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Showing 1 to 12 of 39 entries
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Short-term Effects of Ethanol Intoxication on Ascorbic Acid and Lipid Metabolism and on Drug-metabolizing Enzymes in Liver of Rats.

Bioscience, biotechnology, and biochemistry

Mochizuki S, Oda H, Yoshida A.
PMID: 27280650
Biosci Biotechnol Biochem. 1992 Jan;56(4):576-9. doi: 10.1271/bbb.56.576.

The effects of one-time ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats were investigated. Male Donryu rats that had been fed semi-purified feed were given 5 g/kg ethanol solution (25%, w/v)...

Inhibitory effect of nitric oxide on the metabolism of halogenated volatile anesthetics by cytochrome P-450.

Journal of anesthesia

Masaki E.
PMID: 14530945
J Anesth. 1999;13(2):83-9. doi: 10.1007/s005400050031.

PURPOSE: This study was undertaken to examine the effect of nitric oxide (NO) on the metabolism of halogenated volatile anesthetics (HVA) by cytochrome P-450 (CYP) under both aerobic and anaerobic conditions using rat hepatic microsomes.METHODS: A microsomal fraction was...

MEASUREMENT OF THE EFFECT ON THE PAIN THRESHOLD OF ACETYLSALICYLIC ACID, ACETANILID, ACETOPHENETIDIN, AMINOPYRINE, ETHYL ALCOHOL, TRICHLORETHYLENE, A BARBITURATE, QUININE, ERGOTAMINE TARTRATE AND CAFFEINE: AN ANALYSIS OF THEIR RELATION TO THE PAIN EXPERIENCE.

The Journal of clinical investigation

Wolff HG, Hardy JD, Goodell H.
PMID: 16694809
J Clin Invest. 1941 Jan;20(1):63-80. doi: 10.1172/JCI101196.

No abstract available.

The effect of diet on carbon tetrachloride metabolism.

The Biochemical journal

Seawright AA, McLean AE.
PMID: 16742530
Biochem J. 1967 Dec;105(3):1055-60. doi: 10.1042/bj1051055.

1. Blood and liver concentrations of carbon tetrachloride were measured, at intervals after an oral dose, in rats given stock and protein-free diets. The values did not correlate with the resistance to poisoning found in the rats on protein-free...

Aminopyrine and blood dyscrasias.

Pharmacoepidemiology and drug safety

Kaufman DW, Issaragrisil S.
PMID: 15073782
Pharmacoepidemiol Drug Saf. 1997 Jul;6(4):292. doi: 10.1002/(SICI)1099-1557(199707)6:4<292::AID-PDS302>3.0.CO;2-F.

No abstract available.

Lead exposure alters the drug metabolic activity and the homeostasis of essential metal ions in the lenticular system of the rat.

Environmental pollution (Barking, Essex : 1987)

Dwivedi RS.
PMID: 15093518
Environ Pollut. 1996;94(1):61-6. doi: 10.1016/s0269-7491(96)00057-7.

Potential lead exposure to the eyes as a result of the use of traditional cosmetic Kohl in Asia, Africa and the Middle East has been a subject of recent debate to the scientific community. In continuation of our earlier...

Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats.

Environmental toxicology and pharmacology

Eke BC, Coban T, Vural N, Iscan M.
PMID: 21781847
Environ Toxicol Pharmacol. 1998 Jan;5(1):29-34. doi: 10.1016/s1382-6689(97)10003-5.

The adult male and female rats were exposed to cigarette smoke (CS) 5 times a day, with 1 h intervals, for 3 days in a chamber where smoke and fresh air lead alternatively and were killed 16 h after...

Drug effects on dieldrin storage in rat tissue.

Bulletin of environmental contamination and toxicology

Street JC, Wang M, Blau AD.
PMID: 24192784
Bull Environ Contam Toxicol. 1966 Jan;1(1):6-15. doi: 10.1007/BF01684070.

Selected drugs were tested for effectiveness in reducing dieldrin retention by rats. Female rats were fed diets treated to contain 1 ppm dieldrin. The drugs were administered as feed additives or by i.p. injections. The rats were sacrificed after...

Inhibition by Vitamin E of Cholangiocarcinoma Induction due to Combined Nitrite and Aminopyrine.

Asian Pacific journal of cancer prevention : APJCP

Thamavit W, Pratoomtone P, Kongtim S, Shirai T, Ito N.
PMID: 12718657
Asian Pac J Cancer Prev. 2001;2(1):69-70.

The present experiment was conducted to assess the influence of vitamin E, given in the diet at 0.5 or 1%, on induction of lesions in the Syrian hamster liver by long term combined administration of sodium nitrite and aminopyrine...

Effects of orally applied butyrate bolus on histone acetylation and cytochrome P450 enzyme activity in the liver of chicken - a randomized controlled trial.

Nutrition & metabolism

Mátis G, Neogrády Z, Csikó G, Kulcsár A, Kenéz A, Huber K.
PMID: 23336999
Nutr Metab (Lond). 2013 Jan 22;10(1):12. doi: 10.1186/1743-7075-10-12.

BACKGROUND: Butyrate is known as histone deacetylase inhibitor, inducing histone hyperacetylation in vitro and playing a predominant role in the epigenetic regulation of gene expression and cell function. We hypothesized that butyrate, endogenously produced by intestinal microbial fermentation or...

Comparison of effects of xenobiotics on extrahepatic and hepatic microsomal drug-metabolizing enzymes in mice.

Environmental toxicology and pharmacology

Huang R, Okuno H, Takasu M, Shiozaki Y, Inoue K.
PMID: 21781672
Environ Toxicol Pharmacol. 1996 Apr 15;1(2):123-30. doi: 10.1016/1382-6689(95)00018-6.

The content of microsomal protein is the same in both kidneys and small intestine, corresponding to 57% of the control value expressed as 100% in the untreated liver. The contents of P450 and cytochrome b(5), and the activity of...

ON THE MECHANISM OF DRUG HYDROXYLATION IN RAT LIVER MICROSOMES.

The Journal of cell biology

Orrenius S.
PMID: 19866674
J Cell Biol. 1965 Sep 01;26(3):713-23. doi: 10.1083/jcb.26.3.713.

The TPNH- and O(2)-dependent drug hydroxylation system of liver microsomes has been studied using normal rats and rats in which the drug-hydroxylating activity has been enhanced by repeated injections of phenobarbital. The oxidative demethylation of aminopyrine is employed as...

Showing 1 to 12 of 39 entries