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Showing 1 to 12 of 90 entries
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Screening for antifibrotic compounds using high throughput system based on fluorescence polarization.

Biology

Stefanovic B, Stefanovic L.
PMID: 24833510
Biology (Basel). 2014 Apr 10;3(2):281-94. doi: 10.3390/biology3020281.

Fibroproliferative diseases are one of the leading causes of death worldwide. They are characterized by reactive fibrosis caused by uncontrolled synthesis of type I collagen. There is no cure for fibrosis and development of therapeutics that can inhibit collagen...

Auxin Signaling in Regulation of Plant Translation Reinitiation.

Frontiers in plant science

Schepetilnikov M, Ryabova LA.
PMID: 28659957
Front Plant Sci. 2017 Jun 14;8:1014. doi: 10.3389/fpls.2017.01014. eCollection 2017.

The mRNA translation machinery directs protein production, and thus cell growth, according to prevailing cellular and environmental conditions. The target of rapamycin (TOR) signaling pathway-a major growth-related pathway-plays a pivotal role in optimizing protein synthesis in mammals, while its...

Protein and Genetic Composition of Four Chromatin Types in .

Current genomics

Boldyreva LV, Goncharov FP, Demakova OV, Zykova TY, Levitsky VG, Kolesnikov NN, Pindyurin AV, Semeshin VF, Zhimulev IF.
PMID: 28367077
Curr Genomics. 2017 Apr;18(2):214-226. doi: 10.2174/1389202917666160512164913.

BACKGROUND: Recently, we analyzed genome-wide protein binding data for the Drosophila cell lines S2, Kc, BG3 and Cl.8 (modENCODE Consortium) and identified a set of 12 proteins enriched in the regions corresponding to interbands of salivary gland polytene chromosomes....

The single nucleotide polymorphism story.

Pharmacogenetics

Barbaux S, Cambien F.
PMID: 12893981
Pharmacogenetics. 2003 Aug;13(8):443-4. doi: 10.1097/00008571-200308000-00001.

No abstract available.

Ectopic transcript analysis in human antithrombin deficiency.

Methods in molecular medicine

Perry DJ.
PMID: 21340999
Methods Mol Med. 1999;31:231-7. doi: 10.1385/1-59259-248-1:231.

A number of reports have demonstrated that it is possible to identify correctly spliced low-level transcripts for tissue-specific genes in a number of non-specific tissues (1-3). The number of transcripts is low (approx 1 copy every 500-1000 cells) (2),...

MAPT as a predisposing gene for sporadic amyotrophic lateral sclerosis in the Chinese Han population.

Neural regeneration research

Fang P, Xu W, Wu C, Zhu M, Li X, Hong D.
PMID: 25206632
Neural Regen Res. 2013 Nov 25;8(33):3116-23. doi: 10.3969/j.issn.1673-5374.2013.33.005.

A previous study of European Caucasian patients with sporadic amyotrophic lateral sclerosis demonstrated that a polymorphism in the microtubule-associated protein Tau (MAPT) gene was significantly associated with sporadic amyotrophic lateral sclerosis pathogenesis. Here, we tested this association in 107...

Author Correction: Functional 5' UTR mRNA structures in eukaryotic translation regulation and how to find them.

Nature reviews. Molecular cell biology

Leppek K, Das R, Barna M.
PMID: 30111874
Nat Rev Mol Cell Biol. 2018 Oct;19(10):673. doi: 10.1038/s41580-018-0055-5.

The legend of Figure 1 has been modified to remove misleading referencing to evolution. The title of the legend has been modified from 'Evolutionary expansion of eukaryotic 5' UTR lengths' to 'Interspecies variation in 5' UTR lengths'; the first...

5'-UTR and 3'-UTR Regulation of MICB Expression in Human Cancer Cells by Novel microRNAs.

Genes

Wongfieng W, Jumnainsong A, Chamgramol Y, Sripa B, Leelayuwat C.
PMID: 28850101
Genes (Basel). 2017 Aug 29;8(9). doi: 10.3390/genes8090213.

The treatment of cancer through the induction of natural killer group 2, member D (NKG2D) ligands is of interest, but understanding of mechanisms controlling expression of individual ligand is limited. The major histocompatibility complex (MHC) class I chain related...

Identification and Characterization of 5' Untranslated Regions (5'UTRs) in .

Frontiers in microbiology

Cho SH, Haning K, Shen W, Blome C, Li R, Yang S, Contreras LM.
PMID: 29375488
Front Microbiol. 2017 Dec 08;8:2432. doi: 10.3389/fmicb.2017.02432. eCollection 2017.

Regulatory RNA regions within a transcript, particularly in the 5' untranslated region (5'UTR), have been shown in a variety of organisms to control the expression levels of these mRNAs in response to various metabolites or environmental conditions. Considering the...

Riboswitch Scanner: an efficient pHMM-based web-server to detect riboswitches in genomic sequences.

Bioinformatics (Oxford, England)

Mukherjee S, Sengupta S.
PMID: 26519506
Bioinformatics. 2016 Mar 01;32(5):776-8. doi: 10.1093/bioinformatics/btv640. Epub 2015 Oct 30.

UNLABELLED: Riboswitches are non-coding RNA located in the 5' untranslated regions where they bind a target metabolite used to specify the riboswitch class and control the expression of associated genes. Accurate identification of riboswitches is the first step towards...

Riboswitches as Potential Targets for the Development of Anti-Biofilm Drugs.

Current topics in medicinal chemistry

Reyes-Darias JA, Krell T.
PMID: 28403796
Curr Top Med Chem. 2017 Apr 07; doi: 10.2174/1568026617666170407163517. Epub 2017 Apr 07.

In nature, bacteria can exist as single motile cells or as sessile cellular community, known as microbial biofilms. Bacteria within biofilms are embedded in a self-produced extracellular matrix that makes them more resistant to antibiotic treatment and responses of...

The introduction of an inverted repeat to the 5' untranslated leader sequence of a transgene strongly inhibits gene expression.

Plant cell reports

Groenewald JH, Hiten NF, Botha FC.
PMID: 30754776
Plant Cell Rep. 2000 Nov;19(11):1098-1101. doi: 10.1007/s002990000262.

 Stable secondary structures in naturally occurring 5' untranslated regions have been shown to down-regulate both transcription and translation. We introduced a synthetic GC-rich inverted repeat to the leader sequence of a transgene to determine its influence on gene...

Showing 1 to 12 of 90 entries