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Showing 1 to 12 of 20 entries
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Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle.

Journal of cardiovascular pharmacology and therapeutics

Goldhaber JI, Deutsch N, Alexander LD, Weiss JN.
PMID: 10684479
J Cardiovasc Pharmacol Ther. 1998 Jan;3(1):37-42. doi: 10.1177/107424849800300105.

BACKGROUND: Lysophospholipids such as lysophosphatidylcholine (LPC) have many direct electrophysiological effects on cardiac muscle and have been implicated as a cause of lethal ventricular arrhythmias during acute myocardial ischemia. Because extracellular K(+) accumulation is also a key arrhythmogenic factor...

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Goldhaber JI, Deutsch N, Alexander LD, et al. Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle. J Cardiovasc Pharmacol Ther. 1998;3(1):37-42doi: 10.1177/107424849800300105.
Goldhaber, J. I., Deutsch, N., Alexander, L. D., & Weiss, J. N. (1998). Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle. Journal of cardiovascular pharmacology and therapeutics, 3(1), 37-42. https://doi.org/10.1177/107424849800300105
Goldhaber, et al. "Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle." Journal of cardiovascular pharmacology and therapeutics vol. 3,1 (1998): 37-42. doi: https://doi.org/10.1177/107424849800300105
Goldhaber JI, Deutsch N, Alexander LD, Weiss JN. Lysophosphatidylcholine and Cellular Potassium Loss in Isolated Rabbit Ventricle. J Cardiovasc Pharmacol Ther. 1998 Jan;3(1):37-42. doi: 10.1177/107424849800300105. PMID: 10684479.
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Potassium channel activators decrease endogenous glutamate release from rat cerebellar slices.

Amino acids

Dickie BG, Davies JA.
PMID: 24186325
Amino Acids. 1995 Jun;8(2):159-69. doi: 10.1007/BF00806489.

The effects of the sulphonylurea activators of ATP-sensitive potassium channels (K(+) ATP), cromakalim and pinacidil, on the evoked-release of endogenous glutamate from superfused slices of rat cerebellum was examined. K(+)-stimulated release was Ca(2+)-dependent, whereas tetrapentylammonium (TPeA)-evoked release occurred both...

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Dickie BG, Davies JA. Potassium channel activators decrease endogenous glutamate release from rat cerebellar slices. Amino Acids. 1995;8(2):159-69doi: 10.1007/BF00806489.
Dickie, B. G., & Davies, J. A. (1995). Potassium channel activators decrease endogenous glutamate release from rat cerebellar slices. Amino acids, 8(2), 159-69. https://doi.org/10.1007/BF00806489
Dickie, B G, and Davies, J A. "Potassium channel activators decrease endogenous glutamate release from rat cerebellar slices." Amino acids vol. 8,2 (1995): 159-69. doi: https://doi.org/10.1007/BF00806489
Dickie BG, Davies JA. Potassium channel activators decrease endogenous glutamate release from rat cerebellar slices. Amino Acids. 1995 Jun;8(2):159-69. doi: 10.1007/BF00806489. PMID: 24186325.
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Effects of aging on ATP sensitive K(+) channels and on prostanoid production in the rat mesenteric bed.

Age

Feleder EC, Peredo HA, Mendizábal VE, Adler-Graschinsky E.
PMID: 23604379
Age (Omaha). 1998 Oct;21(4):183-8. doi: 10.1007/s11357-998-0027-3.

The aim of the present work was to evaluate, in the rat isolated mesenteric bed, whether increasing age is associated with alterations in the ATP sensitive K(+) channels functionality. Moreover, studies were performed in order to evaluate the effects...

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Feleder EC, Peredo HA, Mendizábal VE, et al. Effects of aging on ATP sensitive K(+) channels and on prostanoid production in the rat mesenteric bed. Age (Omaha). 1998;21(4):183-8doi: 10.1007/s11357-998-0027-3.
Feleder, E. C., Peredo, H. A., Mendizábal, V. E., & Adler-Graschinsky, E. (1998). Effects of aging on ATP sensitive K(+) channels and on prostanoid production in the rat mesenteric bed. Age, 21(4), 183-8. https://doi.org/10.1007/s11357-998-0027-3
Feleder, E C, et al. "Effects of aging on ATP sensitive K(+) channels and on prostanoid production in the rat mesenteric bed." Age vol. 21,4 (1998): 183-8. doi: https://doi.org/10.1007/s11357-998-0027-3
Feleder EC, Peredo HA, Mendizábal VE, Adler-Graschinsky E. Effects of aging on ATP sensitive K(+) channels and on prostanoid production in the rat mesenteric bed. Age (Omaha). 1998 Oct;21(4):183-8. doi: 10.1007/s11357-998-0027-3. PMID: 23604379; PMCID: PMC3455460.
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Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Roy Chowdhury U, Kudgus RA, Holman BH, Rinkoski TA, Hann CR, Bahler CK, McCloud E, Appt SE, Reid JM, Dosa PI, Fautsch MP.
PMID: 33784195
J Ocul Pharmacol Ther. 2021 Jun;37(5):251-260. doi: 10.1089/jop.2020.0137. Epub 2021 Mar 30.

