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Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione.

Toxicology mechanisms and methods

Lack L, Brownie CF, Ribar TJ, Abou-Donia MB.
PMID: 20021169
Toxicol Mech Methods. 2002;12(4):277-91. doi: 10.1080/15376520208951164.

The neurotoxic industrial solvents n-hexane and methyl n-butyl ketone are toxic by virtue of their common metabolite, 2,5-hexanedione (2,5-HD). Our previous work showed that pyrrole-like substances in solubilized rat hair proteins from rats injected (ip) daily with 2,5-HD demonstrated...

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Lack L, Brownie CF, Ribar TJ, et al. Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione. Toxicol Mech Methods. 2002;12(4):277-91doi: 10.1080/15376520208951164.
Lack, L., Brownie, C. F., Ribar, T. J., & Abou-Donia, M. B. (2002). Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione. Toxicology mechanisms and methods, 12(4), 277-91. https://doi.org/10.1080/15376520208951164
Lack, Leon, et al. "Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione." Toxicology mechanisms and methods vol. 12,4 (2002): 277-91. doi: https://doi.org/10.1080/15376520208951164
Lack L, Brownie CF, Ribar TJ, Abou-Donia MB. Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione. Toxicol Mech Methods. 2002;12(4):277-91. doi: 10.1080/15376520208951164. PMID: 20021169.
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2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex.

Environmental toxicology and pharmacology

Zhang TL, Han XY, Zhao XL, Zhao L, Zhang CL, Yu LH, Yu SF, Xie KQ.
PMID: 21783574
Environ Toxicol Pharmacol. 2005 Jul;20(1):92-8. doi: 10.1016/j.etap.2004.11.003. Epub 2005 Jan 07.

Exposure chronically to n-hexane produces central-peripheral axonopathy mediated by 2,5-hexanedione (HD). Studies have shown neurofilament (NF) subunit proteins are decreased substantially in cerebral cortices, optic axons, spinal cords, and sciatic nerves from HD-exposed rats. To deeply investigate the alterations...

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Zhang TL, Han XY, Zhao XL, et al. 2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex. Environ Toxicol Pharmacol. 2005;20(1):92-8doi: 10.1016/j.etap.2004.11.003.
Zhang, T. L., Han, X. Y., Zhao, X. L., Zhao, L., Zhang, C. L., Yu, L. H., Yu, S. F., & Xie, K. Q. (2005). 2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex. Environmental toxicology and pharmacology, 20(1), 92-8. https://doi.org/10.1016/j.etap.2004.11.003
Zhang, Tian-Liang, et al. "2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex." Environmental toxicology and pharmacology vol. 20,1 (2005): 92-8. doi: https://doi.org/10.1016/j.etap.2004.11.003
Zhang TL, Han XY, Zhao XL, Zhao L, Zhang CL, Yu LH, Yu SF, Xie KQ. 2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex. Environ Toxicol Pharmacol. 2005 Jul;20(1):92-8. doi: 10.1016/j.etap.2004.11.003. Epub 2005 Jan 07. PMID: 21783574.
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Ultrasound-Promoted One-Pot Synthesis of Mono- or Bis-Substituted Organylselanyl Pyrroles.

The Journal of organic chemistry

Peglow TJ, Costa GPD, Duarte LFB, Silva MS, Barcellos T, Perin G, Alves D.
PMID: 31020836
J Org Chem. 2019 May 03;84(9):5471-5482. doi: 10.1021/acs.joc.9b00405. Epub 2019 Apr 25.

A simple method for the direct mono- and bis-organylselenylation of N-substituted pyrroles through a multicomponent reaction promoted by ultrasonic radiation was described. These sonochemical promoted reactions were performed between different primary amines, 2,5-hexanedione and dialkyl, diheteroaryl, or diaryl diselenides,...

