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Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria.

Iranian journal of pharmaceutical research : IJPR

Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, Niknahad H.
PMID: 26330870
Iran J Pharm Res. 2015;14(3):825-32.

Pioglitazone (PG) is one of thiazolidinediones used for the treatment of type II diabetes mellitus. Some reports of its hepatotoxicity exist, but the mechanism of its hepatotoxicity is not well known. In the present study, the protective effect of...

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Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, et al. Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria. Iran J Pharm Res. 2015;14(3):825-32
Rezaiean Mehrabadi, A., Jamshidzadeh, A., Rashedinia, M., & Niknahad, H. (2015). Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria. Iranian journal of pharmaceutical research : IJPR, 14(3), 825-32.
Rezaiean Mehrabadi, Abbas, et al. "Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria." Iranian journal of pharmaceutical research : IJPR vol. 14,3 (2015): 825-32.
Rezaiean Mehrabadi A, Jamshidzadeh A, Rashedinia M, Niknahad H. Study of the Effects of ATP Suppliers and Thiol Reductants on Toxicity of Pioglitazone in Isolated Rat Liver Mitochondria. Iran J Pharm Res. 2015;14(3):825-32. PMID: 26330870; PMCID: PMC4518110.
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JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells.

Oncology letters

Qiu M, Chen L, Tan G, Ke L, Zhang S, Chen H, Liu J.
PMID: 28454225
Oncol Lett. 2017 Mar;13(3):1137-1142. doi: 10.3892/ol.2016.5535. Epub 2016 Dec 27.

Reactive oxygen species (ROS) are chemical species that alter redox status, and are responsible for inducing carcinogenesis. The purpose of the present study was to assess the effects of the glutathione S transferase-activated nitric oxide donor prodrug, JS-K, on...

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Qiu M, Chen L, Tan G, et al. JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells. Oncol Lett. 2016;13(3):1137-1142doi: 10.3892/ol.2016.5535.
Qiu, M., Chen, L., Tan, G., Ke, L., Zhang, S., Chen, H., & Liu, J. (2017). JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells. Oncology letters, 13(3), 1137-1142. https://doi.org/10.3892/ol.2016.5535
Qiu, Mingning, et al. "JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells." Oncology letters vol. 13,3 (2017): 1137-1142. doi: https://doi.org/10.3892/ol.2016.5535
Qiu M, Chen L, Tan G, Ke L, Zhang S, Chen H, Liu J. JS-K promotes apoptosis by inducing ROS production in human prostate cancer cells. Oncol Lett. 2017 Mar;13(3):1137-1142. doi: 10.3892/ol.2016.5535. Epub 2016 Dec 27. PMID: 28454225; PMCID: PMC5403315.
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Cell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor.

Inhalation toxicology

Faux SP, Houghton CE.
PMID: 26368632
Inhal Toxicol. 2000 Jan;12:327-36. doi: 10.1080/08958378.2000.11463242.

Asbestos has been shown to stimulate the mitogen-activated protein kinase signaling cascade after autophosphoryiation of the epidermal growth factor recptor (EGF-R), an event important in regulating the response of cells to extracellular signals. In studies reported here, we have...

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Faux SP, Houghton CE. Cell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor. Inhal Toxicol. 2000;12:327-36doi: 10.1080/08958378.2000.11463242.
Faux, S. P., & Houghton, C. E. (2000). Cell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor. Inhalation toxicology, 12327-36. https://doi.org/10.1080/08958378.2000.11463242
Faux, S P, and Houghton, C E. "Cell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor." Inhalation toxicology vol. 12 (2000): 327-36. doi: https://doi.org/10.1080/08958378.2000.11463242
Faux SP, Houghton CE. Cell Signaling in Mesothelial Cells by Asbestos: Evidence for the Involvement of Oxidative Stress in the Regulation of the Epidermal Growth Factor Receptor. Inhal Toxicol. 2000 Jan;12:327-36. doi: 10.1080/08958378.2000.11463242. PMID: 26368632.
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Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia.

