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Showing 1 to 12 of 25 entries
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Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients.

Cancer medicine

Vanderwalde A, Spetzler D, Xiao N, Gatalica Z, Marshall J.
PMID: 29436178
Cancer Med. 2018 Mar;7(3):746-756. doi: 10.1002/cam4.1372. Epub 2018 Feb 13.

Microsatellite instability (MSI) testing identifies patients who may benefit from immune checkpoint inhibitors. We developed an MSI assay that uses data from a commercially available next-generation sequencing (NGS) panel to determine MSI status. The assay is applicable across cancer...

Concordance of Programmed Death-Ligand 1 Expression between SP142 and 22C3/SP263 Assays in Triple-Negative Breast Cancer.

Journal of breast cancer

Lee SE, Park HY, Lim SD, Han HS, Yoo YB, Kim WS.
PMID: 32595992
J Breast Cancer. 2020 Jun 01;23(3):303-313. doi: 10.4048/jbc.2020.23.e37. eCollection 2020 Jun.

PURPOSE: Triple-negative breast cancer (TNBC) represents a major clinical challenge due to its aggressive and metastatic behavior and the lack of available targeted therapies. Therefore, therapeutic strategies are needed to improve TNBC patient management. Recently, atezolizumab and nab-paclitaxel chemotherapy...

Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity.

Journal for immunotherapy of cancer

Taki S, Matsuoka K, Nishinaga Y, Takahashi K, Yasui H, Koike C, Shimizu M, Sato M, Sato K.
PMID: 34725216
J Immunother Cancer. 2021 Oct;9(11). doi: 10.1136/jitc-2021-003036.

BACKGROUND: Near-infrared photoimmunotherapy (NIR-PIT) is a new modality for treating cancer, which uses antibody-photoabsorber (IRDye700DX) conjugates that specifically bind to target tumor cells. This conjugate is then photoactivated by NIR light, inducing rapid necrotic cell death. NIR-PIT needs a...

miR-195/miR-497 Regulate .

Journal of breast cancer

Yang L, Cai Y, Zhang D, Sun J, Xu C, Zhao W, Jiang W, Pan C.
PMID: 30607158
J Breast Cancer. 2018 Dec;21(4):371-381. doi: 10.4048/jbc.2018.21.e60. Epub 2018 Dec 26.

PURPOSE: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7 family members that were able to predict the immune...

Soluble programmed cell death protein 1 (sPD-1) and the soluble programmed cell death ligands 1 and 2 (sPD-L1 and sPD-L2) in lymphoid malignancies.

European journal of haematology

Mortensen JB, Monrad I, Enemark MB, Ludvigsen M, Kamper P, Bjerre M, d'Amore F.
PMID: 33721375
Eur J Haematol. 2021 Jul;107(1):81-91. doi: 10.1111/ejh.13621. Epub 2021 Apr 12.

BACKGROUND: The programmed cell death protein 1 (PD-1) and its ligand 1 and 2 (PD-L1/PD-L2) regulate the immune system, and the checkpoint pathway can be exploited by malignant cells to evade anti-tumor immune response. Soluble forms (sPD-1/sPD-L1/sPD-L2) exist in...

The PD-1-PD-L1 Axis in Chronic Obstructive Pulmonary Disease.

American journal of respiratory and critical care medicine

Stoll P, Virchow JC, Lommatzsch M.
PMID: 27585389
Am J Respir Crit Care Med. 2016 Sep 01;194(5):644. doi: 10.1164/rccm.201604-0752LE.

No abstract available.

CX-072 (pacmilimab), a Probody .

Journal for immunotherapy of cancer

Naing A, Thistlethwaite F, De Vries EGE, Eskens FALM, Uboha N, Ott PA, LoRusso P, Garcia-Corbacho J, Boni V, Bendell J, Autio KA, Randhawa M, Durm G, Gil-Martin M, Stroh M, Hannah AL, Arkenau HT, Spira A.
PMID: 34301809
J Immunother Cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2021-002447.

BACKGROUND: ProbodyMETHODS: In the dose-escalation phase of this multicenter, open-label study (NCT03013491), adults with advanced solid tumors (naive to programmed-death-1/PD-L1 or cytotoxic T-lymphocyte-associated antigen 4 inhibitors) were enrolled into one of seven dose-escalation cohorts, with pacmilimab administered intravenously every...

CMTM6 and PD-L1 coexpression is associated with an active immune microenvironment and a favorable prognosis in colorectal cancer.

Journal for immunotherapy of cancer

Peng QH, Wang CH, Chen HM, Zhang RX, Pan ZZ, Lu ZH, Wang GY, Yue X, Huang W, Liu RY.
PMID: 33579737
J Immunother Cancer. 2021 Feb;9(2). doi: 10.1136/jitc-2020-001638.

BACKGROUND: CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6), a programmed death-ligand 1 (PD-L1) regulator, is widely expressed in various tumors and regulates the immune microenvironment. However, its prognostic value remains controversial, and the roles of CMTM6 in colorectal cancer (CRC)...

Reply: The PD-1-PD-L1 Axis in Chronic Obstructive Pulmonary Disease.

American journal of respiratory and critical care medicine

Staples KJ, Wilkinson TM.
PMID: 27585390
Am J Respir Crit Care Med. 2016 Sep 01;194(5):644-5. doi: 10.1164/rccm.201604-0863LE.

No abstract available.

PD-L1 IHC assays in melanoma.

Histopathology

Abdul Karim L, Wang P, Chahine J, Kallakury B.
PMID: 28122123
Histopathology. 2017 Jun;70(7):1177-1179. doi: 10.1111/his.13174. Epub 2017 Mar 20.

No abstract available.

Human Rhinovirus Infection Enhances the Th2 Environment in Allergic and Non-allergic Patients with Chronic Rhinosinusitis.

Clinical and experimental otorhinolaryngology

Ko YK, Zhang YL, Wee JH, Han DH, Kim HJ, Rhee CS.
PMID: 32911880
Clin Exp Otorhinolaryngol. 2021 May;14(2):217-224. doi: 10.21053/ceo.2020.00444. Epub 2020 Sep 11.

OBJECTIVES: This study was conducted to determine whether patients with allergic rhinitis might be more susceptible to human rhinovirus (HRV) infection and whether the effects of infection on the elicited immune responses are different in allergic and non-allergic patients...

Can We MIRror the Efficacy of Immune Checkpoints With miRNAs?.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Alexander M, Wrangle J.
PMID: 33148406
J Thorac Oncol. 2020 Nov;15(11):1703-1704. doi: 10.1016/j.jtho.2020.08.007. Epub 2020 Oct 23.

No abstract available.

Showing 1 to 12 of 25 entries