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Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems.

Pathogens (Basel, Switzerland)

Souto EB, Dias-Ferreira J, Craveiro SA, Severino P, Sanchez-Lopez E, Garcia ML, Silva AM, Souto SB, Mahant S.
PMID: 31374930
Pathogens. 2019 Aug 01;8(3). doi: 10.3390/pathogens8030119.

The incidence of neglected diseases in tropical countries, such as Leishmaniasis and Chagas's disease, is attributed to a set of biological and ecological factors associated with the socioeconomic context of developing countries and with a significant burden to health...

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Souto EB, Dias-Ferreira J, Craveiro SA, et al. Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems. Pathogens. 2019;8(3)doi: 10.3390/pathogens8030119.
Souto, E. B., Dias-Ferreira, J., Craveiro, S. A., Severino, P., Sanchez-Lopez, E., Garcia, M. L., Silva, A. M., Souto, S. B., & Mahant, S. (2019). Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems. Pathogens (Basel, Switzerland), 8(3), . https://doi.org/10.3390/pathogens8030119
Souto, Eliana B, et al. "Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems." Pathogens (Basel, Switzerland) vol. 8,3 (2019). doi: https://doi.org/10.3390/pathogens8030119
Souto EB, Dias-Ferreira J, Craveiro SA, Severino P, Sanchez-Lopez E, Garcia ML, Silva AM, Souto SB, Mahant S. Therapeutic Interventions for Countering Leishmaniasis and Chagas's Disease: From Traditional Sources to Nanotechnological Systems. Pathogens. 2019 Aug 01;8(3). doi: 10.3390/pathogens8030119. PMID: 31374930; PMCID: PMC6789685.
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Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents.

Current medicinal chemistry

González-González A, Vazquez-Jimenez LK, Paz-González AD, Bolognesi ML, Rivera G.
PMID: 33820509
Curr Med Chem. 2021 Apr 05; doi: 10.2174/0929867328666210405120330. Epub 2021 Apr 05.

BACKGROUND: Molecules that have a phenothiazine scaffold have been considered versatile organic structures with a wide variety of biological activities: antipsychotic, anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, and trypanocidal, among others. First discovered in the 19th century as a...

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González-González A, Vazquez-Jimenez LK, Paz-González AD, et al. Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Curr Med Chem. 2021;doi: 10.2174/0929867328666210405120330.
González-González, A., Vazquez-Jimenez, L. K., Paz-González, A. D., Bolognesi, M. L., & Rivera, G. (2021). Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Current medicinal chemistry, . https://doi.org/10.2174/0929867328666210405120330
González-González, Alonzo, et al. "Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents." Current medicinal chemistry vol. (2021). doi: https://doi.org/10.2174/0929867328666210405120330
González-González A, Vazquez-Jimenez LK, Paz-González AD, Bolognesi ML, Rivera G. Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Curr Med Chem. 2021 Apr 05; doi: 10.2174/0929867328666210405120330. Epub 2021 Apr 05. PMID: 33820509.
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Antiprotozoal agents: How have they changed over a decade?.

Archiv der Pharmazie

Fernandes VS, da Rosa R, Zimmermann LA, Rogério KR, Kümmerle AE, Bernardes LSC, Graebin CS.
PMID: 34661935
Arch Pharm (Weinheim). 2021 Oct 18;e2100338. doi: 10.1002/ardp.202100338. Epub 2021 Oct 18.

Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low- or low-to-middle-income countries located in tropical and subtropical zones. The number and availability of drugs for treating these diseases are low, the administration route...

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Fernandes VS, da Rosa R, Zimmermann LA, et al. Antiprotozoal agents: How have they changed over a decade?. Arch Pharm (Weinheim). 2021;e2100338doi: 10.1002/ardp.202100338.
Fernandes, V. S., da Rosa, R., Zimmermann, L. A., Rogério, K. R., Kümmerle, A. E., Bernardes, L. S. C., & Graebin, C. S. (2021). Antiprotozoal agents: How have they changed over a decade?. Archiv der Pharmazie, e2100338. https://doi.org/10.1002/ardp.202100338
Fernandes, Vitória de Souza, et al. "Antiprotozoal agents: How have they changed over a decade?." Archiv der Pharmazie vol. (2021): e2100338. doi: https://doi.org/10.1002/ardp.202100338
Fernandes VS, da Rosa R, Zimmermann LA, Rogério KR, Kümmerle AE, Bernardes LSC, Graebin CS. Antiprotozoal agents: How have they changed over a decade?. Arch Pharm (Weinheim). 2021 Oct 18;e2100338. doi: 10.1002/ardp.202100338. Epub 2021 Oct 18. PMID: 34661935.
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Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis.

