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Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells.

Biomolecules & therapeutics

Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ.
PMID: 27956714
Biomol Ther (Seoul). 2017 Mar 01;25(2):177-185. doi: 10.4062/biomolther.2016.223.

Auranofin has been developed as antirheumatic drugs, which is currently under clinical development for the treatment of chronic lymphocytic leukemia. Previous report showed that auranofin induced apoptosis by enhancement of annexin A5 expression in PC-3 cells. To understand the...

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Shin DW, Kwon YJ, Ye DJ, et al. Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells. Biomol Ther (Seoul). 2017;25(2):177-185doi: 10.4062/biomolther.2016.223.
Shin, D. W., Kwon, Y. J., Ye, D. J., Baek, H. S., Lee, J. E., & Chun, Y. J. (2017). Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells. Biomolecules & therapeutics, 25(2), 177-185. https://doi.org/10.4062/biomolther.2016.223
Shin, Dong-Won, et al. "Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells." Biomolecules & therapeutics vol. 25,2 (2017): 177-185. doi: https://doi.org/10.4062/biomolther.2016.223
Shin DW, Kwon YJ, Ye DJ, Baek HS, Lee JE, Chun YJ. Auranofin Suppresses Plasminogen Activator Inhibitor-2 Expression through Annexin A5 Induction in Human Prostate Cancer Cells. Biomol Ther (Seoul). 2017 Mar 01;25(2):177-185. doi: 10.4062/biomolther.2016.223. PMID: 27956714; PMCID: PMC5340543.
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Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells.

Evidence-based complementary and alternative medicine : eCAM

Park HR, Lee SE, Yang H, Son GW, Jin YH, Park YS.
PMID: 26236385
Evid Based Complement Alternat Med. 2015;2015:972040. doi: 10.1155/2015/972040. Epub 2015 Jul 08.

Korean Red Ginseng is a popular herbal medicine and is widely used in many food products. KRG has biological benefits related to vascular diseases including diabetes, hypertension, atherosclerosis, and other cardiac diseases and KRG has antioxidant and anti-hyperlipidemic actions....

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Park HR, Lee SE, Yang H, et al. Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells. Evid Based Complement Alternat Med. 2015;2015:972040doi: 10.1155/2015/972040.
Park, H. R., Lee, S. E., Yang, H., Son, G. W., Jin, Y. H., & Park, Y. S. (2015). Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells. Evidence-based complementary and alternative medicine : eCAM, 2015972040. https://doi.org/10.1155/2015/972040
Park, Hye Rim, et al. "Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 972040. doi: https://doi.org/10.1155/2015/972040
Park HR, Lee SE, Yang H, Son GW, Jin YH, Park YS. Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells. Evid Based Complement Alternat Med. 2015;2015:972040. doi: 10.1155/2015/972040. Epub 2015 Jul 08. PMID: 26236385; PMCID: PMC4510250.
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Treatment of giardiasis: current status and future directions.

Current infectious disease reports

Watkins RR, Eckmann L.
PMID: 24493628
Curr Infect Dis Rep. 2014 Feb;16(2):396. doi: 10.1007/s11908-014-0396-y.

Giardiasis is a common yet neglected cause of diarrheal illness worldwide. Antimicrobial therapy is usually but not always effective and drug resistance has become an increasing concern. Several promising drug candidates have been recently identified that can overcome antibiotic...

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Watkins RR, Eckmann L. Treatment of giardiasis: current status and future directions. Curr Infect Dis Rep. 2014;16(2):396doi: 10.1007/s11908-014-0396-y.
Watkins, R. R., & Eckmann, L. (2014). Treatment of giardiasis: current status and future directions. Current infectious disease reports, 16(2), 396. https://doi.org/10.1007/s11908-014-0396-y
Watkins, Richard R, and Eckmann, Lars. "Treatment of giardiasis: current status and future directions." Current infectious disease reports vol. 16,2 (2014): 396. doi: https://doi.org/10.1007/s11908-014-0396-y
Watkins RR, Eckmann L. Treatment of giardiasis: current status and future directions. Curr Infect Dis Rep. 2014 Feb;16(2):396. doi: 10.1007/s11908-014-0396-y. PMID: 24493628.
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Selection and characterization of a human ovarian cancer cell line resistant to auranofin.

