Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 69 entries
Sorted by: Best Match Show Resources per page
Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway.

Evidence-based complementary and alternative medicine : eCAM

Xian YF, Lin ZX, Mao QQ, Chen JN, Su ZR, Lai XP, Ip PS.
PMID: 24319473
Evid Based Complement Alternat Med. 2013;2013:163057. doi: 10.1155/2013/163057. Epub 2013 Nov 06.

The neurotoxicity of amyloid- β (A β ) has been implicated as a critical cause of Alzheimer's disease. Isorhynchophylline (IRN), an oxindole alkaloid isolated from Uncaria rhynchophylla, exerts neuroprotective effect against Aβ 25-35-induced neurotoxicity in vitro. However, the exact...

Cite
Xian YF, Lin ZX, Mao QQ, et al. Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:163057doi: 10.1155/2013/163057.
Xian, Y. F., Lin, Z. X., Mao, Q. Q., Chen, J. N., Su, Z. R., Lai, X. P., & Ip, P. S. (2013). Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM, 2013163057. https://doi.org/10.1155/2013/163057
Xian, Yan-Fang, et al. "Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 163057. doi: https://doi.org/10.1155/2013/163057
Xian YF, Lin ZX, Mao QQ, Chen JN, Su ZR, Lai XP, Ip PS. Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:163057. doi: 10.1155/2013/163057. Epub 2013 Nov 06. PMID: 24319473; PMCID: PMC3836301.
Copy Download .nbib Format: NLM
MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins.

FEBS open bio

Hunter CJ, Remenyi J, Correa SA, Privitera L, Reyskens KMSE, Martin KJ, Toth R, Frenguelli BG, Arthur JSC.
PMID: 28593137
FEBS Open Bio. 2017 May 11;7(6):821-834. doi: 10.1002/2211-5463.12232. eCollection 2017 Jun.

The immediate early gene activity-regulated cytoskeletal protein (Arc)/Arg3.1 and the neurotrophin brain-derived neurotrophic factor (BDNF) play important roles in synaptic plasticity and learning and memory in the mammalian brain. However, the mechanisms by which BDNF regulates the expression of...

Cite
Hunter CJ, Remenyi J, Correa SA, et al. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS Open Bio. 2017;7(6):821-834doi: 10.1002/2211-5463.12232.
Hunter, C. J., Remenyi, J., Correa, S. A., Privitera, L., Reyskens, K. M. S. E., Martin, K. J., Toth, R., Frenguelli, B. G., & Arthur, J. S. C. (2017). MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS open bio, 7(6), 821-834. https://doi.org/10.1002/2211-5463.12232
Hunter, Chris J, et al. "MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins." FEBS open bio vol. 7,6 (2017): 821-834. doi: https://doi.org/10.1002/2211-5463.12232
Hunter CJ, Remenyi J, Correa SA, Privitera L, Reyskens KMSE, Martin KJ, Toth R, Frenguelli BG, Arthur JSC. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS Open Bio. 2017 May 11;7(6):821-834. doi: 10.1002/2211-5463.12232. eCollection 2017 Jun. PMID: 28593137; PMCID: PMC5458472.
Copy Download .nbib Format: NLM
The cyclic AMP response element-binding protein antisense oligonucleotide induced anti-nociception and decreased the expression of KIF17 in spinal cord after peripheral nerve injury in mice.

International journal of clinical and experimental medicine

Bo J, Zhang W, Sun X, Yang Y, Liu X, Jiang M, Ma Z, Gu X.
PMID: 25664020
Int J Clin Exp Med. 2014 Dec 15;7(12):5181-91. eCollection 2014.

BACKGROUNDS: The cyclic AMP response element-binding protein (CREB) plays an important role in neuropathic pain. Kinesin superfamily motor protein 17 (KIF17) is involved in long-term memory formation. CREB could increase the level of KIF17 when activated by synaptic input....

