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Showing 1 to 12 of 14 entries
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Successful treatment of rhabdomyolysis and acute renal failure following amoxapine overdose.

International journal of psychiatry in clinical practice

Shigemura Tatsuro Kuwahara Soichiro Nomura Akimitsu Yokoyama Hideki Uemura J.
PMID: 24921698
Int J Psychiatry Clin Pract. 2001;5(4):287-90. doi: 10.1080/13651500152733071.

Amoxapine, a tricyclic antidepressant, is widely used by psychiatrists. While overdose of tricyclic antidepressants is known to be dangerous and potentially fatal (causing hypotension, arrhythmia, convulsions, respiratory failure, and other serious complications), overdose of amoxapine can cause other problems,...

Resensitization of methicillin-resistant .

Heliyon

Wilson TJ, Blackledge MS, Vigueira PA.
PMID: 29349359
Heliyon. 2018 Jan 12;4(1):e00501. doi: 10.1016/j.heliyon.2017.e00501. eCollection 2018 Jan.

The rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore...

Amoxapine-induced tardive dyskinesia.

Indian journal of psychiatry

Singh GP.
PMID: 20048464
Indian J Psychiatry. 2009 Oct-Dec;51(4):327. doi: 10.4103/0019-5545.58305.

No abstract available.

Crystal structure of a mixed solvated form of amoxapine acetate.

Acta crystallographica. Section E, Crystallographic communications

Bhardwaj RM, Raval V, Oswald ID, Florence AJ.
PMID: 25878802
Acta Crystallogr E Crystallogr Commun. 2015 Jan 10;71:139-41. doi: 10.1107/S2056989014028096. eCollection 2015 Feb 01.

The mixed solvated salt 4-(2-chloro-dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate-acetic acid-cyclo-hexane (2/2/1), C17H17ClN3O(+)·C2H3O2 (-)·C2H4O2·0.5C6H12, crystallizes with one mol-ecule of protonated amoxapine (AXPN), an acetate anion and a mol-ecule of acetic acid together with half a mol-ecule of cyclo-hexane. In the centrosymmetric crystal, both...

Identification and Functional Analysis of Long Non-coding RNAs in Autism Spectrum Disorders.

Frontiers in genetics

Tong Z, Zhou Y, Wang J.
PMID: 33193567
Front Genet. 2020 Sep 16;11:849. doi: 10.3389/fgene.2020.00849. eCollection 2020.

Genetic and environmental factors, alone or in combination, contribute to the pathogenesis of autism spectrum disorder (ASD). Although many protein-coding genes have now been identified as disease risk genes for ASD, a detailed illustration of long non-coding RNAs (lncRNAs)...

Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Fiscon G, Conte F, Amadio S, Volonté C, Paci P.
PMID: 33987813
Neurotherapeutics. 2021 Jul;18(3):1678-1691. doi: 10.1007/s13311-021-01064-z. Epub 2021 May 13.

The continuous adherence to the conventional "one target, one drug" paradigm has failed so far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases as amyotrophic lateral sclerosis (ALS), a rare progressive and chronic, debilitating neurological disease for...

A possible mechanism of toxicity by the antidepressant amoxapine based on its effects in three in vitro models.

Toxicology in vitro : an international journal published in association with BIBRA

Ferguson LR, Cooper GJ, Loiselle DS, Roberton AM.
PMID: 20702294
Toxicol In Vitro. 1989;3(4):285-91. doi: 10.1016/0887-2333(89)90035-0.

When the antidepressant amoxapine is taken in overdose, it can cause metabolic acidosis, brain damage and sometimes death. In previous studies, biochemical evidence has been presented that amoxapine disrupts reactions of membrane-associated multi-enzyme complexes, and mitochondrial energy conservation may...

The interaction of a benzodiazepine receptor antagonist (Ro15-1788) with GABA and GABA receptor antagonists at the GABA(A) receptor chloride-ionophore complex.

Neurochemistry international

Malatynska E, Dilsaver SC, Knapp RJ, Giroux ML, Ikeda M, Yamamura HI.
PMID: 20504718
Neurochem Int. 1991;18(3):405-10. doi: 10.1016/0197-0186(91)90173-b.

The effect of the GABA(A) receptor antagonists bicuculline and SR 95531 was compared with that of the antidepressants amoxapine and amitriptyline on GABA-stimulated (36)CL(?) uptake using membrane vesicles from the rat cerebral cortex. The interaction of Ro15-1788 with these...

Addition of amoxapine improves positive and negative symptoms in a patient with schizophrenia.

Therapeutic advances in psychopharmacology

Reeves KC, Virk S, Niedermier J, Duchemin AM.
PMID: 24294487
Ther Adv Psychopharmacol. 2013 Dec;3(6):340-2. doi: 10.1177/2045125313499363.

No abstract available.

Phenelzine and Amoxapine Inhibit Tyramine and d-Glucuronic Acid Catabolism in Clinically Significant .

Pathogens (Basel, Switzerland)

Burin R, Shah DH.
PMID: 33924374
Pathogens. 2021 Apr 13;10(4). doi: 10.3390/pathogens10040469.

Non-typhoidal

Antidepressants: which one?.

Canadian family physician Medecin de famille canadien

Remick RA.
PMID: 21267155
Can Fam Physician. 1986 Mar;32:587-92.

There are now 15 effective antidepressant medicines marketed in Canada (eight tricyclic antidepressants, three monoamine oxidase inhibitors, and four medicines with novel chemical structures). The tricyclics remain the drug of first choice for major depressions, because of their proven...

Salts of Amoxapine with Improved Solubility for Enhanced Pharmaceutical Applicability.

ACS omega

Joshi M, Roy Choudhury A.
PMID: 30023832
ACS Omega. 2018 Feb 28;3(2):2406-2416. doi: 10.1021/acsomega.7b02023. Epub 2018 Feb 27.

The objective of pharmaceutical cocrystallization is to create crystalline analogues that have vastly different properties, such as solubility, melting point, stability, and bioavailability from that observed in the pure active pharmaceutical ingredients (APIs). Amoxapine is a benzoxazepine derivative and...

Showing 1 to 12 of 14 entries