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Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies.

JAMA cardiology

Georgakis MK, de Lemos JA, Ayers C, Wang B, Björkbacka H, Pana TA, Thorand B, Sun C, Fani L, Malik R, Dupuis J, Engström G, Orho-Melander M, Melander O, Boekholdt SM, Zierer A, Elhadad MA, Koenig W, Herder C, Hoogeveen RC, Kavousi M, Ballantyne CM, Peters A, Myint PK, Nilsson J, Benjamin EJ, Dichgans M.
PMID: 33146689
JAMA Cardiol. 2021 May 01;6(5):587-592. doi: 10.1001/jamacardio.2020.5392.

IMPORTANCE: Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain...

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Georgakis MK, de Lemos JA, Ayers C, et al. Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies. JAMA Cardiol. 2021;6(5):587-592doi: 10.1001/jamacardio.2020.5392.
Georgakis, M. K., de Lemos, J. A., Ayers, C., Wang, B., Björkbacka, H., Pana, T. A., Thorand, B., Sun, C., Fani, L., Malik, R., Dupuis, J., Engström, G., Orho-Melander, M., Melander, O., Boekholdt, S. M., Zierer, A., Elhadad, M. A., Koenig, W., Herder, C., Hoogeveen, R. C., Kavousi, M., Ballantyne, C. M., Peters, A., Myint, P. K., Nilsson, J., Benjamin, E. J., & Dichgans, M. (2021). Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies. JAMA cardiology, 6(5), 587-592. https://doi.org/10.1001/jamacardio.2020.5392
Georgakis, Marios K, et al. "Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies." JAMA cardiology vol. 6,5 (2021): 587-592. doi: https://doi.org/10.1001/jamacardio.2020.5392
Georgakis MK, de Lemos JA, Ayers C, Wang B, Björkbacka H, Pana TA, Thorand B, Sun C, Fani L, Malik R, Dupuis J, Engström G, Orho-Melander M, Melander O, Boekholdt SM, Zierer A, Elhadad MA, Koenig W, Herder C, Hoogeveen RC, Kavousi M, Ballantyne CM, Peters A, Myint PK, Nilsson J, Benjamin EJ, Dichgans M. Association of Circulating Monocyte Chemoattractant Protein-1 Levels With Cardiovascular Mortality: A Meta-analysis of Population-Based Studies. JAMA Cardiol. 2021 May 01;6(5):587-592. doi: 10.1001/jamacardio.2020.5392. PMID: 33146689; PMCID: PMC8111478.
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Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort.

Antioxidants (Basel, Switzerland)

Mulligan AA, Hayhoe RPG, Luben RN, Welch AA.
PMID: 33499166
Antioxidants (Basel). 2021 Jan 22;10(2). doi: 10.3390/antiox10020159.

The prevalence of sarcopenia, frailty and fractures is increasing. Prevention options are limited, but dietary factors including vitamin E have the potential to confer some protection. This study investigated cross-sectional associations between dietary and plasma concentrations of vitamin E...

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Mulligan AA, Hayhoe RPG, Luben RN, et al. Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort. Antioxidants (Basel). 2021;10(2)doi: 10.3390/antiox10020159.
Mulligan, A. A., Hayhoe, R. P. G., Luben, R. N., & Welch, A. A. (2021). Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort. Antioxidants (Basel, Switzerland), 10(2), . https://doi.org/10.3390/antiox10020159
Mulligan, Angela A, et al. "Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort." Antioxidants (Basel, Switzerland) vol. 10,2 (2021). doi: https://doi.org/10.3390/antiox10020159
Mulligan AA, Hayhoe RPG, Luben RN, Welch AA. Positive Associations of Dietary Intake and Plasma Concentrations of Vitamin E with Skeletal Muscle Mass, Heel Bone Ultrasound Attenuation and Fracture Risk in the EPIC-Norfolk Cohort. Antioxidants (Basel). 2021 Jan 22;10(2). doi: 10.3390/antiox10020159. PMID: 33499166; PMCID: PMC7911901.
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Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment.

