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Bacterial co-expression of the α and β protomers of human l-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the β-subunit.

Protein expression and purification

Karamitros CS, Konrad M.
PMID: 24157738
Protein Expr Purif. 2014 Jan;93:1-10. doi: 10.1016/j.pep.2013.10.007. Epub 2013 Oct 22.

l-asparaginases hydrolyze l-asparagine to l-aspartic acid and ammonia. Enzymes of bacterial origin are used as therapeutic agents for the treatment of acute lymphoblastic leukemia. Recently, the structure of a human homolog, hASNase3, which possesses l-asparaginase activity, was solved setting...

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Karamitros CS, Konrad M. Bacterial co-expression of the α and β protomers of human l-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the β-subunit. Protein Expr Purif. 2013;93:1-10doi: 10.1016/j.pep.2013.10.007.
Karamitros, C. S., & Konrad, M. (2014). Bacterial co-expression of the α and β protomers of human l-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the β-subunit. Protein expression and purification, 931-10. https://doi.org/10.1016/j.pep.2013.10.007
Karamitros, Christos S, and Konrad, Manfred. "Bacterial co-expression of the α and β protomers of human l-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the β-subunit." Protein expression and purification vol. 93 (2014): 1-10. doi: https://doi.org/10.1016/j.pep.2013.10.007
Karamitros CS, Konrad M. Bacterial co-expression of the α and β protomers of human l-asparaginase-3: Achieving essential N-terminal exposure of a catalytically critical threonine located in the β-subunit. Protein Expr Purif. 2014 Jan;93:1-10. doi: 10.1016/j.pep.2013.10.007. Epub 2013 Oct 22. PMID: 24157738.
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Exploration of the binding modes of L-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation.

3 Biotech

Reddy ER, Babu RS, Chandrasai PD, Madhuri P.
PMID: 28330175
3 Biotech. 2016 Jun;6(1):105. doi: 10.1007/s13205-016-0422-x. Epub 2016 Apr 18.

Acute lymphocytic leukemia (ALL) is an outrageous disease worldwide. L-Asparagine (L-Asn) and L-glutamine (L-Gln) deamination plays crucial role in ALL treatment. Role of Erwinaze

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Reddy ER, Babu RS, Chandrasai PD, et al. Exploration of the binding modes of L-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation. 3 Biotech. 2016;6(1):105doi: 10.1007/s13205-016-0422-x.
Reddy, E. R., Babu, R. S., Chandrasai, P. D., & Madhuri, P. (2016). Exploration of the binding modes of L-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation. 3 Biotech, 6(1), 105. https://doi.org/10.1007/s13205-016-0422-x
Reddy, Erva Rajeswara, et al. "Exploration of the binding modes of L-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation." 3 Biotech vol. 6,1 (2016): 105. doi: https://doi.org/10.1007/s13205-016-0422-x
Reddy ER, Babu RS, Chandrasai PD, Madhuri P. Exploration of the binding modes of L-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation. 3 Biotech. 2016 Jun;6(1):105. doi: 10.1007/s13205-016-0422-x. Epub 2016 Apr 18. PMID: 28330175; PMCID: PMC4835421.
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First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up.

Oncology letters

Wang L, Wang ZH, Chen XQ, Wang KF, Huang HQ, Xia ZJ.
PMID: 26622621
Oncol Lett. 2015 Aug;10(2):1036-1040. doi: 10.3892/ol.2015.3327. Epub 2015 Jun 05.

In recent years, asparaginase-based chemotherapy regimens have produced excellent short-term efficacy in patients with extranodal natural killer/T-cell lymphoma (ENKTL). However, few long-term outcomes have been reported to date. A phase II clinical trial evaluating the efficacy and safety of...

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Wang L, Wang ZH, Chen XQ, et al. First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up. Oncol Lett. 2015;10(2):1036-1040doi: 10.3892/ol.2015.3327.
Wang, L., Wang, Z. H., Chen, X. Q., Wang, K. F., Huang, H. Q., & Xia, Z. J. (2015). First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up. Oncology letters, 10(2), 1036-1040. https://doi.org/10.3892/ol.2015.3327
Wang, Liang, et al. "First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up." Oncology letters vol. 10,2 (2015): 1036-1040. doi: https://doi.org/10.3892/ol.2015.3327
Wang L, Wang ZH, Chen XQ, Wang KF, Huang HQ, Xia ZJ. First-line combination of GELOX followed by radiation therapy for patients with stage IE/IIE ENKTL: An updated analysis with long-term follow-up. Oncol Lett. 2015 Aug;10(2):1036-1040. doi: 10.3892/ol.2015.3327. Epub 2015 Jun 05. PMID: 26622621; PMCID: PMC4509369.
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Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?.

