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Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease.

International journal of Alzheimer's disease

Roney CA, Arora V, Kulkarni PV, Antich PP, Bonte FJ.
PMID: 20721294
Int J Alzheimers Dis. 2010 Jan 27;2009. doi: 10.4061/2009/481031.

Detecting aggregated amyloid peptides (Abeta plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity (125)I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. (125)I-CQ-PBCA NPs crossed the BBB (2.3...

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Roney CA, Arora V, Kulkarni PV, et al. Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease. Int J Alzheimers Dis. 2010;2009doi: 10.4061/2009/481031.
Roney, C. A., Arora, V., Kulkarni, P. V., Antich, P. P., & Bonte, F. J. (2010). Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease. International journal of Alzheimer's disease, 2009. https://doi.org/10.4061/2009/481031
Roney, Celeste A, et al. "Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease." International journal of Alzheimer's disease vol. 2009 (2010). doi: https://doi.org/10.4061/2009/481031
Roney CA, Arora V, Kulkarni PV, Antich PP, Bonte FJ. Nanoparticulate radiolabelled quinolines detect amyloid plaques in mouse models of Alzheimer's disease. Int J Alzheimers Dis. 2010 Jan 27;2009. doi: 10.4061/2009/481031. PMID: 20721294; PMCID: PMC2915660.
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A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?.

Journal of clinical research in oncology

Costello LC, Franklin RB.
PMID: 30828702
J Clin Res Oncol. 2019;2(1).

All cases of prostate cancer exhibit the hallmark condition of marked decrease in zinc in malignancy compared to the high zinc levels in the normal and benign prostate. There exists no reported corroborated case of prostate cancer in which...

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Costello LC, Franklin RB. A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?. J Clin Res Oncol. 2019;2(1)
Costello, L. C., & Franklin, R. B. (2019). A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?. Journal of clinical research in oncology, 2(1), .
Costello, Leslie C, and Franklin, Renty B. "A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?." Journal of clinical research in oncology vol. 2,1 (2019).
Costello LC, Franklin RB. A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How?. J Clin Res Oncol. 2019;2(1). PMID: 30828702; PMCID: PMC6392423.
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New insights into the mechanism of antifungal action of 8-hydroxyquinolines.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Pippi B, Lopes W, Reginatto P, Silva FÉK, Joaquim AR, Alves RJ, Silveira GP, Vainstein MH, Andrade SF, Fuentefria AM.
PMID: 30662305
Saudi Pharm J. 2019 Jan;27(1):41-48. doi: 10.1016/j.jsps.2018.07.017. Epub 2018 Jul 20.

The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel derivatives endowed with biological activity. Our research aimed at clarifying the antifungal mechanism of action of clioquinol, 8-hydroxy-5-quinolinesulfonic acid, and 8-hydroxy-7-iodo-5-quinolinesulfonic acid (three 8-hydroxyquinoline derivatives)....

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Pippi B, Lopes W, Reginatto P, et al. New insights into the mechanism of antifungal action of 8-hydroxyquinolines. Saudi Pharm J. 2018;27(1):41-48doi: 10.1016/j.jsps.2018.07.017.
Pippi, B., Lopes, W., Reginatto, P., Silva, F. �. �. K., Joaquim, A. R., Alves, R. J., Silveira, G. P., Vainstein, M. H., Andrade, S. F., & Fuentefria, A. M. (2019). New insights into the mechanism of antifungal action of 8-hydroxyquinolines. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 27(1), 41-48. https://doi.org/10.1016/j.jsps.2018.07.017
Pippi, Bruna, et al. "New insights into the mechanism of antifungal action of 8-hydroxyquinolines." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 27,1 (2019): 41-48. doi: https://doi.org/10.1016/j.jsps.2018.07.017
Pippi B, Lopes W, Reginatto P, Silva FÉK, Joaquim AR, Alves RJ, Silveira GP, Vainstein MH, Andrade SF, Fuentefria AM. New insights into the mechanism of antifungal action of 8-hydroxyquinolines. Saudi Pharm J. 2019 Jan;27(1):41-48. doi: 10.1016/j.jsps.2018.07.017. Epub 2018 Jul 20. PMID: 30662305; PMCID: PMC6323154.
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Zinc: The Wonder Drug for the Treatment of Carcinomas.

Acta scientific cancer biology

Costello LC, Franklin RB.
PMID: 32587956
Acta Sci Cancer Biol. 2020 May;4(5):33-39. doi: 10.31080/ascb.2020.04.0223. Epub 2020 Apr 27.

