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Showing 1 to 12 of 24 entries
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A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases.

Frontiers in endocrinology

Wright JW, Kawas LH, Harding JW.
PMID: 24298267
Front Endocrinol (Lausanne). 2013 Oct 25;4:158. doi: 10.3389/fendo.2013.00158.

The brain renin-angiotensin system (RAS) has available the necessary functional components to produce the active ligands angiotensins II (AngII), angiotensin III, angiotensins (IV), angiotensin (1-7), and angiotensin (3-7). These ligands interact with several receptor proteins including AT1, AT2, AT4,...

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Wright JW, Kawas LH, Harding JW. A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases. Front Endocrinol (Lausanne). 2013;4:158doi: 10.3389/fendo.2013.00158.
Wright, J. W., Kawas, L. H., & Harding, J. W. (2013). A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases. Frontiers in endocrinology, 4158. https://doi.org/10.3389/fendo.2013.00158
Wright, John W, et al. "A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases." Frontiers in endocrinology vol. 4 (2013): 158. doi: https://doi.org/10.3389/fendo.2013.00158
Wright JW, Kawas LH, Harding JW. A Role for the Brain RAS in Alzheimer's and Parkinson's Diseases. Front Endocrinol (Lausanne). 2013 Oct 25;4:158. doi: 10.3389/fendo.2013.00158. PMID: 24298267; PMCID: PMC3829467.
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Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels.

Physiological reports

Park BM, Gao S, Cha SA, Park BH, Kim SH.
PMID: 24400153
Physiol Rep. 2013 Nov;1(6):e00151. doi: 10.1002/phy2.151. Epub 2013 Nov 13.

Angiotensin III (Ang III) has similar effects on blood pressure and aldosterone secretion as Ang II, but cardioprotective effects are also proposed. In this study, we investigated whether Ang III protects the heart against ischemia/reperfusion (I/R) injury. After sacrificing...

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Park BM, Gao S, Cha SA, et al. Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels. Physiol Rep. 2013;1(6):e00151doi: 10.1002/phy2.151.
Park, B. M., Gao, S., Cha, S. A., Park, B. H., & Kim, S. H. (2013). Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels. Physiological reports, 1(6), e00151. https://doi.org/10.1002/phy2.151
Park, Byung Mun, et al. "Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels." Physiological reports vol. 1,6 (2013): e00151. doi: https://doi.org/10.1002/phy2.151
Park BM, Gao S, Cha SA, Park BH, Kim SH. Cardioprotective effects of angiotensin III against ischemic injury via the AT2 receptor and KATP channels. Physiol Rep. 2013 Nov;1(6):e00151. doi: 10.1002/phy2.151. Epub 2013 Nov 13. PMID: 24400153; PMCID: PMC3871466.
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Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension.

Journal of data mining in genomics & proteomics

Holmes RS, Spradling-Reeves KD, Cox LA.
PMID: 29900035
J Data Mining Genomics Proteomics. 2017;8(2). doi: 10.4172/2153-0602.1000211. Epub 2017 Jun 13.

Glutamyl aminopeptidase (ENPEP) is a member of the M1 family of endopeptidases which are mammalian type II integral membrane zinc-containing endopeptidases. ENPEP is involved in the catabolic pathway of the renin-angiotensin system forming angiotensin III, which participates in blood...

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Holmes RS, Spradling-Reeves KD, Cox LA. Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension. J Data Mining Genomics Proteomics. 2017;8(2)doi: 10.4172/2153-0602.1000211.
Holmes, R. S., Spradling-Reeves, K. D., & Cox, L. A. (2017). Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension. Journal of data mining in genomics & proteomics, 8(2), . https://doi.org/10.4172/2153-0602.1000211
Holmes, Roger S, et al. "Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension." Journal of data mining in genomics & proteomics vol. 8,2 (2017). doi: https://doi.org/10.4172/2153-0602.1000211
Holmes RS, Spradling-Reeves KD, Cox LA. Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension. J Data Mining Genomics Proteomics. 2017;8(2). doi: 10.4172/2153-0602.1000211. Epub 2017 Jun 13. PMID: 29900035; PMCID: PMC5995572.
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The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis.

Journal of the renin-angiotensin-aldosterone system : JRAAS

Yao G, Li W, Liu W, Xing J, Zhang C.
PMID: 34603502
J Renin Angiotensin Aldosterone Syst. 2021 Sep 21;2021:1704762. doi: 10.1155/2021/1704762. eCollection 2021.