Immunotherapy

Mota CA, Oyama J, Souza Terron Monich M, Brustolin AÁ, Perez de Souza JV, Murase LS, Ghiraldi Lopes LD, Silva Santos TD, Vieira Teixeira JJ, Verzignassi Silveira TG.
PMID: 33853344
Immunotherapy. 2021 Jun;13(8):693-721. doi: 10.2217/imt-2020-0184. Epub 2021 Apr 15.

No abstract available.

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Mota CA, Oyama J, Souza Terron Monich M, et al. Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis. Immunotherapy. 2021;13(8):693-721doi: 10.2217/imt-2020-0184.
Mota, C. A., Oyama, J., Souza Terron Monich, M., Brustolin, A. �. �., Perez de Souza, J. V., Murase, L. S., Ghiraldi Lopes, L. D., Silva Santos, T. D., Vieira Teixeira, J. J., & Verzignassi Silveira, T. G. (2021). Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis. Immunotherapy, 13(8), 693-721. https://doi.org/10.2217/imt-2020-0184
Mota, Camila Alves, et al. "Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis." Immunotherapy vol. 13,8 (2021): 693-721. doi: https://doi.org/10.2217/imt-2020-0184
Mota CA, Oyama J, Souza Terron Monich M, Brustolin AÁ, Perez de Souza JV, Murase LS, Ghiraldi Lopes LD, Silva Santos TD, Vieira Teixeira JJ, Verzignassi Silveira TG. Three decades of clinical trials on immunotherapy for human leishmaniases: a systematic review and meta-analysis. Immunotherapy. 2021 Jun;13(8):693-721. doi: 10.2217/imt-2020-0184. Epub 2021 Apr 15. PMID: 33853344.
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Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors.

ChemMedChem

Johansson NG, Dreano L, Vidilaseris K, Khattab A, Liu J, Lasbleiz A, Ribeiro O, Kiriazis A, Boije Af Gennäs G, Meri S, Goldman A, Yli-Kauhaluoma J, Xhaard H.
PMID: 34459148
ChemMedChem. 2021 Nov 05;16(21):3360-3367. doi: 10.1002/cmdc.202100392. Epub 2021 Oct 12.

Inhibition of membrane-bound pyrophosphatase (mPPase) with small molecules offer a new approach in the fight against pathogenic protozoan parasites. mPPases are absent in humans, but essential for many protists as they couple pyrophosphate hydrolysis to the active transport of...

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Johansson NG, Dreano L, Vidilaseris K, et al. Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors. ChemMedChem. 2021;16(21):3360-3367doi: 10.1002/cmdc.202100392.
Johansson, N. G., Dreano, L., Vidilaseris, K., Khattab, A., Liu, J., Lasbleiz, A., Ribeiro, O., Kiriazis, A., Boije Af Gennäs, G., Meri, S., Goldman, A., Yli-Kauhaluoma, J., & Xhaard, H. (2021). Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors. ChemMedChem, 16(21), 3360-3367. https://doi.org/10.1002/cmdc.202100392
Johansson, Niklas G, et al. "Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors." ChemMedChem vol. 16,21 (2021): 3360-3367. doi: https://doi.org/10.1002/cmdc.202100392
Johansson NG, Dreano L, Vidilaseris K, Khattab A, Liu J, Lasbleiz A, Ribeiro O, Kiriazis A, Boije Af Gennäs G, Meri S, Goldman A, Yli-Kauhaluoma J, Xhaard H. Exploration of Pyrazolo[1,5-a]pyrimidines as Membrane-Bound Pyrophosphatase Inhibitors. ChemMedChem. 2021 Nov 05;16(21):3360-3367. doi: 10.1002/cmdc.202100392. Epub 2021 Oct 12. PMID: 34459148; PMCID: PMC8597055.
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Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles.

ChemistryOpen

Rosa FA, Mendes de Souza Melo S, Pianoski KE, Poletto J, Dos Santos MG, Vieira da Silva MJ, Lazarin-Bidóia D, Volpato H, Moura S, Nakamura CV.
PMID: 34331350
ChemistryOpen. 2021 Oct;10(10):931-938. doi: 10.1002/open.202100141. Epub 2021 Jul 30.

A series of 60 4-aminomethyl 5-aryl-3-substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas disease, respectively. Thirteen compounds exhibited a...