Evidence is evolving that support the relationship that all carcinomas exhibit the following important relationships: The malignant cells exhibit a significant decreased zinc compared to the normal cells. The higher zinc levels that exist in the normal cells are...

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Costello LC, Franklin RB. Zinc: The Wonder Drug for the Treatment of Carcinomas. Acta Sci Cancer Biol. 2020;4(5):33-39doi: 10.31080/ascb.2020.04.0223.
Costello, L. C., & Franklin, R. B. (2020). Zinc: The Wonder Drug for the Treatment of Carcinomas. Acta scientific cancer biology, 4(5), 33-39. https://doi.org/10.31080/ascb.2020.04.0223
Costello, Leslie C, and Franklin, Renty B. "Zinc: The Wonder Drug for the Treatment of Carcinomas." Acta scientific cancer biology vol. 4,5 (2020): 33-39. doi: https://doi.org/10.31080/ascb.2020.04.0223
Costello LC, Franklin RB. Zinc: The Wonder Drug for the Treatment of Carcinomas. Acta Sci Cancer Biol. 2020 May;4(5):33-39. doi: 10.31080/ascb.2020.04.0223. Epub 2020 Apr 27. PMID: 32587956; PMCID: PMC7316362.
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Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines.

Inorganic chemistry

Summers KL, Pushie MJ, Sopasis GJ, James AK, Dolgova NV, Sokaras D, Kroll T, Harris HH, Pickering IJ, George GN.
PMID: 32936627
Inorg Chem. 2020 Oct 05;59(19):13858-13874. doi: 10.1021/acs.inorgchem.0c01356. Epub 2020 Sep 16.

8-Hydroxyquinolines (8HQs) are a family of lipophilic metal ion chelators that have been used in a range of analytical and pharmaceutical applications over the last 100 years. More recently, CQ (clioquinol; 5-chloro-7-iodo-8-hydroxyquinoline) and PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) have undergone clinical trials...

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Summers KL, Pushie MJ, Sopasis GJ, et al. Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines. Inorg Chem. 2020;59(19):13858-13874doi: 10.1021/acs.inorgchem.0c01356.
Summers, K. L., Pushie, M. J., Sopasis, G. J., James, A. K., Dolgova, N. V., Sokaras, D., Kroll, T., Harris, H. H., Pickering, I. J., & George, G. N. (2020). Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines. Inorganic chemistry, 59(19), 13858-13874. https://doi.org/10.1021/acs.inorgchem.0c01356
Summers, Kelly L, et al. "Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines." Inorganic chemistry vol. 59,19 (2020): 13858-13874. doi: https://doi.org/10.1021/acs.inorgchem.0c01356
Summers KL, Pushie MJ, Sopasis GJ, James AK, Dolgova NV, Sokaras D, Kroll T, Harris HH, Pickering IJ, George GN. Solution Chemistry of Copper(II) Binding to Substituted 8-Hydroxyquinolines. Inorg Chem. 2020 Oct 05;59(19):13858-13874. doi: 10.1021/acs.inorgchem.0c01356. Epub 2020 Sep 16. PMID: 32936627.
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Amplified Peroxidase-like Activity of Co.

Chemistry, an Asian journal

Xu L, Sai J, Xue D, Zhou L, Pei R, Liu A.
PMID: 34605211
Chem Asian J. 2021 Dec 01;16(23):3957-3962. doi: 10.1002/asia.202100997. Epub 2021 Oct 15.

8-Hydroxyquinoline (8HQ) and its derivatives display diverse bioactivities and therapeutic potentials. In this study, we unveiled that 8HQ can boost the peroxidase-like activity of Co

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Xu L, Sai J, Xue D, et al. Amplified Peroxidase-like Activity of Co. Chem Asian J. 2021;16(23):3957-3962doi: 10.1002/asia.202100997.
Xu, L., Sai, J., Xue, D., Zhou, L., Pei, R., & Liu, A. (2021). Amplified Peroxidase-like Activity of Co. Chemistry, an Asian journal, 16(23), 3957-3962. https://doi.org/10.1002/asia.202100997
Xu, Lijun, et al. "Amplified Peroxidase-like Activity of Co." Chemistry, an Asian journal vol. 16,23 (2021): 3957-3962. doi: https://doi.org/10.1002/asia.202100997
Xu L, Sai J, Xue D, Zhou L, Pei R, Liu A. Amplified Peroxidase-like Activity of Co. Chem Asian J. 2021 Dec 01;16(23):3957-3962. doi: 10.1002/asia.202100997. Epub 2021 Oct 15. PMID: 34605211.
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Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies.