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Peglow TJ, Costa GPD, Duarte LFB, et al. Ultrasound-Promoted One-Pot Synthesis of Mono- or Bis-Substituted Organylselanyl Pyrroles. J Org Chem. 2019;84(9):5471-5482doi: 10.1021/acs.joc.9b00405.
Peglow, T. J., Costa, G. P. D., Duarte, L. F. B., Silva, M. S., Barcellos, T., Perin, G., & Alves, D. (2019). Ultrasound-Promoted One-Pot Synthesis of Mono- or Bis-Substituted Organylselanyl Pyrroles. The Journal of organic chemistry, 84(9), 5471-5482. https://doi.org/10.1021/acs.joc.9b00405
Peglow, Thiago J, et al. "Ultrasound-Promoted One-Pot Synthesis of Mono- or Bis-Substituted Organylselanyl Pyrroles." The Journal of organic chemistry vol. 84,9 (2019): 5471-5482. doi: https://doi.org/10.1021/acs.joc.9b00405
Peglow TJ, Costa GPD, Duarte LFB, Silva MS, Barcellos T, Perin G, Alves D. Ultrasound-Promoted One-Pot Synthesis of Mono- or Bis-Substituted Organylselanyl Pyrroles. J Org Chem. 2019 May 03;84(9):5471-5482. doi: 10.1021/acs.joc.9b00405. Epub 2019 Apr 25. PMID: 31020836.
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Iodine-Modified Pd Catalysts Promote the Bifunctional Catalytic Synthesis of 2,5-Hexanedione from C.

ChemSusChem

Tong Z, Li X, Zhu J, Chen S, Dai G, Deng Q, Wang J, Yang W, Zeng Z, Zou JJ.
PMID: 34918485
ChemSusChem. 2021 Dec 17;e202102444. doi: 10.1002/cssc.202102444. Epub 2021 Dec 17.

Currently, low intimacy between hydrogenation sites and acidic sites causes unsatisfactory catalytic activity and selectivity for the synthesis of 2,5-hexanedione from C

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Tong Z, Li X, Zhu J, et al. Iodine-Modified Pd Catalysts Promote the Bifunctional Catalytic Synthesis of 2,5-Hexanedione from C. ChemSusChem. 2021;e202102444doi: 10.1002/cssc.202102444.
Tong, Z., Li, X., Zhu, J., Chen, S., Dai, G., Deng, Q., Wang, J., Yang, W., Zeng, Z., & Zou, J. J. (2021). Iodine-Modified Pd Catalysts Promote the Bifunctional Catalytic Synthesis of 2,5-Hexanedione from C. ChemSusChem, e202102444. https://doi.org/10.1002/cssc.202102444
Tong, Zhikun, et al. "Iodine-Modified Pd Catalysts Promote the Bifunctional Catalytic Synthesis of 2,5-Hexanedione from C." ChemSusChem vol. (2021): e202102444. doi: https://doi.org/10.1002/cssc.202102444
Tong Z, Li X, Zhu J, Chen S, Dai G, Deng Q, Wang J, Yang W, Zeng Z, Zou JJ. Iodine-Modified Pd Catalysts Promote the Bifunctional Catalytic Synthesis of 2,5-Hexanedione from C. ChemSusChem. 2021 Dec 17;e202102444. doi: 10.1002/cssc.202102444. Epub 2021 Dec 17. PMID: 34918485.
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Ruthenium(II) porphyrin catalyzed tandem carbonyl ylide formation and 1,3-dipolar cycloaddition reactions of alpha-diazo ketones.

Organic letters

Zhou CY, Yu WY, Che CM.
PMID: 12227757
Org Lett. 2002 Sep 19;4(19):3235-8. doi: 10.1021/ol0201254.

[reaction: see text] The ruthenium porphyrin-catalyzed reactions of diazo ketones with pi-unsaturated compounds via carbonyl ylide formation/cycloaddition cascade exhibit product yields and selectivities comparable to the analogous reactions with dirhodium carboxylates as catalysts. By grafting a ruthenium porphyrin on...

