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CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy.

Journal of oncology

Saif MW, Makrilia N, Syrigos K.
PMID: 21209714
J Oncol. 2010;2010:934359. doi: 10.1155/2010/934359. Epub 2010 Dec 16.

Intracellular reduced folate exists as a "pool" of more than 6 interconvertable forms. One of these forms, 5,10 methylenetetrahydrofolic acid (CH(2)THF), is the key one-carbon donor and reduced folate substrate for thymidylate synthase (TS). This pathway has been an...

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