Cite
Bo J, Zhang W, Sun X, et al. The cyclic AMP response element-binding protein antisense oligonucleotide induced anti-nociception and decreased the expression of KIF17 in spinal cord after peripheral nerve injury in mice. Int J Clin Exp Med. 2014;7(12):5181-91
Bo, J., Zhang, W., Sun, X., Yang, Y., Liu, X., Jiang, M., Ma, Z., & Gu, X. (2014). The cyclic AMP response element-binding protein antisense oligonucleotide induced anti-nociception and decreased the expression of KIF17 in spinal cord after peripheral nerve injury in mice. International journal of clinical and experimental medicine, 7(12), 5181-91.
Bo, Jinhua, et al. "The cyclic AMP response element-binding protein antisense oligonucleotide induced anti-nociception and decreased the expression of KIF17 in spinal cord after peripheral nerve injury in mice." International journal of clinical and experimental medicine vol. 7,12 (2014): 5181-91.
Bo J, Zhang W, Sun X, Yang Y, Liu X, Jiang M, Ma Z, Gu X. The cyclic AMP response element-binding protein antisense oligonucleotide induced anti-nociception and decreased the expression of KIF17 in spinal cord after peripheral nerve injury in mice. Int J Clin Exp Med. 2014 Dec 15;7(12):5181-91. eCollection 2014. PMID: 25664020; PMCID: PMC4307467.
Copy Download .nbib Format: NLM
ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica

Dong M, Xiong Y, Xu KY, Du YC.
PMID: 12058167
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2000;32(6):575-580.

ZNC(C)PR can facilitate the learning and memory in rat. Transgenic experiments have revealed that long-term memory depended on cyclic AMP-response element binding protein, CREB. CREB phosphorylation at serine-133 is essential for it's transcriptional activity. Here, it was demonstrated that...

Cite
Dong M, Xiong Y, Xu KY, et al. ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2000;32(6):575-580
Dong, M., Xiong, Y., Xu, K. Y., & Du, Y. C. (2000). ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 32(6), 575-580.
Dong, Ming, et al. "ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus." Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica vol. 32,6 (2000): 575-580.
Dong M, Xiong Y, Xu KY, Du YC. ZNC(C)PR Induces Phosphorylation of CREB in Rat Hippocampus. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2000;32(6):575-580. PMID: 12058167.
Copy Download .nbib Format: NLM
Cyclic AMP response element-binding protein and depression.

Expert review of neurotherapeutics

Thome J, Henn FA, Duman RS.
PMID: 19810866
Expert Rev Neurother. 2002 May;2(3):347-54. doi: 10.1586/14737175.2.3.347.

Depression is one of the most common and most devastating psychiatric disorders. Although a variety of treatment strategies is available, a major problem in its therapy consists of the unpredictability of the drug response. Furthermore, most antidepressant drugs, which...

Cite
Thome J, Henn FA, Duman RS. Cyclic AMP response element-binding protein and depression. Expert Rev Neurother. 2002;2(3):347-54doi: 10.1586/14737175.2.3.347.
Thome, J., Henn, F. A., & Duman, R. S. (2002). Cyclic AMP response element-binding protein and depression. Expert review of neurotherapeutics, 2(3), 347-54. https://doi.org/10.1586/14737175.2.3.347
Thome, Johannes, et al. "Cyclic AMP response element-binding protein and depression." Expert review of neurotherapeutics vol. 2,3 (2002): 347-54. doi: https://doi.org/10.1586/14737175.2.3.347
Thome J, Henn FA, Duman RS. Cyclic AMP response element-binding protein and depression. Expert Rev Neurother. 2002 May;2(3):347-54. doi: 10.1586/14737175.2.3.347. PMID: 19810866.
Copy Download .nbib Format: NLM
Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease.

Neurotoxicity research

K C S, Kakoty V, Marathe S, Chitkara D, Taliyan R.
PMID: 32683650
Neurotox Res. 2021 Apr;39(2):240-255. doi: 10.1007/s12640-020-00258-1. Epub 2020 Jul 18.

Alzheimer's disease (AD) is a neurodegenerative disorder imposing great threat to an individual's cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with impaired insulin signalling and glucose metabolism in the brain....

Cite
K C S, Kakoty V, Marathe S, et al. Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease. Neurotox Res. 2020;39(2):240-255doi: 10.1007/s12640-020-00258-1.
K C, S., Kakoty, V., Marathe, S., Chitkara, D., & Taliyan, R. (2021). Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease. Neurotoxicity research, 39(2), 240-255. https://doi.org/10.1007/s12640-020-00258-1
K C, Sarathlal, et al. "Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease." Neurotoxicity research vol. 39,2 (2021): 240-255. doi: https://doi.org/10.1007/s12640-020-00258-1
K C S, Kakoty V, Marathe S, Chitkara D, Taliyan R. Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer's Disease. Neurotox Res. 2021 Apr;39(2):240-255. doi: 10.1007/s12640-020-00258-1. Epub 2020 Jul 18. PMID: 32683650.
Copy Download .nbib Format: NLM
Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation.