Circulation. Genomic and precision medicine

Wu H, Luan J, Forgetta V, Engert JC, Thanassoulis G, Mooser V, Wareham NJ, Langenberg C, Richards JB.
PMID: 34461734
Circ Genom Precis Med. 2021 Oct;14(5):e003312. doi: 10.1161/CIRCGEN.121.003312. Epub 2021 Aug 31.

BACKGROUND: Current lipid guidelines suggest measurement of Lp(a) (lipoprotein[a]) and ApoB (apolipoprotein B) for atherosclerotic cardiovascular disease risk assessment. Polygenic risk scores (PRSs) for Lp(a) and ApoB may identify individuals unlikely to have elevated Lp(a) or ApoB and thus...

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Wu H, Luan J, Forgetta V, et al. Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment. Circ Genom Precis Med. 2021;14(5):e003312doi: 10.1161/CIRCGEN.121.003312.
Wu, H., Luan, J., Forgetta, V., Engert, J. C., Thanassoulis, G., Mooser, V., Wareham, N. J., Langenberg, C., & Richards, J. B. (2021). Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment. Circulation. Genomic and precision medicine, 14(5), e003312. https://doi.org/10.1161/CIRCGEN.121.003312
Wu, Haoyu, et al. "Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment." Circulation. Genomic and precision medicine vol. 14,5 (2021): e003312. doi: https://doi.org/10.1161/CIRCGEN.121.003312
Wu H, Luan J, Forgetta V, Engert JC, Thanassoulis G, Mooser V, Wareham NJ, Langenberg C, Richards JB. Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment. Circ Genom Precis Med. 2021 Oct;14(5):e003312. doi: 10.1161/CIRCGEN.121.003312. Epub 2021 Aug 31. PMID: 34461734.
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Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study.

European journal of preventive cardiology

Pana TA, Luben RN, Mamas MA, Potter JF, Wareham NJ, Khaw KT, Myint PK.
PMID: 34223881
Eur J Prev Cardiol. 2021 Jul 05; doi: 10.1093/eurjpc/zwab104. Epub 2021 Jul 05.

AIMS: We aimed to determine the sex differences in longitudinal systolic and diastolic blood pressure (SBP and DBP) trajectories in mid-life and delineate the associations between these and mortality (all-cause, cardiovascular, and non-cardiovascular) and incident cardiovascular disease (CVD) in...

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Pana TA, Luben RN, Mamas MA, et al. Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. Eur J Prev Cardiol. 2021;doi: 10.1093/eurjpc/zwab104.
Pana, T. A., Luben, R. N., Mamas, M. A., Potter, J. F., Wareham, N. J., Khaw, K. T., & Myint, P. K. (2021). Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. European journal of preventive cardiology, . https://doi.org/10.1093/eurjpc/zwab104
Pana, Tiberiu A, et al. "Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study." European journal of preventive cardiology vol. (2021). doi: https://doi.org/10.1093/eurjpc/zwab104
Pana TA, Luben RN, Mamas MA, Potter JF, Wareham NJ, Khaw KT, Myint PK. Long Term Prognostic Impact of Sex-specific Longitudinal Changes in Blood Pressure. The EPIC-Norfolk Prospective Population Cohort Study. Eur J Prev Cardiol. 2021 Jul 05; doi: 10.1093/eurjpc/zwab104. Epub 2021 Jul 05. PMID: 34223881.
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Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort.

Gut microbes

Butt J, Jenab M, Werner J, Fedirko V, Weiderpass E, Dahm CC, Tjønneland A, Olsen A, Boutron-Ruault MC, Rothwell JA, Severi G, Kaaks R, Turzanski-Fortner R, Aleksandrova K, Schulze M, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita B, Van Gils CH, Gram IT, Lukic M, Sala N, Sánchez Pérez MJ, Ardanaz E, Chirlaque MD, Palmquist R, Löwenmark T, Travis RC, Heath A, Cross AJ, Freisling H, Zouiouich S, Aglago E, Waterboer T, Hughes DJ.
PMID: 33874856
Gut Microbes. 2021 Jan-Dec;13(1):1-14. doi: 10.1080/19490976.2021.1903825.

