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Showing 1 to 12 of 39 entries
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Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells.

Molecular therapy. Methods & clinical development

Galetto R, Lebuhotel C, Poirot L, Gouble A, Toribio ML, Smith J, Scharenberg A.
PMID: 26015965
Mol Ther Methods Clin Dev. 2014 Jun 11;1:14021. doi: 10.1038/mtm.2014.21. eCollection 2014.

Chimeric antigen receptor technology offers a highly effective means for increasing the anti-tumor effects of autologous adoptive T-cell immunotherapy, and could be made widely available if adapted to the use of allogeneic T-cells. Although gene-editing technology can be used...

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Galetto R, Lebuhotel C, Poirot L, et al. Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells. Mol Ther Methods Clin Dev. 2014;1:14021doi: 10.1038/mtm.2014.21.
Galetto, R., Lebuhotel, C., Poirot, L., Gouble, A., Toribio, M. L., Smith, J., & Scharenberg, A. (2014). Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells. Molecular therapy. Methods & clinical development, 114021. https://doi.org/10.1038/mtm.2014.21
Galetto, Román, et al. "Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells." Molecular therapy. Methods & clinical development vol. 1 (2014): 14021. doi: https://doi.org/10.1038/mtm.2014.21
Galetto R, Lebuhotel C, Poirot L, Gouble A, Toribio ML, Smith J, Scharenberg A. Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells. Mol Ther Methods Clin Dev. 2014 Jun 11;1:14021. doi: 10.1038/mtm.2014.21. eCollection 2014. PMID: 26015965; PMCID: PMC4362381.
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MiR-214 regulates CD3ζ expression in T cells.

Central-European journal of immunology

Xiao Y, Guo L, Zhao S, Huang G, Chen S, Yang L, Li Y, Li B.
PMID: 31530981
Cent Eur J Immunol. 2019;44(2):127-131. doi: 10.5114/ceji.2019.87061. Epub 2019 Jul 30.

INTRODUCTION: T-cell activation requires the T-cell receptor (TCR)-CD3 complex, which integrates and transduces signals. CD3ζ plays a vital role in TCR signalling by mediating T-cell activation. Abnormal CD3ζ expression is a common characteristic of haematological malignancies with T-cell immune...

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Xiao Y, Guo L, Zhao S, et al. MiR-214 regulates CD3ζ expression in T cells. Cent Eur J Immunol. 2019;44(2):127-131doi: 10.5114/ceji.2019.87061.
Xiao, Y., Guo, L., Zhao, S., Huang, G., Chen, S., Yang, L., Li, Y., & Li, B. (2019). MiR-214 regulates CD3ζ expression in T cells. Central-European journal of immunology, 44(2), 127-131. https://doi.org/10.5114/ceji.2019.87061
Xiao, Yankai, et al. "MiR-214 regulates CD3ζ expression in T cells." Central-European journal of immunology vol. 44,2 (2019): 127-131. doi: https://doi.org/10.5114/ceji.2019.87061
Xiao Y, Guo L, Zhao S, Huang G, Chen S, Yang L, Li Y, Li B. MiR-214 regulates CD3ζ expression in T cells. Cent Eur J Immunol. 2019;44(2):127-131. doi: 10.5114/ceji.2019.87061. Epub 2019 Jul 30. PMID: 31530981; PMCID: PMC6745543.
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Author Correction: Structural basis of assembly of the human T cell receptor-CD3 complex.

Nature

Dong, Zheng L, Lin J, Zhang B, Zhu Y, Li N, Xie S, Wang Y, Gao N, Huang Z.
PMID: 33526937
Nature. 2021 Feb;590(7846):E52. doi: 10.1038/s41586-021-03245-4.

No abstract available.