OBJECTIVE: Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship...

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Yao G, Li W, Liu W, et al. The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis. J Renin Angiotensin Aldosterone Syst. 2021;2021:1704762doi: 10.1155/2021/1704762.
Yao, G., Li, W., Liu, W., Xing, J., & Zhang, C. (2021). The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis. Journal of the renin-angiotensin-aldosterone system : JRAAS, 20211704762. https://doi.org/10.1155/2021/1704762
Yao, Guoqing, et al. "The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis." Journal of the renin-angiotensin-aldosterone system : JRAAS vol. 2021 (2021): 1704762. doi: https://doi.org/10.1155/2021/1704762
Yao G, Li W, Liu W, Xing J, Zhang C. The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis. J Renin Angiotensin Aldosterone Syst. 2021 Sep 21;2021:1704762. doi: 10.1155/2021/1704762. eCollection 2021. PMID: 34603502; PMCID: PMC8478585.
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Capillary liquid chromatography interfaced to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an on-line coupled piezoelectric flow-through microdispenser.

Journal of mass spectrometry : JMS

Miliotis T, Kjellstrom S, Nilsson J, Laurell T, Edholm LE, Marko-Varga G.
PMID: 10767766
J Mass Spectrom. 2000 Mar;35(3):369-77. doi: 10.1002/(SICI)1096-9888(200003)35:3<369::AID-JMS944>3.0.CO;2-N.

A piezoelectric flow-through microdispenser interfacing capillary liquid chromatography (LC) with matrix-assisted laser desorption/ionization time-of-fight mass spectrometry (MALDI-TOF MS) was developed for the identification of biomolecules. The MALDI target plate was placed on a computer controlled high-resolution x-y stage, on...

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Miliotis T, Kjellstrom S, Nilsson J, et al. Capillary liquid chromatography interfaced to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an on-line coupled piezoelectric flow-through microdispenser. J Mass Spectrom. 2000;35(3):369-77doi: 10.1002/(SICI)1096-9888(200003)35:3<369::AID-JMS944>3.0.CO;2-N.
Miliotis, T., Kjellstrom, S., Nilsson, J., Laurell, T., Edholm, L. E., & Marko-Varga, G. (2000). Capillary liquid chromatography interfaced to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an on-line coupled piezoelectric flow-through microdispenser. Journal of mass spectrometry : JMS, 35(3), 369-77. https://doi.org/10.1002/(SICI)1096-9888(200003)35:3<369::AID-JMS944>3.0.CO;2-N
Miliotis, et al. "Capillary liquid chromatography interfaced to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an on-line coupled piezoelectric flow-through microdispenser." Journal of mass spectrometry : JMS vol. 35,3 (2000): 369-77. doi: https://doi.org/10.1002/(SICI)1096-9888(200003)35:3<369::AID-JMS944>3.0.CO;2-N
Miliotis T, Kjellstrom S, Nilsson J, Laurell T, Edholm LE, Marko-Varga G. Capillary liquid chromatography interfaced to matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using an on-line coupled piezoelectric flow-through microdispenser. J Mass Spectrom. 2000 Mar;35(3):369-77. doi: 10.1002/(SICI)1096-9888(200003)35:3<369::AID-JMS944>3.0.CO;2-N. PMID: 10767766.
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Practical considerations when using radio frequency-only quadrupole ion guide for atmospheric pressure ionization sources with time-of-flight mass spectrometry.

The Analyst

Hang W, Lewis C, Majidi V.
PMID: 12705387
Analyst. 2003 Mar;128(3):273-80. doi: 10.1039/b209109g.

Construction details and performance evaluation of a radio frequency (rf)-only quadrupole ion guide for use with an electrospray ionization time-of-flight mass spectrometer is presented in this paper. Angiotensin III and cytochrome c were used in these experiments to investigate...

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Hang W, Lewis C, Majidi V. Practical considerations when using radio frequency-only quadrupole ion guide for atmospheric pressure ionization sources with time-of-flight mass spectrometry. Analyst. 2003;128(3):273-80doi: 10.1039/b209109g.
Hang, W., Lewis, C., & Majidi, V. (2003). Practical considerations when using radio frequency-only quadrupole ion guide for atmospheric pressure ionization sources with time-of-flight mass spectrometry. The Analyst, 128(3), 273-80. https://doi.org/10.1039/b209109g
Hang, Wei, et al. "Practical considerations when using radio frequency-only quadrupole ion guide for atmospheric pressure ionization sources with time-of-flight mass spectrometry." The Analyst vol. 128,3 (2003): 273-80. doi: https://doi.org/10.1039/b209109g
Hang W, Lewis C, Majidi V. Practical considerations when using radio frequency-only quadrupole ion guide for atmospheric pressure ionization sources with time-of-flight mass spectrometry. Analyst. 2003 Mar;128(3):273-80. doi: 10.1039/b209109g. PMID: 12705387.
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Role of aminopeptidases in the neuroendocrine control of blood pressure in experimental animals.

