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Genome-Wide Association Study of Peripheral Artery Disease.

Circulation. Genomic and precision medicine

van Zuydam NR, Stiby A, Abdalla M, Austin E, Dahlström EH, McLachlan S, Vlachopoulou E, Ahlqvist E, Di Liao C, Sandholm N, Forsblom C, Mahajan A, Robertson NR, Rayner NW, Lindholm E, Sinisalo J, Perola M, Kallio M, Weiss E, Price J, Paterson A, Klein B, Salomaa V, Palmer CNA, Groop PH, Groop L, McCarthy MI, de Andrade M, Morris AP, Hopewell JC, Colhoun HM, Kullo IJ.
PMID: 34601942
Circ Genom Precis Med. 2021 Oct;14(5):e002862. doi: 10.1161/CIRCGEN.119.002862. Epub 2021 Oct 04.

BACKGROUND: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with PAD overall and in the contexts of diabetes and smoking status.METHODS: We identified...

Structure dynamics of HIV-1 Env trimers on native virions engaged with living T cells.

Communications biology

Carlon-Andres I, Malinauskas T, Padilla-Parra S.
PMID: 34707229
Commun Biol. 2021 Oct 27;4(1):1228. doi: 10.1038/s42003-021-02658-1.

The HIV-1 envelope glycoprotein (Env) mediates viral entry into the host cell. Although the highly dynamic nature of Env intramolecular conformations has been shown with single molecule spectroscopy in vitro, the bona fide Env intra- and intermolecular mechanics when...

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