Oncotarget

Landini I, Lapucci A, Pratesi A, Massai L, Napoli C, Perrone G, Pinzani P, Messori L, Mini E, Nobili S.
PMID: 29221187
Oncotarget. 2017 Oct 09;8(56):96062-96078. doi: 10.18632/oncotarget.21708. eCollection 2017 Nov 10.

The anti-arthritic drug auranofin exerts also potent antitumour activity in

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Landini I, Lapucci A, Pratesi A, et al. Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017;8(56):96062-96078doi: 10.18632/oncotarget.21708.
Landini, I., Lapucci, A., Pratesi, A., Massai, L., Napoli, C., Perrone, G., Pinzani, P., Messori, L., Mini, E., & Nobili, S. (2017). Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget, 8(56), 96062-96078. https://doi.org/10.18632/oncotarget.21708
Landini, Ida, et al. "Selection and characterization of a human ovarian cancer cell line resistant to auranofin." Oncotarget vol. 8,56 (2017): 96062-96078. doi: https://doi.org/10.18632/oncotarget.21708
Landini I, Lapucci A, Pratesi A, Massai L, Napoli C, Perrone G, Pinzani P, Messori L, Mini E, Nobili S. Selection and characterization of a human ovarian cancer cell line resistant to auranofin. Oncotarget. 2017 Oct 09;8(56):96062-96078. doi: 10.18632/oncotarget.21708. eCollection 2017 Nov 10. PMID: 29221187; PMCID: PMC5707081.
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Targeting Oxidative Stress With Auranofin or Prima-1.

Frontiers in oncology

Tessoulin B, Descamps G, Dousset C, Amiot M, Pellat-Deceunynck C.
PMID: 30895171
Front Oncol. 2019 Mar 06;9:128. doi: 10.3389/fonc.2019.00128. eCollection 2019.

Prima-1

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Tessoulin B, Descamps G, Dousset C, et al. Targeting Oxidative Stress With Auranofin or Prima-1. Front Oncol. 2019;9:128doi: 10.3389/fonc.2019.00128.
Tessoulin, B., Descamps, G., Dousset, C., Amiot, M., & Pellat-Deceunynck, C. (2019). Targeting Oxidative Stress With Auranofin or Prima-1. Frontiers in oncology, 9128. https://doi.org/10.3389/fonc.2019.00128
Tessoulin, Benoit, et al. "Targeting Oxidative Stress With Auranofin or Prima-1." Frontiers in oncology vol. 9 (2019): 128. doi: https://doi.org/10.3389/fonc.2019.00128
Tessoulin B, Descamps G, Dousset C, Amiot M, Pellat-Deceunynck C. Targeting Oxidative Stress With Auranofin or Prima-1. Front Oncol. 2019 Mar 06;9:128. doi: 10.3389/fonc.2019.00128. eCollection 2019. PMID: 30895171; PMCID: PMC6414792.
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Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases.

Frontiers in neuroscience

Yumnamcha T, Devi TS, Singh LP.
PMID: 31649499
Front Neurosci. 2019 Oct 10;13:1065. doi: 10.3389/fnins.2019.01065. eCollection 2019.

PURPOSE: Photoreceptor degeneration occurs in various retinal diseases including age-related macular degeneration (AMD), Retinitis pigmentosa (RP), and diabetic retinopathy (DR). However, molecular mechanisms are not fully understood yet. The retinal pigment epithelium (RPE) forms the outer blood retinal barrier...

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Yumnamcha T, Devi TS, Singh LP. Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases. Front Neurosci. 2019;13:1065doi: 10.3389/fnins.2019.01065.
Yumnamcha, T., Devi, T. S., & Singh, L. P. (2019). Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases. Frontiers in neuroscience, 131065. https://doi.org/10.3389/fnins.2019.01065
Yumnamcha, Thangal, et al. "Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases." Frontiers in neuroscience vol. 13 (2019): 1065. doi: https://doi.org/10.3389/fnins.2019.01065
Yumnamcha T, Devi TS, Singh LP. Auranofin Mediates Mitochondrial Dysregulation and Inflammatory Cell Death in Human Retinal Pigment Epithelial Cells: Implications of Retinal Neurodegenerative Diseases. Front Neurosci. 2019 Oct 10;13:1065. doi: 10.3389/fnins.2019.01065. eCollection 2019. PMID: 31649499; PMCID: PMC6795687.
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The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles.