No abstract available.

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Roy Chowdhury U, Kudgus RA, Holman BH, et al. Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates. J Ocul Pharmacol Ther. 2021;37(5):251-260doi: 10.1089/jop.2020.0137.
Roy Chowdhury, U., Kudgus, R. A., Holman, B. H., Rinkoski, T. A., Hann, C. R., Bahler, C. K., McCloud, E., Appt, S. E., Reid, J. M., Dosa, P. I., & Fautsch, M. P. (2021). Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 37(5), 251-260. https://doi.org/10.1089/jop.2020.0137
Roy Chowdhury, Uttio, et al. "Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates." Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics vol. 37,5 (2021): 251-260. doi: https://doi.org/10.1089/jop.2020.0137
Roy Chowdhury U, Kudgus RA, Holman BH, Rinkoski TA, Hann CR, Bahler CK, McCloud E, Appt SE, Reid JM, Dosa PI, Fautsch MP. Pharmacological Profile and Ocular Hypotensive Effects of Cromakalim Prodrug 1, a Novel ATP-Sensitive Potassium Channel Opener, in Normotensive Dogs and Nonhuman Primates. J Ocul Pharmacol Ther. 2021 Jun;37(5):251-260. doi: 10.1089/jop.2020.0137. Epub 2021 Mar 30. PMID: 33784195; PMCID: PMC8215408.
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Role of the Inward K Rectifier in the Repetitive Activity at the Depolarized Level in Single Ventricular Myocytes.

Journal of biomedical science

Vassalle M, Valenzuela F.
PMID: 11725024
J Biomed Sci. 1994 Jun;1(3):179-192. doi: 10.1007/BF02253348.

The role of the inward K(+) rectifier in the repetitive activity at depolarized levels was studied in guinea pig single ventricular myocytes by voltage- and current-clamp methods. In action potentials arrested at the plateau by a depolarizing current, small...

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Vassalle M, Valenzuela F. Role of the Inward K Rectifier in the Repetitive Activity at the Depolarized Level in Single Ventricular Myocytes. J Biomed Sci. 1994;1(3):179-192doi: 10.1007/BF02253348.
Vassalle, M., & Valenzuela, F. (1994). Role of the Inward K Rectifier in the Repetitive Activity at the Depolarized Level in Single Ventricular Myocytes. Journal of biomedical science, 1(3), 179-192. https://doi.org/10.1007/BF02253348
Vassalle, M., and Valenzuela, F.. "Role of the Inward K Rectifier in the Repetitive Activity at the Depolarized Level in Single Ventricular Myocytes." Journal of biomedical science vol. 1,3 (1994): 179-192. doi: https://doi.org/10.1007/BF02253348
Vassalle M, Valenzuela F. Role of the Inward K Rectifier in the Repetitive Activity at the Depolarized Level in Single Ventricular Myocytes. J Biomed Sci. 1994 Jun;1(3):179-192. doi: 10.1007/BF02253348. PMID: 11725024.
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Role of potassium channels in stretch-promoted atrial natriuretic factor secretion.

Journal of the American Society of Hypertension : JASH

Ogawa T, Forero M, Burgon PG, Kuroski de Bold ML, Georgalis T, de Bold AJ.
PMID: 20409940
J Am Soc Hypertens. 2009 Jan-Feb;3(1):9-18. doi: 10.1016/j.jash.2008.07.002. Epub 2008 Oct 31.

The cardiac polypeptide hormone atrial natriuretic factor (ANF) plays important roles in the regulation of blood volume and pressure. Few specific details are known about basal or stretch-promoted ANF secretion. Here, we investigated the involvement of K(+) channels in...

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Ogawa T, Forero M, Burgon PG, et al. Role of potassium channels in stretch-promoted atrial natriuretic factor secretion. J Am Soc Hypertens. 2008;3(1):9-18doi: 10.1016/j.jash.2008.07.002.
Ogawa, T., Forero, M., Burgon, P. G., Kuroski de Bold, M. L., Georgalis, T., & de Bold, A. J. (2009). Role of potassium channels in stretch-promoted atrial natriuretic factor secretion. Journal of the American Society of Hypertension : JASH, 3(1), 9-18. https://doi.org/10.1016/j.jash.2008.07.002
Ogawa, Tsuneo, et al. "Role of potassium channels in stretch-promoted atrial natriuretic factor secretion." Journal of the American Society of Hypertension : JASH vol. 3,1 (2009): 9-18. doi: https://doi.org/10.1016/j.jash.2008.07.002
Ogawa T, Forero M, Burgon PG, Kuroski de Bold ML, Georgalis T, de Bold AJ. Role of potassium channels in stretch-promoted atrial natriuretic factor secretion. J Am Soc Hypertens. 2009 Jan-Feb;3(1):9-18. doi: 10.1016/j.jash.2008.07.002. Epub 2008 Oct 31. PMID: 20409940.
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Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol-response curve in porcine detrusor muscle.

