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Showing 1 to 12 of 107 entries
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Tumor stroma and chemokines control T-cell migration into melanoma following Temozolomide treatment.

Oncoimmunology

Tan KW, Evrard M, Tham M, Hong M, Huang C, Kato M, Prevost-Blondel A, Donnadieu E, Ng LG, Abastado JP.
PMID: 25949877
Oncoimmunology. 2015 Feb 25;4(2):e978709. doi: 10.4161/2162402X.2014.978709. eCollection 2015 Feb.

The infiltration of T lymphocytes within tumors is associated with better outcomes in cancer patients, yet current understanding of factors that influence T-lymphocyte infiltration into tumors remains incomplete. In our study, Temozolomide (TMZ), a chemotherapeutic drug used to treat...

IFNγ-Inducible Chemokines Decrease upon Selenomethionine Supplementation in Women with Euthyroid Autoimmune Thyroiditis: Comparison between Two Doses of Selenomethionine (80 or 160 μg) versus Placebo.

European thyroid journal

Pilli T, Cantara S, Schomburg L, Cenci V, Cardinale S, Heid EC, Kühn EC, Cevenini G, Sestini F, Fioravanti C, D'Hauw G, Pacini F.
PMID: 26835425
Eur Thyroid J. 2015 Dec;4(4):226-33. doi: 10.1159/000439589. Epub 2015 Oct 08.

BACKGROUND: Several studies have suggested that selenium may influence the natural history of autoimmune thyroiditis (AIT). Recently, IFNγ-inducible chemokines (CXCL-9, -10 and -11) were shown to be elevated in AIT patients.OBJECTIVE: This prospective, randomized, controlled study was conducted to...

Urinary CXCL9 and CXCL10 Levels and Acute Renal Graft Rejection.

International journal of organ transplantation medicine

Ciftci HS, Tefik T, Savran MK, Demir E, Caliskan Y, Ogret YD, Oktar T, Sanlı O, Kocak T, Ozluk Y, Oguz FS, Kilicaslan I, Aydın F, Turkmen A, Nane I.
PMID: 31285802
Int J Organ Transplant Med. 2019;10(2):53-63. Epub 2019 May 01.

BACKGROUND: Monitoring of chemokines, CXCL9 and CXCL10, in serum may present a non-invasive detection method for rejection.OBJECTIVE: To investigate the relationship between urinary levels of CXCL9 and CXCL10 and graft function following renal transplantation.METHODS: 75 living-related donor renal transplant...

Human Novel MicroRNA Seq-915_x4024 in Keratinocytes Contributes to Skin Regeneration by Suppressing Scar Formation.

Molecular therapy. Nucleic acids

Zhao F, Lang H, Wang Z, Zhang T, Zhang D, Wang R, Lin X, Liu X, Shi P, Pang X.
PMID: 30731322
Mol Ther Nucleic Acids. 2019 Mar 01;14:410-423. doi: 10.1016/j.omtn.2018.12.016. Epub 2019 Jan 10.

Early in gestation, wounds in fetal skin heal by regeneration, in which microRNAs play key roles. Seq-915_x4024 is a novel microRNA candidate confirmed by deep sequencing and mirTools 2.0. It is highly expressed in fetal keratinocytes during early gestation....

The Correlation Between Serum Chemokines and Clinical Outcome in Patients with Advanced Biliary Tract Cancer.

Translational oncology

Lee SJ, Kim JE, Kim ST, Lee J, Park SH, Park JO, Kang WK, Park YS, Lim HY.
PMID: 29448202
Transl Oncol. 2018 Apr;11(2):353-357. doi: 10.1016/j.tranon.2018.01.007. Epub 2018 Feb 20.

BACKGROUND: Biliary tract cancers (BTCs) are known to have a dismal prognosis. A number of chemokines play important roles in the progress of BTCs. However, the serum levels of chemokines in BTCs have not yet been explored.METHODS: The sera...

Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade.

Oncoimmunology

Eissler N, Mao Y, Brodin D, Reuterswärd P, Andersson Svahn H, Johnsen JI, Kiessling R, Kogner P.
PMID: 28123870
Oncoimmunology. 2016 Sep 09;5(12):e1232222. doi: 10.1080/2162402X.2016.1232222. eCollection 2016.