Chemico-biological interactions

Weber AG, Birk B, Müller C, Schneider S, van Ravenzwaay B, Funk-Weyer D, Landsiedel R.
PMID: 34662569
Chem Biol Interact. 2021 Oct 16;351:109709. doi: 10.1016/j.cbi.2021.109709. Epub 2021 Oct 16.

The selenocysteine-containing enzyme class deiodinases (DIO) consists of three isoforms. DIOs play a role in regulation of thyroid hormone (TH) signaling through the removal of iodide from TH leading to TH that interact with the hypothalamic-pituitary-thyroid (HPT) axis with...

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Weber AG, Birk B, Müller C, et al. The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chem Biol Interact. 2021;351:109709doi: 10.1016/j.cbi.2021.109709.
Weber, A. G., Birk, B., Müller, C., Schneider, S., van Ravenzwaay, B., Funk-Weyer, D., & Landsiedel, R. (2021). The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chemico-biological interactions, 351109709. https://doi.org/10.1016/j.cbi.2021.109709
Weber, Andreas Georg, et al. "The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles." Chemico-biological interactions vol. 351 (2021): 109709. doi: https://doi.org/10.1016/j.cbi.2021.109709
Weber AG, Birk B, Müller C, Schneider S, van Ravenzwaay B, Funk-Weyer D, Landsiedel R. The thyroid hormone converting enzyme human deiodinase 1 is inhibited by gold ions from inorganic salts, organic substances, and by small-size nanoparticles. Chem Biol Interact. 2021 Oct 16;351:109709. doi: 10.1016/j.cbi.2021.109709. Epub 2021 Oct 16. PMID: 34662569.
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Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.

Frontiers in veterinary science

Lin Z, Lin Z, Zhao Y, Cheng N, Zhang D, Lin J, Zhang H, Lin D.
PMID: 34977210
Front Vet Sci. 2021 Dec 15;8:772687. doi: 10.3389/fvets.2021.772687. eCollection 2021.

Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold...

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Lin Z, Lin Z, Zhao Y, et al. Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway. Front Vet Sci. 2021;8:772687doi: 10.3389/fvets.2021.772687.
Lin, Z., Lin, Z., Zhao, Y., Cheng, N., Zhang, D., Lin, J., Zhang, H., & Lin, D. (2021). Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway. Frontiers in veterinary science, 8772687. https://doi.org/10.3389/fvets.2021.772687
Lin, Zhaoyan, et al. "Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway." Frontiers in veterinary science vol. 8 (2021): 772687. doi: https://doi.org/10.3389/fvets.2021.772687
Lin Z, Lin Z, Zhao Y, Cheng N, Zhang D, Lin J, Zhang H, Lin D. Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway. Front Vet Sci. 2021 Dec 15;8:772687. doi: 10.3389/fvets.2021.772687. eCollection 2021. PMID: 34977210; PMCID: PMC8714754.
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New Auranofin Analogs with Antibacterial Properties against .

Antibiotics (Basel, Switzerland)

Maydaniuk D, Wu B, Truong D, Liyanage SH, Hogan AM, Yap ZL, Yan M, Cardona ST.
PMID: 34943654
Antibiotics (Basel). 2021 Nov 24;10(12). doi: 10.3390/antibiotics10121443.

Bacteria of the genus

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Maydaniuk D, Wu B, Truong D, et al. New Auranofin Analogs with Antibacterial Properties against . Antibiotics (Basel). 2021;10(12)doi: 10.3390/antibiotics10121443.
Maydaniuk, D., Wu, B., Truong, D., Liyanage, S. H., Hogan, A. M., Yap, Z. L., Yan, M., & Cardona, S. T. (2021). New Auranofin Analogs with Antibacterial Properties against . Antibiotics (Basel, Switzerland), 10(12), . https://doi.org/10.3390/antibiotics10121443
Maydaniuk, Dustin, et al. "New Auranofin Analogs with Antibacterial Properties against ." Antibiotics (Basel, Switzerland) vol. 10,12 (2021). doi: https://doi.org/10.3390/antibiotics10121443
Maydaniuk D, Wu B, Truong D, Liyanage SH, Hogan AM, Yap ZL, Yan M, Cardona ST. New Auranofin Analogs with Antibacterial Properties against . Antibiotics (Basel). 2021 Nov 24;10(12). doi: 10.3390/antibiotics10121443. PMID: 34943654.
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Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe .

