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Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.

Nature communications

Sanders B, D'Andrea D, Collins MO, Rees E, Steward TGJ, Zhu Y, Chapman G, Legge SE, Pardiñas AF, Harwood AJ, Gray WP, O'Donovan MC, Owen MJ, Errington AC, Blake DJ, Whitcomb DJ, Pocklington AJ, Shin E.
PMID: 35031607
Nat Commun. 2022 Jan 14;13(1):27. doi: 10.1038/s41467-021-27601-0.

Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem...

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Sanders B, D'Andrea D, Collins MO, et al. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nat Commun. 2022;13(1):27doi: 10.1038/s41467-021-27601-0.
Sanders, B., D'Andrea, D., Collins, M. O., Rees, E., Steward, T. G. J., Zhu, Y., Chapman, G., Legge, S. E., Pardiñas, A. F., Harwood, A. J., Gray, W. P., O'Donovan, M. C., Owen, M. J., Errington, A. C., Blake, D. J., Whitcomb, D. J., Pocklington, A. J., & Shin, E. (2022). Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nature communications, 13(1), 27. https://doi.org/10.1038/s41467-021-27601-0
Sanders, Bret, et al. "Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants." Nature communications vol. 13,1 (2022): 27. doi: https://doi.org/10.1038/s41467-021-27601-0
Sanders B, D'Andrea D, Collins MO, Rees E, Steward TGJ, Zhu Y, Chapman G, Legge SE, Pardiñas AF, Harwood AJ, Gray WP, O'Donovan MC, Owen MJ, Errington AC, Blake DJ, Whitcomb DJ, Pocklington AJ, Shin E. Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. Nat Commun. 2022 Jan 14;13(1):27. doi: 10.1038/s41467-021-27601-0. PMID: 35031607.
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Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.

Genome biology

Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, Wallace L, Henders AK, Zwamborn RAJ, Hop PJ, Lunnon K, Pishva E, Roubroeks JAY, Soininen H, Tsolaki M, Mecocci P, Lovestone S, Kłoszewska I, Vellas B, Furlong S, Garton FC, Henderson RD, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson G, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Anderson TJ, Bentley SR, Dalrymple-Alford J, Fowder J, Gratten J, Halliday G, Hickie IB, Kennedy M, Lewis SJG, Montgomery GW, Pearson J, Pitcher TL, Silburn P, Zhang F, Visscher PM, Yang J, Stevenson AJ, Hillary RF, Marioni RE, Harris SE, Deary IJ, Jones AR, Shatunov A, Iacoangeli A, van Rheenen W, van den Berg LH, Shaw PJ, Shaw CE, Morrison KE, Al-Chalabi A, Veldink JH, Hannon E, Mill J, Wray NR, McRae AF.
PMID: 33771206
Genome Biol. 2021 Mar 26;22(1):90. doi: 10.1186/s13059-021-02275-5.

BACKGROUND: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined...

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Nabais MF, Laws SM, Lin T, et al. Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol. 2021;22(1):90doi: 10.1186/s13059-021-02275-5.
Nabais, M. F., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., Kwok, J. B., Mather, K. A., Mellick, G. D., Sachdev, P. S., Wallace, L., Henders, A. K., Zwamborn, R. A. J., Hop, P. J., Lunnon, K., Pishva, E., Roubroeks, J. A. Y., Soininen, H., Tsolaki, M., Mecocci, P., Lovestone, S., Kłoszewska, I., Vellas, B., Furlong, S., Garton, F. C., Henderson, R. D., Mathers, S., McCombe, P. A., Needham, M., Ngo, S. T., Nicholson, G., Pamphlett, R., Rowe, D. B., Steyn, F. J., Williams, K. L., Anderson, T. J., Bentley, S. R., Dalrymple-Alford, J., Fowder, J., Gratten, J., Halliday, G., Hickie, I. B., Kennedy, M., Lewis, S. J. G., Montgomery, G. W., Pearson, J., Pitcher, T. L., Silburn, P., Zhang, F., Visscher, P. M., Yang, J., Stevenson, A. J., Hillary, R. F., Marioni, R. E., Harris, S. E., Deary, I. J., Jones, A. R., Shatunov, A., Iacoangeli, A., van Rheenen, W., van den Berg, L. H., Shaw, P. J., Shaw, C. E., Morrison, K. E., Al-Chalabi, A., Veldink, J. H., Hannon, E., Mill, J., Wray, N. R., & McRae, A. F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome biology, 22(1), 90. https://doi.org/10.1186/s13059-021-02275-5
Nabais, Marta F, et al. "Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders." Genome biology vol. 22,1 (2021): 90. doi: https://doi.org/10.1186/s13059-021-02275-5
Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, Wallace L, Henders AK, Zwamborn RAJ, Hop PJ, Lunnon K, Pishva E, Roubroeks JAY, Soininen H, Tsolaki M, Mecocci P, Lovestone S, Kłoszewska I, Vellas B, Furlong S, Garton FC, Henderson RD, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson G, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Anderson TJ, Bentley SR, Dalrymple-Alford J, Fowder J, Gratten J, Halliday G, Hickie IB, Kennedy M, Lewis SJG, Montgomery GW, Pearson J, Pitcher TL, Silburn P, Zhang F, Visscher PM, Yang J, Stevenson AJ, Hillary RF, Marioni RE, Harris SE, Deary IJ, Jones AR, Shatunov A, Iacoangeli A, van Rheenen W, van den Berg LH, Shaw PJ, Shaw CE, Morrison KE, Al-Chalabi A, Veldink JH, Hannon E, Mill J, Wray NR, McRae AF. Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol. 2021 Mar 26;22(1):90. doi: 10.1186/s13059-021-02275-5. PMID: 33771206; PMCID: PMC8004462.
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Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America

Lord J, Jermy B, Green R, Wong A, Xu J, Legido-Quigley C, Dobson R, Richards M, Proitsi P.
PMID: 33879569
Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). doi: 10.1073/pnas.2009808118.

There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an understanding of preclinical causal biomarkers to help target disease pathogenesis in the earliest phases remains elusive. Here, we investigated whether 19 metabolites previously associated with midlife cognition-a...

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Lord J, Jermy B, Green R, et al. Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease. Proc Natl Acad Sci U S A. 2021;118(16)doi: 10.1073/pnas.2009808118.
Lord, J., Jermy, B., Green, R., Wong, A., Xu, J., Legido-Quigley, C., Dobson, R., Richards, M., & Proitsi, P. (2021). Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America, 118(16), . https://doi.org/10.1073/pnas.2009808118
Lord, Jodie, et al. "Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease." Proceedings of the National Academy of Sciences of the United States of America vol. 118,16 (2021). doi: https://doi.org/10.1073/pnas.2009808118
Lord J, Jermy B, Green R, Wong A, Xu J, Legido-Quigley C, Dobson R, Richards M, Proitsi P. Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). doi: 10.1073/pnas.2009808118. PMID: 33879569; PMCID: PMC8072203.
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Showing 1 to 3 of 3 entries