Intensive care medicine experimental

Ergin B, Guerci P, Zafrani L, Nocken F, Kandil A, Gurel-Gurevin E, Demirci-Tansel C, Ince C.
PMID: 27671340
Intensive Care Med Exp. 2016 Dec;4(1):29. doi: 10.1186/s40635-016-0106-1. Epub 2016 Sep 26.

BACKGROUND: Modulation of inflammation and oxidative stress appears to limit sepsis-induced damage in experimental models. The kidney is one of the most sensitive organs to injury during septic shock. In this study, we evaluated the effect of N-acetylcysteine (NAC)...

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Ergin B, Guerci P, Zafrani L, et al. Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive Care Med Exp. 2016;4(1):29doi: 10.1186/s40635-016-0106-1.
Ergin, B., Guerci, P., Zafrani, L., Nocken, F., Kandil, A., Gurel-Gurevin, E., Demirci-Tansel, C., & Ince, C. (2016). Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive care medicine experimental, 4(1), 29. https://doi.org/10.1186/s40635-016-0106-1
Ergin, Bulent, et al. "Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia." Intensive care medicine experimental vol. 4,1 (2016): 29. doi: https://doi.org/10.1186/s40635-016-0106-1
Ergin B, Guerci P, Zafrani L, Nocken F, Kandil A, Gurel-Gurevin E, Demirci-Tansel C, Ince C. Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive Care Med Exp. 2016 Dec;4(1):29. doi: 10.1186/s40635-016-0106-1. Epub 2016 Sep 26. PMID: 27671340; PMCID: PMC5037099.
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Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis.

Core evidence

Inomata M, Nishioka Y, Azuma A.
PMID: 26346347
Core Evid. 2015 Aug 27;10:89-98. doi: 10.2147/CE.S82905. eCollection 2015.

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis. The molecular mechanisms involved in the progression of IPF are not fully understood; however, the platelet-derived growth factor (PDGF)/PDGF receptor pathway is thought to play a critical role...

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Inomata M, Nishioka Y, Azuma A. Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis. Core Evid. 2015;10:89-98doi: 10.2147/CE.S82905.
Inomata, M., Nishioka, Y., & Azuma, A. (2015). Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis. Core evidence, 1089-98. https://doi.org/10.2147/CE.S82905
Inomata, Minoru, et al. "Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis." Core evidence vol. 10 (2015): 89-98. doi: https://doi.org/10.2147/CE.S82905
Inomata M, Nishioka Y, Azuma A. Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis. Core Evid. 2015 Aug 27;10:89-98. doi: 10.2147/CE.S82905. eCollection 2015. PMID: 26346347; PMCID: PMC4555978.
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Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes.

Oncotarget

Tao S, Yuan Q, Mao L, Chen FL, Ji F, Cui ZH.
PMID: 28978056
Oncotarget. 2017 Jun 28;8(40):67605-67613. doi: 10.18632/oncotarget.18754. eCollection 2017 Sep 15.

Vitamin D deficiency could cause insulin resistance. However, the underlying mechanisms are unclear. The 1α-Hydroxylase ["1α(OH)ase"] is a key enzyme for activate vitamin D3 synthesis. Here, we show that 1α(OH)ase stable knockdown by targeted shRNA led to vitamin D3...

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Tao S, Yuan Q, Mao L, et al. Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes. Oncotarget. 2017;8(40):67605-67613doi: 10.18632/oncotarget.18754.
Tao, S., Yuan, Q., Mao, L., Chen, F. L., Ji, F., & Cui, Z. H. (2017). Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes. Oncotarget, 8(40), 67605-67613. https://doi.org/10.18632/oncotarget.18754
Tao, Sha, et al. "Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes." Oncotarget vol. 8,40 (2017): 67605-67613. doi: https://doi.org/10.18632/oncotarget.18754
Tao S, Yuan Q, Mao L, Chen FL, Ji F, Cui ZH. Vitamin D deficiency causes insulin resistance by provoking oxidative stress in hepatocytes. Oncotarget. 2017 Jun 28;8(40):67605-67613. doi: 10.18632/oncotarget.18754. eCollection 2017 Sep 15. PMID: 28978056; PMCID: PMC5620196.
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Acetylcysteine and Acetaminophen Overdose: The Many Shades of Gray.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Chyka PA.
PMID: 26170767
J Pediatr Pharmacol Ther. 2015 May-Jun;20(3):160-2. doi: 10.5863/1551-6776-20.3.160.

