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Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

Nature medicine

[No authors listed]
PMID: 34782789
Nat Med. 2021 Nov;27(11):1876-1884. doi: 10.1038/s41591-021-01549-6. Epub 2021 Nov 15.

Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include cost-effective enhancement of primary disease...

Cite
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Nat Med. 2021;27(11):1876-1884doi: 10.1038/s41591-021-01549-6.
(2021). Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Nature medicine, 27(11), 1876-1884. https://doi.org/10.1038/s41591-021-01549-6
"Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps." Nature medicine vol. 27,11 (2021): 1876-1884. doi: https://doi.org/10.1038/s41591-021-01549-6
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Nat Med. 2021 Nov;27(11):1876-1884. doi: 10.1038/s41591-021-01549-6. Epub 2021 Nov 15. PMID: 34782789.
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In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure.

BMC research notes

Udosen B, Soremekun O, Ekenna C, Idowu Omotuyi O, Chikowore T, Nashiru O, Fatumo S.
PMID: 34930451
BMC Res Notes. 2021 Dec 20;14(1):457. doi: 10.1186/s13104-021-05879-z.

OBJECTIVE: The Angiotensin 1 converting enzyme (ACE1) gene plays a critical role in regulating blood pressure and thus, it has become a major therapeutic target of antihypertensives. Single nucleotide polymorphisms (SNPs) occurring within a gene most especially at the...

Cite
Udosen B, Soremekun O, Ekenna C, et al. In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure. BMC Res Notes. 2021;14(1):457doi: 10.1186/s13104-021-05879-z.
Udosen, B., Soremekun, O., Ekenna, C., Idowu Omotuyi, O., Chikowore, T., Nashiru, O., & Fatumo, S. (2021). In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure. BMC research notes, 14(1), 457. https://doi.org/10.1186/s13104-021-05879-z
Udosen, Brenda, et al. "In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure." BMC research notes vol. 14,1 (2021): 457. doi: https://doi.org/10.1186/s13104-021-05879-z
Udosen B, Soremekun O, Ekenna C, Idowu Omotuyi O, Chikowore T, Nashiru O, Fatumo S. In-silico analysis reveals druggable single nucleotide polymorphisms in angiotensin 1 converting enzyme involved in the onset of blood pressure. BMC Res Notes. 2021 Dec 20;14(1):457. doi: 10.1186/s13104-021-05879-z. PMID: 34930451.
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Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps.

Nature medicine

[No authors listed]
PMID: 34782789
Nat Med. 2021 Nov;27(11):1876-1884. doi: 10.1038/s41591-021-01549-6. Epub 2021 Nov 15.

Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human genome to estimate the risk of a disease or disease-related trait for an individual. The potential benefits of PRSs include cost-effective enhancement of primary disease...

Cite
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Nat Med. 2021;27(11):1876-1884doi: 10.1038/s41591-021-01549-6.
(2021). Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Nature medicine, 27(11), 1876-1884. https://doi.org/10.1038/s41591-021-01549-6
"Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps." Nature medicine vol. 27,11 (2021): 1876-1884. doi: https://doi.org/10.1038/s41591-021-01549-6
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps. Nat Med. 2021 Nov;27(11):1876-1884. doi: 10.1038/s41591-021-01549-6. Epub 2021 Nov 15. PMID: 34782789.
Copy Download .nbib Format: NLM
Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis.

Stroke

Fatumo S, Karhunen V, Chikowore T, Sounkou T, Udosen B, Ezenwa C, Nakabuye M, Soremekun O, Daghlas I, Ryan DK, Taylor A, Mason AM, Damrauer SM, Vujkovic M, Keene KL, Fornage M, Järvelin MR, Burgess S, Gill D.
PMID: 34078102
Stroke. 2021 Aug;52(8):2680-2684. doi: 10.1161/STROKEAHA.121.034747. Epub 2021 Jun 03.

BACKGROUND AND PURPOSE: Metabolic traits affect ischemic stroke (IS) risk, but the degree to which this varies across different ethnic ancestries is not known. Our aim was to apply Mendelian randomization to investigate the causal effects of type 2...

Cite
Fatumo S, Karhunen V, Chikowore T, et al. Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis. Stroke. 2021;52(8):2680-2684doi: 10.1161/STROKEAHA.121.034747.
Fatumo, S., Karhunen, V., Chikowore, T., Sounkou, T., Udosen, B., Ezenwa, C., Nakabuye, M., Soremekun, O., Daghlas, I., Ryan, D. K., Taylor, A., Mason, A. M., Damrauer, S. M., Vujkovic, M., Keene, K. L., Fornage, M., Järvelin, M. R., Burgess, S., & Gill, D. (2021). Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis. Stroke, 52(8), 2680-2684. https://doi.org/10.1161/STROKEAHA.121.034747
Fatumo, Segun, et al. "Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis." Stroke vol. 52,8 (2021): 2680-2684. doi: https://doi.org/10.1161/STROKEAHA.121.034747
Fatumo S, Karhunen V, Chikowore T, Sounkou T, Udosen B, Ezenwa C, Nakabuye M, Soremekun O, Daghlas I, Ryan DK, Taylor A, Mason AM, Damrauer SM, Vujkovic M, Keene KL, Fornage M, Järvelin MR, Burgess S, Gill D. Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis. Stroke. 2021 Aug;52(8):2680-2684. doi: 10.1161/STROKEAHA.121.034747. Epub 2021 Jun 03. PMID: 34078102; PMCID: PMC8312569.
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