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Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model.

Glia

Smit T, Deshayes NAC, Borchelt DR, Kamphuis W, Middeldorp J, Hol EM.
PMID: 33634529
Glia. 2021 Aug;69(8):1852-1881. doi: 10.1002/glia.23981. Epub 2021 Feb 25.

Astrocytes regulate synaptic communication and are essential for proper brain functioning. In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an increased expression of intermediate filament proteins and cellular hypertrophy. Reactive astrocytes are found in close association...

Showing 1 to 1 of 1 entries