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Showing 1 to 12 of 19 entries
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Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma.

Oncology letters

Xia Y, Liu L, Bai Q, Long Q, Wang J, Xi W, Xu J, Guo J.
PMID: 29113209
Oncol Lett. 2017 Nov;14(5):5791-5800. doi: 10.3892/ol.2017.6942. Epub 2017 Sep 14.

Clear cell renal cell carcinoma (ccRCC) features a Von Hippel-Lindau mutation, associated with a hypoxia-inducible factor (HIF) imbalance. Copper transporter 1 (CTR1) may also promote tumor progression through the modulation of the HIF pathway by copper. Therefore, the present...

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Xia Y, Liu L, Bai Q, et al. Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma. Oncol Lett. 2017;14(5):5791-5800doi: 10.3892/ol.2017.6942.
Xia, Y., Liu, L., Bai, Q., Long, Q., Wang, J., Xi, W., Xu, J., & Guo, J. (2017). Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma. Oncology letters, 14(5), 5791-5800. https://doi.org/10.3892/ol.2017.6942
Xia, Yu, et al. "Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma." Oncology letters vol. 14,5 (2017): 5791-5800. doi: https://doi.org/10.3892/ol.2017.6942
Xia Y, Liu L, Bai Q, Long Q, Wang J, Xi W, Xu J, Guo J. Prognostic value of copper transporter 1 expression in patients with clear cell renal cell carcinoma. Oncol Lett. 2017 Nov;14(5):5791-5800. doi: 10.3892/ol.2017.6942. Epub 2017 Sep 14. PMID: 29113209; PMCID: PMC5661472.
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Role of transporters in the distribution of platinum-based drugs.

Frontiers in pharmacology

Harrach S, Ciarimboli G.
PMID: 25964760
Front Pharmacol. 2015 Apr 24;6:85. doi: 10.3389/fphar.2015.00085. eCollection 2015.

Platinum derivatives used as chemotherapeutic drugs such as cisplatin and oxaliplatin have a potent antitumor activity. However, severe side effects such as nephro-, oto-, and neurotoxicity are associated with their use. Effects and side effects of platinum-based drugs are...

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Harrach S, Ciarimboli G. Role of transporters in the distribution of platinum-based drugs. Front Pharmacol. 2015;6:85doi: 10.3389/fphar.2015.00085.
Harrach, S., & Ciarimboli, G. (2015). Role of transporters in the distribution of platinum-based drugs. Frontiers in pharmacology, 685. https://doi.org/10.3389/fphar.2015.00085
Harrach, Saliha, and Ciarimboli, Giuliano. "Role of transporters in the distribution of platinum-based drugs." Frontiers in pharmacology vol. 6 (2015): 85. doi: https://doi.org/10.3389/fphar.2015.00085
Harrach S, Ciarimboli G. Role of transporters in the distribution of platinum-based drugs. Front Pharmacol. 2015 Apr 24;6:85. doi: 10.3389/fphar.2015.00085. eCollection 2015. PMID: 25964760; PMCID: PMC4408848.
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Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer.

Breast cancer : basic and clinical research

Takeda R, Naka A, Ogane N, Kameda Y, Kawachi K, Shimizu S, Kamoshida S.
PMID: 26309405
Breast Cancer (Auckl). 2015 Aug 04;9:49-57. doi: 10.4137/BCBCR.S27534. eCollection 2015.

Adding platinum drugs to anthracycline/taxane (ANC-Tax)-based neoadjuvant chemotherapy (NAC) improves pathological complete response (pCR) rates in triple-negative breast cancer (TNBC). Copper transporter 1 (CTR1) and organic cation transporter 2 (OCT2) critically affect the uptake and cytotoxicity of platinum drugs....

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Takeda R, Naka A, Ogane N, et al. Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer. Breast Cancer (Auckl). 2015;9:49-57doi: 10.4137/BCBCR.S27534.
Takeda, R., Naka, A., Ogane, N., Kameda, Y., Kawachi, K., Shimizu, S., & Kamoshida, S. (2015). Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer. Breast cancer : basic and clinical research, 949-57. https://doi.org/10.4137/BCBCR.S27534
Takeda, Risa, et al. "Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer." Breast cancer : basic and clinical research vol. 9 (2015): 49-57. doi: https://doi.org/10.4137/BCBCR.S27534
Takeda R, Naka A, Ogane N, Kameda Y, Kawachi K, Shimizu S, Kamoshida S. Impact of Expression Levels of Platinum-uptake Transporters Copper Transporter 1 and Organic Cation Transporter 2 on Resistance to Anthracycline/Taxane-based Chemotherapy in Triple-negative Breast Cancer. Breast Cancer (Auckl). 2015 Aug 04;9:49-57. doi: 10.4137/BCBCR.S27534. eCollection 2015. PMID: 26309405; PMCID: PMC4527352.
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Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity.

