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Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens.

Environmental toxicology and pharmacology

Dawson DA, Scott BD, Ellenberger MJ, Pöch G, Rinaldi AC.
PMID: 21782690
Environ Toxicol Pharmacol. 2004 Mar;16(1):13-23. doi: 10.1016/j.etap.2003.08.002.

Single-chemical and mixture concentration-response curves generated using a frog embryo model were examined for value in assessing whether chemicals exert toxic effects at the same or at different molecular sites of action. Toxicity tests were conducted on a series...

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Dawson DA, Scott BD, Ellenberger MJ, et al. Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens. Environ Toxicol Pharmacol. 2004;16(1):13-23doi: 10.1016/j.etap.2003.08.002.
Dawson, D. A., Scott, B. D., Ellenberger, M. J., Pöch, G., & Rinaldi, A. C. (2004). Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens. Environmental toxicology and pharmacology, 16(1), 13-23. https://doi.org/10.1016/j.etap.2003.08.002
Dawson, Douglas A, et al. "Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens." Environmental toxicology and pharmacology vol. 16,1 (2004): 13-23. doi: https://doi.org/10.1016/j.etap.2003.08.002
Dawson DA, Scott BD, Ellenberger MJ, Pöch G, Rinaldi AC. Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens. Environ Toxicol Pharmacol. 2004 Mar;16(1):13-23. doi: 10.1016/j.etap.2003.08.002. PMID: 21782690.
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Comparison of rat and chick limb bud micromass cultures for developmental toxicity screening.

Toxicology in vitro : an international journal published in association with BIBRA

Brown NA, Wiger R.
PMID: 20732099
Toxicol In Vitro. 1992 Mar;6(2):101-7. doi: 10.1016/0887-2333(92)90002-9.

This study compares the responses of rat and chick limb bud micromass cultures to chemical treatment. Eight chemicals, of diverse structure, potency and mechanism, were tested, using two endpoints: extractable alcian blue stain as a measure of differentiation to...

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Brown NA, Wiger R. Comparison of rat and chick limb bud micromass cultures for developmental toxicity screening. Toxicol In Vitro. 1992;6(2):101-7doi: 10.1016/0887-2333(92)90002-9.
Brown, N. A., & Wiger, R. (1992). Comparison of rat and chick limb bud micromass cultures for developmental toxicity screening. Toxicology in vitro : an international journal published in association with BIBRA, 6(2), 101-7. https://doi.org/10.1016/0887-2333(92)90002-9
Brown, N A, and Wiger, R. "Comparison of rat and chick limb bud micromass cultures for developmental toxicity screening." Toxicology in vitro : an international journal published in association with BIBRA vol. 6,2 (1992): 101-7. doi: https://doi.org/10.1016/0887-2333(92)90002-9
Brown NA, Wiger R. Comparison of rat and chick limb bud micromass cultures for developmental toxicity screening. Toxicol In Vitro. 1992 Mar;6(2):101-7. doi: 10.1016/0887-2333(92)90002-9. PMID: 20732099.
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Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats.

Journal of neurosurgical sciences

Shimoda Y, Nakayama N, Moriwaki T, Abumiya T, Kawabori M, Kurisu K, Gekka M, Hokari M, Ito Y, Houkin K.
PMID: 32031355
J Neurosurg Sci. 2020 Feb 04; doi: 10.23736/S0390-5616.19.04819-7. Epub 2020 Feb 04.

BACKGROUND: It is necessary and useful to obtain an experimental model which steadily and rapidly induces aneurysms for investigation of the pathogenesis of cerebral aneurysm. We attempted to examine whether intraperitoneal administration of β-aminopropionitrile fumarate (BAPN-F) with additional treatments...

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Shimoda Y, Nakayama N, Moriwaki T, et al. Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats. J Neurosurg Sci. 2020;doi: 10.23736/S0390-5616.19.04819-7.
Shimoda, Y., Nakayama, N., Moriwaki, T., Abumiya, T., Kawabori, M., Kurisu, K., Gekka, M., Hokari, M., Ito, Y., & Houkin, K. (2020). Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats. Journal of neurosurgical sciences, . https://doi.org/10.23736/S0390-5616.19.04819-7
Shimoda, Yusuke, et al. "Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats." Journal of neurosurgical sciences vol. (2020). doi: https://doi.org/10.23736/S0390-5616.19.04819-7
Shimoda Y, Nakayama N, Moriwaki T, Abumiya T, Kawabori M, Kurisu K, Gekka M, Hokari M, Ito Y, Houkin K. Induction of large cerebral aneurysms by intraperitoneal administration of β-aminopropionitrile fumarate in male rats. J Neurosurg Sci. 2020 Feb 04; doi: 10.23736/S0390-5616.19.04819-7. Epub 2020 Feb 04. PMID: 32031355.
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Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence.

