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Showing 1 to 12 of 62 entries
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Clinical Neuroscience in Practice: An Experiential Learning Course for Undergraduates Offered by Neurosurgeons and Neuroscientists.

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience

Simonds GR, Marvin EA, Apfel LS, Elias Z, Howes GA, Witcher MR, Weaver EN, Fraser JC, Synkowski JJ, Prickett JT, Rogers CM, Busch CM, Benko MJ, Sou N, Churning MJ, Summers DC, Sontheimer H.
PMID: 30057492
J Undergrad Neurosci Educ. 2018 Jun 15;16(2):A112-A119. eCollection 2018.

Many pre-health students pursue extracurricular shadowing opportunities to gain clinical experience. The Virginia Tech School of Neuroscience introduced a formal course that provides a clinical experience superior to that received by many medical students. This course is composed of...

All-optical control and super-resolution imaging of quantum emitters in layered materials.

Nature communications

Kianinia M, Bradac C, Sontheimer B, Wang F, Tran TT, Nguyen M, Kim S, Xu ZQ, Jin D, Schell AW, Lobo CJ, Aharonovich I, Toth M.
PMID: 29491451
Nat Commun. 2018 Feb 28;9(1):874. doi: 10.1038/s41467-018-03290-0.

Layered van der Waals materials are emerging as compelling two-dimensional platforms for nanophotonics, polaritonics, valleytronics and spintronics, and have the potential to transform applications in sensing, imaging and quantum information processing. Among these, hexagonal boron nitride (hBN) is known...

Polymer Composite with Carbon Nanofibers Aligned during Thermal Drawing as a Microelectrode for Chronic Neural Interfaces.

ACS nano

Guo Y, Jiang S, Grena BJB, Kimbrough IF, Thompson EG, Fink Y, Sontheimer H, Yoshinobu T, Jia X.
PMID: 28570813
ACS Nano. 2017 Jul 25;11(7):6574-6585. doi: 10.1021/acsnano.6b07550. Epub 2017 Jun 13.

Microelectrodes provide a direct pathway to investigate brain activities electrically from the external world, which has advanced our fundamental understanding of brain functions and has been utilized for rehabilitative applications as brain-machine interfaces. However, minimizing the tissue response and...

Transcriptional Regulation of Amino Acid Transport in Glioblastoma Multiforme.

Cancers

Umans RA, Martin J, Harrigan ME, Patel DC, Chaunsali L, Roshandel A, Iyer K, Powell MD, Oestreich K, Sontheimer H.
PMID: 34944790
Cancers (Basel). 2021 Dec 07;13(24). doi: 10.3390/cancers13246169.

Glioblastoma multiforme (GBM) is a deadly brain tumor with a large unmet therapeutic need. Here, we tested the hypothesis that wild-type p53 is a negative transcriptional regulator of

Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop.

Epilepsia open

Galanopoulou AS, Löscher W, Lubbers L, O'Brien TJ, Staley K, Vezzani A, D'Ambrosio R, White HS, Sontheimer H, Wolf JA, Twyman R, Whittemore V, Wilcox KS, Klein B.
PMID: 34033232
Epilepsia Open. 2021 Jun;6(2):276-296. doi: 10.1002/epi4.12490. Epub 2021 May 06.

Epilepsy is one of the most common chronic brain diseases and is often associated with cognitive, behavioral, or other medical conditions. The need for therapies that would prevent, ameliorate, or cure epilepsy and the attendant comorbidities is a priority...

Disrupted Pallido-Thalamo-Cortical Functional Connectivity in Chronic Disorders of Consciousness.

Brain sciences

Sontheimer A, Pontier B, Claise B, Chassain C, Coste J, Lemaire JJ.
PMID: 33799582
Brain Sci. 2021 Mar 11;11(3). doi: 10.3390/brainsci11030356.

Chronic disorders of consciousness (DOC) encompass unresponsive wakefulness syndrome and minimally conscious state. Their anatomo-functional correlates are not clearly defined yet, although impairments of functional cortical networks have been reported, as well as the implication of the thalamus and...

Resting-State Functional Connectivity following Phonological Component Analysis: The Combined Action of Phonology and Visual Orthographic Cues.

Brain sciences

Masson-Trottier M, Sontheimer A, Durand E, Ansaldo AI.
PMID: 34827457
Brain Sci. 2021 Nov 02;11(11). doi: 10.3390/brainsci11111458.

Anomia is the most frequent and pervasive symptom for people with aphasia (PWA). Phonological component analysis (PCA) is a therapy incorporating phonological cues to treat anomia. Investigations of neural correlates supporting improvements following PCA remain scarce. Resting-state functional connectivity...

Perineuronal Net Dynamics in the Pathophysiology of Epilepsy.

Epilepsy currents

Chaunsali L, Tewari BP, Sontheimer H.
PMID: 34690566
Epilepsy Curr. 2021 May 27;21(4):273-281. doi: 10.1177/15357597211018688. eCollection 2021.

Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) assemblies of polyanionic chondroitin sulfate proteoglycans, hyaluronan, and tenascins that primarily wrap around GABAergic parvalbumin (PV) interneurons. During development, PNN formation terminates the critical period of neuroplasticity, a process that can...

Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development.

Frontiers in cell and developmental biology

Umans RA, Pollock C, Mills WA, Clark KC, Pan YA, Sontheimer H.
PMID: 34268301
Front Cell Dev Biol. 2021 Jun 29;9:654338. doi: 10.3389/fcell.2021.654338. eCollection 2021.

An emerging area of interest in Neuroscience is the cellular relationship between glia and blood vessels, as many of the presumptive support roles of glia require an association with the vasculature. These interactions are best studied

Quit stalling or you'll be silenced.

Cell

Kim Guisbert KS, Sontheimer EJ.
PMID: 23452843
Cell. 2013 Feb 28;152(5):938-9. doi: 10.1016/j.cell.2013.02.025.

The use of small RNAs to program gene regulation and genome defense necessitates ever-changing choices about the sequences used for small-RNA biogenesis. Dumesic et al. now reveal stalled spliceosomes as a trigger for small-RNA biogenesis in the pathogenic fungus...

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.

Nature communications

Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP.
PMID: 34836963
Nat Commun. 2021 Nov 26;12(1):6931. doi: 10.1038/s41467-021-27190-y.

Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose and lipid fluxes and severe comorbidities including cardiovascular disease and steatohepatitis. Whole body metabolism is regulated by lipid-storing white adipocytes as well as "brown" and "brite/beige" adipocytes...

Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos.

Genetics

Takasugi PR, Wang S, Truong KT, Drage EP, Kanishka SN, Higbee MA, Bamidele N, Ojelabi O, Sontheimer EJ, Gagnon JA.
PMID: 34735006
Genetics. 2021 Nov 04; doi: 10.1093/genetics/iyab196. Epub 2021 Nov 04.

The CRISPR-Cas universe continues to expand. The type II CRISPR-Cas system from Streptococcus pyogenes (SpyCas9) is the most widely used for genome editing due to its high efficiency in cells and organisms. However, concentrating on a single CRISPR-Cas system...

Showing 1 to 12 of 62 entries