Acta pharmaceutica Sinica. B

Jilek JL, Frost KL, Jacobus KA, He W, Toth EL, Goedken M, Cherrington NJ.
PMID: 35024313
Acta Pharm Sin B. 2021 Dec;11(12):3869-3878. doi: 10.1016/j.apsb.2021.05.030. Epub 2021 Jun 02.

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter expression have been discovered during nonalcoholic steatohepatitis...

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Jilek JL, Frost KL, Jacobus KA, et al. Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. Acta Pharm Sin B. 2021;11(12):3869-3878doi: 10.1016/j.apsb.2021.05.030.
Jilek, J. L., Frost, K. L., Jacobus, K. A., He, W., Toth, E. L., Goedken, M., & Cherrington, N. J. (2021). Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. Acta pharmaceutica Sinica. B, 11(12), 3869-3878. https://doi.org/10.1016/j.apsb.2021.05.030
Jilek, Joseph L, et al. "Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity." Acta pharmaceutica Sinica. B vol. 11,12 (2021): 3869-3878. doi: https://doi.org/10.1016/j.apsb.2021.05.030
Jilek JL, Frost KL, Jacobus KA, He W, Toth EL, Goedken M, Cherrington NJ. Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. Acta Pharm Sin B. 2021 Dec;11(12):3869-3878. doi: 10.1016/j.apsb.2021.05.030. Epub 2021 Jun 02. PMID: 35024313; PMCID: PMC8727892.
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Reduction in Copper Uptake and Inhibition of Prostate Cancer Cell Proliferation by Novel Steroid-based Compounds.

Anticancer research

Xie F, Peng F.
PMID: 34848449
Anticancer Res. 2021 Dec;41(12):5953-5958. doi: 10.21873/anticanres.15414.

BACKGROUND/AIM: Knockdown of human copper transporter 1 has been associated with reduction in copper uptake and suppression of prostate cancer cell proliferation and tumor growth. This study evaluated the effects of steroid-based compounds on copper uptake and proliferation of...

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Xie F, Peng F. Reduction in Copper Uptake and Inhibition of Prostate Cancer Cell Proliferation by Novel Steroid-based Compounds. Anticancer Res. 2021;41(12):5953-5958doi: 10.21873/anticanres.15414.
Xie, F., & Peng, F. (2021). Reduction in Copper Uptake and Inhibition of Prostate Cancer Cell Proliferation by Novel Steroid-based Compounds. Anticancer research, 41(12), 5953-5958. https://doi.org/10.21873/anticanres.15414
Xie, Fang, and Peng, Fangyu. "Reduction in Copper Uptake and Inhibition of Prostate Cancer Cell Proliferation by Novel Steroid-based Compounds." Anticancer research vol. 41,12 (2021): 5953-5958. doi: https://doi.org/10.21873/anticanres.15414
Xie F, Peng F. Reduction in Copper Uptake and Inhibition of Prostate Cancer Cell Proliferation by Novel Steroid-based Compounds. Anticancer Res. 2021 Dec;41(12):5953-5958. doi: 10.21873/anticanres.15414. PMID: 34848449.
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High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells.

Cellular signalling

Aloysius Dhivya M, Sulochana KN, Devi SRB.
PMID: 34999205
Cell Signal. 2022 Jan 06;110244. doi: 10.1016/j.cellsig.2022.110244. Epub 2022 Jan 06.

Altered trace element homeostasis is associated with diabetic complications, and studies have shown elevated copper levels in the serum of individuals with type 1 & 2 diabetes. Copper chelation has been shown to be beneficial by preventing or reversing...

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Aloysius Dhivya M, Sulochana KN, Devi SRB. High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells. Cell Signal. 2022;110244doi: 10.1016/j.cellsig.2022.110244.
Aloysius Dhivya, M., Sulochana, K. N., & Devi, S. R. B. (2022). High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells. Cellular signalling, 110244. https://doi.org/10.1016/j.cellsig.2022.110244
Aloysius Dhivya, M, et al. "High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells." Cellular signalling vol. (2022): 110244. doi: https://doi.org/10.1016/j.cellsig.2022.110244
Aloysius Dhivya M, Sulochana KN, Devi SRB. High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells. Cell Signal. 2022 Jan 06;110244. doi: 10.1016/j.cellsig.2022.110244. Epub 2022 Jan 06. PMID: 34999205.
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Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity.