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Rosa FA, Mendes de Souza Melo S, Pianoski KE, et al. Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles. ChemistryOpen. 2021;10(10):931-938doi: 10.1002/open.202100141.
Rosa, F. A., Mendes de Souza Melo, S., Pianoski, K. E., Poletto, J., Dos Santos, M. G., Vieira da Silva, M. J., Lazarin-Bidóia, D., Volpato, H., Moura, S., & Nakamura, C. V. (2021). Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles. ChemistryOpen, 10(10), 931-938. https://doi.org/10.1002/open.202100141
Rosa, Fernanda Andreia, et al. "Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles." ChemistryOpen vol. 10,10 (2021): 931-938. doi: https://doi.org/10.1002/open.202100141
Rosa FA, Mendes de Souza Melo S, Pianoski KE, Poletto J, Dos Santos MG, Vieira da Silva MJ, Lazarin-Bidóia D, Volpato H, Moura S, Nakamura CV. Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles. ChemistryOpen. 2021 Oct;10(10):931-938. doi: 10.1002/open.202100141. Epub 2021 Jul 30. PMID: 34331350; PMCID: PMC8485799.
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Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum.

Evidence-based complementary and alternative medicine : eCAM

Reimão JQ, Mesquita JT, Ferreira DD, Tempone AG.
PMID: 26941821
Evid Based Complement Alternat Med. 2016;2016:1523691. doi: 10.1155/2016/1523691. Epub 2016 Jan 28.

Leishmaniasis and Chagas disease are neglected parasitic diseases endemic in developing countries; efforts to find new therapies remain a priority. Calcium channel blockers (CCBs) are drugs in clinical use for hypertension and other heart pathologies. Based on previous reports...

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Reimão JQ, Mesquita JT, Ferreira DD, et al. Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evid Based Complement Alternat Med. 2016;2016:1523691doi: 10.1155/2016/1523691.
Reimão, J. Q., Mesquita, J. T., Ferreira, D. D., & Tempone, A. G. (2016). Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evidence-based complementary and alternative medicine : eCAM, 20161523691. https://doi.org/10.1155/2016/1523691
Reimão, Juliana Quero, et al. "Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum." Evidence-based complementary and alternative medicine : eCAM vol. 2016 (2016): 1523691. doi: https://doi.org/10.1155/2016/1523691
Reimão JQ, Mesquita JT, Ferreira DD, Tempone AG. Investigation of Calcium Channel Blockers as Antiprotozoal Agents and Their Interference in the Metabolism of Leishmania (L.) infantum. Evid Based Complement Alternat Med. 2016;2016:1523691. doi: 10.1155/2016/1523691. Epub 2016 Jan 28. PMID: 26941821; PMCID: PMC4749844.
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Amino Acid Based Antimicrobial Agents - Synthesis and Properties.

ChemMedChem

Nowak MG, Skwarecki AS, Milewska MJ.
PMID: 34596961
ChemMedChem. 2021 Dec 06;16(23):3513-3544. doi: 10.1002/cmdc.202100503. Epub 2021 Oct 01.

Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they...

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Nowak MG, Skwarecki AS, Milewska MJ. Amino Acid Based Antimicrobial Agents - Synthesis and Properties. ChemMedChem. 2021;16(23):3513-3544doi: 10.1002/cmdc.202100503.
Nowak, M. G., Skwarecki, A. S., & Milewska, M. J. (2021). Amino Acid Based Antimicrobial Agents - Synthesis and Properties. ChemMedChem, 16(23), 3513-3544. https://doi.org/10.1002/cmdc.202100503
Nowak, Michał G, et al. "Amino Acid Based Antimicrobial Agents - Synthesis and Properties." ChemMedChem vol. 16,23 (2021): 3513-3544. doi: https://doi.org/10.1002/cmdc.202100503
Nowak MG, Skwarecki AS, Milewska MJ. Amino Acid Based Antimicrobial Agents - Synthesis and Properties. ChemMedChem. 2021 Dec 06;16(23):3513-3544. doi: 10.1002/cmdc.202100503. Epub 2021 Oct 01. PMID: 34596961.
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Antiprotozoal .

Antibiotics (Basel, Switzerland)

Szabó LU, Kaiser M, Mäser P, Schmidt TJ.
PMID: 34200688
Antibiotics (Basel). 2021 Jun 10;10(6). doi: 10.3390/antibiotics10060696.

Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for new antiprotozoal agents. In a previous study, O-tigloylcyclovirobuxeine-B was recovered from a

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Szabó LU, Kaiser M, Mäser P, et al. Antiprotozoal . Antibiotics (Basel). 2021;10(6)doi: 10.3390/antibiotics10060696.
Szabó, L. U., Kaiser, M., Mäser, P., & Schmidt, T. J. (2021). Antiprotozoal . Antibiotics (Basel, Switzerland), 10(6), . https://doi.org/10.3390/antibiotics10060696
Szabó, Lara U, et al. "Antiprotozoal ." Antibiotics (Basel, Switzerland) vol. 10,6 (2021). doi: https://doi.org/10.3390/antibiotics10060696
Szabó LU, Kaiser M, Mäser P, Schmidt TJ. Antiprotozoal . Antibiotics (Basel). 2021 Jun 10;10(6). doi: 10.3390/antibiotics10060696. PMID: 34200688; PMCID: PMC8228141.
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Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity.

