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LC-MS/MS Analysis of Cerebrospinal Fluid Metabolites in the Pterin Biosynthetic Pathway.

JIMD reports

Arning E, Bottiglieri T.
PMID: 25213568
JIMD Rep. 2016;29:1-9. doi: 10.1007/8904_2014_336. Epub 2014 Sep 12.

The analysis of (6R)-5,6,7,8-tetrahydrobiopterin (BH4) and neopterin in cerebrospinal fluid (CSF) is often used to identify defects in the pterin biosynthetic pathway affecting monoamine metabolism that can lead to pediatric neurotransmitter diseases. Low levels of BH4 and neopterin alone...

Biopterin : II. Evidence for cerebral synthesis of 7,8-dihydrobiopterin in vivo and in vitro.

Neurochemical research

Gál EM, Sherman AD.
PMID: 24271746
Neurochem Res. 1976 Dec;1(6):627-39. doi: 10.1007/BF00965603.

The active synthesis of [(14)C]7,8-dihydrobiopterin (BH2) from intraventricularly administered U-[(14)C]GTP was demonstrated in rat brain. The identity of [(14)C]BH2 isolated from brain was confirmed by mass fragmentography. Evidence is presented that [(14)C]BH2 in brain was not synthesized in the...

Showing 1 to 2 of 2 entries