Acta pharmaceutica Sinica. B

Jilek JL, Frost KL, Jacobus KA, He W, Toth EL, Goedken M, Cherrington NJ.
PMID: 35024313
Acta Pharm Sin B. 2021 Dec;11(12):3869-3878. doi: 10.1016/j.apsb.2021.05.030. Epub 2021 Jun 02.

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter expression have been discovered during nonalcoholic steatohepatitis...

Cite
Jilek JL, Frost KL, Jacobus KA, et al. Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. Acta Pharm Sin B. 2021;11(12):3869-3878doi: 10.1016/j.apsb.2021.05.030.
Jilek, J. L., Frost, K. L., Jacobus, K. A., He, W., Toth, E. L., Goedken, M., & Cherrington, N. J. (2021). Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. Acta pharmaceutica Sinica. B, 11(12), 3869-3878. https://doi.org/10.1016/j.apsb.2021.05.030
Jilek, Joseph L, et al. "Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity." Acta pharmaceutica Sinica. B vol. 11,12 (2021): 3869-3878. doi: https://doi.org/10.1016/j.apsb.2021.05.030
Jilek JL, Frost KL, Jacobus KA, He W, Toth EL, Goedken M, Cherrington NJ. Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity. Acta Pharm Sin B. 2021 Dec;11(12):3869-3878. doi: 10.1016/j.apsb.2021.05.030. Epub 2021 Jun 02. PMID: 35024313; PMCID: PMC8727892.
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Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, Hu C, Wu X, Jiang Q, Wu D, Okada H, Pandolfi PP, Wei W.
PMID: 34278744
Adv Sci (Weinh). 2021 Sep;8(18):e2004303. doi: 10.1002/advs.202004303. Epub 2021 Jul 18.

Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human tumorigenesis is not well defined. Here, it is revealed that copper activates the phosphoinositide 3-kinase (PI3K)-protein kinase B (PKB, also termed AKT) oncogenic signaling pathway to...

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Guo J, Cheng J, Zheng N, et al. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Adv Sci (Weinh). 2021;8(18):e2004303doi: 10.1002/advs.202004303.
Guo, J., Cheng, J., Zheng, N., Zhang, X., Dai, X., Zhang, L., Hu, C., Wu, X., Jiang, Q., Wu, D., Okada, H., Pandolfi, P. P., & Wei, W. (2021). Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(18), e2004303. https://doi.org/10.1002/advs.202004303
Guo, Jianping, et al. "Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 8,18 (2021): e2004303. doi: https://doi.org/10.1002/advs.202004303
Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, Hu C, Wu X, Jiang Q, Wu D, Okada H, Pandolfi PP, Wei W. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Adv Sci (Weinh). 2021 Sep;8(18):e2004303. doi: 10.1002/advs.202004303. Epub 2021 Jul 18. PMID: 34278744; PMCID: PMC8456201.
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Membrane transporters as mediators of Cisplatin effects and side effects.

Scientifica

Ciarimboli G.
PMID: 24278698
Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25.

Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects, metabolism, and excretion of many drugs such as cisplatin. Cisplatin is a potent cytostatic drug, whose use is limited by...

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Ciarimboli G. Membrane transporters as mediators of Cisplatin effects and side effects. Scientifica (Cairo). 2012;2012:473829doi: 10.6064/2012/473829.
Ciarimboli, G. (2012). Membrane transporters as mediators of Cisplatin effects and side effects. Scientifica, 2012473829. https://doi.org/10.6064/2012/473829
Ciarimboli, Giuliano. "Membrane transporters as mediators of Cisplatin effects and side effects." Scientifica vol. 2012 (2012): 473829. doi: https://doi.org/10.6064/2012/473829
Ciarimboli G. Membrane transporters as mediators of Cisplatin effects and side effects. Scientifica (Cairo). 2012;2012:473829. doi: 10.6064/2012/473829. Epub 2012 Nov 25. PMID: 24278698; PMCID: PMC3820462.
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Rapid diagnosis of cisplatin-sensitive and resistant cervical squamous cell carcinomas by reverse transcription loop-mediated isothermal amplification.

International journal of clinical and experimental pathology

Wu X, Chen L, Guo T, Wu X, Cai H.
PMID: 31938179
Int J Clin Exp Pathol. 2018 Feb 01;11(2):882-887. eCollection 2018.

Cisplatin is a widely used platinum anticancer drug in cervical cancer chemotherapy; however, its use is limited by the development of drug resistance, which is often rationalized via effects on cellular uptake. Human copper transporter 1 (hCTR1) was proven...

