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Showing 1 to 12 of 87 entries
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Use of a flumazenil infusion to treat chlordiazepoxide toxicity.

Acute medicine

Wallace IR, Campbell EC, Trimble M.
PMID: 28424803
Acute Med. 2017;16(1):30-34.

"Alcohol detox" is a common presentation to acute medical services and is usually managed via standardised guidelines and protocols. We present a case of chlordiazepoxide toxicity, requiring repeated bolus doses and subsequently 24 hours of an intravenous infusion of...

Alcohol detoxification in Ysbyty Gwynedd: Two small sips or one big gulp? Two-step screening more reliable for identification of alcohol dependency syndrome at risk of delirium tremens for routine care.

BMJ quality improvement reports

Salman M, Subbe C.
PMID: 26734413
BMJ Qual Improv Rep. 2015 Jul 16;4(1). doi: 10.1136/bmjquality.u206149.w2528. eCollection 2015.

Compliance with pathways for hospitalised patients with alcohol dependency syndrome is often poor. A pathway for recognition and treatment of alcohol dependency was redesigned as part of a 12 month service improvement project in the acute medical unit using...

Actions of ritanserin, a 5-HT(2/1C) antagonist, in benzodiazepine-dependent rats.

Behavioural pharmacology

Goudie AJ, Leathley MJ.
PMID: 11224192
Behav Pharmacol. 1993 Jun;4(3):247-255.

The effects of ritanserin on spontaneous benzodiazepine (BZ) withdrawal-induced weight loss, anorexia and hypodipsia were studied. Groups of female rats initially received i.p. injections b.i.d. (11.00 and 17.00h) of either saline or chlordiazepoxide (CDP). CDP doses increased by 2mg/kg/day...

Anxiolytic profile of GR 38032F in the potentiated startle paradigm.

Behavioural pharmacology

Glenn B, Green S.
PMID: 11175391
Behav Pharmacol. 1989;1(1):91-94. doi: 10.1097/00008877-198900110-00011.

The potentiated startle paradigm has been demonstrated to be a model of anxiety sensitive to a range of established and putative anxiolytics. This study reports a preliminary investigation of the effects of the 5-HT(3) antagonist GR 38032F on potentiated...

A model of 'antipredator' defense in Swiss-Webster mice: effects of benzodiazepine receptor ligands with different intrinsic activities.

Behavioural pharmacology

Griebel G, Blanchard DC, Jung A, Blanchard RJ.
PMID: 11224376
Behav Pharmacol. 1995 Nov;6(7):732-745.

A mouse defense test battery (MDTB) has been designed to assess defensive reactions of Swiss-Webster mice to situations associated with nonpainful threat. When compared to mice approached by a leather glove, animals confronted with an anesthetized or a conscious...

The psychiatric management of patients with alcohol dependence.

Current treatment options in neurology

Ritvo JI, Park C.
PMID: 17716602
Curr Treat Options Neurol. 2007 Sep;9(5):381-92.

Alcohol dependence is a chronic, relapsing biobehavioral disease mediated by various parts of the brain, including reward systems, memory circuits, and the prefrontal cortex. It is characterized by loss of the ability to drink alcohol in moderation and continued...

Simultaneous spectrophotometric estimation of imipramine hydrochloride and chlordiazepoxide in tablets.

Indian journal of pharmaceutical sciences

Patel S, Patel NJ, Patel SA.
PMID: 20502561
Indian J Pharm Sci. 2009 Jul;71(4):468-72. doi: 10.4103/0250-474X.57304.

A binary mixture of imipramine HCl and chlordiazepoxide was determined by three different spectrophotometric methods. The first method involved determination of imipramine HCl and chlordiazepoxide using the simultaneous equations and the second method involved absorbance ratio method. Imipramine has...

Benzodiazepine receptor agonists and inverse agonists yield concordant rather than opposing effects on startle responses.

Journal of psychopharmacology (Oxford, England)

Berntson G, Sarter M, Ruland S, Hart S, Ronis V.
PMID: 22302979
J Psychopharmacol. 1996 Jan;10(4):309-12. doi: 10.1177/026988119601000409.

Benzodiazepine receptor agonists and inverse agonists exert generally opposite actions at both the cellular and behavioural levels. The present study, however, reveals that both the benzodiazepine receptor agonist, chlordiazepoxide and the partial inverse agonist, FG7142, yield a dose-dependent (2-16...

Spectrofluorimetric and spectrophotometric determination of pregabalin in capsules and urine samples.

International journal of biomedical science : IJBS

Shaalan RA.
PMID: 23675201
Int J Biomed Sci. 2010 Sep;6(3):260-7.

Three new, simple, sensitive and selective spectrofluorimetric and spectrophotometric methods were developed for the determination of the γ-amino-n-butyric acid derivative, pregabalin. Pregabalin as a primary amine reacts with fluorescamine to yield a fluorescent product (Method I), with 2,4-dinitrofluorobenzene (Method...

Naloxone and chlordiazepoxide: effects on acquisition of DRL and signalled DRL.

Journal of psychopharmacology (Oxford, England)

Tripp G, McNaughton N.
PMID: 22291247
J Psychopharmacol. 1992 Jan;6(1):88-94. doi: 10.1177/026988119200600116.

The ability of the opiate antagonist, naloxone, to block the anti-conflict effects of the benzodiazepines suggests endogenous opioid involvement in the mechanism of action of these drugs. However naloxone's ability to attenuate the effects of the benzodiazepines in animal...

Synthesis of mesoporous silica for adsorption of chlordiazepoxide and its determination by HPLC: Experimental design.

Journal of separation science

Momtazan F, Khodadoust S, Zeraatpisheh F, Behbahani M.
PMID: 31461204
J Sep Sci. 2019 Aug 28; doi: 10.1002/jssc.201900373. Epub 2019 Aug 28.

In this work, mesoporous silica (SBA-15-NH

The discriminative stimulus produced by pentylenetetrazol: effects of systemic anxiolytics and anxiogenics, aggressive defeat and midazolam or muscimol infused into the amygdala.

Journal of psychopharmacology (Oxford, England)

Vellucci SV, Martin PJ, Everitt BJ.
PMID: 22155842
J Psychopharmacol. 1988 Jan;2(2):80-93. doi: 10.1177/026988118800200203.

Rats were trained to discriminate the interoceptive stimulus generated by systemic administration of pentylenetetrazol. A series of experiments confirmed earlier studies that rats generalized to the pentylenetetrazol cue following treatment with drugs purported to have anxiogenic properties, such as...

Showing 1 to 12 of 87 entries