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Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model.

Glia

Smit T, Deshayes NAC, Borchelt DR, Kamphuis W, Middeldorp J, Hol EM.
PMID: 33634529
Glia. 2021 Aug;69(8):1852-1881. doi: 10.1002/glia.23981. Epub 2021 Feb 25.

Astrocytes regulate synaptic communication and are essential for proper brain functioning. In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an increased expression of intermediate filament proteins and cellular hypertrophy. Reactive astrocytes are found in close association...

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Smit T, Deshayes NAC, Borchelt DR, et al. Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model. Glia. 2021;69(8):1852-1881doi: 10.1002/glia.23981.
Smit, T., Deshayes, N. A. C., Borchelt, D. R., Kamphuis, W., Middeldorp, J., & Hol, E. M. (2021). Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model. Glia, 69(8), 1852-1881. https://doi.org/10.1002/glia.23981
Smit, Tamar, et al. "Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model." Glia vol. 69,8 (2021): 1852-1881. doi: https://doi.org/10.1002/glia.23981
Smit T, Deshayes NAC, Borchelt DR, Kamphuis W, Middeldorp J, Hol EM. Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model. Glia. 2021 Aug;69(8):1852-1881. doi: 10.1002/glia.23981. Epub 2021 Feb 25. PMID: 33634529; PMCID: PMC8247905.
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Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice.

Glia

Huffels CFM, Osborn LM, Hulshof LA, Kooijman L, Henning L, Steinhäuser C, Hol EM.
PMID: 34981861
Glia. 2022 Jan 04; doi: 10.1002/glia.24137. Epub 2022 Jan 04.

Alzheimer pathology is accompanied by astrogliosis. Reactive astrocytes surrounding amyloid plaques may directly affect neuronal communication, and one of the mechanisms by which astrocytes impact neuronal function is by affecting K

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Huffels CFM, Osborn LM, Hulshof LA, et al. Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice. Glia. 2022;doi: 10.1002/glia.24137.
Huffels, C. F. M., Osborn, L. M., Hulshof, L. A., Kooijman, L., Henning, L., Steinhäuser, C., & Hol, E. M. (2022). Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice. Glia, . https://doi.org/10.1002/glia.24137
Huffels, Christiaan F M, et al. "Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice." Glia vol. (2022). doi: https://doi.org/10.1002/glia.24137
Huffels CFM, Osborn LM, Hulshof LA, Kooijman L, Henning L, Steinhäuser C, Hol EM. Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice. Glia. 2022 Jan 04; doi: 10.1002/glia.24137. Epub 2022 Jan 04. PMID: 34981861.
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Physiological and Pathological Ageing of Astrocytes in the Human Brain.

Neurochemical research

Verkerke M, Hol EM, Middeldorp J.
PMID: 33559106
Neurochem Res. 2021 Oct;46(10):2662-2675. doi: 10.1007/s11064-021-03256-7. Epub 2021 Feb 08.

Ageing is the greatest risk factor for dementia, although physiological ageing by itself does not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk factor for Alzheimer's disease and is highly expressed in...

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Verkerke M, Hol EM, Middeldorp J. Physiological and Pathological Ageing of Astrocytes in the Human Brain. Neurochem Res. 2021;46(10):2662-2675doi: 10.1007/s11064-021-03256-7.
Verkerke, M., Hol, E. M., & Middeldorp, J. (2021). Physiological and Pathological Ageing of Astrocytes in the Human Brain. Neurochemical research, 46(10), 2662-2675. https://doi.org/10.1007/s11064-021-03256-7
Verkerke, Marloes, et al. "Physiological and Pathological Ageing of Astrocytes in the Human Brain." Neurochemical research vol. 46,10 (2021): 2662-2675. doi: https://doi.org/10.1007/s11064-021-03256-7
Verkerke M, Hol EM, Middeldorp J. Physiological and Pathological Ageing of Astrocytes in the Human Brain. Neurochem Res. 2021 Oct;46(10):2662-2675. doi: 10.1007/s11064-021-03256-7. Epub 2021 Feb 08. PMID: 33559106; PMCID: PMC8437874.
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