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Wu X, Chen L, Guo T, et al. Rapid diagnosis of cisplatin-sensitive and resistant cervical squamous cell carcinomas by reverse transcription loop-mediated isothermal amplification. Int J Clin Exp Pathol. 2018;11(2):882-887
Wu, X., Chen, L., Guo, T., Wu, X., & Cai, H. (2018). Rapid diagnosis of cisplatin-sensitive and resistant cervical squamous cell carcinomas by reverse transcription loop-mediated isothermal amplification. International journal of clinical and experimental pathology, 11(2), 882-887.
Wu, Xiuli, et al. "Rapid diagnosis of cisplatin-sensitive and resistant cervical squamous cell carcinomas by reverse transcription loop-mediated isothermal amplification." International journal of clinical and experimental pathology vol. 11,2 (2018): 882-887.
Wu X, Chen L, Guo T, Wu X, Cai H. Rapid diagnosis of cisplatin-sensitive and resistant cervical squamous cell carcinomas by reverse transcription loop-mediated isothermal amplification. Int J Clin Exp Pathol. 2018 Feb 01;11(2):882-887. eCollection 2018. PMID: 31938179; PMCID: PMC6958034.
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Evaluation of non-small cell lung cancer by PET/CT with .

American journal of nuclear medicine and molecular imaging

García-Pérez FO, Medina-Ornelas SS, Barron-Barron F, Arrieta-Rodriguez O.
PMID: 32704405
Am J Nucl Med Mol Imaging. 2020 Jun 15;10(3):143-150. eCollection 2020.

Human copper transporter 1 (hCtr1) is the main transporter of copper which has been involved as an essential cofactor in biological processes and mechanisms of action for cisplatin and its analogues. Although expression of hCtr1 is present in all...

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García-Pérez FO, Medina-Ornelas SS, Barron-Barron F, et al. Evaluation of non-small cell lung cancer by PET/CT with . Am J Nucl Med Mol Imaging. 2020;10(3):143-150
García-Pérez, F. O., Medina-Ornelas, S. S., Barron-Barron, F., & Arrieta-Rodriguez, O. (2020). Evaluation of non-small cell lung cancer by PET/CT with . American journal of nuclear medicine and molecular imaging, 10(3), 143-150.
García-Pérez, Francisco Osvaldo, et al. "Evaluation of non-small cell lung cancer by PET/CT with ." American journal of nuclear medicine and molecular imaging vol. 10,3 (2020): 143-150.
García-Pérez FO, Medina-Ornelas SS, Barron-Barron F, Arrieta-Rodriguez O. Evaluation of non-small cell lung cancer by PET/CT with . Am J Nucl Med Mol Imaging. 2020 Jun 15;10(3):143-150. eCollection 2020. PMID: 32704405; PMCID: PMC7364381.
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Expression of the copper transporters hCtr1, ATP7A and ATP7B is associated with the response to chemotherapy and survival time in patients with resected non-small cell lung cancer.

Oncology letters

Yang T, Chen M, Chen T, Thakur A.
PMID: 26622894
Oncol Lett. 2015 Oct;10(4):2584-2590. doi: 10.3892/ol.2015.3531. Epub 2015 Jul 24.

Copper transporter family proteins may regulate the chemoresistance of non-small cell lung cancer (NSCLC) to platinum-based anticancer drugs. The present study aimed to investigate the expression of these proteins in lung cancer tissue specimens for association with clinicopathological data...

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Yang T, Chen M, Chen T, et al. Expression of the copper transporters hCtr1, ATP7A and ATP7B is associated with the response to chemotherapy and survival time in patients with resected non-small cell lung cancer. Oncol Lett. 2015;10(4):2584-2590doi: 10.3892/ol.2015.3531.
Yang, T., Chen, M., Chen, T., & Thakur, A. (2015). Expression of the copper transporters hCtr1, ATP7A and ATP7B is associated with the response to chemotherapy and survival time in patients with resected non-small cell lung cancer. Oncology letters, 10(4), 2584-2590. https://doi.org/10.3892/ol.2015.3531
Yang, Tian, et al. "Expression of the copper transporters hCtr1, ATP7A and ATP7B is associated with the response to chemotherapy and survival time in patients with resected non-small cell lung cancer." Oncology letters vol. 10,4 (2015): 2584-2590. doi: https://doi.org/10.3892/ol.2015.3531
Yang T, Chen M, Chen T, Thakur A. Expression of the copper transporters hCtr1, ATP7A and ATP7B is associated with the response to chemotherapy and survival time in patients with resected non-small cell lung cancer. Oncol Lett. 2015 Oct;10(4):2584-2590. doi: 10.3892/ol.2015.3531. Epub 2015 Jul 24. PMID: 26622894; PMCID: PMC4580033.
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Showing 1 to 12 of 19 entries