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Dong, Zheng L, Lin J, et al. Author Correction: Structural basis of assembly of the human T cell receptor-CD3 complex. Nature. 2021;590(7846):E52doi: 10.1038/s41586-021-03245-4.
Dong, Zheng, L., Lin, J., Zhang, B., Zhu, Y., Li, N., Xie, S., Wang, Y., Gao, N., & Huang, Z. (2021). Author Correction: Structural basis of assembly of the human T cell receptor-CD3 complex. Nature, 590(7846), E52. https://doi.org/10.1038/s41586-021-03245-4
Dong, De, et al. "Author Correction: Structural basis of assembly of the human T cell receptor-CD3 complex." Nature vol. 590,7846 (2021): E52. doi: https://doi.org/10.1038/s41586-021-03245-4
Dong, Zheng L, Lin J, Zhang B, Zhu Y, Li N, Xie S, Wang Y, Gao N, Huang Z. Author Correction: Structural basis of assembly of the human T cell receptor-CD3 complex. Nature. 2021 Feb;590(7846):E52. doi: 10.1038/s41586-021-03245-4. PMID: 33526937.
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Bispecific antibodies in cancer immunotherapy.

Therapeutic advances in vaccines and immunotherapy

Dahlén E, Veitonmäki N, Norlén P.
PMID: 29998217
Ther Adv Vaccines Immunother. 2018 Feb;6(1):3-17. doi: 10.1177/2515135518763280. Epub 2018 Mar 28.

Following the clinical success of immune checkpoint antibodies targeting CTLA-4, PD-1 or PD-L1 in cancer treatment, bispecific antibodies are now emerging as a growing class of immunotherapies with potential to further improve clinical efficacy and safety. We describe three...

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Dahlén E, Veitonmäki N, Norlén P. Bispecific antibodies in cancer immunotherapy. Ther Adv Vaccines Immunother. 2018;6(1):3-17doi: 10.1177/2515135518763280.
Dahlén, E., Veitonmäki, N., & Norlén, P. (2018). Bispecific antibodies in cancer immunotherapy. Therapeutic advances in vaccines and immunotherapy, 6(1), 3-17. https://doi.org/10.1177/2515135518763280
Dahlén, Eva, et al. "Bispecific antibodies in cancer immunotherapy." Therapeutic advances in vaccines and immunotherapy vol. 6,1 (2018): 3-17. doi: https://doi.org/10.1177/2515135518763280
Dahlén E, Veitonmäki N, Norlén P. Bispecific antibodies in cancer immunotherapy. Ther Adv Vaccines Immunother. 2018 Feb;6(1):3-17. doi: 10.1177/2515135518763280. Epub 2018 Mar 28. PMID: 29998217; PMCID: PMC5933537.
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Characterization of CD3γ/δ.

Developmental and comparative immunology

Qin Y, Sun Z, Wang W, Xu J, Wang B, Jia Z, Li X, Wang J, Gao Q, Chen X, Zou J.
PMID: 32784010
Dev Comp Immunol. 2021 Jan;114:103791. doi: 10.1016/j.dci.2020.103791. Epub 2020 Aug 09.

CD3 is an essential component of the TCR-CD3 complex which plays a key role in adaptive immunity. Non-mammalian CD3 complex consists of CD3γ/δ, CD3ε and CD3ζ subunits. In this study, homologues of CD3γ/δ and CD3ε (termed CiCD3γ/δ and CiCD3ε)...

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Qin Y, Sun Z, Wang W, et al. Characterization of CD3γ/δ. Dev Comp Immunol. 2020;114:103791doi: 10.1016/j.dci.2020.103791.
Qin, Y., Sun, Z., Wang, W., Xu, J., Wang, B., Jia, Z., Li, X., Wang, J., Gao, Q., Chen, X., & Zou, J. (2021). Characterization of CD3γ/δ. Developmental and comparative immunology, 114103791. https://doi.org/10.1016/j.dci.2020.103791
Qin, Yuting, et al. "Characterization of CD3γ/δ." Developmental and comparative immunology vol. 114 (2021): 103791. doi: https://doi.org/10.1016/j.dci.2020.103791
Qin Y, Sun Z, Wang W, Xu J, Wang B, Jia Z, Li X, Wang J, Gao Q, Chen X, Zou J. Characterization of CD3γ/δ. Dev Comp Immunol. 2021 Jan;114:103791. doi: 10.1016/j.dci.2020.103791. Epub 2020 Aug 09. PMID: 32784010.
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Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance.