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Zhou CY, Yu WY, Che CM. Ruthenium(II) porphyrin catalyzed tandem carbonyl ylide formation and 1,3-dipolar cycloaddition reactions of alpha-diazo ketones. Org Lett. 2002;4(19):3235-8doi: 10.1021/ol0201254.
Zhou, C. Y., Yu, W. Y., & Che, C. M. (2002). Ruthenium(II) porphyrin catalyzed tandem carbonyl ylide formation and 1,3-dipolar cycloaddition reactions of alpha-diazo ketones. Organic letters, 4(19), 3235-8. https://doi.org/10.1021/ol0201254
Zhou, Cong-Ying, et al. "Ruthenium(II) porphyrin catalyzed tandem carbonyl ylide formation and 1,3-dipolar cycloaddition reactions of alpha-diazo ketones." Organic letters vol. 4,19 (2002): 3235-8. doi: https://doi.org/10.1021/ol0201254
Zhou CY, Yu WY, Che CM. Ruthenium(II) porphyrin catalyzed tandem carbonyl ylide formation and 1,3-dipolar cycloaddition reactions of alpha-diazo ketones. Org Lett. 2002 Sep 19;4(19):3235-8. doi: 10.1021/ol0201254. PMID: 12227757.
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Hexanedione from Hydrocarbon Polymer Oxidation.

Science (New York, N.Y.)

Bevilacqua EM, Norling PM.
PMID: 17788209
Science. 1965 Jan 15;147(3655):289-90. doi: 10.1126/science.147.3655.289.

The diketone 2,5-hexanedione has been isolated as a product of the thermal oxidation of cis-1,4-polysioprene and of copolymers of ethylene and propylene. This is confirmatory evidence for the formation of acetonyl radicals during oxidation of these polymers and their...

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Bevilacqua EM, Norling PM. Hexanedione from Hydrocarbon Polymer Oxidation. Science. 1965;147(3655):289-90doi: 10.1126/science.147.3655.289.
Bevilacqua, E. M., & Norling, P. M. (1965). Hexanedione from Hydrocarbon Polymer Oxidation. Science (New York, N.Y.), 147(3655), 289-90. https://doi.org/10.1126/science.147.3655.289
Bevilacqua, E M, and Norling, P M. "Hexanedione from Hydrocarbon Polymer Oxidation." Science (New York, N.Y.) vol. 147,3655 (1965): 289-90. doi: https://doi.org/10.1126/science.147.3655.289
Bevilacqua EM, Norling PM. Hexanedione from Hydrocarbon Polymer Oxidation. Science. 1965 Jan 15;147(3655):289-90. doi: 10.1126/science.147.3655.289. PMID: 17788209.
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Pd(0)-catalyzed conjugate addition of benzylzinc chlorides to alpha,beta-enones in an atmosphere of carbon monoxide: preparation of 1,4-diketones.

The Journal of organic chemistry

Yuguchi M, Tokuda M, Orito K.
PMID: 14750821
J Org Chem. 2004 Feb 06;69(3):908-14. doi: 10.1021/jo035468+.

Pd(0)-catalyzed conjugate addition of benzylzinc chloride to methyl vinyl ketone in the presence of chlorotrimethylsilane and lithium chloride in an atmosphere of carbon monoxide at room temperature afforded 1-phenyl-2,5-hexanedione monosilyl enol ether. In this catalytic carbonylation, four components are...

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Yuguchi M, Tokuda M, Orito K. Pd(0)-catalyzed conjugate addition of benzylzinc chlorides to alpha,beta-enones in an atmosphere of carbon monoxide: preparation of 1,4-diketones. J Org Chem. 2004;69(3):908-14doi: 10.1021/jo035468+.
Yuguchi, M., Tokuda, M., & Orito, K. (2004). Pd(0)-catalyzed conjugate addition of benzylzinc chlorides to alpha,beta-enones in an atmosphere of carbon monoxide: preparation of 1,4-diketones. The Journal of organic chemistry, 69(3), 908-14. https://doi.org/10.1021/jo035468+
Yuguchi, Motoki, et al. "Pd(0)-catalyzed conjugate addition of benzylzinc chlorides to alpha,beta-enones in an atmosphere of carbon monoxide: preparation of 1,4-diketones." The Journal of organic chemistry vol. 69,3 (2004): 908-14. doi: https://doi.org/10.1021/jo035468+
Yuguchi M, Tokuda M, Orito K. Pd(0)-catalyzed conjugate addition of benzylzinc chlorides to alpha,beta-enones in an atmosphere of carbon monoxide: preparation of 1,4-diketones. J Org Chem. 2004 Feb 06;69(3):908-14. doi: 10.1021/jo035468+. PMID: 14750821.
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2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways.

