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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates.

Pharmaceutics

Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T.
PMID: 32585880
Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578.

Buprenorphine plays a crucial role in the therapeutic management of pain in adults, adolescents and pediatric subpopulations. However, only few pharmacokinetic studies of buprenorphine in children, particularly neonates, are available as conducting clinical trials in this population is especially...

Cite
Kovar L, Schräpel C, Selzer D, et al. Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics. 2020;12(6)doi: 10.3390/pharmaceutics12060578.
Kovar, L., Schräpel, C., Selzer, D., Kohl, Y., Bals, R., Schwab, M., & Lehr, T. (2020). Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics, 12(6), . https://doi.org/10.3390/pharmaceutics12060578
Kovar, Lukas, et al. "Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates." Pharmaceutics vol. 12,6 (2020). doi: https://doi.org/10.3390/pharmaceutics12060578
Kovar L, Schräpel C, Selzer D, Kohl Y, Bals R, Schwab M, Lehr T. Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates. Pharmaceutics. 2020 Jun 23;12(6). doi: 10.3390/pharmaceutics12060578. PMID: 32585880; PMCID: PMC7355427.
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Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients.

Pharmaceutics

Kovar L, Weber A, Zemlin M, Kohl Y, Bals R, Meibohm B, Selzer D, Lehr T.
PMID: 32977559
Pharmaceutics. 2020 Sep 23;12(10). doi: 10.3390/pharmaceutics12100908.

Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging. Physiologically-based pharmacokinetic (PBPK) modeling...

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Kovar L, Weber A, Zemlin M, et al. Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients. Pharmaceutics. 2020;12(10)doi: 10.3390/pharmaceutics12100908.
Kovar, L., Weber, A., Zemlin, M., Kohl, Y., Bals, R., Meibohm, B., Selzer, D., & Lehr, T. (2020). Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients. Pharmaceutics, 12(10), . https://doi.org/10.3390/pharmaceutics12100908
Kovar, Lukas, et al. "Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients." Pharmaceutics vol. 12,10 (2020). doi: https://doi.org/10.3390/pharmaceutics12100908
Kovar L, Weber A, Zemlin M, Kohl Y, Bals R, Meibohm B, Selzer D, Lehr T. Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients. Pharmaceutics. 2020 Sep 23;12(10). doi: 10.3390/pharmaceutics12100908. PMID: 32977559; PMCID: PMC7598194.
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A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies.

Pharmaceutics

Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T.
PMID: 32560124
Pharmaceutics. 2020 Jun 16;12(6). doi: 10.3390/pharmaceutics12060556.

The calcium channel blocker and antiarrhythmic agent verapamil is recommended by the FDA for drug-drug interaction (DDI) studies as a moderate clinical CYP3A4 index inhibitor and as a clinical Pgp inhibitor. The purpose of the presented work was to...

Cite
Hanke N, Türk D, Selzer D, et al. A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies. Pharmaceutics. 2020;12(6)doi: 10.3390/pharmaceutics12060556.
Hanke, N., Türk, D., Selzer, D., Wiebe, S., Fernandez, �. �., Stopfer, P., Nock, V., & Lehr, T. (2020). A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies. Pharmaceutics, 12(6), . https://doi.org/10.3390/pharmaceutics12060556
Hanke, Nina, et al. "A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies." Pharmaceutics vol. 12,6 (2020). doi: https://doi.org/10.3390/pharmaceutics12060556
Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T. A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies. Pharmaceutics. 2020 Jun 16;12(6). doi: 10.3390/pharmaceutics12060556. PMID: 32560124; PMCID: PMC7355632.
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Showing 1 to 3 of 3 entries