Surgical technology international

Kapur S, Sharma V, Khanna A, Li B, Sukol K, Suthanthiran M.
PMID: 15858746
Surg Technol Int. 1996;5:233-40.

Activated T cells playa central role in the rejection of histoincompatible organ allografts. Studies of trans- membrane signaling requirements ofT cells, by identifying molecular and cellular mechanisms ofT-cell activation, can lead to rational therapeutic strategies for the regulation of...

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Kapur S, Sharma V, Khanna A, et al. Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance. Surg Technol Int. 1996;5:233-40
Kapur, S., Sharma, V., Khanna, A., Li, B., Sukol, K., & Suthanthiran, M. (1996). Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance. Surgical technology international, 5233-40.
Kapur, S, et al. "Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance." Surgical technology international vol. 5 (1996): 233-40.
Kapur S, Sharma V, Khanna A, Li B, Sukol K, Suthanthiran M. Regulation of the anti-allograft response by targeting the CD2 antigen: a potential strategy for the creation of transplant tolerance. Surg Technol Int. 1996;5:233-40. PMID: 15858746.
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CTLA4-Ig: Progress with a Novel Immunosuppressive Agent in Experimental Solid Organ Transplantation.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

Pagani FD, Bolling SF.
PMID: 18020496
BioDrugs. 1997 Aug;8(2):81-6. doi: 10.2165/00063030-199708020-00001.

The process of allograft rejection is a T cell-dependent phenomenon that occurs as a result of binding of foreign antigen and major histocompatibility complex (MHC) expressed on antigen-presenting cells to the T cell receptor/CD3 complex. Evidence suggests that binding...

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Pagani FD, Bolling SF. CTLA4-Ig: Progress with a Novel Immunosuppressive Agent in Experimental Solid Organ Transplantation. BioDrugs. 1997;8(2):81-6doi: 10.2165/00063030-199708020-00001.
Pagani, F. D., & Bolling, S. F. (1997). CTLA4-Ig: Progress with a Novel Immunosuppressive Agent in Experimental Solid Organ Transplantation. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 8(2), 81-6. https://doi.org/10.2165/00063030-199708020-00001
Pagani, F D, and Bolling, S F. "CTLA4-Ig: Progress with a Novel Immunosuppressive Agent in Experimental Solid Organ Transplantation." BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy vol. 8,2 (1997): 81-6. doi: https://doi.org/10.2165/00063030-199708020-00001
Pagani FD, Bolling SF. CTLA4-Ig: Progress with a Novel Immunosuppressive Agent in Experimental Solid Organ Transplantation. BioDrugs. 1997 Aug;8(2):81-6. doi: 10.2165/00063030-199708020-00001. PMID: 18020496.
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The effect of in vitro phorone exposure on glutathione content and T cell antigen receptor (CD3)-stimulated calcium mobilization in murine splenic T lymphocytes.

Toxicology in vitro : an international journal published in association with BIBRA

Potter AJ, Grossmann A, Rabinovitch PS, Eaton DL, Kavanagh TJ.
PMID: 20654322
Toxicol In Vitro. 1997 Aug;11(4):355-63. doi: 10.1016/s0887-2333(97)82756-7.

An increase in cytosolic free calcium ([Ca(2+)](i)) is one of the earliest events to occur in T lymphocytes following stimulation of the transmembrane T cell receptor/CD3 complex (TCR/CD3). This [Ca(2+)](i) mobilization has been found to be sensitive to intracellular...