Bioorganic chemistry

Wali S, Atia-Tul-Wahab, Ullah S, Khan MA, Hussain S, Shaikh M, Atta-Ur-Rahman, Choudhary MI.
PMID: 34896920
Bioorg Chem. 2021 Nov 23;119:105506. doi: 10.1016/j.bioorg.2021.105506. Epub 2021 Nov 23.

Diabetes mellitus is a chronic metabolic disorder with increasing prevalence and long-term complications. The aim of this study was to identify α-glucosidase inhibitory compounds with potential anti-hyperglycemic activity. For this purpose, a series of new clioquinol derivatives 2a-11a was...

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Wali S, Atia-Tul-Wahab, Ullah S, et al. Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorg Chem. 2021;119:105506doi: 10.1016/j.bioorg.2021.105506.
Wali, S., Atia-Tul-Wahab, Ullah, S., Khan, M. A., Hussain, S., Shaikh, M., Atta-Ur-Rahman, & Choudhary, M. I. (2021). Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorganic chemistry, 119105506. https://doi.org/10.1016/j.bioorg.2021.105506
Wali, Shoukat, et al. "Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies." Bioorganic chemistry vol. 119 (2021): 105506. doi: https://doi.org/10.1016/j.bioorg.2021.105506
Wali S, Atia-Tul-Wahab, Ullah S, Khan MA, Hussain S, Shaikh M, Atta-Ur-Rahman, Choudhary MI. Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorg Chem. 2021 Nov 23;119:105506. doi: 10.1016/j.bioorg.2021.105506. Epub 2021 Nov 23. PMID: 34896920.
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Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies.

Bioorganic chemistry

Wali S, Atia-Tul-Wahab, Ullah S, Khan MA, Hussain S, Shaikh M, Atta-Ur-Rahman, Choudhary MI.
PMID: 34896920
Bioorg Chem. 2021 Nov 23;119:105506. doi: 10.1016/j.bioorg.2021.105506. Epub 2021 Nov 23.

Diabetes mellitus is a chronic metabolic disorder with increasing prevalence and long-term complications. The aim of this study was to identify α-glucosidase inhibitory compounds with potential anti-hyperglycemic activity. For this purpose, a series of new clioquinol derivatives 2a-11a was...

Cite
Wali S, Atia-Tul-Wahab, Ullah S, et al. Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorg Chem. 2021;119:105506doi: 10.1016/j.bioorg.2021.105506.
Wali, S., Atia-Tul-Wahab, Ullah, S., Khan, M. A., Hussain, S., Shaikh, M., Atta-Ur-Rahman, & Choudhary, M. I. (2021). Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorganic chemistry, 119105506. https://doi.org/10.1016/j.bioorg.2021.105506
Wali, Shoukat, et al. "Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies." Bioorganic chemistry vol. 119 (2021): 105506. doi: https://doi.org/10.1016/j.bioorg.2021.105506
Wali S, Atia-Tul-Wahab, Ullah S, Khan MA, Hussain S, Shaikh M, Atta-Ur-Rahman, Choudhary MI. Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorg Chem. 2021 Nov 23;119:105506. doi: 10.1016/j.bioorg.2021.105506. Epub 2021 Nov 23. PMID: 34896920.
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Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction .

Heliyon

Olaleye OA, Kaur M, Onyenaka C, Adebusuyi T.
PMID: 33732940
Heliyon. 2021 Mar;7(3):e06426. doi: 10.1016/j.heliyon.2021.e06426. Epub 2021 Mar 11.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19. Hence, there is an urgent need to accelerate the...

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Olaleye OA, Kaur M, Onyenaka C, et al. Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction . Heliyon. 2021;7(3):e06426doi: 10.1016/j.heliyon.2021.e06426.
Olaleye, O. A., Kaur, M., Onyenaka, C., & Adebusuyi, T. (2021). Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction . Heliyon, 7(3), e06426. https://doi.org/10.1016/j.heliyon.2021.e06426
Olaleye, Omonike A, et al. "Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction ." Heliyon vol. 7,3 (2021): e06426. doi: https://doi.org/10.1016/j.heliyon.2021.e06426
Olaleye OA, Kaur M, Onyenaka C, Adebusuyi T. Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction . Heliyon. 2021 Mar;7(3):e06426. doi: 10.1016/j.heliyon.2021.e06426. Epub 2021 Mar 11. PMID: 33732940; PMCID: PMC7951571.
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Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies.

Bioorganic chemistry

Wali S, Atia-Tul-Wahab, Ullah S, Khan MA, Hussain S, Shaikh M, Atta-Ur-Rahman, Choudhary MI.
PMID: 34896920
Bioorg Chem. 2021 Nov 23;119:105506. doi: 10.1016/j.bioorg.2021.105506. Epub 2021 Nov 23.

