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Showing 1 to 12 of 339 entries
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Angiotensin II Type 1 Receptor Blockade: a Novel Therapeutic Concept.

Blood pressure

Johnston CI.
PMID: 28425795
Blood Press. 2000;9:9-13. doi: 10.1080/080370500439155.

Angiotensin II type 1 (AT 1 ) receptor blockers, such as candesartan, are attractive alternatives to ACE inhibitors in the treatment of hypertension and cardiovascular disease. Although angiotensin-converting enzyme (ACE) inhibitors are able to suppress the renin-angiotensin system (RAS),...

ACE for all - a molecular perspective.

Journal of cell communication and signaling

Harrison C, Acharya KR.
PMID: 25027949
J Cell Commun Signal. 2014 Sep;8(3):195-210. doi: 10.1007/s12079-014-0236-8. Epub 2014 Jul 16.

Angiotensin-I converting enzyme (ACE, EC 3.4.15.1) is a zinc dependent dipeptidyl carboxypeptidase with an essential role in mammalian blood pressure regulation as part of the renin-angiotensin aldosterone system (RAAS). As such, it has long been targeted in the treatment...

In vitro, ex vivo and in vivo anti-hypertensive activity of Chrysophyllum cainito L. extract.

International journal of clinical and experimental medicine

Mao LM, Qi XW, Hao JH, Liu HF, Xu QH, Bu PL.
PMID: 26770385
Int J Clin Exp Med. 2015 Oct 15;8(10):17912-21. eCollection 2015.

Chrysophyllum cainito L., a traditional herbal medicine, could have the potential for management of hypertension due to presence of polyphenolic compounds. The extracts and fractions of the pulp of plant were evaluated for in vitro (inhibition of angiotensin I...

Identification of bioactive peptide from Oreochromis niloticus skin gelatin.

Journal of food science and technology

Choonpicharn S, Tateing S, Jaturasitha S, Rakariyatham N, Suree N, Niamsup H.
PMID: 27162402
J Food Sci Technol. 2016 Feb;53(2):1222-9. doi: 10.1007/s13197-015-2091-x. Epub 2015 Nov 14.

Fish skin, one type of wastes generated from Nile tilapia processing, is still a good source of collagen and gelatin. Bioactive peptides can be obtained from Nile tilapia skin gelatin by trypsin digestion. Trypsin hydrolysate was subsequently purified by...

QM/MM investigation of the catalytic mechanism of angiotensin-converting enzyme.

Journal of molecular modeling

Mu X, Zhang C, Xu D.
PMID: 27184002
J Mol Model. 2016 Jun;22(6):132. doi: 10.1007/s00894-016-3004-2. Epub 2016 May 16.

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II and degrades bradykinin and other vasoactive peptides. ACE inhibitors are used to treat diseases such as hypertension and heart failure. It is thus highly desirable to understand the catalytic mechanism...

Isolation and biochemical characterization of bradykinin-potentiating peptides from .

The journal of venomous animals and toxins including tropical diseases

Fucase TM, Sciani JM, Cavalcante I, Viala VL, Chagas BB, Pimenta DC, Spencer PJ.
PMID: 28670326
J Venom Anim Toxins Incl Trop Dis. 2017 Jun 26;23:33. doi: 10.1186/s40409-017-0124-9. eCollection 2017.

BACKGROUND: Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (BPPs) comprise a class of angiotensin-I converting enzyme (ACE) inhibitors. The BPPs...

The Interaction of Apolipoprotein E and Angiotensin I-Converting Enzyme Dna Polymorphisms with Hypertension on Early Ischemic Stroke Risk.

EJIFCC

Stankovic S, Stankovic A, Asanin M, Jovanovic-Markovic Z, Alavantic D, Majkic-Singh N.
PMID: 27683351
EJIFCC. 2010 Mar 25;21(1):13-8. eCollection 2010 Mar.

Combinations of multiple predisposing polymorphisms and their interactions with modifiable factors may result in synergistic effects on early ischemic stroke risk. We evaluated the potential interaction of apolipoprotein (apo) E and angiotensin I-converting enzyme (ACE) gene polymorphisms and hypertension...

Distribution of Phenolic Contents, Antidiabetic Potentials, Antihypertensive Properties, and Antioxidative Effects of Soursop (Annona muricata L.) Fruit Parts In Vitro.

Biochemistry research international

Adefegha SA, Oyeleye SI, Oboh G.
PMID: 26788368
Biochem Res Int. 2015;2015:347673. doi: 10.1155/2015/347673. Epub 2015 Dec 15.

Soursop fruit has been used in folklore for the management of type-2 diabetes and hypertension with limited information on the scientific backing. This study investigated the effects of aqueous extracts (1 : 100 w/v) of Soursop fruit part (pericarp,...

Efficacy and safety of a novel multi-electrode radiofrequency ablation catheter for renal sympathetic denervation in pigs.

Journal of geriatric cardiology : JGC

Gan Q, Qu XK, Gong KZ, Guan SF, Han WZ, Dai JJ, Li RG, Zhang M, Liu H, Xu YJ, Zhang YJ, Fang WY.
PMID: 26788038
J Geriatr Cardiol. 2015 Nov;12(6):618-25. doi: 10.11909/j.issn.1671-5411.2015.06.006.

OBJECTIVE: To investigate the safety and efficacy of a self-developed novel multi-electrode radiofrequency ablation catheter (Spark) for catheter-based renal denervation (RDN).METHODS: A total of 14 experimental miniature pigs were randomly divided into four groups (55°& 5-watt, 55°& 8-watt, 65°&...

The Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and the Risk for Restenosis After PTCA.

The International journal of angiology : official publication of the International College of Angiology, Inc

Völzke H, Hertwig S, Rettig R.
PMID: 10758202
Int J Angiol. 2000 Mar;9(2):82-86. doi: 10.1007/BF01617046.

The therapeutic benefit of percutaneous transluminal coronary angioplasty (PTCA) is limited by restenosis in about 30% of patients. The underlying mechanisms are currently not well understood. Besides clinical and angiographic variables, genetic factors may be involved. We determined the...

Microfabricated PDMS multichannel emitter for electrospray ionization mass spectrometry.

Journal of the American Society for Mass Spectrometry

Kim JS, Knapp DR.
PMID: 11322193
J Am Soc Mass Spectrom. 2001 Apr;12(4):463-9. doi: 10.1016/S1044-0305(01)00219-7.

A novel microfabricated multichannel emitter for electrospray ionization mass spectrometry (ESI-MS) was implemented with polydimethylsiloxane (PDMS) using a soft lithography technique. The emitters are formed as electrospray tips along a thin membrane on the edge of the device with...

Quantitative analysis of an oligomeric hindered amine light stabilizer in polypropylene by matrix-assisted laser desorption/ionization mass spectrometry using a solid sampling technique.

Rapid communications in mass spectrometry : RCM

Taguchi Y, Ishida Y, Matsubara H, Ohtani H.
PMID: 16555367
Rapid Commun Mass Spectrom. 2006;20(8):1345-50. doi: 10.1002/rcm.2452.

A small amount of an oligomeric hindered amine light stabilizer (HALS) (Adekastab LA-68LD) in polypropylene (PP) materials was directly determined by solid sampling matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) using an internal standard method. First the matrix reagent (dithranol),...

Showing 1 to 12 of 339 entries