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion

Banegas I, Ramírez M, Alba F, Vives F, de Gasparo M, Belén Segarra A, Hermoso F, Durán R, Prieto I.
PMID: 22974453
Endocrinol Nutr. 2008 Oct;55(9):402-8. doi: 10.1016/S1575-0922(08)75077-0. Epub 2009 Jan 07.

Control of blood pressure is partially accomplished by several proteolytic enzymes included in the renin-angiotensin system. These enzymes produce several peptides that form the active components of the system. Study of these enzymes is essential for a deep understanding...

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Banegas I, Ramírez M, Alba F, et al. Role of aminopeptidases in the neuroendocrine control of blood pressure in experimental animals. Endocrinol Nutr. 2009;55(9):402-8doi: 10.1016/S1575-0922(08)75077-0.
Banegas, I., Ramírez, M., Alba, F., Vives, F., de Gasparo, M., Belén Segarra, A., Hermoso, F., Durán, R., & Prieto, I. (2008). Role of aminopeptidases in the neuroendocrine control of blood pressure in experimental animals. Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 55(9), 402-8. https://doi.org/10.1016/S1575-0922(08)75077-0
Banegas, Inmaculada, et al. "Role of aminopeptidases in the neuroendocrine control of blood pressure in experimental animals." Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion vol. 55,9 (2008): 402-8. doi: https://doi.org/10.1016/S1575-0922(08)75077-0
Banegas I, Ramírez M, Alba F, Vives F, de Gasparo M, Belén Segarra A, Hermoso F, Durán R, Prieto I. Role of aminopeptidases in the neuroendocrine control of blood pressure in experimental animals. Endocrinol Nutr. 2008 Oct;55(9):402-8. doi: 10.1016/S1575-0922(08)75077-0. Epub 2009 Jan 07. Spanish. PMID: 22974453.
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Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension.

International journal of hypertension

Wright JW, Mizutani S, Harding JW.
PMID: 22792446
Int J Hypertens. 2012;2012:124758. doi: 10.1155/2012/124758. Epub 2012 Jun 26.

The classic renin-angiotensin system (RAS) was initially described as a hormone system designed to mediate cardiovascular and body water regulation. The discovery of a brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins, and specific receptor proteins)...

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Wright JW, Mizutani S, Harding JW. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension. Int J Hypertens. 2012;2012:124758doi: 10.1155/2012/124758.
Wright, J. W., Mizutani, S., & Harding, J. W. (2012). Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension. International journal of hypertension, 2012124758. https://doi.org/10.1155/2012/124758
Wright, John W, et al. "Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension." International journal of hypertension vol. 2012 (2012): 124758. doi: https://doi.org/10.1155/2012/124758
Wright JW, Mizutani S, Harding JW. Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension. Int J Hypertens. 2012;2012:124758. doi: 10.1155/2012/124758. Epub 2012 Jun 26. PMID: 22792446; PMCID: PMC3389720.
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Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes.

International journal of hypertension

Clark MA, Nguyen C, Tran H.
PMID: 23476748
Int J Hypertens. 2013;2013:782861. doi: 10.1155/2013/782861. Epub 2013 Feb 14.

It is postulated that central effects of angiotensin (Ang) II may be indirect due to rapid conversion to Ang III by aminopeptidase A (APA). Previously, we showed that Ang II and Ang III induced mitogen-activated protein (MAP) kinases ERK1/2...

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Clark MA, Nguyen C, Tran H. Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes. Int J Hypertens. 2013;2013:782861doi: 10.1155/2013/782861.
Clark, M. A., Nguyen, C., & Tran, H. (2013). Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes. International journal of hypertension, 2013782861. https://doi.org/10.1155/2013/782861
Clark, Michelle A, et al. "Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes." International journal of hypertension vol. 2013 (2013): 782861. doi: https://doi.org/10.1155/2013/782861
Clark MA, Nguyen C, Tran H. Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes. Int J Hypertens. 2013;2013:782861. doi: 10.1155/2013/782861. Epub 2013 Feb 14. PMID: 23476748; PMCID: PMC3586509.
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Estrogen modulation of angiotensin-stimulated phosphoinositide hydrolysis in slices of rat anterior pituitary.