Brain sciences

Kim WI, Han JY, Song MK, Park HK, Jo J.
PMID: 32806774
Brain Sci. 2020 Aug 12;10(8). doi: 10.3390/brainsci10080547.

Anodal transcranial direct current stimulation (tDCS) is a painless noninvasive method that reportedly improves cognitive function in Alzheimer's disease (AD) by stimulating the brain. However, its underlying mechanism remains unclear. Thus, the present study investigates the cognitive effects in...

Cite
Kim WI, Han JY, Song MK, et al. Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation. Brain Sci. 2020;10(8)doi: 10.3390/brainsci10080547.
Kim, W. I., Han, J. Y., Song, M. K., Park, H. K., & Jo, J. (2020). Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation. Brain sciences, 10(8), . https://doi.org/10.3390/brainsci10080547
Kim, Wang-In, et al. "Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation." Brain sciences vol. 10,8 (2020). doi: https://doi.org/10.3390/brainsci10080547
Kim WI, Han JY, Song MK, Park HK, Jo J. Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation. Brain Sci. 2020 Aug 12;10(8). doi: 10.3390/brainsci10080547. PMID: 32806774; PMCID: PMC7464566.
Copy Download .nbib Format: NLM
Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale.

Journal of Alzheimer's disease reports

Sanders O, Rajagopal L.
PMID: 32715279
J Alzheimers Dis Rep. 2020 Jun 16;4(1):185-215. doi: 10.3233/ADR-200191.

BACKGROUND: Preclinical studies, clinical trials, and reviews suggest increasing 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) with phosphodiesterase inhibitors is disease-modifying in Alzheimer's disease (AD). cAMP/protein kinase A (PKA) and cGMP/protein kinase G (PKG) signaling are disrupted...

Cite
Sanders O, Rajagopal L. Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale. J Alzheimers Dis Rep. 2020;4(1):185-215doi: 10.3233/ADR-200191.
Sanders, O., & Rajagopal, L. (2020). Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale. Journal of Alzheimer's disease reports, 4(1), 185-215. https://doi.org/10.3233/ADR-200191
Sanders, Owen, and Rajagopal, Lekshmy. "Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale." Journal of Alzheimer's disease reports vol. 4,1 (2020): 185-215. doi: https://doi.org/10.3233/ADR-200191
Sanders O, Rajagopal L. Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale. J Alzheimers Dis Rep. 2020 Jun 16;4(1):185-215. doi: 10.3233/ADR-200191. PMID: 32715279; PMCID: PMC7369141.
Copy Download .nbib Format: NLM
Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis.

Experimental neurology

Wang J, Liu B, Xu Y, Luan H, Wang C, Yang M, Zhao R, Song M, Liu J, Sun L, You J, Wang W, Sun F, Yan H.
PMID: 34563511
Exp Neurol. 2022 Jan;347:113870. doi: 10.1016/j.expneurol.2021.113870. Epub 2021 Sep 23.

Alzheimer's disease (AD) is an age-related neurodegenerative disease, which characterized by deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, neuronal loss, and accompanied by neuroinflammation. Neuroinflammatory processes are well acknowledged to contribute to the progression of AD pathology. Histamine H3...

Cite
Wang J, Liu B, Xu Y, et al. Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis. Exp Neurol. 2021;347:113870doi: 10.1016/j.expneurol.2021.113870.
Wang, J., Liu, B., Xu, Y., Luan, H., Wang, C., Yang, M., Zhao, R., Song, M., Liu, J., Sun, L., You, J., Wang, W., Sun, F., & Yan, H. (2022). Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis. Experimental neurology, 347113870. https://doi.org/10.1016/j.expneurol.2021.113870
Wang, Jiangong, et al. "Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis." Experimental neurology vol. 347 (2022): 113870. doi: https://doi.org/10.1016/j.expneurol.2021.113870
Wang J, Liu B, Xu Y, Luan H, Wang C, Yang M, Zhao R, Song M, Liu J, Sun L, You J, Wang W, Sun F, Yan H. Thioperamide attenuates neuroinflammation and cognitive impairments in Alzheimer's disease via inhibiting gliosis. Exp Neurol. 2022 Jan;347:113870. doi: 10.1016/j.expneurol.2021.113870. Epub 2021 Sep 23. PMID: 34563511.
Copy Download .nbib Format: NLM
Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease.

