Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 11 of 11 entries
Sorted by: Best Match Show Resources per page
A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins.

ALTEX

Diamant E, Torgeman A, Epstein E, Mechaly A, David AB, Levin L, Schwartz A, Dor E, Girshengorn M, Barnea A, Mazor O, Zichel R.
PMID: 34798660
ALTEX. 2022;39(1):113-122. doi: 10.14573/altex.2105251. Epub 2021 Nov 19.

The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of phar­maceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and, thus, an alternative in vitro method to replace it is needed....

Foodborne Botulism: Neglected Diagnosis.

European journal of case reports in internal medicine

Palma NZ, da Cruz M, Fagundes V, Pires L.
PMID: 31157190
Eur J Case Rep Intern Med. 2019 May 17;6(5):001122. doi: 10.12890/2019_001122. eCollection 2019.

Botulism is rare neuroparalytic disease caused by botulinum toxin, one of the most toxic substances known. Foodborne botulism is caused by consumption of foods contaminated with botulinum toxin. The clinical manifestations are flaccid, symmetrical, descending paralysis affecting cranial and...

A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins.

ALTEX

Diamant E, Torgeman A, Epstein E, Mechaly A, David AB, Levin L, Schwartz A, Dor E, Girshengorn M, Barnea A, Mazor O, Zichel R.
PMID: 34798660
ALTEX. 2021 Nov 19; doi: 10.14573/altex.2105251. Epub 2021 Nov 19.

The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of pharmaceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and thus, an alternative in vitro method to replace it is needed....

A Four-Monoclonal Antibody Combination Potently Neutralizes Multiple Botulinum Neurotoxin Serotypes C and D.

Toxins

Garcia-Rodriguez C, Yan S, Geren IN, Knopp KA, Dong J, Sun Z, Lou J, Conrad F, Wen WH, Farr-Jones S, Smith TJ, Brown JL, Skerry JC, Smith LA, Marks JD.
PMID: 34564645
Toxins (Basel). 2021 Sep 10;13(9). doi: 10.3390/toxins13090641.

Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and their mosaic toxins. This work built on our success...

Outbreak of Foodborne Botulism Associated With Prepackaged Pouches of Liquid Herbal Tea.

Open forum infectious diseases

Kim M, Zahn M, Reporter R, Askar Z, Green N, Needham M, Rosen H, Kimura A, Terashita D.
PMID: 30793007
Open Forum Infect Dis. 2019 Feb 09;6(2):ofz014. doi: 10.1093/ofid/ofz014. eCollection 2019 Feb.

BACKGROUND: In 2017, local public health authorities in California received reports of 2 elderly patients with suspected botulism who knew each other socially. A multijurisdictional investigation was conducted to determine the source.METHODS: Investigators reviewed medical records, interviewed family to...

Cranial Neuropathies and Neuromuscular Weakness: A Case of Mistaken Identity.

Clinical practice and cases in emergency medicine

Adams DZ, King A, Kaide C.
PMID: 29849352
Clin Pract Cases Emerg Med. 2017 Jul 14;1(3):238-241. doi: 10.5811/cpcem.2017.4.33728. eCollection 2017 Aug.

We describe a case of wound botulism initially thought to represent Miller-Fisher variant Guillain-Barré syndrome (MFS). Botulism classically presents with the so-called "four D's" (diplopia, dysarthria, dysphagia, dry mouth) with symmetric, descending weakness. MFS presents with a triad of...

Botulism.

Current treatment options in neurology

Davis LE.
PMID: 12521561
Curr Treat Options Neurol. 2003 Jan;5(1):23-31. doi: 10.1007/s11940-003-0020-1.

Botulinum toxin is the most potent toxin known to humans and as little as 100 ng can be lethal. The toxin blocks peripheral cholinergic neurotransmission at the neuromuscular junction and cholinergic autonomic nervous system by introducing an endopeptadase enzyme...

A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins.

ALTEX

Diamant E, Torgeman A, Epstein E, Mechaly A, David AB, Levin L, Schwartz A, Dor E, Girshengorn M, Barnea A, Mazor O, Zichel R.
PMID: 34798660
ALTEX. 2022;39(1):113-122. doi: 10.14573/altex.2105251. Epub 2021 Nov 19.

The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of phar­maceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and, thus, an alternative in vitro method to replace it is needed....

Foodborne Illnesses.

Current treatment options in gastroenterology

Gill CJ, Hamer DH.
PMID: 11177679
Curr Treat Options Gastroenterol. 2001 Feb;4(1):23-38. doi: 10.1007/s11938-001-0044-0.

Foodborne illnesses cause a substantial human and financial burden. Despite sanitary infrastructure improvements, the incidence of foodborne bacterial infections due to non-typhoidal salmonellae (NTS), Campylobacter jejuni, and enterohemorrhagic Escherichia coli (EHEC) has risen over the last two decades. Overall,...

Letter to the editor on Ghitani SA et al. Outbreak of foodborne botulism in Alexandria, Egypt. Modulating indications for administration of heptavalent botulinum antitoxin DOI: 10.1007/s11356-021-14909-z.

Environmental science and pollution research international

Claytor L.
PMID: 35031984
Environ Sci Pollut Res Int. 2022 Jan 15; doi: 10.1007/s11356-021-18035-8. Epub 2022 Jan 15.

No abstract available.

Foodborne Botulism, I Only Had Nacho Cheese: A Case Report.

Cureus

Choudhry SA, Anwar MJ, Afzal M, Shah A.
PMID: 29152423
Cureus. 2017 Sep 08;9(9):e1666. doi: 10.7759/cureus.1666.

A 32-year-old female presented to the emergency department with complaints of diplopia, followed by dyspnea, chest tightness, congestion, and dysphagia. The patient was resuscitated and initial investigations were done. Within a few hours of the admission, she started developing...

Showing 1 to 11 of 11 entries