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Showing 1 to 7 of 7 entries
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Suppression of olfactory signal transduction by insecticides.

NPJ science of food

Takeuchi H, Kurahashi T.
PMID: 31304281
NPJ Sci Food. 2019 Jun 03;3:9. doi: 10.1038/s41538-019-0042-z. eCollection 2019.

2,4,6-Trichloroanisole (TCA) is a well-known, potent off-flavour compound present in various foods and beverages. TCA has been hypothesised to be a universal cause of flavour loss experienced in daily life. Here, however, we show that titres for the suppression...

Calcium Signals from the Vacuole.

Plants (Basel, Switzerland)

Schönknecht G.
PMID: 27137394
Plants (Basel). 2013 Oct 14;2(4):589-614. doi: 10.3390/plants2040589.

The vacuole is by far the largest intracellular Ca(2+) store in most plant cells. Here, the current knowledge about the molecular mechanisms of vacuolar Ca(2+) release and Ca(2+) uptake is summarized, and how different vacuolar Ca(2+) channels and Ca(2+)...

Ion Channels of Pituitary Gonadotrophs and Their Roles in Signaling and Secretion.

Frontiers in endocrinology

Stojilkovic SS, Bjelobaba I, Zemkova H.
PMID: 28649232
Front Endocrinol (Lausanne). 2017 Jun 09;8:126. doi: 10.3389/fendo.2017.00126. eCollection 2017.

Gonadotrophs are basophilic cells of the anterior pituitary gland specialized to secrete gonadotropins in response to elevation in intracellular calcium concentration. These cells fire action potentials (APs) spontaneously, coupled with voltage-gated calcium influx of insufficient amplitude to trigger gonadotropin...

Evolutionary and structural perspectives of plant cyclic nucleotide-gated cation channels.

Frontiers in plant science

Zelman AK, Dawe A, Gehring C, Berkowitz GA.
PMID: 22661976
Front Plant Sci. 2012 May 29;3:95. doi: 10.3389/fpls.2012.00095. eCollection 2012.

Ligand-gated cation channels are a frequent component of signaling cascades in eukaryotes. Eukaryotes contain numerous diverse gene families encoding ion channels, some of which are shared and some of which are unique to particular kingdoms. Among the many different...

An integrated review on new targets in the treatment of neuropathic pain.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Khangura RK, Sharma J, Bali A, Singh N, Jaggi AS.
PMID: 30627005
Korean J Physiol Pharmacol. 2019 Jan;23(1):1-20. doi: 10.4196/kjpp.2019.23.1.1. Epub 2018 Dec 26.

Neuropathic pain is a complex chronic pain state caused by the dysfunction of somatosensory nervous system, and it affects the millions of people worldwide. At present, there are very few medical treatments available for neuropathic pain management and the...

Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities.

Frontiers in pharmacology

Pikul P, Jamrógiewicz M, Nowakowska J, Hewelt-Belka W, Ciura K.
PMID: 27199759
Front Pharmacol. 2016 May 04;7:117. doi: 10.3389/fphar.2016.00117. eCollection 2016.

All activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable...

Cyclic nucleotide-gated cation channels molecular diversity, structure, and cellular functions.

Trends in cardiovascular medicine

Biel M, Zong X, Hofmann F.
PMID: 21232308
Trends Cardiovasc Med. 1996 Nov;6(8):274-80. doi: 10.1016/S1050-1738(96)00105-3.

Cyclic nucleotide-gated (CNG) channels comprise an extended family of cation channels that are directly activated by the binding of cGMP or cAMP. These channels are abundantly expressed in visual and olfactory neurons, where they play important roles in sensory...

Showing 1 to 7 of 7 entries