Blood research

Özdemir ZC, Turhan AB, Eren M, Bor Ö.
PMID: 28401107
Blood Res. 2017 Mar;52(1):69-71. doi: 10.5045/br.2017.52.1.69. Epub 2017 Mar 27.

No abstract available.

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Özdemir ZC, Turhan AB, Eren M, et al. Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?. Blood Res. 2017;52(1):69-71doi: 10.5045/br.2017.52.1.69.
Özdemir, Z. C., Turhan, A. B., Eren, M., & Bor, �. �. (2017). Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?. Blood research, 52(1), 69-71. https://doi.org/10.5045/br.2017.52.1.69
Özdemir, Zeynep Canan, et al. "Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?." Blood research vol. 52,1 (2017): 69-71. doi: https://doi.org/10.5045/br.2017.52.1.69
Özdemir ZC, Turhan AB, Eren M, Bor Ö. Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?. Blood Res. 2017 Mar;52(1):69-71. doi: 10.5045/br.2017.52.1.69. Epub 2017 Mar 27. PMID: 28401107; PMCID: PMC5383593.
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Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy.

Angewandte Chemie (International ed. in English)

Giuntini S, Balducci E, Cerofolini L, Ravera E, Fragai M, Berti F, Luchinat C.
PMID: 29024352
Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14997-15001. doi: 10.1002/anie.201709274. Epub 2017 Oct 19.

Carbohydrate-based vaccines are among the safest and most effective vaccines and represent potent tools for prevention of life-threatening bacterial infectious diseases, like meningitis and pneumonia. The chemical conjugation of a weak antigen to protein as a source of T-cell...

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Giuntini S, Balducci E, Cerofolini L, et al. Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy. Angew Chem Int Ed Engl. 2017;56(47):14997-15001doi: 10.1002/anie.201709274.
Giuntini, S., Balducci, E., Cerofolini, L., Ravera, E., Fragai, M., Berti, F., & Luchinat, C. (2017). Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy. Angewandte Chemie (International ed. in English), 56(47), 14997-15001. https://doi.org/10.1002/anie.201709274
Giuntini, Stefano, et al. "Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy." Angewandte Chemie (International ed. in English) vol. 56,47 (2017): 14997-15001. doi: https://doi.org/10.1002/anie.201709274
Giuntini S, Balducci E, Cerofolini L, Ravera E, Fragai M, Berti F, Luchinat C. Characterization of the Conjugation Pattern in Large Polysaccharide-Protein Conjugates by NMR Spectroscopy. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14997-15001. doi: 10.1002/anie.201709274. Epub 2017 Oct 19. PMID: 29024352; PMCID: PMC5813213.
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Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds.

Evidence-based complementary and alternative medicine : eCAM

Mohamed SA, Elshal MF, Kumosani TA, Aldahlawi AM.
PMID: 26413120
Evid Based Complement Alternat Med. 2015;2015:309214. doi: 10.1155/2015/309214. Epub 2015 Aug 27.

L-asparaginase from bacteria has been used in treatment of acute lymphoblastic leukemia. The aim of this study was to purify and characterize L-asparaginase from Phaseolus vulgaris seeds instead of microbial sources. L-asparaginase was purified to apparent homogeneity. The enzyme...

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Mohamed SA, Elshal MF, Kumosani TA, et al. Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds. Evid Based Complement Alternat Med. 2015;2015:309214doi: 10.1155/2015/309214.
Mohamed, S. A., Elshal, M. F., Kumosani, T. A., & Aldahlawi, A. M. (2015). Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds. Evidence-based complementary and alternative medicine : eCAM, 2015309214. https://doi.org/10.1155/2015/309214
Mohamed, Saleh A, et al. "Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 309214. doi: https://doi.org/10.1155/2015/309214
Mohamed SA, Elshal MF, Kumosani TA, Aldahlawi AM. Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds. Evid Based Complement Alternat Med. 2015;2015:309214. doi: 10.1155/2015/309214. Epub 2015 Aug 27. PMID: 26413120; PMCID: PMC4564614.
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Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy.

Journal of clinical imaging science

Rota E, Vallisa D, Morelli N, Scagnelli P.
PMID: 27014503
J Clin Imaging Sci. 2016 Feb 26;6:7. doi: 10.4103/2156-7514.177553. eCollection 2016.

Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiological syndrome mostly related to hypertension, eclampsia, renal failure, or to chemotherapy and/or immunosuppressive drugs. Although the PRES pathophysiology is multifactorial, hypertension and endothelial dysfunction are hypothesized to be the...