Cancers

Alfano M, Locatelli I, D'Arrigo C, Mora M, Vozzi G, De Acutis A, Pece R, Tavella S, Costa D, Poggi A, Zocchi MR.
PMID: 35008423
Cancers (Basel). 2022 Jan 05;14(1). doi: 10.3390/cancers14010259.

PURPOSE: The biochemical composition and architecture of the extracellular matrix (ECM) is known to condition development and invasiveness of neoplasms. To clarify this point, we analyzed ECM stiffness, collagen cross-linking and anisotropy in lymph nodes (LN) of Hodgkin lymphomas...

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Alfano M, Locatelli I, D'Arrigo C, et al. Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence. Cancers (Basel). 2022;14(1)doi: 10.3390/cancers14010259.
Alfano, M., Locatelli, I., D'Arrigo, C., Mora, M., Vozzi, G., De Acutis, A., Pece, R., Tavella, S., Costa, D., Poggi, A., & Zocchi, M. R. (2022). Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence. Cancers, 14(1), . https://doi.org/10.3390/cancers14010259
Alfano, Massimo, et al. "Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence." Cancers vol. 14,1 (2022). doi: https://doi.org/10.3390/cancers14010259
Alfano M, Locatelli I, D'Arrigo C, Mora M, Vozzi G, De Acutis A, Pece R, Tavella S, Costa D, Poggi A, Zocchi MR. Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence. Cancers (Basel). 2022 Jan 05;14(1). doi: 10.3390/cancers14010259. PMID: 35008423.
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Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm.

Journal of the American Heart Association

Zhang C, Mohan A, Shi H, Yan C.
PMID: 34984916
J Am Heart Assoc. 2022 Jan 05;e023053. doi: 10.1161/JAHA.121.023053. Epub 2022 Jan 05.

Background cGMP-hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP-dependent protein kinase I (PKGI)-dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have been used for...

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Zhang C, Mohan A, Shi H, et al. Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm. J Am Heart Assoc. 2022;e023053doi: 10.1161/JAHA.121.023053.
Zhang, C., Mohan, A., Shi, H., & Yan, C. (2022). Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm. Journal of the American Heart Association, e023053. https://doi.org/10.1161/JAHA.121.023053
Zhang, Chongyang, et al. "Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm." Journal of the American Heart Association vol. (2022): e023053. doi: https://doi.org/10.1161/JAHA.121.023053
Zhang C, Mohan A, Shi H, Yan C. Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm. J Am Heart Assoc. 2022 Jan 05;e023053. doi: 10.1161/JAHA.121.023053. Epub 2022 Jan 05. PMID: 34984916.
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Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages.

Frontiers in cardiovascular medicine

Wang Q, Chen Z, Peng X, Zheng Z, Le A, Guo J, Ma L, Shi H, Yao K, Zhang S, Zheng Z, Zhu J.
PMID: 34869700
Front Cardiovasc Med. 2021 Nov 18;8:788645. doi: 10.3389/fcvm.2021.788645. eCollection 2021.

Inflammation plays an important role in aortic dissection (AD). Macrophages are critically involved in the inflammation after aortic injury. Neuraminidases (NEUs) are a family of enzymes that catalyze the cleavage of terminal sialic acids from glycoproteins or glycolipids, which...

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Wang Q, Chen Z, Peng X, et al. Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages. Front Cardiovasc Med. 2021;8:788645doi: 10.3389/fcvm.2021.788645.
Wang, Q., Chen, Z., Peng, X., Zheng, Z., Le, A., Guo, J., Ma, L., Shi, H., Yao, K., Zhang, S., Zheng, Z., & Zhu, J. (2021). Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages. Frontiers in cardiovascular medicine, 8788645. https://doi.org/10.3389/fcvm.2021.788645
Wang, Qian, et al. "Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages." Frontiers in cardiovascular medicine vol. 8 (2021): 788645. doi: https://doi.org/10.3389/fcvm.2021.788645
Wang Q, Chen Z, Peng X, Zheng Z, Le A, Guo J, Ma L, Shi H, Yao K, Zhang S, Zheng Z, Zhu J. Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages. Front Cardiovasc Med. 2021 Nov 18;8:788645. doi: 10.3389/fcvm.2021.788645. eCollection 2021. PMID: 34869700; PMCID: PMC8639188.
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BAPN-induced rodent model of aortic dissecting aneurysm and related complications.

Journal of thoracic disease

Chen T, Jiang N, Zhang S, Chen Q, Guo Z.
PMID: 34277056
J Thorac Dis. 2021 Jun;13(6):3643-3651. doi: 10.21037/jtd-21-605.

