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Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents.

MedChemComm

Omar AM, David T, Pagare PP, Ghatge MS, Chen Q, Mehta A, Zhang Y, Abdulmalik O, Naghi AH, El-Araby ME, Safo MK.
PMID: 32206236
Medchemcomm. 2019 Aug 23;10(11):1900-1906. doi: 10.1039/c9md00291j. eCollection 2019 Nov 01.

The intracellular polymerization and the concomitant sickling processes, central to the pathology of sickle cell disease, can be mitigated by increasing the oxygen affinity of sickle hemoglobin (HbS). Attempts to develop azolylacryloyl derivatives to covalently interact with βCys93 and...

Cite
Omar AM, David T, Pagare PP, et al. Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Medchemcomm. 2019;10(11):1900-1906doi: 10.1039/c9md00291j.
Omar, A. M., David, T., Pagare, P. P., Ghatge, M. S., Chen, Q., Mehta, A., Zhang, Y., Abdulmalik, O., Naghi, A. H., El-Araby, M. E., & Safo, M. K. (2019). Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents. MedChemComm, 10(11), 1900-1906. https://doi.org/10.1039/c9md00291j
Omar, A M, et al. "Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents." MedChemComm vol. 10,11 (2019): 1900-1906. doi: https://doi.org/10.1039/c9md00291j
Omar AM, David T, Pagare PP, Ghatge MS, Chen Q, Mehta A, Zhang Y, Abdulmalik O, Naghi AH, El-Araby ME, Safo MK. Structural modification of azolylacryloyl derivatives yields a novel class of covalent modifiers of hemoglobin as potential antisickling agents. Medchemcomm. 2019 Aug 23;10(11):1900-1906. doi: 10.1039/c9md00291j. eCollection 2019 Nov 01. PMID: 32206236; PMCID: PMC7069400.
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Search for antisickling agents from plants.

Pharmacognosy reviews

Dash BP, Archana Y, Satapathy N, Naik SK.
PMID: 23922457
Pharmacogn Rev. 2013 Jan;7(13):53-60. doi: 10.4103/0973-7847.112849.

The sickle cell disease is fatal in nature. Thousands of children are dying off due to this health problem throughout the globe. Due to the rapid development of diagnosis and clinical managements such patients are living up to a...

Cite
Dash BP, Archana Y, Satapathy N, et al. Search for antisickling agents from plants. Pharmacogn Rev. 2013;7(13):53-60doi: 10.4103/0973-7847.112849.
Dash, B. P., Archana, Y., Satapathy, N., & Naik, S. K. (2013). Search for antisickling agents from plants. Pharmacognosy reviews, 7(13), 53-60. https://doi.org/10.4103/0973-7847.112849
Dash, Bisnu Prasad, et al. "Search for antisickling agents from plants." Pharmacognosy reviews vol. 7,13 (2013): 53-60. doi: https://doi.org/10.4103/0973-7847.112849
Dash BP, Archana Y, Satapathy N, Naik SK. Search for antisickling agents from plants. Pharmacogn Rev. 2013 Jan;7(13):53-60. doi: 10.4103/0973-7847.112849. PMID: 23922457; PMCID: PMC3731880.
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