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Showing 1 to 12 of 62 entries
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A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals.

Annals of translational medicine

Summers EM, Blickenstaff NR, Coman GC, Martins TB, Hill HR, Sontheimer RD.
PMID: 29152493
Ann Transl Med. 2017 Oct;5(20):393. doi: 10.21037/atm.2017.07.16.

BACKGROUND: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliable METHODS: This was a single center, proof-of-concept pilot study at the University of Utah Hospital,...

Cas9 gets a classmate.

Nature biotechnology

Sontheimer EJ, Wolfe SA.
PMID: 26650011
Nat Biotechnol. 2015 Dec 09;33(12):1240-1241. doi: 10.1038/nbt.3426.

No abstract available.

Wiring up pre-characterized single-photon emitters by laser lithography.

Scientific reports

Shi Q, Sontheimer B, Nikolay N, Schell AW, Fischer J, Naber A, Benson O, Wegener M.
PMID: 27507165
Sci Rep. 2016 Aug 10;6:31135. doi: 10.1038/srep31135.

Future quantum optical chips will likely be hybrid in nature and include many single-photon emitters, waveguides, filters, as well as single-photon detectors. Here, we introduce a scalable optical localization-selection-lithography procedure for wiring up a large number of single-photon emitters...

The Neural Cell Adhesion Molecule (N-CAM) Modulates K+ Channels in Cultured Glial Precursor Cells.

The European journal of neuroscience

Sontheimer H, Kettenmann H, Schachner M, Trotter J.
PMID: 12106200
Eur J Neurosci. 1991;3(3):230-236. doi: 10.1111/j.1460-9568.1991.tb00084.x.

Application of antibodies against the neural cell adhesion molecule (N-CAM) to O4-positive murine glial precursor cells in vitro results in a reduction of two distinct K+ currents measured using the whole cell patch clamp technique. Both the A-type and...

A role for ion channels in glioma cell invasion.

Neuron glia biology

McFerrin MB, Sontheimer H.
PMID: 16520829
Neuron Glia Biol. 2006 Feb;2(1):39-49. doi: 10.1017/S17440925X06000044.

Many cells, including neuronal and glial progenitor cells, stem cells and microglial cells, have the capacity to move through the extracellular spaces of the developing and mature brain. This is particularly pronounced in astrocyte-derived tumors, gliomas, which diffusely infiltrate...

Large-area 2D periodic crystalline silicon nanodome arrays on nanoimprinted glass exhibiting photonic band structure effects.

Nanotechnology

Becker C, Lockau D, Sontheimer T, Schubert-Bischoff P, Rudigier-Voigt E, Bockmeyer M, Schmidt F, Rech B.
PMID: 22422473
Nanotechnology. 2012 Apr 06;23(13):135302. doi: 10.1088/0957-4484/23/13/135302.

Two-dimensional silicon nanodome arrays are prepared on large areas up to 50 cm² exhibiting photonic band structure effects in the near-infrared and visible wavelength region by downscaling a recently developed fabrication method based on nanoimprint-patterned glass, high-rate electron-beam evaporation...

Small RNAs of opposite sign… but same absolute value.

Cell

Sontheimer EJ.
PMID: 23217700
Cell. 2012 Dec 07;151(6):1157-8. doi: 10.1016/j.cell.2012.11.032.

In ciliates, small RNAs have been shown to target foreign sequences for silencing via elimination from the somatic genome. Fang et al. now reveal a set of Piwi-interacting RNAs (piRNAs) in Oxytricha trifallax that likewise enable genomic self versus...

Nonhealing Right Lower Leg Ulcer: Challenge.

The American Journal of dermatopathology

Blue E, Abbott J, Laggis C, Duffy K, Sontheimer R, Klein S.
PMID: 31592863
Am J Dermatopathol. 2021 Jan 01;43(1):e3-e4. doi: 10.1097/DAD.0000000000001538.

No abstract available.

James Neil Gilliam, MD-the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease.

Annals of translational medicine

Sontheimer RD.
PMID: 30023380
Ann Transl Med. 2018 Jun;6(11):217. doi: 10.21037/atm.2018.05.20.

James Neil Gilliam, MD, was an American academic physician who was trained in internal medicine, dermatology, dermatopathology and rheumatology. This "quadruple-threat" profile of postgraduate medical training provided him with a rather unique perspective on genetically-complex, environmentally-impacted human autoimmune disorders...

Protocol to quantitatively assess the structural integrity of Perineuronal Nets .

Bio-protocol

Tewari BP, Sontheimer H.
PMID: 33654764
Bio Protoc. 2019 May 20;9(10):e3234. doi: 10.21769/BioProtoc.3234. eCollection 2019 May 20.

Perineuronal nets (PNNs) are extracellular matrix assemblies of highly negatively charged proteoglycans that wrap around fast-spiking parvalbumin (PV) expressing interneurons in the cerebral cortex. PNNs play important roles in neuronal plasticity and modulate biophysical properties of the enclosed interneurons....

Early Deformation of Deep Brain Stimulation Electrodes Following Surgical Implantation: Intracranial, Brain, and Electrode Mechanics.

Frontiers in bioengineering and biotechnology

Chapelle F, Manciet L, Pereira B, Sontheimer A, Coste J, El Ouadih Y, Cimpeanu R, Gouot D, Lapusta Y, Claise B, Sautou V, Bouattour Y, Marques A, Wohrer A, Lemaire JJ.
PMID: 34178958
Front Bioeng Biotechnol. 2021 Jun 11;9:657875. doi: 10.3389/fbioe.2021.657875. eCollection 2021.

INTRODUCTION: Although deep brain stimulation is nowadays performed worldwide, the biomechanical aspects of electrode implantation received little attention, mainly as physicians focused on the medical aspects, such as the optimal indication of the surgical procedure, the positive and adverse...

Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos.

Genetics

Takasugi PR, Wang S, Truong KT, Drage EP, Kanishka SN, Higbee MA, Bamidele N, Ojelabi O, Sontheimer EJ, Gagnon JA.
PMID: 34735006
Genetics. 2021 Nov 04; doi: 10.1093/genetics/iyab196. Epub 2021 Nov 04.

The CRISPR-Cas universe continues to expand. The type II CRISPR-Cas system from Streptococcus pyogenes (SpyCas9) is the most widely used for genome editing due to its high efficiency in cells and organisms. However, concentrating on a single CRISPR-Cas system...

Showing 1 to 12 of 62 entries