BACKGROUND: The aim of this study was to investigate the effects of beta-aminopropionitrile (BAPN) on the arterial walls of rodents, and to analyze the gross or pathological changes of arterial and other tissues of rodents treated with BAPN at...

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Chen T, Jiang N, Zhang S, et al. BAPN-induced rodent model of aortic dissecting aneurysm and related complications. J Thorac Dis. 2021;13(6):3643-3651doi: 10.21037/jtd-21-605.
Chen, T., Jiang, N., Zhang, S., Chen, Q., & Guo, Z. (2021). BAPN-induced rodent model of aortic dissecting aneurysm and related complications. Journal of thoracic disease, 13(6), 3643-3651. https://doi.org/10.21037/jtd-21-605
Chen, Tongyun, et al. "BAPN-induced rodent model of aortic dissecting aneurysm and related complications." Journal of thoracic disease vol. 13,6 (2021): 3643-3651. doi: https://doi.org/10.21037/jtd-21-605
Chen T, Jiang N, Zhang S, Chen Q, Guo Z. BAPN-induced rodent model of aortic dissecting aneurysm and related complications. J Thorac Dis. 2021 Jun;13(6):3643-3651. doi: 10.21037/jtd-21-605. PMID: 34277056; PMCID: PMC8264692.
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Progression and Regression of Abdominal Aortic Aneurysms in Mice.

Current medical science

Ding YC, Zhang XJ, Zhang JX, Zhai ZY, Zhang MX, Jiang BH.
PMID: 34643880
Curr Med Sci. 2021 Oct;41(5):901-908. doi: 10.1007/s11596-021-2425-z. Epub 2021 Oct 13.

OBJECTIVE: Abdominal aortic aneurysm (AAA) is a significant medical problem with a high mortality rate. Nevertheless, the underlying mechanism for the progression and regression of AAA is unknown.METHODS: Experimental model of AAA was first created by porcine pancreatic elastase...

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Ding YC, Zhang XJ, Zhang JX, et al. Progression and Regression of Abdominal Aortic Aneurysms in Mice. Curr Med Sci. 2021;41(5):901-908doi: 10.1007/s11596-021-2425-z.
Ding, Y. C., Zhang, X. J., Zhang, J. X., Zhai, Z. Y., Zhang, M. X., & Jiang, B. H. (2021). Progression and Regression of Abdominal Aortic Aneurysms in Mice. Current medical science, 41(5), 901-908. https://doi.org/10.1007/s11596-021-2425-z
Ding, Yu-Chao, et al. "Progression and Regression of Abdominal Aortic Aneurysms in Mice." Current medical science vol. 41,5 (2021): 901-908. doi: https://doi.org/10.1007/s11596-021-2425-z
Ding YC, Zhang XJ, Zhang JX, Zhai ZY, Zhang MX, Jiang BH. Progression and Regression of Abdominal Aortic Aneurysms in Mice. Curr Med Sci. 2021 Oct;41(5):901-908. doi: 10.1007/s11596-021-2425-z. Epub 2021 Oct 13. PMID: 34643880.
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LOXL2 Inhibitors and Breast Cancer Progression.

Antioxidants (Basel, Switzerland)

Ferreira S, Saraiva N, Rijo P, Fernandes AS.
PMID: 33669630
Antioxidants (Basel). 2021 Feb 19;10(2). doi: 10.3390/antiox10020312.

LOX (lysyl oxidase) and lysyl oxidase like-1-4 (LOXL 1-4) are amine oxidases, which catalyze cross-linking reactions of elastin and collagen in the connective tissue. These amine oxidases also allow the cross-link of collagen and elastin in the extracellular matrix...

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Ferreira S, Saraiva N, Rijo P, et al. LOXL2 Inhibitors and Breast Cancer Progression. Antioxidants (Basel). 2021;10(2)doi: 10.3390/antiox10020312.
Ferreira, S., Saraiva, N., Rijo, P., & Fernandes, A. S. (2021). LOXL2 Inhibitors and Breast Cancer Progression. Antioxidants (Basel, Switzerland), 10(2), . https://doi.org/10.3390/antiox10020312
Ferreira, Sandra, et al. "LOXL2 Inhibitors and Breast Cancer Progression." Antioxidants (Basel, Switzerland) vol. 10,2 (2021). doi: https://doi.org/10.3390/antiox10020312
Ferreira S, Saraiva N, Rijo P, Fernandes AS. LOXL2 Inhibitors and Breast Cancer Progression. Antioxidants (Basel). 2021 Feb 19;10(2). doi: 10.3390/antiox10020312. PMID: 33669630; PMCID: PMC7921998.
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Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition.

