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Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway.

Experimental and therapeutic medicine

Zhao J, Ren J, Liu S, Gong Y, Meng P, Tan H, Chen Y.
PMID: 34721684
Exp Ther Med. 2021 Dec;22(6):1442. doi: 10.3892/etm.2021.10877. Epub 2021 Oct 13.

Sevoflurane (Sev) anesthesia is widely used in pediatrics due to its low blood-gas partition coefficient and lack of pungency. However, Sev treatment may lead to cognitive dysfunction in later life. The current study administered Sev to neonatal rats to...

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Zhao J, Ren J, Liu S, et al. Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway. Exp Ther Med. 2021;22(6):1442doi: 10.3892/etm.2021.10877.
Zhao, J., Ren, J., Liu, S., Gong, Y., Meng, P., Tan, H., & Chen, Y. (2021). Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway. Experimental and therapeutic medicine, 22(6), 1442. https://doi.org/10.3892/etm.2021.10877
Zhao, Jili, et al. "Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway." Experimental and therapeutic medicine vol. 22,6 (2021): 1442. doi: https://doi.org/10.3892/etm.2021.10877
Zhao J, Ren J, Liu S, Gong Y, Meng P, Tan H, Chen Y. Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway. Exp Ther Med. 2021 Dec;22(6):1442. doi: 10.3892/etm.2021.10877. Epub 2021 Oct 13. PMID: 34721684; PMCID: PMC8549089.
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