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Showing 1 to 8 of 8 entries
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Effect of Alpha 1-Adrnoceptor Antagonists on Postsynaptic Sensitivity in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats Using Slice Patch-Clamp Technique for mEPSC.

International neurourology journal

Uta D, Hattori T, Yoshimura M.
PMID: 32615675
Int Neurourol J. 2020 Jun;24(2):135-143. doi: 10.5213/inj.1938250.125. Epub 2020 Jun 30.

PURPOSE: Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms (LUTS). However, the mechanism of action of these compounds remains unclear. To clarify the mechanism of the α1-adrenoceptor antagonists, the amplitude of miniature excitatory postsynaptic currents...

Differential Effects of Alpha 1-Adrenoceptor Antagonists on the Postsynaptic Sensitivity: Using Slice Patch-Clamp Technique for Inhibitory Postsynaptic Current in Substantia Gelatinosa Neurons From Lumbosacral Spinal Cord in Rats.

International neurourology journal

Uta D, Hattori T, Yoshimura M.
PMID: 32615674
Int Neurourol J. 2020 Jun;24(2):127-134. doi: 10.5213/inj.1938248.124. Epub 2020 Jun 30.

PURPOSE: Alpha1-adrenoceptors participate in improving storage symptoms of male lower urinary tract symptoms. However, the mechanism of action of these compounds remains unclear. The goal of the present study was to clarify the effect of α1- adrenoceptor antagonists on...

α-Blockers for the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Update on Current Clinical Evidence.

Reviews in urology

Nickel JC, Touma N.
PMID: 23526487
Rev Urol. 2012;14(3):56-64.

The pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is multifactorial, making its treatment difficult. Multimodal therapy including α-adrenergic antagonists (α-blockers), anti-inflammatory agents, and other pain treatments may provide optimal management for CP/CPPS. Although α-blockers are the most prescribed...

Analysis of prescriptions of alpha-blockers and phosphodiesterase 5 inhibitors from the urology department and other departments.

International neurourology journal

Kang DH, Lee JY, Chung JH, Cho HJ, Cho JM, Moon HS, Kim YT, Yoo TK, Choi HY, Park HY, Lee SW.
PMID: 22259736
Int Neurourol J. 2011 Dec;15(4):216-21. doi: 10.5213/inj.2011.15.4.216. Epub 2011 Dec 31.

PURPOSE: We analyzed the prescriptions of alpha-blockers and phosphodiesterase 5 inhibitors (PDE5Is) in the urology department as well as in other departments of the general hospital.METHODS: We investigated the frequency of prescription of alpha-blockers and PDE5Is from 3 general...

α-blocker monotherapy and α-blocker plus 5-alpha-reductase inhibitor combination treatment in benign prostatic hyperplasia; 10 years' long-term results.

Korean journal of urology

Shin TJ, Kim CI, Park CH, Kim BH, Kwon YK.
PMID: 22536467
Korean J Urol. 2012 Apr;53(4):248-52. doi: 10.4111/kju.2012.53.4.248. Epub 2012 Apr 18.

PURPOSE: We compared the effects of alpha-adrenergic receptor blocker (α-blocker) monotherapy with those of combination therapy with α-blocker and 5-alpha-reductase inhibitor (5-ARI) on benign prostatic hyperplasia (BPH) progression for over 10 years.MATERIALS AND METHODS: A total of 620 patients...

Long-term Combination Therapy With α-Blockers and 5α-Reductase Inhibitors in Benign Prostatic Hyperplasia: Patient Adherence and Causes of Withdrawal From Medication.

International neurourology journal

Ong HL, Liao CH, Kuo HC.
PMID: 28043104
Int Neurourol J. 2016 Dec;20(4):356-362. doi: 10.5213/inj.1632526.263. Epub 2016 Dec 26.

PURPOSE: To investigate long-term therapeutic effects and patient adherence to a combination therapy of a 5α-reductase inhibitor and an α-blocker and to identify causes of withdrawal from medication in patients with clinical benign prostatic hyperplasia (BPH).METHODS: BPH patients with...

Impact of intravesical protrusion of the prostate in the treatment of lower urinary tract symptoms/benign prostatic hyperplasia of moderate size by alpha receptor antagonist.

International neurourology journal

Seo YM, Kim HJ.
PMID: 23346485
Int Neurourol J. 2012 Dec;16(4):187-90. doi: 10.5213/inj.2012.16.4.187. Epub 2012 Dec 31.

PURPOSE: To evaluate whether intravesical protrusion of the prostate (IPP) is related to the treatment effect of alpha-1 receptor antagonist in patients with lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) with a prostate size of less than 40...

Association of alpha-1-adrenergic antagonist use with the risk of gout development in benign prostatic hyperplasia patients: a population-based cohort study.

Family practice

Hsu WH, Lai JN, Lin CL, Loh CH, Huang HK, Huang LK.
PMID: 34964888
Fam Pract. 2021 Dec 29; doi: 10.1093/fampra/cmab163. Epub 2021 Dec 29.

BACKGROUND: Men are more likely to develop benign prostatic hyperplasia (BPH) and gout as they age. However, the role of alpha-1-adrenergic antagonists, the medication for BPH, in the development of gout is uncertain.OBJECTIVE: To investigate the effect of alpha-1-adrenergic...

Showing 1 to 8 of 8 entries