Bioscience reports

Luo M, Shi X, Guo Q, Li S, Zhang Q, Sun X, Piao F.
PMID: 33792642
Biosci Rep. 2021 Apr 30;41(4). doi: 10.1042/BSR20204264.

Increasing evidence suggests that n-hexane induces nerve injury via neuronal apoptosis induced by its active metabolite 2,5-hexanedione (HD). However, the underlying mechanism remains unknown. Studies have confirmed that pro-nerve growth factor (proNGF), a precursor of mature nerve growth factor...

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Luo M, Shi X, Guo Q, et al. 2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways. Biosci Rep. 2021;41(4)doi: 10.1042/BSR20204264.
Luo, M., Shi, X., Guo, Q., Li, S., Zhang, Q., Sun, X., & Piao, F. (2021). 2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways. Bioscience reports, 41(4), . https://doi.org/10.1042/BSR20204264
Luo, Mengxin, et al. "2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways." Bioscience reports vol. 41,4 (2021). doi: https://doi.org/10.1042/BSR20204264
Luo M, Shi X, Guo Q, Li S, Zhang Q, Sun X, Piao F. 2,5-Hexanedione induced apoptosis in rat spinal cord neurons and VSC4.1 cells via the proNGF/p75NTR and JNK pathways. Biosci Rep. 2021 Apr 30;41(4). doi: 10.1042/BSR20204264. PMID: 33792642; PMCID: PMC8035625.
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Efficient catalytic effects of Lewis acids in the 1,3-dipolar cycloaddition reactions of carbonyl ylides with imines.

The Journal of organic chemistry

Suga H, Ebiura Y, Fukushima K, Kakehi A, Baba T.
PMID: 16356001
J Org Chem. 2005 Dec 23;70(26):10782-91. doi: 10.1021/jo051743b.

[reactions: see text] 1,3-Dipolar cycloaddition reactions between imines and carbonyl ylides generated by tandem intramolecular carbenoid-carbonyl cyclizations were found to be effectively catalyzed by Lewis acids (10 mol %). The Rh2(OAc)4-catalyzed reactions of o-(methoxycarbonyl)-alpha-diazoacetophenone with imines such as N-[2-(benzyloxy)benzylidene]aniline...

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Suga H, Ebiura Y, Fukushima K, et al. Efficient catalytic effects of Lewis acids in the 1,3-dipolar cycloaddition reactions of carbonyl ylides with imines. J Org Chem. 2005;70(26):10782-91doi: 10.1021/jo051743b.
Suga, H., Ebiura, Y., Fukushima, K., Kakehi, A., & Baba, T. (2005). Efficient catalytic effects of Lewis acids in the 1,3-dipolar cycloaddition reactions of carbonyl ylides with imines. The Journal of organic chemistry, 70(26), 10782-91. https://doi.org/10.1021/jo051743b
Suga, Hiroyuki, et al. "Efficient catalytic effects of Lewis acids in the 1,3-dipolar cycloaddition reactions of carbonyl ylides with imines." The Journal of organic chemistry vol. 70,26 (2005): 10782-91. doi: https://doi.org/10.1021/jo051743b
Suga H, Ebiura Y, Fukushima K, Kakehi A, Baba T. Efficient catalytic effects of Lewis acids in the 1,3-dipolar cycloaddition reactions of carbonyl ylides with imines. J Org Chem. 2005 Dec 23;70(26):10782-91. doi: 10.1021/jo051743b. PMID: 16356001.
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The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro.

Toxicology in vitro : an international journal published in association with BIBRA

Tähti H, Hyppönen S.
PMID: 20702200
Toxicol In Vitro. 1990;4(4):389-90. doi: 10.1016/0887-2333(90)90086-9.