No abstract available.

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Chyka PA. Acetylcysteine and Acetaminophen Overdose: The Many Shades of Gray. J Pediatr Pharmacol Ther. 2015;20(3):160-2doi: 10.5863/1551-6776-20.3.160.
Chyka, P. A. (2015). Acetylcysteine and Acetaminophen Overdose: The Many Shades of Gray. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 20(3), 160-2. https://doi.org/10.5863/1551-6776-20.3.160
Chyka, Peter A. "Acetylcysteine and Acetaminophen Overdose: The Many Shades of Gray." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 20,3 (2015): 160-2. doi: https://doi.org/10.5863/1551-6776-20.3.160
Chyka PA. Acetylcysteine and Acetaminophen Overdose: The Many Shades of Gray. J Pediatr Pharmacol Ther. 2015 May-Jun;20(3):160-2. doi: 10.5863/1551-6776-20.3.160. PMID: 26170767; PMCID: PMC4471709.
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Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors.

Data in brief

Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH.
PMID: 27437434
Data Brief. 2016 Jun 23;8:618-27. doi: 10.1016/j.dib.2016.06.018. eCollection 2016 Sep.

This article contains data on the variation in several physiological parameters of red blood cells (RBCs) donated by eligible glucose-6-phosphate dehydrogenase (G6PD) deficient donors during storage in standard blood bank conditions compared to control, G6PD sufficient (G6PD(+)) cells. Intracellular...

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Tzounakas VL, Kriebardis AG, Georgatzakou HT, et al. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data Brief. 2016;8:618-27doi: 10.1016/j.dib.2016.06.018.
Tzounakas, V. L., Kriebardis, A. G., Georgatzakou, H. T., Foudoulaki-Paparizos, L. E., Dzieciatkowska, M., Wither, M. J., Nemkov, T., Hansen, K. C., Papassideri, I. S., D'Alessandro, A., & Antonelou, M. H. (2016). Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data in brief, 8618-27. https://doi.org/10.1016/j.dib.2016.06.018
Tzounakas, Vassilis L, et al. "Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors." Data in brief vol. 8 (2016): 618-27. doi: https://doi.org/10.1016/j.dib.2016.06.018
Tzounakas VL, Kriebardis AG, Georgatzakou HT, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri IS, D'Alessandro A, Antonelou MH. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data Brief. 2016 Jun 23;8:618-27. doi: 10.1016/j.dib.2016.06.018. eCollection 2016 Sep. PMID: 27437434; PMCID: PMC4939423.
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Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy.

Journal of renal injury prevention

Pezeshgi A, Parsamanesh N, Farhood G, Mahmoodi K.
PMID: 26693496
J Renal Inj Prev. 2015 Sep 01;4(4):109-12. doi: 10.12861/jrip.2015.23. eCollection 2015.

INTRODUCTION: Intravenous contrast agents can cause acute decline in kidney function, especially in patients with risk factors.OBJECTIVES: In this study, we aimed to examine the ameliorative effect N-acetylcysteine (NAC) to reduce the incidence of contrast nephropathy.PATIENTS AND METHODS: This...

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Pezeshgi A, Parsamanesh N, Farhood G, et al. Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy. J Renal Inj Prev. 2015;4(4):109-12doi: 10.12861/jrip.2015.23.
Pezeshgi, A., Parsamanesh, N., Farhood, G., & Mahmoodi, K. (2015). Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy. Journal of renal injury prevention, 4(4), 109-12. https://doi.org/10.12861/jrip.2015.23
Pezeshgi, Aiyoub, et al. "Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy." Journal of renal injury prevention vol. 4,4 (2015): 109-12. doi: https://doi.org/10.12861/jrip.2015.23
Pezeshgi A, Parsamanesh N, Farhood G, Mahmoodi K. Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy. J Renal Inj Prev. 2015 Sep 01;4(4):109-12. doi: 10.12861/jrip.2015.23. eCollection 2015. PMID: 26693496; PMCID: PMC4685979.
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Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver.