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Potter AJ, Grossmann A, Rabinovitch PS, et al. The effect of in vitro phorone exposure on glutathione content and T cell antigen receptor (CD3)-stimulated calcium mobilization in murine splenic T lymphocytes. Toxicol In Vitro. 1997;11(4):355-63doi: 10.1016/s0887-2333(97)82756-7.
Potter, A. J., Grossmann, A., Rabinovitch, P. S., Eaton, D. L., & Kavanagh, T. J. (1997). The effect of in vitro phorone exposure on glutathione content and T cell antigen receptor (CD3)-stimulated calcium mobilization in murine splenic T lymphocytes. Toxicology in vitro : an international journal published in association with BIBRA, 11(4), 355-63. https://doi.org/10.1016/s0887-2333(97)82756-7
Potter, A J, et al. "The effect of in vitro phorone exposure on glutathione content and T cell antigen receptor (CD3)-stimulated calcium mobilization in murine splenic T lymphocytes." Toxicology in vitro : an international journal published in association with BIBRA vol. 11,4 (1997): 355-63. doi: https://doi.org/10.1016/s0887-2333(97)82756-7
Potter AJ, Grossmann A, Rabinovitch PS, Eaton DL, Kavanagh TJ. The effect of in vitro phorone exposure on glutathione content and T cell antigen receptor (CD3)-stimulated calcium mobilization in murine splenic T lymphocytes. Toxicol In Vitro. 1997 Aug;11(4):355-63. doi: 10.1016/s0887-2333(97)82756-7. PMID: 20654322.
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A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs).

Oncoimmunology

Stone JD, Aggen DH, Schietinger A, Schreiber H, Kranz DM.
PMID: 23162754
Oncoimmunology. 2012 Sep 01;1(6):863-873. doi: 10.4161/onci.20592.

Although T cells can mediate potent antitumor responses, immune tolerance mechanisms often result in the deletion or inactivation of T cells that express T-cell receptors (TCRs) against potentially effective target epitopes. Various approaches have been devised to circumvent this...

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Stone JD, Aggen DH, Schietinger A, et al. A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunology. 2012;1(6):863-873doi: 10.4161/onci.20592.
Stone, J. D., Aggen, D. H., Schietinger, A., Schreiber, H., & Kranz, D. M. (2012). A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunology, 1(6), 863-873. https://doi.org/10.4161/onci.20592
Stone, Jennifer D, et al. "A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs)." Oncoimmunology vol. 1,6 (2012): 863-873. doi: https://doi.org/10.4161/onci.20592
Stone JD, Aggen DH, Schietinger A, Schreiber H, Kranz DM. A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunology. 2012 Sep 01;1(6):863-873. doi: 10.4161/onci.20592. PMID: 23162754; PMCID: PMC3489742.
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A PCR-Based Method to Genotype Mice Knocked Out for All Four CD3 Subunits, the Standard Recipient Strain for Retrogenic TCR/CD3 Bone Marrow Reconstitution Technology.

BioResearch open access

Ferrer A, Schrum AG, Gil D.
PMID: 23741635
Biores Open Access. 2013 Jun;2(3):222-6. doi: 10.1089/biores.2013.0002.

The novel T-cell receptor (TCR)/CD3-retrogenic-reconstitution system represents a very useful strategy for studying TCR/CD3 signaling. Two retroviral vectors containing genes for all six subunits of the TCR/CD3 complex are used to transduce bone marrow precursors and reconstitute lethally irradiated...