Diabetes mellitus is a chronic metabolic disorder with increasing prevalence and long-term complications. The aim of this study was to identify α-glucosidase inhibitory compounds with potential anti-hyperglycemic activity. For this purpose, a series of new clioquinol derivatives 2a-11a was...

Cite
Wali S, Atia-Tul-Wahab, Ullah S, et al. Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorg Chem. 2021;119:105506doi: 10.1016/j.bioorg.2021.105506.
Wali, S., Atia-Tul-Wahab, Ullah, S., Khan, M. A., Hussain, S., Shaikh, M., Atta-Ur-Rahman, & Choudhary, M. I. (2021). Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorganic chemistry, 119105506. https://doi.org/10.1016/j.bioorg.2021.105506
Wali, Shoukat, et al. "Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies." Bioorganic chemistry vol. 119 (2021): 105506. doi: https://doi.org/10.1016/j.bioorg.2021.105506
Wali S, Atia-Tul-Wahab, Ullah S, Khan MA, Hussain S, Shaikh M, Atta-Ur-Rahman, Choudhary MI. Synthesis of new clioquinol derivatives as potent α-glucosidase inhibitors; molecular docking, kinetic and structure-activity relationship studies. Bioorg Chem. 2021 Nov 23;119:105506. doi: 10.1016/j.bioorg.2021.105506. Epub 2021 Nov 23. PMID: 34896920.
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Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities.

Biochemistry and biophysics reports

Cherdtrakulkiat R, Boonpangrak S, Sinthupoom N, Prachayasittikul S, Ruchirawat S, Prachayasittikul V.
PMID: 29214226
Biochem Biophys Rep. 2016 Mar 24;6:135-141. doi: 10.1016/j.bbrep.2016.03.014. eCollection 2016 Jul.

8-Hydroxyquinoline (8HQ) compounds have been reported to possess diverse bioactivities. In recent years, drug repositioning has gained considerable attention in drug discovery and development. Herein, 8HQ (

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Cherdtrakulkiat R, Boonpangrak S, Sinthupoom N, et al. Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities. Biochem Biophys Rep. 2016;6:135-141doi: 10.1016/j.bbrep.2016.03.014.
Cherdtrakulkiat, R., Boonpangrak, S., Sinthupoom, N., Prachayasittikul, S., Ruchirawat, S., & Prachayasittikul, V. (2016). Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities. Biochemistry and biophysics reports, 6135-141. https://doi.org/10.1016/j.bbrep.2016.03.014
Cherdtrakulkiat, Rungrot, et al. "Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities." Biochemistry and biophysics reports vol. 6 (2016): 135-141. doi: https://doi.org/10.1016/j.bbrep.2016.03.014
Cherdtrakulkiat R, Boonpangrak S, Sinthupoom N, Prachayasittikul S, Ruchirawat S, Prachayasittikul V. Derivatives (halogen, nitro and amino) of 8-hydroxyquinoline with highly potent antimicrobial and antioxidant activities. Biochem Biophys Rep. 2016 Mar 24;6:135-141. doi: 10.1016/j.bbrep.2016.03.014. eCollection 2016 Jul. PMID: 29214226; PMCID: PMC5689172.
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Drugs that target metal beta-amyloid interactions can effect Alzheimer's disease. Commentary: Metal-protein attenuation with iodochlorohydroxyquine (clioquinol) targeting beta-amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists

Guay DR.
PMID: 16553493
Consult Pharm. 2004 Jul;19(7):637-8.

No abstract available.

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Guay DR. Drugs that target metal beta-amyloid interactions can effect Alzheimer's disease. Commentary: Metal-protein attenuation with iodochlorohydroxyquine (clioquinol) targeting beta-amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Consult Pharm. 2004;19(7):637-8
Guay, D. R. (2004). Drugs that target metal beta-amyloid interactions can effect Alzheimer's disease. Commentary: Metal-protein attenuation with iodochlorohydroxyquine (clioquinol) targeting beta-amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 19(7), 637-8.
Guay, David R P. "Drugs that target metal beta-amyloid interactions can effect Alzheimer's disease. Commentary: Metal-protein attenuation with iodochlorohydroxyquine (clioquinol) targeting beta-amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial." The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists vol. 19,7 (2004): 637-8.
Guay DR. Drugs that target metal beta-amyloid interactions can effect Alzheimer's disease. Commentary: Metal-protein attenuation with iodochlorohydroxyquine (clioquinol) targeting beta-amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Consult Pharm. 2004 Jul;19(7):637-8. PMID: 16553493.
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Showing 1 to 12 of 51 entries