Toxicological research

Heidari R, Esmailie N, Azarpira N, Najibi A, Niknahad H.
PMID: 27123164
Toxicol Res. 2016 Apr;32(2):133-40. doi: 10.5487/TR.2016.32.2.133. Epub 2016 Apr 30.

Sulfasalzine is a widely administered drug against inflammatory-based disorders in human. However several cases of liver injury are associated with its administration. There is no stabilized safe protective agent against sulfasalazine-induced liver injury. Current investigation was designed to evaluate...

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Heidari R, Esmailie N, Azarpira N, et al. Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver. Toxicol Res. 2016;32(2):133-40doi: 10.5487/TR.2016.32.2.133.
Heidari, R., Esmailie, N., Azarpira, N., Najibi, A., & Niknahad, H. (2016). Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver. Toxicological research, 32(2), 133-40. https://doi.org/10.5487/TR.2016.32.2.133
Heidari, Reza, et al. "Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver." Toxicological research vol. 32,2 (2016): 133-40. doi: https://doi.org/10.5487/TR.2016.32.2.133
Heidari R, Esmailie N, Azarpira N, Najibi A, Niknahad H. Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver. Toxicol Res. 2016 Apr;32(2):133-40. doi: 10.5487/TR.2016.32.2.133. Epub 2016 Apr 30. PMID: 27123164; PMCID: PMC4843982.
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Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis.

Clinical drug investigation

Sharer NM, Scott PD, Deardon DJ, Lee SH, Taylor PM, Braganza JM.
PMID: 27519198
Clin Drug Investig. 1995 Sep;10(3):147-57. doi: 10.2165/00044011-199510030-00003.

The depletion of thiols in pancreatic acinar cells, as a consequence of oxidative stress, seems to underlie acute pancreatitis. Therefore, immediate parenteral treatment with agents to refurbish tissue thiols should accelerate recovery. We tested this hypothesis in a randomised...

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Sharer NM, Scott PD, Deardon DJ, et al. Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis. Clin Drug Investig. 1995;10(3):147-57doi: 10.2165/00044011-199510030-00003.
Sharer, N. M., Scott, P. D., Deardon, D. J., Lee, S. H., Taylor, P. M., & Braganza, J. M. (1995). Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis. Clinical drug investigation, 10(3), 147-57. https://doi.org/10.2165/00044011-199510030-00003
Sharer, N M, et al. "Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis." Clinical drug investigation vol. 10,3 (1995): 147-57. doi: https://doi.org/10.2165/00044011-199510030-00003
Sharer NM, Scott PD, Deardon DJ, Lee SH, Taylor PM, Braganza JM. Clinical Trial of 24 Hours' Treatment with Glutathione Precursors in Acute Pancreatitis. Clin Drug Investig. 1995 Sep;10(3):147-57. doi: 10.2165/00044011-199510030-00003. PMID: 27519198.
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An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-Acetylcysteine.

Annals of emergency medicine

Langferd JS, Sheikh S.
PMID: 28140071
Ann Emerg Med. 1999 Oct;34(4):538-541.

We describe the case of an adolescent girl who received high-dose metoclopramide in combination with oral N-acetylcysteine therapy for acute acetaminophen toxicity. Whole blood-sample analysis for abnormal hemoglobin pigments established the diagnosis of sulfhemoglobinemia. Metoclopramide has been shown to...

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Langferd JS, Sheikh S. An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-Acetylcysteine. Ann Emerg Med. 1999;34(4):538-541
Langferd, J. S., & Sheikh, S. (1999). An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-Acetylcysteine. Annals of emergency medicine, 34(4), 538-541.
Langferd, Joseph S, and Sheikh, Shahid. "An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-Acetylcysteine." Annals of emergency medicine vol. 34,4 (1999): 538-541.
Langferd JS, Sheikh S. An adolescent case of sulfhemoglobinemia associated with high-dose metoclopramide and N-Acetylcysteine. Ann Emerg Med. 1999 Oct;34(4):538-541. PMID: 28140071.
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Showing 1 to 12 of 1089 entries