Neurochemistry international

Schoepp DD, Bailly DA.
PMID: 20501155
Neurochem Int. 1987;11(2):149-54. doi: 10.1016/0197-0186(87)90003-9.

In this study, slices of rat anterior pituitary were prelabeled with [(3)H]myo-inositol and the ability of angiotensins II and III to stimulate [(3)H]phosphoinositide hydrolysis was characterized. When using tissue derived from ovariectomized rats, dose-response experiments revealed that angiotensin II...

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Schoepp DD, Bailly DA. Estrogen modulation of angiotensin-stimulated phosphoinositide hydrolysis in slices of rat anterior pituitary. Neurochem Int. 1987;11(2):149-54doi: 10.1016/0197-0186(87)90003-9.
Schoepp, D. D., & Bailly, D. A. (1987). Estrogen modulation of angiotensin-stimulated phosphoinositide hydrolysis in slices of rat anterior pituitary. Neurochemistry international, 11(2), 149-54. https://doi.org/10.1016/0197-0186(87)90003-9
Schoepp, D D, and Bailly, D A. "Estrogen modulation of angiotensin-stimulated phosphoinositide hydrolysis in slices of rat anterior pituitary." Neurochemistry international vol. 11,2 (1987): 149-54. doi: https://doi.org/10.1016/0197-0186(87)90003-9
Schoepp DD, Bailly DA. Estrogen modulation of angiotensin-stimulated phosphoinositide hydrolysis in slices of rat anterior pituitary. Neurochem Int. 1987;11(2):149-54. doi: 10.1016/0197-0186(87)90003-9. PMID: 20501155.
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Association study: the aminopeptidase a gene and essential hypertension.

International journal of biomedical science : IJBS

Sano M, Kuroi N, Nakayama T, Sato N, Izumi Y, Soma M.
PMID: 23674950
Int J Biomed Sci. 2005 Jun;1(1):16-22.

Aminopeptidase A (APA) cleaves the N-terminal aspartyl acid residue of angiotensin II (Ang II) to produce angiotensin III (Ang III). It has been reported that the APA knockout mouse exhibits elevated blood pressure. Therefore, the APA gene is thought...

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Sano M, Kuroi N, Nakayama T, et al. Association study: the aminopeptidase a gene and essential hypertension. Int J Biomed Sci. 2005;1(1):16-22
Sano, M., Kuroi, N., Nakayama, T., Sato, N., Izumi, Y., & Soma, M. (2005). Association study: the aminopeptidase a gene and essential hypertension. International journal of biomedical science : IJBS, 1(1), 16-22.
Sano, Morihiko, et al. "Association study: the aminopeptidase a gene and essential hypertension." International journal of biomedical science : IJBS vol. 1,1 (2005): 16-22.
Sano M, Kuroi N, Nakayama T, Sato N, Izumi Y, Soma M. Association study: the aminopeptidase a gene and essential hypertension. Int J Biomed Sci. 2005 Jun;1(1):16-22. PMID: 23674950; PMCID: PMC3614582.
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Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension.

Cardiology in review

Khosla J, Aronow WS, Frishman WH.
PMID: 33027067
Cardiol Rev. 2022 Jan-Feb 01;30(1):50-55. doi: 10.1097/CRD.0000000000000360.

Systemic hypertension is the leading cause of death and disability worldwide. The management of hypertension is challenging in the high-risk patient population with high salt-sensitivity and low serum renin levels. The renin-angiotensin system (RAS) plays a central role in...

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Khosla J, Aronow WS, Frishman WH. Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension. Cardiol Rev. 2022;30(1):50-55doi: 10.1097/CRD.0000000000000360.
Khosla, J., Aronow, W. S., & Frishman, W. H. (2022). Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension. Cardiology in review, 30(1), 50-55. https://doi.org/10.1097/CRD.0000000000000360
Khosla, Jagjit, et al. "Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension." Cardiology in review vol. 30,1 (2022): 50-55. doi: https://doi.org/10.1097/CRD.0000000000000360
Khosla J, Aronow WS, Frishman WH. Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension. Cardiol Rev. 2022 Jan-Feb 01;30(1):50-55. doi: 10.1097/CRD.0000000000000360. PMID: 33027067.
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Showing 1 to 12 of 24 entries