The aim of the present study was to find a method for in vitro studies of the neurotoxic mechanism of industrial solvents. The effects of carbon disulphide and n-hexane and its metabolites were studied. Cell membrane changes were studied...

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Tähti H, Hyppönen S. The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro. Toxicol In Vitro. 1990;4(4):389-90doi: 10.1016/0887-2333(90)90086-9.
Tähti, H., & Hyppönen, S. (1990). The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro. Toxicology in vitro : an international journal published in association with BIBRA, 4(4), 389-90. https://doi.org/10.1016/0887-2333(90)90086-9
Tähti, H, and Hyppönen, S. "The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro." Toxicology in vitro : an international journal published in association with BIBRA vol. 4,4 (1990): 389-90. doi: https://doi.org/10.1016/0887-2333(90)90086-9
Tähti H, Hyppönen S. The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro. Toxicol In Vitro. 1990;4(4):389-90. doi: 10.1016/0887-2333(90)90086-9. PMID: 20702200.
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Biological monitoring of n-hexane exposure in shoe workers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Sema Burgaz Ismet Cok Lutfu Ulusoy Umit Tarhan Neslihan Aygun And Ali Esat Karakaya.
PMID: 23899151
Biomarkers. 1997;2(1):25-8. doi: 10.1080/135475097231931.

To analyse working conditions and to provide information about the degree to which shoe workers are exposed to n-hexane, the urinary excretion of total 2,5-hexanedione (2,5-HD) was determined in 81 employees in 12 shoe factories. Twenty-five individuals who had...

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Sema Burgaz Ismet Cok Lutfu Ulusoy Umit Tarhan Neslihan Aygun And Ali Esat Karakaya. Biological monitoring of n-hexane exposure in shoe workers. Biomarkers. 1997;2(1):25-8doi: 10.1080/135475097231931.
Sema Burgaz Ismet Cok Lutfu Ulusoy Umit Tarhan Neslihan Aygun And Ali Esat Karakaya. (1997). Biological monitoring of n-hexane exposure in shoe workers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2(1), 25-8. https://doi.org/10.1080/135475097231931
Sema Burgaz Ismet Cok Lutfu Ulusoy Umit Tarhan Neslihan Aygun And Ali Esat Karakaya. "Biological monitoring of n-hexane exposure in shoe workers." Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals vol. 2,1 (1997): 25-8. doi: https://doi.org/10.1080/135475097231931
Sema Burgaz Ismet Cok Lutfu Ulusoy Umit Tarhan Neslihan Aygun And Ali Esat Karakaya. Biological monitoring of n-hexane exposure in shoe workers. Biomarkers. 1997;2(1):25-8. doi: 10.1080/135475097231931. PMID: 23899151.
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External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals.

Safety and health at work

Lee MY, Yang JS, Kang SK.
PMID: 22953206
Saf Health Work. 2011 Sep;2(3):229-35. doi: 10.5491/SHAW.2011.2.3.229. Epub 2011 Sep 30.

OBJECTIVES: In this study, we summarized the External Quality Assessment Scheme (EQAS) for the biological monitoring of occupational exposure to toxic chemicals which started in 1995 and continued until a 31(st) round robin in the spring of 2010. The...

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Lee MY, Yang JS, Kang SK. External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals. Saf Health Work. 2011;2(3):229-35doi: 10.5491/SHAW.2011.2.3.229.
Lee, M. Y., Yang, J. S., & Kang, S. K. (2011). External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals. Safety and health at work, 2(3), 229-35. https://doi.org/10.5491/SHAW.2011.2.3.229
Lee, Mi-Young, et al. "External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals." Safety and health at work vol. 2,3 (2011): 229-35. doi: https://doi.org/10.5491/SHAW.2011.2.3.229
Lee MY, Yang JS, Kang SK. External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals. Saf Health Work. 2011 Sep;2(3):229-35. doi: 10.5491/SHAW.2011.2.3.229. Epub 2011 Sep 30. PMID: 22953206; PMCID: PMC3430898.
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Showing 1 to 12 of 29 entries