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Rota E, Vallisa D, Morelli N, et al. Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy. J Clin Imaging Sci. 2016;6:7doi: 10.4103/2156-7514.177553.
Rota, E., Vallisa, D., Morelli, N., & Scagnelli, P. (2016). Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy. Journal of clinical imaging science, 67. https://doi.org/10.4103/2156-7514.177553
Rota, Eugenia, et al. "Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy." Journal of clinical imaging science vol. 6 (2016): 7. doi: https://doi.org/10.4103/2156-7514.177553
Rota E, Vallisa D, Morelli N, Scagnelli P. Iatrogenic Coagulopathy and the Development of Posterior Reversible Encephalopathy Syndrome after L-asparaginase Chemotherapy. J Clin Imaging Sci. 2016 Feb 26;6:7. doi: 10.4103/2156-7514.177553. eCollection 2016. PMID: 27014503; PMCID: PMC4785783.
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L-Asparaginase Activity of Fungal Endophytes from Tabernaemontana heyneana Wall. (Apocynaceae), Endemic to the Western Ghats (India).

International scholarly research notices

Manasa C, Nalini MS.
PMID: 27382605
Int Sch Res Notices. 2014 Dec 11;2014:925131. doi: 10.1155/2014/925131. eCollection 2014.

"Endophytes," the microbes residing within the plant tissues, are important sources of secondary metabolites. Tabernaemontana heyneana Wall., a medicinal tree, endemic to the Western Ghats with rich ethnobotanical history and unique chemical diversity, was selected to study fungal endophytes...

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Manasa C, Nalini MS. L-Asparaginase Activity of Fungal Endophytes from Tabernaemontana heyneana Wall. (Apocynaceae), Endemic to the Western Ghats (India). Int Sch Res Notices. 2014;2014:925131doi: 10.1155/2014/925131.
Manasa, C., & Nalini, M. S. (2014). L-Asparaginase Activity of Fungal Endophytes from Tabernaemontana heyneana Wall. (Apocynaceae), Endemic to the Western Ghats (India). International scholarly research notices, 2014925131. https://doi.org/10.1155/2014/925131
Manasa, Chandramouli, and Nalini, Monnanda Somaiah. "L-Asparaginase Activity of Fungal Endophytes from Tabernaemontana heyneana Wall. (Apocynaceae), Endemic to the Western Ghats (India)." International scholarly research notices vol. 2014 (2014): 925131. doi: https://doi.org/10.1155/2014/925131
Manasa C, Nalini MS. L-Asparaginase Activity of Fungal Endophytes from Tabernaemontana heyneana Wall. (Apocynaceae), Endemic to the Western Ghats (India). Int Sch Res Notices. 2014 Dec 11;2014:925131. doi: 10.1155/2014/925131. eCollection 2014. PMID: 27382605; PMCID: PMC4897040.
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Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization.

Journal of bacteriology

Sabag-Daigle A, Sengupta A, Blunk HM, Biswas PK, Cron MC, Bogard AJ, Behrman EJ, Gopalan V, Ahmer BMM.
PMID: 28847920
J Bacteriol. 2017 Oct 17;199(22). doi: 10.1128/JB.00330-17. Print 2017 Nov 15.

No abstract available.

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Sabag-Daigle A, Sengupta A, Blunk HM, et al. Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization. J Bacteriol. 2017;199(22)doi: 10.1128/JB.00330-17.
Sabag-Daigle, A., Sengupta, A., Blunk, H. M., Biswas, P. K., Cron, M. C., Bogard, A. J., Behrman, E. J., Gopalan, V., & Ahmer, B. M. M. (2017). Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization. Journal of bacteriology, 199(22), . https://doi.org/10.1128/JB.00330-17
Sabag-Daigle, Anice, et al. "Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization." Journal of bacteriology vol. 199,22 (2017). doi: https://doi.org/10.1128/JB.00330-17
Sabag-Daigle A, Sengupta A, Blunk HM, Biswas PK, Cron MC, Bogard AJ, Behrman EJ, Gopalan V, Ahmer BMM. Salmonella FraE, an Asparaginase Homolog, Contributes to Fructose-Asparagine but Not Asparagine Utilization. J Bacteriol. 2017 Oct 17;199(22). doi: 10.1128/JB.00330-17. Print 2017 Nov 15. PMID: 28847920; PMCID: PMC5648864.
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Oxygen fluorescence quenching studies with single tryptophan-containing proteins.

Journal of fluorescence

Eftink MR, Ghiron CA.
PMID: 24233381
J Fluoresc. 1994 Jun;4(2):187-93. doi: 10.1007/BF01881887.

The work of Lakowicz and Weber [Biochemistry 12, 4161 (1973)] demonstrated that molecular oxygen is a powerful quencher of tryptophan fluorescence in proteins. Here we report studies of the oxygen quenching of several proteins that have a single, internal...