Arab journal of urology

Badawi JK, Kirschner-Hermanns R, Ding A.
PMID: 26558027
Arab J Urol. 2012 Jun;10(2):207-15. doi: 10.1016/j.aju.2011.12.009. Epub 2012 Mar 03.

AIMS: ATP-sensitive potassium channels represent promising drug targets for treating specific bladder diseases. The inhibitory effects of ATP-selective potassium channel openers (PCOs) on the carbachol-response curve in porcine detrusor muscle were examined.MATERIALS AND METHODS: Each of the three substances...

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Badawi JK, Kirschner-Hermanns R, Ding A. Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol-response curve in porcine detrusor muscle. Arab J Urol. 2012;10(2):207-15doi: 10.1016/j.aju.2011.12.009.
Badawi, J. K., Kirschner-Hermanns, R., & Ding, A. (2012). Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol-response curve in porcine detrusor muscle. Arab journal of urology, 10(2), 207-15. https://doi.org/10.1016/j.aju.2011.12.009
Badawi, Jasmin Katrin, et al. "Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol-response curve in porcine detrusor muscle." Arab journal of urology vol. 10,2 (2012): 207-15. doi: https://doi.org/10.1016/j.aju.2011.12.009
Badawi JK, Kirschner-Hermanns R, Ding A. Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol-response curve in porcine detrusor muscle. Arab J Urol. 2012 Jun;10(2):207-15. doi: 10.1016/j.aju.2011.12.009. Epub 2012 Mar 03. PMID: 26558027; PMCID: PMC4442889.
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Correction: Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems.

PloS one

Roy Chowdhury U, Bahler CK, Holman BH, Dosa PI, Fautsch MP.
PMID: 26669304
PLoS One. 2015 Dec 15;10(12):e0144791. doi: 10.1371/journal.pone.0144791. eCollection 2015.

No abstract available.

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Roy Chowdhury U, Bahler CK, Holman BH, et al. Correction: Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems. PLoS One. 2015;10(12):e0144791doi: 10.1371/journal.pone.0144791.
Roy Chowdhury, U., Bahler, C. K., Holman, B. H., Dosa, P. I., & Fautsch, M. P. (2015). Correction: Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems. PloS one, 10(12), e0144791. https://doi.org/10.1371/journal.pone.0144791
Roy Chowdhury, Uttio, et al. "Correction: Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems." PloS one vol. 10,12 (2015): e0144791. doi: https://doi.org/10.1371/journal.pone.0144791
Roy Chowdhury U, Bahler CK, Holman BH, Dosa PI, Fautsch MP. Correction: Ocular Hypotensive Effects of the ATP-Sensitive Potassium Channel Opener Cromakalim in Human and Murine Experimental Model Systems. PLoS One. 2015 Dec 15;10(12):e0144791. doi: 10.1371/journal.pone.0144791. eCollection 2015. PMID: 26669304; PMCID: PMC4684394.
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Opening of ATP sensitive potassium channels causes migraine attacks with aura.

Brain : a journal of neurology

Al-Karagholi MA, Ghanizada H, Nielsen CAW, Hougaard A, Ashina M.
PMID: 33768245
Brain. 2021 Sep 04;144(8):2322-2332. doi: 10.1093/brain/awab136.

Migraine afflicts more than one billion individuals worldwide and is a leading cause of years lived with disability. In about a third of individuals with migraine aura occur in relation to migraine headache. The common pathophysiological mechanisms underlying migraine...

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Al-Karagholi MA, Ghanizada H, Nielsen CAW, et al. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain. 2021;144(8):2322-2332doi: 10.1093/brain/awab136.
Al-Karagholi, M. A., Ghanizada, H., Nielsen, C. A. W., Hougaard, A., & Ashina, M. (2021). Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain : a journal of neurology, 144(8), 2322-2332. https://doi.org/10.1093/brain/awab136
Al-Karagholi, Mohammad Al-Mahdi, et al. "Opening of ATP sensitive potassium channels causes migraine attacks with aura." Brain : a journal of neurology vol. 144,8 (2021): 2322-2332. doi: https://doi.org/10.1093/brain/awab136
Al-Karagholi MA, Ghanizada H, Nielsen CAW, Hougaard A, Ashina M. Opening of ATP sensitive potassium channels causes migraine attacks with aura. Brain. 2021 Sep 04;144(8):2322-2332. doi: 10.1093/brain/awab136. PMID: 33768245.
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The Effect of Cromakalim on the Hindlimb Vascular Bed of the Male Rat: Do Glybenclamide and/or Nitric Oxide Modulate the Vasodilation?.

