rossi PJ, Chen H, Liu Y, Master VA, Jani AB.
PMID: 24674002
Pract Radiat Oncol. 2011 Oct-Dec;1(4):243-50. doi: 10.1016/j.prro.2011.02.008. Epub 2011 May 14.

PURPOSE: Intensity modulated radiation therapy (IMRT) has allowed accurate delivery of prostate radiotherapy; Volumetric modulated arc therapy (VMAT) offers an advancement of this technique with possible dosimetric advantages and delivery in a shorter time than standard IMRT. We hypothesize...

A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia.

JCI insight

Luskin MR, Gimotty PA, Smith C, Loren AW, Figueroa ME, Harrison J, Sun Z, Tallman MS, Paietta EM, Litzow MR, Melnick AM, Levine RL, Fernandez HF, Luger SM, Carroll M, Master SR, Wertheim GB.
PMID: 27446991
JCI Insight. 2016 Jun 16;1(9). doi: 10.1172/jci.insight.87323.

BACKGROUND: Variable response to chemotherapy in acute myeloid leukemia (AML) represents a major treatment challenge. Clinical and genetic features incompletely predict outcome. The value of clinical epigenetic assays for risk classification has not been extensively explored. We assess the...

Lipopolysaccharide exposure during the early postnatal period adversely affects the structure and function of the developing rat carotid body.

Journal of applied physiology (Bethesda, Md. : 1985)

Master ZR, Porzionato A, Kesavan K, Mason A, Chavez-Valdez R, Shirahata M, Gauda EB.
PMID: 27418689
J Appl Physiol (1985). 2016 Sep 01;121(3):816-827. doi: 10.1152/japplphysiol.01094.2015. Epub 2016 Jul 14.

The carotid body (CB) substantially influences breathing in premature infants by affecting the frequency of apnea and periodic breathing. In adult animals, inflammation alters the structure and chemosensitivity of the CB, yet it is not known if this pertains...

The Clinical Implications of Youth Sports Concussion Laws: A Review.

American journal of lifestyle medicine

Bell JM, Master CL, Lionbarger MR.
PMID: 28943830
Am J Lifestyle Med. 2019 Mar;13(2):172-181. Epub 2017 Jan 20.

The recent passage of state youth sports concussion laws across the country introduces clinical implications for health care professionals caring for student-athletes. Although the laws were established to provide protections for student-athletes and prevent adverse outcomes, efforts aimed at...

Fourier transform spectral interferometric coherent anti-Stokes Raman scattering (FTSI-CARS) spectroscopy.

Optics letters

Lim SH, Caster AG, Leone SR.
PMID: 17440578
Opt Lett. 2007 May 15;32(10):1332-4. doi: 10.1364/ol.32.001332.

A novel Fourier transform spectral interferometric (FTSI) multiplex coherent anti-Stokes Raman scattering (CARS) technique is developed to extract the vibrational spectrum equivalent to the spontaneous Raman scattering. The conventional FTSI method is modified to use the internal nonresonant CARS...

Two-color visible/vacuum ultraviolet photoelectron imaging dynamics of Br2.

The Journal of chemical physics

Plenge J, Nicolas C, Caster AG, Ahmed M, Leone SR.
PMID: 17029468
J Chem Phys. 2006 Oct 07;125(13):133315. doi: 10.1063/1.2217375.

An experimental two-color photoionization dynamics study of laser-excited Br2 molecules is presented, combining pulsed visible laser excitation and tunable vacuum ultraviolet (VUV) synchrotron radiation with photoelectron imaging. The X 1Sigmag + -B 3Pi0+u transition in Br2 is excited at...

Resilience in developing systems: progress and promise as the fourth wave rises.

Development and psychopathology

Masten AS.
PMID: 17705908
Dev Psychopathol. 2007;19(3):921-30. doi: 10.1017/S0954579407000442.

Perspectives based on the first three waves of resilience research are discussed with the goal of informing the fourth wave of work, which is characterized by a focus on multilevel analysis and the dynamics of adaptation and change. Resilience...

Characterization of primary prostate carcinoma by anti-1-amino-2-[(18)F] -fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) uptake.

American journal of nuclear medicine and molecular imaging

Schuster DM, Taleghani PA, Nieh PT, Master VA, Amzat R, Savir-Baruch B, Halkar RK, Fox T, Osunkoya AO, Moreno CS, Nye JA, Yu W, Fei B, Wang Z, Chen Z, Goodman MM.
PMID: 23342303
Am J Nucl Med Mol Imaging. 2013;3(1):85-96. Epub 2013 Jan 05.

Anti-1-amino-3-[(18)F] fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim of this study is to correlate uptake of anti-3-[(18)F] FACBC with histology of...

Developmental processes and mechanisms: ages 0-10.

Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism

Zucker RA, Donovan JE, Masten AS, Mattson ME, Moss HB.
PMID: 23104444
Alcohol Res Health. 2009;32(1):16-29.

Little information is available on alcohol use in children up to age 10, although rates appear to be low. This age-group is not without risk, however. In fact, numerous nonspecific and specific risk factors for subsequent alcohol use are...

A Multidimensional Approach to Post-concussion Symptoms in Mild Traumatic Brain Injury.

Frontiers in neurology

Polinder S, Cnossen MC, Real RGL, Covic A, Gorbunova A, Voormolen DC, Master CL, Haagsma JA, Diaz-Arrastia R, von Steinbuechel N.
PMID: 30619066
Front Neurol. 2018 Dec 19;9:1113. doi: 10.3389/fneur.2018.01113. eCollection 2018.

Mild traumatic brain injury (mTBI) presents a substantial burden to patients, families, and health care systems. Whereas, recovery can be expected in the majority of patients, a subset continues to report persisting somatic, cognitive, emotional, and/or behavioral problems, generally...

The Microbiome of .

Frontiers in microbiology

Kohn T, Rast P, Kallscheuer N, Wiegand S, Boedeker C, Jetten MSM, Jeske O, Vollmers J, Kaster AK, Rohde M, Jogler M, Jogler C.
PMID: 32754127
Front Microbiol. 2020 Jul 10;11:1458. doi: 10.3389/fmicb.2020.01458. eCollection 2020.

Seagrass meadows are ubiquitous, fragile and endangered marine habitats, which serve as fish breeding grounds, stabilize ocean floor substrates, retain nutrients and serve as important carbon sinks, counteracting climate change. In the Mediterranean Sea, seagrass meadows are mostly formed...

Showing 1 to 12 of 314 entries