Antibiotics (Basel, Switzerland)

Lu H, Lu W, Zhu Y, Wang C, Shi L, Li X, Wu Z, Wang G, Dong W, Tan C, Liu M.
PMID: 33396878
Antibiotics (Basel). 2020 Dec 30;10(1). doi: 10.3390/antibiotics10010026.

Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the

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Lu H, Lu W, Zhu Y, et al. Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe . Antibiotics (Basel). 2020;10(1)doi: 10.3390/antibiotics10010026.
Lu, H., Lu, W., Zhu, Y., Wang, C., Shi, L., Li, X., Wu, Z., Wang, G., Dong, W., Tan, C., & Liu, M. (2020). Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe . Antibiotics (Basel, Switzerland), 10(1), . https://doi.org/10.3390/antibiotics10010026
Lu, Hao, et al. "Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe ." Antibiotics (Basel, Switzerland) vol. 10,1 (2020). doi: https://doi.org/10.3390/antibiotics10010026
Lu H, Lu W, Zhu Y, Wang C, Shi L, Li X, Wu Z, Wang G, Dong W, Tan C, Liu M. Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe . Antibiotics (Basel). 2020 Dec 30;10(1). doi: 10.3390/antibiotics10010026. PMID: 33396878; PMCID: PMC7823847.
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The mechanisms and therapeutic targets of ferroptosis in cancer.

Expert opinion on therapeutic targets

Ye L, Jin F, Kumar SK, Dai Y.
PMID: 34821176
Expert Opin Ther Targets. 2021 Dec 30;1-22. doi: 10.1080/14728222.2021.2011206. Epub 2021 Dec 30.

INTRODUCTION: Ferroptosis, a form of programmed cell death, is mediated primarily by lipid peroxidation via a unique iron-dependent process. The mechanisms of ferroptosis involve the metabolisms of amino acids, irons, and lipids, and the regulation of antioxidant systems. Evidence...

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Ye L, Jin F, Kumar SK, et al. The mechanisms and therapeutic targets of ferroptosis in cancer. Expert Opin Ther Targets. 2021;1-22doi: 10.1080/14728222.2021.2011206.
Ye, L., Jin, F., Kumar, S. K., & Dai, Y. (2021). The mechanisms and therapeutic targets of ferroptosis in cancer. Expert opinion on therapeutic targets, 1-22. https://doi.org/10.1080/14728222.2021.2011206
Ye, Long, et al. "The mechanisms and therapeutic targets of ferroptosis in cancer." Expert opinion on therapeutic targets vol. (2021): 1-22. doi: https://doi.org/10.1080/14728222.2021.2011206
Ye L, Jin F, Kumar SK, Dai Y. The mechanisms and therapeutic targets of ferroptosis in cancer. Expert Opin Ther Targets. 2021 Dec 30;1-22. doi: 10.1080/14728222.2021.2011206. Epub 2021 Dec 30. PMID: 34821176.
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Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes.

Biomedicines

Abás E, Aguirre-Ramírez D, Laguna M, Grasa L.
PMID: 34944591
Biomedicines. 2021 Nov 26;9(12). doi: 10.3390/biomedicines9121775.

New dithiocarbamate cycloaurated complexes have been synthesized and their physicochemical and in vitro antitumor properties have been evaluated. All the performed studies highlighted good transport through the blood and biodistribution, according to the balance between the properties of hydrophilicity/lipophilicity...

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Abás E, Aguirre-Ramírez D, Laguna M, et al. Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes. Biomedicines. 2021;9(12)doi: 10.3390/biomedicines9121775.
Abás, E., Aguirre-Ramírez, D., Laguna, M., & Grasa, L. (2021). Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes. Biomedicines, 9(12), . https://doi.org/10.3390/biomedicines9121775
Abás, Elisa, et al. "Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes." Biomedicines vol. 9,12 (2021). doi: https://doi.org/10.3390/biomedicines9121775
Abás E, Aguirre-Ramírez D, Laguna M, Grasa L. Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes. Biomedicines. 2021 Nov 26;9(12). doi: 10.3390/biomedicines9121775. PMID: 34944591; PMCID: PMC8698672.
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Showing 1 to 12 of 128 entries