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Eftink MR, Ghiron CA. Oxygen fluorescence quenching studies with single tryptophan-containing proteins. J Fluoresc. 1994;4(2):187-93doi: 10.1007/BF01881887.
Eftink, M. R., & Ghiron, C. A. (1994). Oxygen fluorescence quenching studies with single tryptophan-containing proteins. Journal of fluorescence, 4(2), 187-93. https://doi.org/10.1007/BF01881887
Eftink, M R, and Ghiron, C A. "Oxygen fluorescence quenching studies with single tryptophan-containing proteins." Journal of fluorescence vol. 4,2 (1994): 187-93. doi: https://doi.org/10.1007/BF01881887
Eftink MR, Ghiron CA. Oxygen fluorescence quenching studies with single tryptophan-containing proteins. J Fluoresc. 1994 Jun;4(2):187-93. doi: 10.1007/BF01881887. PMID: 24233381.
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Preparation and nanoencapsulation of l-asparaginase II in chitosan-tripolyphosphate nanoparticles and in vitro release study.

Nanoscale research letters

Bahreini E, Aghaiypour K, Abbasalipourkabir R, Mokarram AR, Goodarzi MT, Saidijam M.
PMID: 25114635
Nanoscale Res Lett. 2014 Jul 09;9(1):340. doi: 10.1186/1556-276X-9-340. eCollection 2014.

This paper describes the production, purification, and immobilization of l-asparaginase II (ASNase II) in chitosan nanoparticles (CSNPs). ASNase II is an effective antineoplastic agent, used in the acute lymphoblastic leukemia chemotherapy. Cloned ASNase II gene (ansB) in pAED4 plasmid...

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Bahreini E, Aghaiypour K, Abbasalipourkabir R, et al. Preparation and nanoencapsulation of l-asparaginase II in chitosan-tripolyphosphate nanoparticles and in vitro release study. Nanoscale Res Lett. 2014;9(1):340doi: 10.1186/1556-276X-9-340.
Bahreini, E., Aghaiypour, K., Abbasalipourkabir, R., Mokarram, A. R., Goodarzi, M. T., & Saidijam, M. (2014). Preparation and nanoencapsulation of l-asparaginase II in chitosan-tripolyphosphate nanoparticles and in vitro release study. Nanoscale research letters, 9(1), 340. https://doi.org/10.1186/1556-276X-9-340
Bahreini, Elham, et al. "Preparation and nanoencapsulation of l-asparaginase II in chitosan-tripolyphosphate nanoparticles and in vitro release study." Nanoscale research letters vol. 9,1 (2014): 340. doi: https://doi.org/10.1186/1556-276X-9-340
Bahreini E, Aghaiypour K, Abbasalipourkabir R, Mokarram AR, Goodarzi MT, Saidijam M. Preparation and nanoencapsulation of l-asparaginase II in chitosan-tripolyphosphate nanoparticles and in vitro release study. Nanoscale Res Lett. 2014 Jul 09;9(1):340. doi: 10.1186/1556-276X-9-340. eCollection 2014. PMID: 25114635; PMCID: PMC4110547.
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Regulation of asparaginase, glutamine synthetase, and glutamate dehydrogenase in response to medium nitrogen concentrations in a euryhaline chlamydomonas species.

Plant physiology

Paul JH, Cooksey KE.
PMID: 16662109
Plant Physiol. 1981 Dec;68(6):1364-8. doi: 10.1104/pp.68.6.1364.

The ammonium assimilatory enzymes glutamine synthetase (EC 6.3.1.2) and glutamate dehydrogenase (EC 1.4.1.3) were investigated for a possible role in the regulation of asparaginase (EC 3.5.1.1) in a Chlamydomonas species isolated from a marine environment. Cells grown under nitrogen...

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Paul JH, Cooksey KE. Regulation of asparaginase, glutamine synthetase, and glutamate dehydrogenase in response to medium nitrogen concentrations in a euryhaline chlamydomonas species. Plant Physiol. 1981;68(6):1364-8doi: 10.1104/pp.68.6.1364.
Paul, J. H., & Cooksey, K. E. (1981). Regulation of asparaginase, glutamine synthetase, and glutamate dehydrogenase in response to medium nitrogen concentrations in a euryhaline chlamydomonas species. Plant physiology, 68(6), 1364-8. https://doi.org/10.1104/pp.68.6.1364
Paul, J H, and Cooksey, K E. "Regulation of asparaginase, glutamine synthetase, and glutamate dehydrogenase in response to medium nitrogen concentrations in a euryhaline chlamydomonas species." Plant physiology vol. 68,6 (1981): 1364-8. doi: https://doi.org/10.1104/pp.68.6.1364
Paul JH, Cooksey KE. Regulation of asparaginase, glutamine synthetase, and glutamate dehydrogenase in response to medium nitrogen concentrations in a euryhaline chlamydomonas species. Plant Physiol. 1981 Dec;68(6):1364-8. doi: 10.1104/pp.68.6.1364. PMID: 16662109; PMCID: PMC426104.
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Showing 1 to 12 of 472 entries