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Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides.

The Journal of organic chemistry

Lebedev AY, Khartulyari AS, Voskoboynikov AZ.
PMID: 15651807
J Org Chem. 2005 Jan 21;70(2):596-602. doi: 10.1021/jo048671t.

Palladium-catalyzed cyclization of arylhydrazones of 2-bromoaldehydes and 2-bromoacetophenones to give 1-aryl-1H-indazoles has been studied in detail. The cyclization of arylhydrazone of 2-bromobenzaldehydes can be performed with good to high yields using Pd(dba)2 and chelating phosphines, of which the most...

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Lebedev AY, Khartulyari AS, Voskoboynikov AZ. Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides. J Org Chem. 2005;70(2):596-602doi: 10.1021/jo048671t.
Lebedev, A. Y., Khartulyari, A. S., & Voskoboynikov, A. Z. (2005). Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides. The Journal of organic chemistry, 70(2), 596-602. https://doi.org/10.1021/jo048671t
Lebedev, Artyom Y, et al. "Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides." The Journal of organic chemistry vol. 70,2 (2005): 596-602. doi: https://doi.org/10.1021/jo048671t
Lebedev AY, Khartulyari AS, Voskoboynikov AZ. Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides. J Org Chem. 2005 Jan 21;70(2):596-602. doi: 10.1021/jo048671t. PMID: 15651807.
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The gramine route to pyrido[4,3-b]indol-3-ones - identification of a new cytotoxic lead.

Scientia pharmaceutica

Wollein U, Bracher F.
PMID: 21617772
Sci Pharm. 2011 Jan-Mar;79(1):59-68. doi: 10.3797/scipharm.1011-11. Epub 2010 Dec 18.

A novel approach to 3-oxo-γ-carbolines was worked out starting from methyl indol-2-ylacetate via a gramine derivative. After quaternization, ammonia and 4-methoxybenzylamine could be inserted giving appropriate 3-oxo-γ-carbolines. Condensation with 2-chlorobenzaldehyde under microwave irradiation gave a 4-(2-chlorobenzyl)-3-oxo-γ-carboline. N-methylation lead to...

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Wollein U, Bracher F. The gramine route to pyrido[4,3-b]indol-3-ones - identification of a new cytotoxic lead. Sci Pharm. 2010;79(1):59-68doi: 10.3797/scipharm.1011-11.
Wollein, U., & Bracher, F. (2011). The gramine route to pyrido[4,3-b]indol-3-ones - identification of a new cytotoxic lead. Scientia pharmaceutica, 79(1), 59-68. https://doi.org/10.3797/scipharm.1011-11
Wollein, Uwe, and Bracher, Franz. "The gramine route to pyrido[4,3-b]indol-3-ones - identification of a new cytotoxic lead." Scientia pharmaceutica vol. 79,1 (2011): 59-68. doi: https://doi.org/10.3797/scipharm.1011-11
Wollein U, Bracher F. The gramine route to pyrido[4,3-b]indol-3-ones - identification of a new cytotoxic lead. Sci Pharm. 2011 Jan-Mar;79(1):59-68. doi: 10.3797/scipharm.1011-11. Epub 2010 Dec 18. PMID: 21617772; PMCID: PMC3097496.
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Synthesis, anticancer evaluation and molecular docking studies of methotrexate's novel Schiff base derivatives against malignant glioma cell lines.

Journal of biomolecular structure & dynamics

Nemat A, Khan IN, Kalsoom S, Malik SA, Ayub S, Adnan F, Kamal MA, Iqbal M.
PMID: 33183168
J Biomol Struct Dyn. 2020 Nov 13;1-13. doi: 10.1080/07391102.2020.1844053. Epub 2020 Nov 13.

Recent years have witnessed advancement in cancer research that has led to the development of improved cytotoxic therapies with reduced side effects. Methotrexate (MTX) is a commonly used anticancer drug having robust activity, but with serious side effects. Several...

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Nemat A, Khan IN, Kalsoom S, et al. Synthesis, anticancer evaluation and molecular docking studies of methotrexate's novel Schiff base derivatives against malignant glioma cell lines. J Biomol Struct Dyn. 2020;1-13doi: 10.1080/07391102.2020.1844053.
Nemat, A., Khan, I. N., Kalsoom, S., Malik, S. A., Ayub, S., Adnan, F., Kamal, M. A., & Iqbal, M. (2020). Synthesis, anticancer evaluation and molecular docking studies of methotrexate's novel Schiff base derivatives against malignant glioma cell lines. Journal of biomolecular structure & dynamics, 1-13. https://doi.org/10.1080/07391102.2020.1844053
Nemat, Aifa, et al. "Synthesis, anticancer evaluation and molecular docking studies of methotrexate's novel Schiff base derivatives against malignant glioma cell lines." Journal of biomolecular structure & dynamics vol. (2020): 1-13. doi: https://doi.org/10.1080/07391102.2020.1844053
Nemat A, Khan IN, Kalsoom S, Malik SA, Ayub S, Adnan F, Kamal MA, Iqbal M. Synthesis, anticancer evaluation and molecular docking studies of methotrexate's novel Schiff base derivatives against malignant glioma cell lines. J Biomol Struct Dyn. 2020 Nov 13;1-13. doi: 10.1080/07391102.2020.1844053. Epub 2020 Nov 13. PMID: 33183168.
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Synthesis, spectral and antibacterial studies of binuclear titanium(IV) / zirconium(IV) complexes of piperazine dithiosemicarbazones.

