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Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning.

Cell systems

Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M.
PMID: 27136353
Cell Syst. 2015 Dec 23;1(6):383-95. doi: 10.1016/j.cels.2015.12.003. Epub 2015 Dec 23.

The structure of genetic interaction networks predicts that, analogous to synthetic lethal interactions between non-essential genes, combinations of compounds with latent activities may exhibit potent synergism. To test this hypothesis, we generated a chemical-genetic matrix of 195 diverse yeast...

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