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Showing 1 to 12 of 22 entries
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Characterization of monoamine oxidase activity during early stages of quail embryogenesis.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Pintar JE, Maxwell GD, Breakefield XO.
PMID: 24875606
Int J Dev Neurosci. 1983;1(1):49-57. doi: 10.1016/0736-5748(83)90010-2.

Catecholamines and other biogenic amines may play a role in early embryogenesis in addition to functioning as neurotransmitters after neuronal differentiation. Regulation of amine levels is mediated by several different parameters including activity levels of degradative enzymes. Since monoamine...

Both zimelidine and clorgyline decrease preprotachykinin mRNA in adult medullary raphe nuclei.

Molecular and cellular neurosciences

Riley LA, Hart RP, Jonakait GM.
PMID: 19912792
Mol Cell Neurosci. 1991 Apr;2(2):139-44. doi: 10.1016/1044-7431(91)90006-a.

Neurons of the medullary raphe nuclei contain multiple neurotransmitters including the monoamine neurotransmitter serotonin (5-HT) and the tachykinin substance P (SP). Previously, we showed that inhibition of serotonin synthesis increased levels of mRNA coding for preprotachykinin (PPT), the prohormone...

Mao-a enzyme binding in bladder-cancer characterized with [C-11] harmine in frozen-section autoradiography.

Oncology reports

Goller L, Bergstrom M, Nilsson S, Westerberg G, Langstrom B.
PMID: 21597803
Oncol Rep. 1995 Sep;2(5):717-21. doi: 10.3892/or.2.5.717.

Operative specimens from 7 patients with urinary bladder cancer and with only inflammatory tissue in the operative sample from one patient, were used for frozen section autoradiography using [C-11]harmine to characterize the expression of the enzyme monoamine oxidase A...

Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions.

Drug target insights

Kitanaka J, Kitanaka N, Takemura M.
PMID: 21901055
Drug Target Insights. 2006;1:19-28. Epub 2006 Nov 09.

Methamphetamine (METH) abuse is a serious health and social problem worldwide. At present, however, there are no effective medications for the treatment of METH abuse. Of the intracellular METH target proteins, monoamine oxidase (MAO) is involved in the regulation...

Neurotoxicity of 1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) and effects on catecholamine homeostasis in SH-SY5Y cells.

Environmental toxicology and pharmacology

Willets JM, Lambert DG, Lunec J, Griffiths HR, Phillipson O.
PMID: 21781702
Environ Toxicol Pharmacol. 1996 Aug 15;2(1):59-68. doi: 10.1016/1382-6689(96)00030-0.

We have investigated the potential neurotoxicity of the catecholamine depleting agent 1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) in SH-SY5Y neuroblastoma cells. TMIQ induced a time and dose related inhibition of 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; thiazoyl blue (MTT) reduction and an increase in lactate dehydrogenase release....

Effects of combined treatment with clorgyline and selegiline on extracellular noradrenaline and serotonin levels.

Acta neuropsychiatrica

Kitaichi Y, Inoue T, Nakagawa S, Boku S, Koyama T.
PMID: 25287180
Acta Neuropsychiatr. 2012 Dec;24(6):369-73. doi: 10.1111/j.1601-5215.2012.00652.x.

No abstract available.

Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry.

Journal of pharmaceutical analysis

Wang Z, Olenyuk BZ, Shih JC, Wang J.
PMID: 29922483
J Pharm Anal. 2018 Jun;8(3):153-159. doi: 10.1016/j.jpha.2017.10.001. Epub 2017 Oct 20.

A high-performance liquid chromatography-electrospray ionization tandem mass spectrometric (HPLC-ESI-MS/MS) method was developed for the quantification of MHI148-clorgyline amide (NMI-amide), a novel tumor-targeting monoamine oxidase A inhibitor, in mouse plasma. The method was validated in terms of sensitivity, precision, accuracy,...

Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice.

Evidence-based complementary and alternative medicine : eCAM

Hsu LC, Ko YJ, Cheng HY, Chang CW, Lin YC, Cheng YH, Hsieh MT, Peng WH.
PMID: 22567032
Evid Based Complement Alternat Med. 2012;2012:497302. doi: 10.1155/2012/497302. Epub 2012 Apr 09.

This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (UL(EtOH)) for two-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like activity of UL(EtOH)...

Accumulation of Azole Drugs in the Fungal Plant Pathogen .

Frontiers in microbiology

Esquivel BD, White TC.
PMID: 28751884
Front Microbiol. 2017 Jul 13;8:1320. doi: 10.3389/fmicb.2017.01320. eCollection 2017.

No abstract available.

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection.

Frontiers in pharmacology

Bellusci L, Laurino A, Sabatini M, Sestito S, Lenzi P, Raimondi L, Rapposelli S, Biagioni F, Fornai F, Salvetti A, Rossi L, Zucchi R, Chiellini G.
PMID: 29311919
Front Pharmacol. 2017 Dec 12;8:905. doi: 10.3389/fphar.2017.00905. eCollection 2017.

3-Iodothyronamine (T1AM) is an endogenous high-affinity ligand of the trace amine-associated receptor 1 (TAAR1), detected in mammals in many organs, including the brain. Recent evidence indicates that pharmacological TAAR1 activation may offer a novel therapeutic option for the treatment...

Expression of A and B types of monoamine oxidase in neuroblastoma hybrid cells.

Neurochemistry international

Nagatsu T, Nakano T, Kato T, Higashida H.
PMID: 20487817
Neurochem Int. 1981;3(2):137-42. doi: 10.1016/0197-0186(81)90032-2.

Monoamine oxidase (MAO) activity towards kynuramine as substrate was measured in 6 hybrid cells derived by fusion of neuroblastoma and glioma, liver or brain cells, and was compared with that of parental or non-parental clones. Activities varied from the...

Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells.

BMC medical genomics

Zhao H, Flamand V, Peehl DM.
PMID: 19691856
BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.

BACKGROUND: Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). Clorgyline,...

Showing 1 to 12 of 22 entries