Bioinorganic chemistry and applications

Pandey OP, Sengupta SK, Mishra MK, Tripathi CM.
PMID: 18365041
Bioinorg Chem Appl. 2003;35-44. doi: 10.1155/S1565363303000037.

The reactions of mono(cyclopentadienyl)titanium(IV) trichloride and bis(cyclopentadienyl)titanium(IV)/ zirconium(IV) dichloride with a new class of dithiosemicarbazone, derived by condensing piperazine dithiosemicarbazide with benzaldehyde (L(1)H(2)), 2-chlorobenzaldehyde (L(2)H(2)), 4-nitrobenzaldehyde (L(3)H(2)) or salicylaldehyde (L(4)H(4)) have been studied and different types of binuclear products,...

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Pandey OP, Sengupta SK, Mishra MK, et al. Synthesis, spectral and antibacterial studies of binuclear titanium(IV) / zirconium(IV) complexes of piperazine dithiosemicarbazones. Bioinorg Chem Appl. 2003;35-44doi: 10.1155/S1565363303000037.
Pandey, O. P., Sengupta, S. K., Mishra, M. K., & Tripathi, C. M. (2003). Synthesis, spectral and antibacterial studies of binuclear titanium(IV) / zirconium(IV) complexes of piperazine dithiosemicarbazones. Bioinorganic chemistry and applications, 35-44. https://doi.org/10.1155/S1565363303000037
Pandey, O P, et al. "Synthesis, spectral and antibacterial studies of binuclear titanium(IV) / zirconium(IV) complexes of piperazine dithiosemicarbazones." Bioinorganic chemistry and applications vol. (2003): 35-44. doi: https://doi.org/10.1155/S1565363303000037
Pandey OP, Sengupta SK, Mishra MK, Tripathi CM. Synthesis, spectral and antibacterial studies of binuclear titanium(IV) / zirconium(IV) complexes of piperazine dithiosemicarbazones. Bioinorg Chem Appl. 2003;35-44. doi: 10.1155/S1565363303000037. PMID: 18365041; PMCID: PMC2267046.
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Investigation of catalytic characterization of two-dimensional molecular space with regular ammonium and pyridine groups.

Langmuir : the ACS journal of surfaces and colloids

Chen J, Yao K, Shangguan W, Yuan J.
PMID: 19296641
Langmuir. 2009 May 19;25(10):5993-9. doi: 10.1021/la8042523.

Novel two-dimensional molecular space with regular pyridine groups layered pyridine-4-amidepropylsilica (PAPS) and pyridine-4-amidephenylsilica (PAPhS) were successfully synthesized through grafting pyridine groups in the layer structure of two-dimensional molecular space with regular ammonium groups layered aminopropylsilica (ATMS-DS) and layered aminophenylsilica...

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Chen J, Yao K, Shangguan W, et al. Investigation of catalytic characterization of two-dimensional molecular space with regular ammonium and pyridine groups. Langmuir. 2009;25(10):5993-9doi: 10.1021/la8042523.
Chen, J., Yao, K., Shangguan, W., & Yuan, J. (2009). Investigation of catalytic characterization of two-dimensional molecular space with regular ammonium and pyridine groups. Langmuir : the ACS journal of surfaces and colloids, 25(10), 5993-9. https://doi.org/10.1021/la8042523
Chen, Jianming, et al. "Investigation of catalytic characterization of two-dimensional molecular space with regular ammonium and pyridine groups." Langmuir : the ACS journal of surfaces and colloids vol. 25,10 (2009): 5993-9. doi: https://doi.org/10.1021/la8042523
Chen J, Yao K, Shangguan W, Yuan J. Investigation of catalytic characterization of two-dimensional molecular space with regular ammonium and pyridine groups. Langmuir. 2009 May 19;25(10):5993-9. doi: 10.1021/la8042523. PMID: 19296641.
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Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds.

Organic letters

Mu B, Li J, Zou D, Wu Y, Chang J, Wu Y.
PMID: 27700122
Org Lett. 2016 Oct 21;18(20):5260-5263. doi: 10.1021/acs.orglett.6b02571. Epub 2016 Oct 04.

The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation reaction proceeded smoothly without the aid of directing groups and in the presence...