Removal of immuno-suppression has been reported to enhance antitumor immunity primed by checkpoint inhibitors. Although PD-1 blockade failed to control tumor growth in a transgenic murine neuroblastoma model, concurrent inhibition of colony stimulating factor 1 receptor (CSF-1R) by BLZ945...

Role of CXC group chemokines in lung cancer development and progression.

Journal of thoracic disease

Spaks A.
PMID: 28446981
J Thorac Dis. 2017 Apr;9:S164-S171. doi: 10.21037/jtd.2017.03.61.

BACKGROUND: Clinical and translational research on lung cancer patients undergoing surgical treatment can provide valuable scientific data and unique opportunity to study tumor microenvironment. CXC chemokines, which are members of a big family of cytokines, are undoubtedly involved in...

Expression and Function of Chemokines CXCL9-11 in Micturition Pathways in Cyclophosphamide (CYP)-Induced Cystitis and Somatic Sensitivity in Mice.

Frontiers in systems neuroscience

Guo M, Chang P, Hauke E, Girard BM, Tooke K, Ojala J, Malley SM, Hsiang H, Vizzard MA.
PMID: 29681802
Front Syst Neurosci. 2018 Apr 06;12:9. doi: 10.3389/fnsys.2018.00009. eCollection 2018.

Changes in urinary bladder function and somatic sensation may be mediated, in part, by inflammatory changes in the urinary bladder including the expression of chemokines. Male and female C57BL/6 mice were treated with cyclophosphamide (CYP; 75 mg/kg, 200 mg/kg,...

Potential Effects of CXCL9 and CCL20 on Cardiac Fibrosis in Patients with Myocardial Infarction and Isoproterenol-Treated Rats.

Journal of clinical medicine

Lin CF, Su CJ, Liu JH, Chen ST, Huang HL, Pan SL.
PMID: 31083544
J Clin Med. 2019 May 11;8(5). doi: 10.3390/jcm8050659.

The chemokines CXCL9 and CCL20 have been reported to be associated with ventricular dysfunction. This study was aimed to investigate the effects of CXCL9/CCL20 on cardiac fibrosis following myocardial infarction (MI). Blood samples of patients with MI were obtained...

Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

Huoman J, Haider S, Simpson A, Murray CS, Custovic A, Jenmalm MC.
PMID: 34101271
Pediatr Allergy Immunol. 2021 Nov;32(8):1824-1832. doi: 10.1111/pai.13574. Epub 2021 Jun 28.

BACKGROUND: Chemokines are important mediators in immune cell recruitment, contributing to allergy development. However, extensive studies of chemokines in the circulation in relation to the presence and development of allergic diseases remain scarce. Our aim was to investigate associations...

Immune responses following tocilizumab therapy to desensitize HLA-sensitized kidney transplant candidates.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Jouve T, Laheurte C, Noble J, Weinhard J, Daligault M, Renaudin A, Naciri Bennani H, Masson D, Gravelin E, Bugnazet M, Bardy B, Malvezzi P, Saas P, Rostaing L.
PMID: 34080291
Am J Transplant. 2022 Jan;22(1):71-84. doi: 10.1111/ajt.16709. Epub 2021 Jun 23.

Kidney transplant candidates (KTCs) who are HLA highly sensitized (calculated panel-reactive alloantibodies >95%) have poor access to deceased kidney transplantation. In this single-center prospective study, 13 highly sensitized desensitization-naïve KTCs received IV tocilizumab (8 mg/kg) every 4 weeks. We...

Role of Substance P-Dependent Chemotactic Signaling in Postoperative Adhesion Formation.

The Journal of surgical research

Kosaka H, Kaibori M, Chu DI, Stucchi AF, Sekimoto M.
PMID: 34638093
J Surg Res. 2022 Feb;270:49-57. doi: 10.1016/j.jss.2021.08.038. Epub 2021 Oct 09.

BACKGROUND: Postoperative adhesions are a potentially life-threatening complication of abdominal surgery. We previously showed that substance P (SP), acting through the neurokinin-1 receptor (NK-1R), is an important early mediator of adhesiogenesis through its regulation of the tissue plasminogen activator/plasminogen...

Showing 1 to 12 of 107 entries