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Ferrer A, Schrum AG, Gil D. A PCR-Based Method to Genotype Mice Knocked Out for All Four CD3 Subunits, the Standard Recipient Strain for Retrogenic TCR/CD3 Bone Marrow Reconstitution Technology. Biores Open Access. 2013;2(3):222-6doi: 10.1089/biores.2013.0002.
Ferrer, A., Schrum, A. G., & Gil, D. (2013). A PCR-Based Method to Genotype Mice Knocked Out for All Four CD3 Subunits, the Standard Recipient Strain for Retrogenic TCR/CD3 Bone Marrow Reconstitution Technology. BioResearch open access, 2(3), 222-6. https://doi.org/10.1089/biores.2013.0002
Ferrer, Alejandro, et al. "A PCR-Based Method to Genotype Mice Knocked Out for All Four CD3 Subunits, the Standard Recipient Strain for Retrogenic TCR/CD3 Bone Marrow Reconstitution Technology." BioResearch open access vol. 2,3 (2013): 222-6. doi: https://doi.org/10.1089/biores.2013.0002
Ferrer A, Schrum AG, Gil D. A PCR-Based Method to Genotype Mice Knocked Out for All Four CD3 Subunits, the Standard Recipient Strain for Retrogenic TCR/CD3 Bone Marrow Reconstitution Technology. Biores Open Access. 2013 Jun;2(3):222-6. doi: 10.1089/biores.2013.0002. PMID: 23741635; PMCID: PMC3666262.
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Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes.

Results in immunology

Weder P, Schumacher TN, Spits H, Luiten RM.
PMID: 24371571
Results Immunol. 2012 May 10;2:88-96. doi: 10.1016/j.rinim.2012.04.001. eCollection 2012.

HLA/peptide tetramers are frequently used for ex vivo monitoring of disease- or vaccine-induced T cell immune responses and for T cell epitope identification. However, when low-levels HLA/peptide tetramer-positive T cell populations are encountered, it is difficult to ascertain whether...

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Weder P, Schumacher TN, Spits H, et al. Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes. Results Immunol. 2012;2:88-96doi: 10.1016/j.rinim.2012.04.001.
Weder, P., Schumacher, T. N., Spits, H., & Luiten, R. M. (2012). Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes. Results in immunology, 288-96. https://doi.org/10.1016/j.rinim.2012.04.001
Weder, Pauline, et al. "Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes." Results in immunology vol. 2 (2012): 88-96. doi: https://doi.org/10.1016/j.rinim.2012.04.001
Weder P, Schumacher TN, Spits H, Luiten RM. Testing for HLA/peptide tetramer-binding to the T cell receptor complex on human T lymphocytes. Results Immunol. 2012 May 10;2:88-96. doi: 10.1016/j.rinim.2012.04.001. eCollection 2012. PMID: 24371571; PMCID: PMC3862383.
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Expression Dynamics of the .

Frontiers in immunology

Gómez-Henao W, Saavedra R, Chávez-Sánchez FR, Lascurain R, Zenteno E, Tenorio EP.
PMID: 34917095
Front Immunol. 2021 Nov 30;12:788880. doi: 10.3389/fimmu.2021.788880. eCollection 2021.

T lymphocyte activation begins with antigen/MHC recognition by the TCR/CD3 complex followed by a costimulatory signal provided by CD28. The search for novel costimulatory molecules has been extensive due to their potential use as immunotherapeutic targets. Although some molecules...

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Gómez-Henao W, Saavedra R, Chávez-Sánchez FR, et al. Expression Dynamics of the . Front Immunol. 2021;12:788880doi: 10.3389/fimmu.2021.788880.
Gómez-Henao, W., Saavedra, R., Chávez-Sánchez, F. R., Lascurain, R., Zenteno, E., & Tenorio, E. P. (2021). Expression Dynamics of the . Frontiers in immunology, 12788880. https://doi.org/10.3389/fimmu.2021.788880
Gómez-Henao, Wilton, et al. "Expression Dynamics of the ." Frontiers in immunology vol. 12 (2021): 788880. doi: https://doi.org/10.3389/fimmu.2021.788880
Gómez-Henao W, Saavedra R, Chávez-Sánchez FR, Lascurain R, Zenteno E, Tenorio EP. Expression Dynamics of the . Front Immunol. 2021 Nov 30;12:788880. doi: 10.3389/fimmu.2021.788880. eCollection 2021. PMID: 34917095; PMCID: PMC8669815.
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Showing 1 to 12 of 39 entries