Experimental evidence has implicated genotoxic

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Butt J, Jenab M, Werner J, et al. Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort. Gut Microbes. 2021;13(1):1-14doi: 10.1080/19490976.2021.1903825.
Butt, J., Jenab, M., Werner, J., Fedirko, V., Weiderpass, E., Dahm, C. C., Tjønneland, A., Olsen, A., Boutron-Ruault, M. C., Rothwell, J. A., Severi, G., Kaaks, R., Turzanski-Fortner, R., Aleksandrova, K., Schulze, M., Palli, D., Pala, V., Panico, S., Tumino, R., Sacerdote, C., Bueno-de-Mesquita, B., Van Gils, C. H., Gram, I. T., Lukic, M., Sala, N., Sánchez Pérez, M. J., Ardanaz, E., Chirlaque, M. D., Palmquist, R., Löwenmark, T., Travis, R. C., Heath, A., Cross, A. J., Freisling, H., Zouiouich, S., Aglago, E., Waterboer, T., & Hughes, D. J. (2021). Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort. Gut microbes, 13(1), 1-14. https://doi.org/10.1080/19490976.2021.1903825
Butt, Julia, et al. "Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort." Gut microbes vol. 13,1 (2021): 1-14. doi: https://doi.org/10.1080/19490976.2021.1903825
Butt J, Jenab M, Werner J, Fedirko V, Weiderpass E, Dahm CC, Tjønneland A, Olsen A, Boutron-Ruault MC, Rothwell JA, Severi G, Kaaks R, Turzanski-Fortner R, Aleksandrova K, Schulze M, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita B, Van Gils CH, Gram IT, Lukic M, Sala N, Sánchez Pérez MJ, Ardanaz E, Chirlaque MD, Palmquist R, Löwenmark T, Travis RC, Heath A, Cross AJ, Freisling H, Zouiouich S, Aglago E, Waterboer T, Hughes DJ. Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort. Gut Microbes. 2021 Jan-Dec;13(1):1-14. doi: 10.1080/19490976.2021.1903825. PMID: 33874856; PMCID: PMC8078709.
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Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the .

Diabetes

Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C.
PMID: 34426508
Diabetes. 2021 Nov;70(11):2706-2719. doi: 10.2337/db21-0103. Epub 2021 Aug 23.

There is considerable interest in GIPR agonism to enhance the insulinotropic and extrapancreatic effects of GIP, thereby improving glycemic and weight control in type 2 diabetes (T2D) and obesity. Recent genetic epidemiological evidence has implicated higher GIPR-mediated GIP levels...

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Bowker N, Hansford R, Burgess S, et al. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the . Diabetes. 2021;70(11):2706-2719doi: 10.2337/db21-0103.
Bowker, N., Hansford, R., Burgess, S., Foley, C. N., Auyeung, V. P. W., Erzurumluoglu, A. M., Stewart, I. D., Wheeler, E., Pietzner, M., Gribble, F., Reimann, F., Bhatnagar, P., Coghlan, M. P., Wareham, N. J., & Langenberg, C. (2021). Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the . Diabetes, 70(11), 2706-2719. https://doi.org/10.2337/db21-0103
Bowker, Nicholas, et al. "Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the ." Diabetes vol. 70,11 (2021): 2706-2719. doi: https://doi.org/10.2337/db21-0103
Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the . Diabetes. 2021 Nov;70(11):2706-2719. doi: 10.2337/db21-0103. Epub 2021 Aug 23. PMID: 34426508; PMCID: PMC8564402.
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Showing 1 to 6 of 6 entries