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Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives.

Organic letters

Yang S, Liu L, Zhou Z, Huang Z, Zhao Y.
PMID: 33370124
Org Lett. 2021 Jan 15;23(2):296-299. doi: 10.1021/acs.orglett.0c03773. Epub 2020 Dec 28.

We report herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported,...

On the mechanism of the selenolactonization reaction with selenenyl halides.

The Journal of organic chemistry

Denmark SE, Edwards MG.
PMID: 16958523
J Org Chem. 2006 Sep 15;71(19):7293-306. doi: 10.1021/jo0610457.

The mechanism of selenocyclization reactions of beta,gamma-unsaturated acids and their derivatives has been studied. The reactions of (E)-4-phenyl-3-butenoic acid 10 and its silyl and alkyl esters with benzeneselenenyl chloride (PhSeCl) and bromide (PhSeBr) have been examined by VT-NMR and...

Showing 1 to 2 of 2 entries