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Showing 1 to 12 of 54 entries
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Isolation of Biopterin-alpha-glucoside from Spirulina (Arthrospira) platensis and Its Physiologic Function.

Marine biotechnology (New York, N.Y.)

Noguchi Y, Ishii A, Matsushima A, Haishi D, Yasumuro K, Moriguchi T, Wada T, Kodera Y, Hiroto M, Nishimura H, Sekine M, Inada Y.
PMID: 10373630
Mar Biotechnol (NY). 1999 Mar;1(2):207-210. doi: 10.1007/pl00011769.

: A fluorescent substance was isolated from the cyanobacterium with a yield of 4.5 mg per 10 g of dried Spirulina (Arthrospira) platensis cells by gentle extraction and ethanol fractionation followed by column chromatography. The fluorescent substance, which has...

Interactive Effects of Nicotine and MPTP on Striatal Tetrahydrobiopterin in Mice.

Journal of biomedical science

Tsai MJ, Wang HL, Lee EH.
PMID: 11725082
J Biomed Sci. 1996 Jan;3(1):47-53. doi: 10.1007/BF02253578.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin known to cause dopamine (DA) neuron degeneration, while the psychoactive compound nicotine is known to excite DA neurons. Tetrahydrobiopterin is the cofactor for tyrosine hydroxylase (TOH) in the regulation of DA biosynthesis. The present...

Urinary neopterin and phenylalanine loading test as tools for the biochemical diagnosis of segawa disease.

JIMD reports

Leuzzi V, Carducci C, Chiarotti F, D'Agnano D, Giannini MT, Antonozzi I, Carducci C.
PMID: 23430498
JIMD Rep. 2013;7:67-75. doi: 10.1007/8904_2012_144. Epub 2012 Apr 18.

Background. The diagnosis of autosomal dominant GTP-cyclohydrolase deficiency relies on the examination of the GCH1 gene and/or pterins and neurotransmitters in CSF. The aim of the study was to assess the diagnostic value, if any, of pterins in urine...

Protective effects of (6R)-5,6,7,8-tetrahydro-l-biopterin on local ischemia/reperfusion-induced suppression of reactive hyperemia in rat gingiva.

Journal of clinical biochemistry and nutrition

Tanaka Y, Toyama T, Wada-Takahashi S, Sasaki H, Miyamoto C, Maehata Y, Yoshino F, Yoshida A, Takahashi SS, Watanabe K, Lee MC, Todoki K, Hamada N.
PMID: 26798200
J Clin Biochem Nutr. 2016 Jan;58(1):69-75. doi: 10.3164/jcbn.15-69. Epub 2015 Dec 08.

We herein investigated the regulatory mechanism in the circulation responsible for rat gingival reactive hyperemia (RH) associated with ischemia/reperfusion (I/R). RH was analyzed using a laser Doppler flowmeter. RH and I/R were elicited by gingival compression and release with...

Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?.

Integrated blood pressure control

Rubio-Guerra AF, Vargas-Robles H, Ramos-Brizuela LM, Escalante-Acosta BA.
PMID: 21949628
Integr Blood Press Control. 2010;3:125-32. doi: 10.2147/IBPC.S7479. Epub 2010 Sep 29.

Nitric oxide (NO) is an important regulator of vascular tone, and is also an antithrombotic, anti-inflammatory, antiproliferative, and antiatherogenic factor. Endothelial function is altered in patients with coronary artery disease, stroke, and peripheral artery disease, and endothelial dysfunction correlates...

Phenylalanine hydroxylase (PAH) plays a positive role during WSSV and Vibrio parahaemolyticus infection in Litopenaeus vannamei.

Fish & shellfish immunology

Yao Y, Shi L, Xiao W, Guo S, Liu S, Li H, Zhang S.
PMID: 34952194
Fish Shellfish Immunol. 2021 Dec 21;120:515-525. doi: 10.1016/j.fsi.2021.12.028. Epub 2021 Dec 21.

Phenylalanine hydroxylase (PAH) is involved in immune defence reactions by providing the starting material, tyrosine, to synthesise catecholamines and melanin. PAH is an important metabolic enzyme of aromatic amino acids and the rate-limiting enzyme in the hydroxylation of amino...

Phenylalanine hydroxylase (PAH) plays a positive role during WSSV and Vibrio parahaemolyticus infection in Litopenaeus vannamei.

