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Nitrate-promoted Selective C-H Fluorination of Benzamides and Benzeneacetamides.

Organic letters

Ning XQ, Lou SJ, Mao YJ, Xu ZY, Xu DQ.
PMID: 29634276
Org Lett. 2018 Apr 20;20(8):2445-2448. doi: 10.1021/acs.orglett.8b00793. Epub 2018 Apr 10.

A versatile and site-selective nitrate-promoted C-H bond fluorination using various weak coordinating amides as intrinsic directing groups was developed. Diverse tertiary and secondary amides underwent selective aromatic C-H bond fluorination, which features broad substrate scope, good regioselectivity, and mild...

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