Brain sciences

Gonzalo-Gobernado R, Reimers D, Casarejos MJ, Calatrava Ferreras L, Vallejo-Muñoz M, Jiménez-Escrig A, Diaz-Gil JJ, Ulzurrun de Asanza GM, Bazán E.
PMID: 32455921
Brain Sci. 2020 May 22;10(5). doi: 10.3390/brainsci10050315.

Parkinson's disease is a neurodegenerative disorder characterized by the progressive death of dopaminergic (DA) neurons in the substantia nigra (SN), which leads to a loss of the neurotransmitter dopamine in the basal ganglia. Current treatments relieve the symptoms of...

Cite
Gonzalo-Gobernado R, Reimers D, Casarejos MJ, et al. Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease. Brain Sci. 2020;10(5)doi: 10.3390/brainsci10050315.
Gonzalo-Gobernado, R., Reimers, D., Casarejos, M. J., Calatrava Ferreras, L., Vallejo-Muñoz, M., Jiménez-Escrig, A., Diaz-Gil, J. J., Ulzurrun de Asanza, G. M., & Bazán, E. (2020). Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease. Brain sciences, 10(5), . https://doi.org/10.3390/brainsci10050315
Gonzalo-Gobernado, Rafael, et al. "Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease." Brain sciences vol. 10,5 (2020). doi: https://doi.org/10.3390/brainsci10050315
Gonzalo-Gobernado R, Reimers D, Casarejos MJ, Calatrava Ferreras L, Vallejo-Muñoz M, Jiménez-Escrig A, Diaz-Gil JJ, Ulzurrun de Asanza GM, Bazán E. Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease. Brain Sci. 2020 May 22;10(5). doi: 10.3390/brainsci10050315. PMID: 32455921; PMCID: PMC7287666.
Copy Download .nbib Format: NLM
Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update.

Cancers

Sapio L, Salzillo A, Ragone A, Illiano M, Spina A, Naviglio S.
PMID: 33126560
Cancers (Basel). 2020 Oct 28;12(11). doi: 10.3390/cancers12113166.

Intratumor heterogeneity (ITH) is considered the major disorienting factor in cancer treatment. As a result of stochastic genetic and epigenetic alterations, the appearance of a branched evolutionary shape confers tumor plasticity, causing relapse and unfavorable clinical prognosis. The growing...

Cite
Sapio L, Salzillo A, Ragone A, et al. Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update. Cancers (Basel). 2020;12(11)doi: 10.3390/cancers12113166.
Sapio, L., Salzillo, A., Ragone, A., Illiano, M., Spina, A., & Naviglio, S. (2020). Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update. Cancers, 12(11), . https://doi.org/10.3390/cancers12113166
Sapio, Luigi, et al. "Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update." Cancers vol. 12,11 (2020). doi: https://doi.org/10.3390/cancers12113166
Sapio L, Salzillo A, Ragone A, Illiano M, Spina A, Naviglio S. Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An Update. Cancers (Basel). 2020 Oct 28;12(11). doi: 10.3390/cancers12113166. PMID: 33126560; PMCID: PMC7693618.
Copy Download .nbib Format: NLM
Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells.

Cancers

Che M, Kweon SM, Teo JL, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY.
PMID: 32516943
Cancers (Basel). 2020 Jun 05;12(6). doi: 10.3390/cancers12061476.

BACKGROUND: Although cyclic AMP-response element binding protein-binding protein (CBP)/β-catenin signaling is known to promote proliferation and fibrosis in various organ systems, its role in the activation of pancreatic stellate cells (PSCs), the key effector cells of desmoplasia in pancreatic...

Cite
Che M, Kweon SM, Teo JL, et al. Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers (Basel). 2020;12(6)doi: 10.3390/cancers12061476.
Che, M., Kweon, S. M., Teo, J. L., Yuan, Y. C., Melstrom, L. G., Waldron, R. T., Lugea, A., Urrutia, R. A., Pandol, S. J., & Lai, K. K. Y. (2020). Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers, 12(6), . https://doi.org/10.3390/cancers12061476
Che, Mingtian, et al. "Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells." Cancers vol. 12,6 (2020). doi: https://doi.org/10.3390/cancers12061476
Che M, Kweon SM, Teo JL, Yuan YC, Melstrom LG, Waldron RT, Lugea A, Urrutia RA, Pandol SJ, Lai KKY. Targeting the CBP/β-Catenin Interaction to Suppress Activation of Cancer-Promoting Pancreatic Stellate Cells. Cancers (Basel). 2020 Jun 05;12(6). doi: 10.3390/cancers12061476. PMID: 32516943; PMCID: PMC7352534.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 69 entries