American journal of therapeutics

Jahr JS, Feng CJ, Wang J, Holton R, Cheng DY.
PMID: 11835061
Am J Ther. 1994 Jun;1(1):8-14. doi: 10.1097/00045391-199406000-00003.

Cromakalim, a benzopyran derivative, is a member of a novel class of antihypertensive agents that increase membrane K(+) conductance through ATP-sensitive K(+) channels. The effects of glybenclamide and N(omega)-L-arginine methyl ester (L-NAME), a specific inhibitor of nitric oxide synthesis...

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Jahr JS, Feng CJ, Wang J, et al. The Effect of Cromakalim on the Hindlimb Vascular Bed of the Male Rat: Do Glybenclamide and/or Nitric Oxide Modulate the Vasodilation?. Am J Ther. 1994;1(1):8-14doi: 10.1097/00045391-199406000-00003.
Jahr, J. S., Feng, C. J., Wang, J., Holton, R., & Cheng, D. Y. (1994). The Effect of Cromakalim on the Hindlimb Vascular Bed of the Male Rat: Do Glybenclamide and/or Nitric Oxide Modulate the Vasodilation?. American journal of therapeutics, 1(1), 8-14. https://doi.org/10.1097/00045391-199406000-00003
Jahr, Jonathan S., et al. "The Effect of Cromakalim on the Hindlimb Vascular Bed of the Male Rat: Do Glybenclamide and/or Nitric Oxide Modulate the Vasodilation?." American journal of therapeutics vol. 1,1 (1994): 8-14. doi: https://doi.org/10.1097/00045391-199406000-00003
Jahr JS, Feng CJ, Wang J, Holton R, Cheng DY. The Effect of Cromakalim on the Hindlimb Vascular Bed of the Male Rat: Do Glybenclamide and/or Nitric Oxide Modulate the Vasodilation?. Am J Ther. 1994 Jun;1(1):8-14. doi: 10.1097/00045391-199406000-00003. PMID: 11835061.
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Mechanism of Vasorelaxation Caused by N-Benzylsecoboldine in Rat Thoracic Aorta.

Journal of biomedical science

Teng CM, Yu SM, Pan CP, Lee SS.
PMID: 11725007
J Biomed Sci. 1994 Dec;1(1):54-60.

The vasorelaxing effect of N-benzylsecoboldine on the rat thoracic aorta was investigated, and we also compare it with nifedipine and cromakalim. In high K(+) (60 mM) medium, Ca(2+) (0.03-3 mM)-induced vasoconstriction was inhibited concentration-dependently by N-benzylsecoboldine, whereas this contraction...

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Teng CM, Yu SM, Pan CP, et al. Mechanism of Vasorelaxation Caused by N-Benzylsecoboldine in Rat Thoracic Aorta. J Biomed Sci. 1994;1(1):54-60
Teng, C. M., Yu, S. M., Pan, C. P., & Lee, S. S. (1994). Mechanism of Vasorelaxation Caused by N-Benzylsecoboldine in Rat Thoracic Aorta. Journal of biomedical science, 1(1), 54-60.
Teng, C.M., et al. "Mechanism of Vasorelaxation Caused by N-Benzylsecoboldine in Rat Thoracic Aorta." Journal of biomedical science vol. 1,1 (1994): 54-60.
Teng CM, Yu SM, Pan CP, Lee SS. Mechanism of Vasorelaxation Caused by N-Benzylsecoboldine in Rat Thoracic Aorta. J Biomed Sci. 1994 Dec;1(1):54-60. PMID: 11725007.
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SB-204269 SmithKline Beecham.

IDrugs : the investigational drugs journal

Crespi F.
PMID: 18465599
IDrugs. 1998 Sep;1(5):595-8.

SB-204269 is an anticonvulsant agent under development by SmithKline Beecham, It is in phase II clinical trials as a potential treatment for epilepsy [243338]. The compound is structurally-related to the benzopyran ATP-sensitive potassium channel (KATP) opener, cromakalim, but has...

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Crespi F. SB-204269 SmithKline Beecham. IDrugs. 1998;1(5):595-8
Crespi, F. (1998). SB-204269 SmithKline Beecham. IDrugs : the investigational drugs journal, 1(5), 595-8.
Crespi, F. "SB-204269 SmithKline Beecham." IDrugs : the investigational drugs journal vol. 1,5 (1998): 595-8.
Crespi F. SB-204269 SmithKline Beecham. IDrugs. 1998 Sep;1(5):595-8. PMID: 18465599.
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Showing 1 to 12 of 20 entries