Scientific reports

Berman AG, Romary DJ, Kerr KE, Gorazd NE, Wigand MM, Patnaik SS, Finol EA, Cox AD, Goergen CJ.
PMID: 34997075
Sci Rep. 2022 Jan 07;12(1):99. doi: 10.1038/s41598-021-04089-8.

Abdominal aortic aneurysm (AAA) formation and expansion is highly complex and multifactorial, and the improvement of animal models is an important step to enhance our understanding of AAA pathophysiology. In this study, we explore our ability to influence aneurysm...

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Berman AG, Romary DJ, Kerr KE, et al. Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition. Sci Rep. 2022;12(1):99doi: 10.1038/s41598-021-04089-8.
Berman, A. G., Romary, D. J., Kerr, K. E., Gorazd, N. E., Wigand, M. M., Patnaik, S. S., Finol, E. A., Cox, A. D., & Goergen, C. J. (2022). Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition. Scientific reports, 12(1), 99. https://doi.org/10.1038/s41598-021-04089-8
Berman, Alycia G, et al. "Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition." Scientific reports vol. 12,1 (2022): 99. doi: https://doi.org/10.1038/s41598-021-04089-8
Berman AG, Romary DJ, Kerr KE, Gorazd NE, Wigand MM, Patnaik SS, Finol EA, Cox AD, Goergen CJ. Experimental aortic aneurysm severity and growth depend on topical elastase concentration and lysyl oxidase inhibition. Sci Rep. 2022 Jan 07;12(1):99. doi: 10.1038/s41598-021-04089-8. PMID: 34997075.
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Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence.

Cancers

Alfano M, Locatelli I, D'Arrigo C, Mora M, Vozzi G, De Acutis A, Pece R, Tavella S, Costa D, Poggi A, Zocchi MR.
PMID: 35008423
Cancers (Basel). 2022 Jan 05;14(1). doi: 10.3390/cancers14010259.

PURPOSE: The biochemical composition and architecture of the extracellular matrix (ECM) is known to condition development and invasiveness of neoplasms. To clarify this point, we analyzed ECM stiffness, collagen cross-linking and anisotropy in lymph nodes (LN) of Hodgkin lymphomas...

Cite
Alfano M, Locatelli I, D'Arrigo C, et al. Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence. Cancers (Basel). 2022;14(1)doi: 10.3390/cancers14010259.
Alfano, M., Locatelli, I., D'Arrigo, C., Mora, M., Vozzi, G., De Acutis, A., Pece, R., Tavella, S., Costa, D., Poggi, A., & Zocchi, M. R. (2022). Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence. Cancers, 14(1), . https://doi.org/10.3390/cancers14010259
Alfano, Massimo, et al. "Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence." Cancers vol. 14,1 (2022). doi: https://doi.org/10.3390/cancers14010259
Alfano M, Locatelli I, D'Arrigo C, Mora M, Vozzi G, De Acutis A, Pece R, Tavella S, Costa D, Poggi A, Zocchi MR. Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence. Cancers (Basel). 2022 Jan 05;14(1). doi: 10.3390/cancers14010259. PMID: 35008423; PMCID: PMC8750937.
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Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice.

PloS one

Hammond MA, Laine TJ, Berman AG, Wallace JM.
PMID: 27655444
PLoS One. 2016 Sep 21;11(9):e0163273. doi: 10.1371/journal.pone.0163273. eCollection 2016.

The specifics of how the nanoscale properties of collagen (e.g., the crosslinking profile) affect the mechanical integrity of bone at larger length scales is poorly understood despite growing evidence that collagen's nanoscale properties are altered with disease. Additionally, mass...

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Hammond MA, Laine TJ, Berman AG, et al. Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice. PLoS One. 2016;11(9):e0163273doi: 10.1371/journal.pone.0163273.
Hammond, M. A., Laine, T. J., Berman, A. G., & Wallace, J. M. (2016). Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice. PloS one, 11(9), e0163273. https://doi.org/10.1371/journal.pone.0163273
Hammond, Max A, et al. "Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice." PloS one vol. 11,9 (2016): e0163273. doi: https://doi.org/10.1371/journal.pone.0163273
Hammond MA, Laine TJ, Berman AG, Wallace JM. Treadmill Exercise Improves Fracture Toughness and Indentation Modulus without Altering the Nanoscale Morphology of Collagen in Mice. PLoS One. 2016 Sep 21;11(9):e0163273. doi: 10.1371/journal.pone.0163273. eCollection 2016. PMID: 27655444; PMCID: PMC5031456.
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Showing 1 to 12 of 39 entries