Fish & shellfish immunology

Yao Y, Shi L, Xiao W, Guo S, Liu S, Li H, Zhang S.
PMID: 34952194
Fish Shellfish Immunol. 2021 Dec 21;120:515-525. doi: 10.1016/j.fsi.2021.12.028. Epub 2021 Dec 21.

Phenylalanine hydroxylase (PAH) is involved in immune defence reactions by providing the starting material, tyrosine, to synthesise catecholamines and melanin. PAH is an important metabolic enzyme of aromatic amino acids and the rate-limiting enzyme in the hydroxylation of amino...

Ascending Lipopolysaccharide-Induced Intrauterine Inflammation in Near-Term Rabbits Leading to Newborn Neurobehavioral Deficits.

Developmental neuroscience

Shi Z, Vasquez-Vivar J, Luo K, Yan Y, Northington F, Mehrmohammadi M, Tan S.
PMID: 31163416
Dev Neurosci. 2018;40(5):534-546. doi: 10.1159/000499960. Epub 2019 Jun 04.

BACKGROUND: Chorioamnionitis from ascending bacterial infection through the endocervix is a potential risk factor for cerebral palsy. Tetrahydrobiopterin, an essential cofactor for nitric oxide synthase (NOS) and amino acid hydroxylases, when augmented in the fetal brain, prevents some of...

Phenylalanine hydroxylase (PAH) plays a positive role during WSSV and Vibrio parahaemolyticus infection in Litopenaeus vannamei.

Fish & shellfish immunology

Yao Y, Shi L, Xiao W, Guo S, Liu S, Li H, Zhang S.
PMID: 34952194
Fish Shellfish Immunol. 2021 Dec 21; doi: 10.1016/j.fsi.2021.12.028. Epub 2021 Dec 21.

Phenylalanine hydroxylase (PAH) is involved in immune defence reactions by providing the starting material, tyrosine, to synthesise catecholamines and melanin. PAH is an important metabolic enzyme of aromatic amino acids and the rate-limiting enzyme in the hydroxylation of amino...

Phenylalanine hydroxylase (PAH) plays a positive role during WSSV and Vibrio parahaemolyticus infection in Litopenaeus vannamei.

Fish & shellfish immunology

Yao Y, Shi L, Xiao W, Guo S, Liu S, Li H, Zhang S.
PMID: 34952194
Fish Shellfish Immunol. 2021 Dec 21;120:515-525. doi: 10.1016/j.fsi.2021.12.028. Epub 2021 Dec 21.

Phenylalanine hydroxylase (PAH) is involved in immune defence reactions by providing the starting material, tyrosine, to synthesise catecholamines and melanin. PAH is an important metabolic enzyme of aromatic amino acids and the rate-limiting enzyme in the hydroxylation of amino...

Role of the Transient Receptor Potential Vanilloid Type 1 (TRPV1) in the Regulation of Nitric Oxide Release in Wistar Rat Aorta.

Oxidative medicine and cellular longevity

Varela-López E, Del Valle-Mondragón L, Castrejón-Téllez V, Pérez-Torres I, Arenas AP, Rojas FM, Guarner-Lans V, Vargas-González A, Pastelín-Hernández G, Torres-Narváez JC.
PMID: 34394835
Oxid Med Cell Longev. 2021 Aug 02;2021:8531975. doi: 10.1155/2021/8531975. eCollection 2021.

The potential transient vanilloid receptor type 1 (TRPV1) plays important functional roles in the vascular system. In the present study, we explored the role of the TRPV1 in the production of nitric oxide (NO), biopterines (BH4 and BH2), cyclic...

The effect of 1 week of repeated ischaemic leg preconditioning on simulated Keirin cycling performance: a randomised trial.

BMJ open sport & exercise medicine

Lindsay A, Petersen C, Blackwell G, Ferguson H, Parker G, Steyn N, Gieseg SP.
PMID: 28761713
BMJ Open Sport Exerc Med. 2017 May 31;3(1):e000229. doi: 10.1136/bmjsem-2017-000229. eCollection 2017.

BACKGROUND: Coaches continually seek new ways of doing things and also refine existing techniques to improve sporting performance. Coaches are currently experimenting using ischaemic preconditioning (IPC) over consecutive days in the hope of improving competitive performances.AIMS: First, to quantify...

Showing 1 to 12 of 54 entries