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Mu B, Li J, Zou D, et al. Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds. Org Lett. 2016;18(20):5260-5263doi: 10.1021/acs.orglett.6b02571.
Mu, B., Li, J., Zou, D., Wu, Y., Chang, J., & Wu, Y. (2016). Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds. Organic letters, 18(20), 5260-5263. https://doi.org/10.1021/acs.orglett.6b02571
Mu, Bing, et al. "Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds." Organic letters vol. 18,20 (2016): 5260-5263. doi: https://doi.org/10.1021/acs.orglett.6b02571
Mu B, Li J, Zou D, Wu Y, Chang J, Wu Y. Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds. Org Lett. 2016 Oct 21;18(20):5260-5263. doi: 10.1021/acs.orglett.6b02571. Epub 2016 Oct 04. PMID: 27700122.
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Synthesis, Crystal Structure, and Second-Order Optical Nonlinearity of Bis(2-chlorobenzaldehyde thiosemicarbazone)cadmium Halides (CdL(2)X(2); X = Br, I).

Inorganic chemistry

Tian Yp, Duan Cy, Zhao Cy, You Xz, Mak TC, Zhang Zy.
PMID: 11669693
Inorg Chem. 1997 Mar 12;36(6):1247-1252. doi: 10.1021/ic9603870.

The new Schiff base ligand 2-chlorobenzaldehyde thiosemicarbazone (L, 1) has been synthesized and characterized by spectral techniques and single-crystal X-ray analysis. Crystals of 1 are monoclinic, space group P2(1)/n with a = 12.964(4) Å, b = 5.131(5) Å, c...

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Tian Yp, Duan Cy, Zhao Cy, et al. Synthesis, Crystal Structure, and Second-Order Optical Nonlinearity of Bis(2-chlorobenzaldehyde thiosemicarbazone)cadmium Halides (CdL(2)X(2); X = Br, I). Inorg Chem. 1997;36(6):1247-1252doi: 10.1021/ic9603870.
Tian Yp, Duan Cy, Zhao Cy, You Xz, Mak, T. C., & Zhang Zy. (1997). Synthesis, Crystal Structure, and Second-Order Optical Nonlinearity of Bis(2-chlorobenzaldehyde thiosemicarbazone)cadmium Halides (CdL(2)X(2); X = Br, I). Inorganic chemistry, 36(6), 1247-1252. https://doi.org/10.1021/ic9603870
Tian Yp, Yu-peng, et al. "Synthesis, Crystal Structure, and Second-Order Optical Nonlinearity of Bis(2-chlorobenzaldehyde thiosemicarbazone)cadmium Halides (CdL(2)X(2); X = Br, I)." Inorganic chemistry vol. 36,6 (1997): 1247-1252. doi: https://doi.org/10.1021/ic9603870
Tian Yp, Duan Cy, Zhao Cy, You Xz, Mak TC, Zhang Zy. Synthesis, Crystal Structure, and Second-Order Optical Nonlinearity of Bis(2-chlorobenzaldehyde thiosemicarbazone)cadmium Halides (CdL(2)X(2); X = Br, I). Inorg Chem. 1997 Mar 12;36(6):1247-1252. doi: 10.1021/ic9603870. PMID: 11669693.
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Soft threshold partial least squares predicts the survival fraction of malignant glioma cells against different concentrations of methotrexate's derivatives.

Scientific reports

Mehmood T, Iqbal M.
PMID: 34548518
Sci Rep. 2021 Sep 21;11(1):18741. doi: 10.1038/s41598-021-97891-3.

Chemotherapy appeared to be a significant advancement in cancer research, with fewer side effects. Methotrexate (MTX) is a widely used anticancer drug with strong activity but serious side effects. Several MTX derivatives have been reported, with modifications at various...

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Mehmood T, Iqbal M. Soft threshold partial least squares predicts the survival fraction of malignant glioma cells against different concentrations of methotrexate's derivatives. Sci Rep. 2021;11(1):18741doi: 10.1038/s41598-021-97891-3.
Mehmood, T., & Iqbal, M. (2021). Soft threshold partial least squares predicts the survival fraction of malignant glioma cells against different concentrations of methotrexate's derivatives. Scientific reports, 11(1), 18741. https://doi.org/10.1038/s41598-021-97891-3
Mehmood, Tahir, and Iqbal, Mudassir. "Soft threshold partial least squares predicts the survival fraction of malignant glioma cells against different concentrations of methotrexate's derivatives." Scientific reports vol. 11,1 (2021): 18741. doi: https://doi.org/10.1038/s41598-021-97891-3
Mehmood T, Iqbal M. Soft threshold partial least squares predicts the survival fraction of malignant glioma cells against different concentrations of methotrexate's derivatives. Sci Rep. 2021 Sep 21;11(1):18741. doi: 10.1038/s41598-021-97891-3. PMID: 34548518; PMCID: PMC8455530.
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Showing 1 to 8 of 8 entries