ChemMedChem

Ropponen HK, Bader CD, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch AKH.
PMID: 33844432
ChemMedChem. 2021 Jul 06;16(13):2089-2093. doi: 10.1002/cmdc.202100067. Epub 2021 May 07.

Chemical decomposition of DMSO stock solutions is a common incident that can mislead biological screening campaigns. Here, we share our case study of 2-aminothiazole 1, originating from an antimalarial class that undergoes chemical decomposition in DMSO at room temperature....

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Ropponen HK, Bader CD, Diamanti E, et al. Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity. ChemMedChem. 2021;16(13):2089-2093doi: 10.1002/cmdc.202100067.
Ropponen, H. K., Bader, C. D., Diamanti, E., Illarionov, B., Rottmann, M., Fischer, M., Witschel, M., Müller, R., & Hirsch, A. K. H. (2021). Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity. ChemMedChem, 16(13), 2089-2093. https://doi.org/10.1002/cmdc.202100067
Ropponen, Henni-Karoliina, et al. "Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity." ChemMedChem vol. 16,13 (2021): 2089-2093. doi: https://doi.org/10.1002/cmdc.202100067
Ropponen HK, Bader CD, Diamanti E, Illarionov B, Rottmann M, Fischer M, Witschel M, Müller R, Hirsch AKH. Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity. ChemMedChem. 2021 Jul 06;16(13):2089-2093. doi: 10.1002/cmdc.202100067. Epub 2021 May 07. PMID: 33844432; PMCID: PMC8360061.
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Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents.

Current medicinal chemistry

González-González A, Vazquez-Jimenez LK, Paz-González AD, Bolognesi ML, Rivera G.
PMID: 33820509
Curr Med Chem. 2021 Apr 05; doi: 10.2174/0929867328666210405120330. Epub 2021 Apr 05.

BACKGROUND: Molecules that have a phenothiazine scaffold have been considered versatile organic structures with a wide variety of biological activities: antipsychotic, anticancer, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, and trypanocidal, among others. First discovered in the 19th century as a...

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González-González A, Vazquez-Jimenez LK, Paz-González AD, et al. Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Curr Med Chem. 2021;doi: 10.2174/0929867328666210405120330.
González-González, A., Vazquez-Jimenez, L. K., Paz-González, A. D., Bolognesi, M. L., & Rivera, G. (2021). Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Current medicinal chemistry, . https://doi.org/10.2174/0929867328666210405120330
González-González, Alonzo, et al. "Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents." Current medicinal chemistry vol. (2021). doi: https://doi.org/10.2174/0929867328666210405120330
González-González A, Vazquez-Jimenez LK, Paz-González AD, Bolognesi ML, Rivera G. Recent Advances in the Medicinal Chemistry of Phenothiazines. New Anticancer and Antiprotozoal Agents. Curr Med Chem. 2021 Apr 05; doi: 10.2174/0929867328666210405120330. Epub 2021 Apr 05. PMID: 33820509.
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Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?.

Mini reviews in medicinal chemistry

Rivera G.
PMID: 33573542
Mini Rev Med Chem. 2021 Jan 26; doi: 10.2174/1389557521666210126142541. Epub 2021 Jan 26.

BACKGROUND: For decades, the quinoxaline 1,4-di-N-oxide ring has been considered a privileged structure to develop new antibacterial, antitumoural, and antiprotozoal agents, among others, however its mechanism of action is not clear.OBJECTIVE: The main aim of this mini-review was to...

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Rivera G. Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?. Mini Rev Med Chem. 2021;doi: 10.2174/1389557521666210126142541.
Rivera, G. (2021). Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?. Mini reviews in medicinal chemistry, . https://doi.org/10.2174/1389557521666210126142541
Rivera, Gildardo. "Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?." Mini reviews in medicinal chemistry vol. (2021). doi: https://doi.org/10.2174/1389557521666210126142541
Rivera G. Quinoxaline 1,4-di-N-Oxide Derivatives: Are They Unselective or Selective Inhibitors?. Mini Rev Med Chem. 2021 Jan 26; doi: 10.2174/1389557521666210126142541. Epub 2021 Jan 26. PMID: 33573542.
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