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Showing 1 to 12 of 75 entries
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Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury.

Journal of neuroinflammation

Lin HW, Basu A, Druckman C, Cicchese M, Krady JK, Levison SW.
PMID: 16808851
J Neuroinflammation. 2006 Jun 30;3:15. doi: 10.1186/1742-2094-3-15.

The cytokines IL-1alpha and IL-1beta are induced rapidly after insults to the CNS, and their subsequent signaling through the type 1 IL-1 receptor (IL-1R1) has been regarded as essential for a normal astroglial and microglial/macrophage response. To determine whether...

A Newly Defined Area of the Mouse Anterior Hypothalamus Involved in Septohypothalamic Circuit: Perifornical Area of the Anterior Hypothalamus, PeFAH.

Acta histochemica et cytochemica

Horii-Hayashi N, Nishi M.
PMID: 29622845
Acta Histochem Cytochem. 2018 Feb 27;51(1):1-8. doi: 10.1267/ahc.17030. Epub 2018 Feb 21.

Although the hypothalamus is classified into more than 10 compartments, it still contains uncharacterized areas. In this study, we identified a new triangular-shaped area between the paraventricular hypothalamic nucleus (PVN) and the fornix area in the mouse anterior hypothalamus,...

Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix.

Frontiers in cellular neuroscience

Hayani H, Song I, Dityatev A.
PMID: 29899690
Front Cell Neurosci. 2018 May 30;12:149. doi: 10.3389/fncel.2018.00149. eCollection 2018.

The neural extracellular matrix (ECM) is enriched with hyaluronic acid, chondroitin sulfate proteoglycans (CSPGs) and the glycoprotein tenascin-R, which play important roles in synaptic plasticity, as shown by studies of the CA1 region of the hippocampus. However, ECM molecules...

Effect of papaverine on axonal outgrowth of primary retinal ganglion cells of Sprague Dawley rats.

Experimental eye research

Ma S, Zhang K, Zhu Y, Cao X, Wang L.
PMID: 34687724
Exp Eye Res. 2021 Nov;212:108797. doi: 10.1016/j.exer.2021.108797. Epub 2021 Oct 20.

Increasing the level of cyclic adenosine 3, 5'-monophosphate is an important mechanism for axon outgrowth and recovery of central nervous system function. This study aimed to investigate the effects of papaverine, a non-specific phosphodiesterase inhibitor, on axon outgrowth of...

Epidural electrical stimulation for spinal cord injury.

Neural regeneration research

Choi EH, Gattas S, Brown NJ, Hong JD, Limbo JN, Chan AY, Oh MY.
PMID: 33907008
Neural Regen Res. 2021 Dec;16(12):2367-2375. doi: 10.4103/1673-5374.313017.

A long-standing goal of spinal cord injury research is to develop effective repair strategies, which can restore motor and sensory functions to near-normal levels. Recent advances in clinical management of spinal cord injury have significantly improved the prognosis, survival...

Pericytes as mediators of infiltration of macrophages in multiple sclerosis.

Journal of neuroinflammation

Kaushik DK, Bhattacharya A, Lozinski BM, Wee Yong V.
PMID: 34952601
J Neuroinflammation. 2021 Dec 24;18(1):301. doi: 10.1186/s12974-021-02358-x.

BACKGROUND: Multiple sclerosis (MS) is a neurodegenerative condition of the central nervous system (CNS). It is associated with blood-brain barrier (BBB) breakdown and intravasation of leukocytes, particularly monocyte-derived macrophages, into the CNS. Pericytes are mural cells that are encased...

PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury.

Frontiers in cellular neuroscience

Rodemer W, Zhang G, Sinitsa I, Hu J, Jin LQ, Li S, Selzer ME.
PMID: 32265663
Front Cell Neurosci. 2020 Mar 19;14:61. doi: 10.3389/fncel.2020.00061. eCollection 2020.

Traumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the mammalian CNS. After SCI, chondroitin sulfate proteoglycans (CSPGs) inhibit axon regrowth

Traffic lights for axon growth: proteoglycans and their neuronal receptors.

Neural regeneration research

Shen Y.
PMID: 25206823
Neural Regen Res. 2014 Feb 15;9(4):356-61. doi: 10.4103/1673-5374.128236.

Axon growth is a central event in the development and post-injury plasticity of the nervous system. Growing axons encounter a wide variety of environmental instructions. Much like traffic lights in controlling the migrating axons, chondroitin sulfate proteoglycans (CSPGs) and...

Chondroitinase ABC Promotes Axon Regeneration and Reduces Retrograde Apoptosis Signaling in Lamprey.

Frontiers in cell and developmental biology

Hu J, Rodemer W, Zhang G, Jin LQ, Li S, Selzer ME.
PMID: 33842481
Front Cell Dev Biol. 2021 Mar 25;9:653638. doi: 10.3389/fcell.2021.653638. eCollection 2021.

Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is believed that axon growth is inhibited by the presence of several types of inhibitory molecules in central nervous system (CNS), including the chondroitin sulfate...

Effects of methylprednisolone and treadmill training on spinal cord injury in experimental rats.

Experimental and therapeutic medicine

Liu JT, Wang SY, Xiao HP, Gu B, Li HN.
PMID: 34676006
Exp Ther Med. 2021 Dec;22(6):1413. doi: 10.3892/etm.2021.10849. Epub 2021 Oct 08.

Methylprednisolone (MP) is widely used to treat clinical spinal cord injury (SCI). Treadmill training is also considered an important treatment after SCI to improve motor function in patients, resulting in an evident improvement. Therefore, the present study was designed...

5-Year Survival in Gastric Adenocarcinoma with Epithelial and Stromal Versican Expression.

Iranian journal of pathology

Sanei MH, Mirmosayyeb O, Chehrei A, Ansari J, Saberi E.
PMID: 31531098
Iran J Pathol. 2019;14(1):26-32. doi: 10.30699/IJP.14.1.26. Epub 2018 Dec 27.

BACKGROUND & OBJECTIVE: Gastric cancer is the second most frequent cause of cancer death worldwide, despite dif- ferences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival...

Inhibition of Autophagy Flux Promotes Secretion of Chondroitin Sulfate Proteoglycans in Primary Rat Astrocytes.

Molecular neurobiology

Alizadeh J, Kochan MM, Stewart VD, Drewnik DA, Hannila SS, Ghavami S.
PMID: 34449046
Mol Neurobiol. 2021 Dec;58(12):6077-6091. doi: 10.1007/s12035-021-02533-4. Epub 2021 Aug 27.

Following spinal cord injury (SCI), reactive astrocytes in the glial scar produce high levels of chondroitin sulfate proteoglycans (CSPGs), which are known to inhibit axonal regeneration. Transforming growth factor beta (TGFβ) is a well-known factor that induces the production...

Showing 1 to 12 of 75 entries